Category: 622-95-7

Samanta, Partha Kumar; Biswas, Rima; Bhaduri, Samanka Narayan; Ray, Shounak; Biswas, Papu published their research in Microporous and Mesoporous Materials in 2021. The article was titled 《Copper(0) nanoparticles immobilized on SBA-15: a versatile recyclable heterogeneous catalyst for solvent and ligand free C-S coupling reaction from diverse substrates》.HPLC of Formula: 622-95-7 The article contains the following contents:

A SBA-15 supported copper(0) nanoparticles based catalyst (Cu(0)MS) has been prepared using wet impregnation method. The catalyst was thoroughly characterized by several techniques including powder X-ray diffraction, nitrogen adsorption-desorption, field emission SEM-energy dispersive X-ray, transmission electron microscopy, high angle annular dark field scanning transmission electron microscopy and inductively coupled plasma-optical emission spectrometry. This mesoporous silica supported copper(0) nanoparticles had been exploited as a catalyst for ligand-free and solvent-free C-S cross-coupling reactions. Sym./unsym. aryl/alkyl sulfides R1SR2 (R1 = Ph, 2-MeOC6H4, PhCH2, PhCH:CH, 2-thienyl, etc.; R2 = Ph, n-octyl, PhCH2CH2, 2-pyridyl, etc.) had been synthesized by the S-arylation of aromatic, heteroaromatic and aliphatic thiols R2SH with aryl, heteroaryl or vinyl halides R1X (X = I, Br). Aryl chlorides also responded the reaction very well to produce aryl sulfides. The applicability of the current protocol had also been explored for the synthesis of the starting materials of different C-S bond containing pharmaceuticals. In addition, the present catalytic system was also suitable for the synthesis of a variety of sym. diaryl sulfides from aryl halides using thiourea as a sulfur source. Furthermore, it was also found that the Cu(0)MS catalyst could be reused five times without substantial loss in activity. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Category: chlorides-buliding-blocksIn 2020 ,《Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy)acetamide-based antituberculosis agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Borsoi, Ana Flavia; Paz, Josiane Delgado; Abbadi, Bruno Lopes; Macchi, Fernanda Souza; Sperotto, Nathalia; Pissinate, Kenia; Rambo, Raoni S.; Ramos, Alessandro Silva; Machado, Diana; Viveiros, Miguel; Bizarro, Cristiano Valim; Basso, Luiz Augusto; Machado, Pablo. The article conveys some information:

Using a classical mol. simplification approach, a series of 36 quinolines I [R1 = H, Me; R2 = Ph, 4-MeC6H4, 4-FC6H4, etc.] and II [R3 = Ph, Bn, 2-naphthyl, etc.] were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M. tuberculosis) growth. Structure-activity relationship (SAR) studies leaded to potent antitubercular agents, with min. inhibitory concentration (MIC) values as low as 0.3μM against M. tuberculosis H37Rv reference strain. Furthermore, the lead compounds were active against multidrug-resistant strains, without cross-resistance with some first- and second-line drugs. Testing the mols. against a spontaneous mutant strain containing a single mutation in the qcrB gene (T313A) indicated that the synthesized quinolines targeted the cytochrome bc1 complex. In addition, leading compounds were devoid of apparent toxicity to HepG2 and Vero cells and showed moderate elimination rates in human liver S9 fractions. Finally, the selected structures inhibited M. tuberculosis growth in a macrophage model of tuberculosis infection. Taken together, these data indicated that this class of compounds may furnish candidates for the future development of antituberculosis drugs. In the part of experimental materials, we found many familiar compounds, such as 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Category: chlorides-buliding-blocks)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Category: chlorides-buliding-blocks It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Journal of the Brazilian Chemical Society included an article by Dias, Maria C. F.; Gularte, Thiago Q.; Teixeira, Robson R.; Santos, Jorge A. N.; Pilau, Eduardo J.; Mendes, Tiago A. O.; Demuner, Antonio J.; dos Santos, Marcelo H.. Safety of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Synthesis of 1,2,3-triazole derivatives of 4,4′-dihydroxybenzophenone and evaluation of their elastase inhibitory activity》. The information in the text is summarized as follows:

The synthesis of a series of novel triazole derivatives I (R = 4-iodophenyl, 2-methylphenyl, 2,6-dichlorophenyl, etc.) from 4,4′-dihydroxybenzophenone along with their elastase inhibitory activity has been described. The 1,2,3-triazoles I were obtained via the copper(I)-catalyzed azide-alkyne cycloaddition reaction (CuAAC), also known as click reaction, between bis(4-(prop-2-yn-1-yloxy))benzophenone and several benzyl azides RCH2N3. It was found that five derivatives exhibited significant inhibitory effects, presenting half maximal inhibitory concentration (IC50) values in the range of 16.6 to 72.1 μM. The most active compound, namely I (R = 4-iodophenyl) (IC50 = 16.6 ± 1.9 μM), was found to bind to elastase with the inhibition constant (Ki) of 11.12 μM, thereby illustrating competitive inhibitory behavior. Further, docking investigations provided insights on the possible binding mode of the most active compound with the elastase. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Safety of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Safety of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis and evaluation of nematicidal activity of compounds derived from norbornadiene》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Gomes, Anni C. S.; Demuner, Antonio J.; Alvarenga, Elson S.; Gondim, Joao P. E.; Fonseca, Andressa R.; Buonicontro, Dalila S.; Pilau, Eduardo J.; Silva, Evandro. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

Nematode is a major problem in agriculture, the effective way to control this pest is through chem. control, but the efficient mols. present in the market have great toxicity to mammals and birds. Thus, there is a constant demand for the development of new nematicide mols. This study describes the synthesis of norbornadiene derived esters I (R = H, Me, Bn, etc.) and evaluation of their potential activity against Meloidogyne javanica. The esters I presented 50% mortality of the nematodes. The compounds acid II and the ester I (R = Me) caused 96 and 93% mortality of the nematodes, resp. The lethal concentration to kill 50% of the nematodes (LD50) were determined as being 11.8μg mL-1 for the acid II and 99.4μg mL-1 for the ester I (R = Me). According to the results obtained it is believed that polarity seems to be a key factor for the higher activity of compound II compared to structurally similar ester derivatives After reading the article, we found that the author used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis of 1,2,3-triazole benzophenone derivatives and evaluation of in vitro sun protection, antioxidant properties, and antiproliferative activity on HT-144 melanoma cells》 was written by Dias, Maria C. F.; de Sousa, Bianca L.; Ionta, Marisa; Teixeira, Robson R.; Goulart, Thiago Q.; Ferreira-Silva, Guilherme A.; Pilau, Eduardo J.; dos Santos, Marcelo H.. Product Details of 622-95-7This research focused ontriazole benzophenone derivative antioxidant antitumor photoprotective human. The article conveys some information:

Two series of 1,2,3-triazole-benzophenone derivatives I [R = R1 = Ph, 3-MeC6H4, 4-ClC6H4, etc.] and II [R2 = Ph, 2-pyridyl, 4-BrC6H4, etc.] were synthesized and their antioxidant, anticancer and photoprotective effects evaluated. For the compounds synthesis, 4,4′-dihydroxybenzophenone and 2,4-dihydroxybenzophenone were propargylated and afforded alkynes, bis(4-(prop-2-yn 1-yloxy))benzophenone and (2-hydroxy-4-(prop-2-yn-1-yloxy))benzophenone, resp. The copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction between the alkynes and several benzyl azides gave the compounds I and II with yields ranging from 35 to 95%. Compounds I and II at the concentration of 0.2μg mL-1 (a no-cytotoxic concentration) exhibited a solar protection factor (SPF) comparable to pos. control benzophonen-3 (BP-3). Concerning their antioxidant and cytotoxic effects, the derivatives from 2,4-dihydroxybenzophenone showed high in vitro antioxidant effects as well as cytotoxicity against A549 (lung carcinoma), MCF-7 (breast carcinoma) and HT-144 (metastatic melanoma) cell lines, without significant cytotoxicity to a non-cancerous cell line. Derivatives II [R2 = Ph, 4-MeC6H4, 2,4-F2C6H3] induced cell death and cell cycle arrest at G1/S in HT-144 melanoma cells. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Product Details of 622-95-7) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Product Details of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Zheng, Yu; He, Xian-Chen; Gao, Jie; Xie, Zhen-Zhen; Wang, Zhi-Wei; Liu, Zhi-Lin; Chen, Kai; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes》.Electric Literature of C7H6BrCl The author mentioned the following in the article:

A tunable iodization/deuterolysis protocol for phosphonium ylides by employing D2O as the deuterium source were designed. Notably, this process was manipulated by tuning the base, thus leading to two valuable deuterated building blocks – benzyl iodides and aromatic aldehydes with broad substrate scope, good functional group compatibility and excellent deuteration degree. Concise syntheses of a series of deuterated drug analogs was achieved based on the developed deuteration reaction platform. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Electric Literature of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Electric Literature of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Multicomponent click reaction catalyzed by organic surfactant-free copper sulfide (sf-CuS) nano/micro flowers》 was written by Velpuri, Venkateswara Rao; Muralidharan, Krishnamurthi. Related Products of 622-95-7This research focused ontriazole preparation green chem; benzyl bromide epoxide azide phenylacetylene multicomponent click reaction; surfactant free copper sulfide nano micro flower catalyst. The article conveys some information:

The copper sulfide (sf-CuS) nano/micro particles without having organic surfactant mols. as the capping agent is synthesized. These particles with a flower-like architecture (micro flowers, mf) were obtained readily under the supersaturated condition at room temperature In these particles, the surface was freely available for adsorption and desorption reactions. When utilized as a catalyst in multicomponent cycloaddition reactions, the sf-CuS mf exhibited excellent catalytic activity compared with some other nanoparticles with surfactants. This sf-CuS mf catalyzed the one-pot synthesis of 1,2,3-triazole and β-hydroxy-1,2,3-triazole effectively from a variety of benzyl bromide derivatives and epoxides resp. Both these reactions proceeded in the presence of azide and phenylacetylene in the water at room temperature The catalyst was reusable, and there was no catalyst leaching observed during reactions. Synthesis of β-hydroxy triazoles and 1,2,3-triazoles under exceptionally mild conditions with high yields proved the sf-CuS mf as the robust and recyclable catalyst. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Related Products of 622-95-7)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Related Products of 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2022,Li, Shichao; Li, Muyao; Li, Shu-Sen; Wang, Jianbo published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates》.Synthetic Route of C7H6BrCl The author mentioned the following in the article:

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Synthetic Route of C7H6BrCl) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) undergoes carbonylation in the presence of dimer of chloro(1,5-cyclooctadiene)rhodium(I) to yield the corresponding phenylacetic acid.Synthetic Route of C7H6BrCl It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Chen, Xin-Lei; Zhou, Sheng-Hua; Lin, Jin-Hong; Deng, Qing-Hai; Xiao, Ji-Chang. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene. The article was titled 《Difluorocarbene-derived trifluoromethylselenolation of benzyl halides》. The information in the text is summarized as follows:

Cu-Promoted difluorocarbene-derived trifluoromethylselenolation of benzyl halides RX [R = C6H5(CH2)2, naphthalen-2-ylmethyl, (3,4-dichlorophenyl)methyl, etc.; X = Cl, Br] with the Ph3P+CF2CO2-/Se/F- system is described. Three new carbon-heteroatom bonds, a Se-CF2 bond, SeCF2-F bond, and C-SeCF3 bond, were sequentially formed in the reaction. This work represents the first trifluoromethylselenolation protocol involving an external fluoride for the generation of the key intermediate, CF3Se- anion. The experimental process involved the reaction of 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene)

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides by carbene migratory insertion》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yan, Kaichuan; He, Maoyao; Li, Jianglian; He, Hua; Lai, Ruizhi; Luo, Yi; Guo, Li; Wu, Yong. Reference of 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:

A palladium-catalyzed cross-coupling reaction of sulfoxonium ylides 3-R-4-R1-C6H3C(C(O)OR2)=S(O)(CH3)2 [R = H, OMe; R1 = H, Cl, Me; R2 = Et, i-Bu] and benzyl bromides R3CH(R4)Br (R3 = ethenyl, Ph, naphthalen-2-yl, etc.; R4 = H, Ph) has been developed, which has potential safety advantages over previous carbene coupling reactions using either diazo compounds or their in situ precursors. This reaction affords polysubstituted olefins (Z/E)-3-R-4-R1-C6H3C(C(O)OR2)=C(R3)R4, and features good substrate tolerance and is suitable for late-stage modification of biol. active mols. Pd-carbene migratory insertion is supposed to be involved in this coupling reaction.1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Reference of 1-(Bromomethyl)-4-chlorobenzene) was used in this study.

1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) is a useful reagent for the preparation of panicinotam derivatives for use as anti-inflammatory agents or immunomodulators.Reference of 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics