Category: 6223-78-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, A new synthetic method of this compound is introduced below., SDS of cas: 6223-78-5

To 2,5-dimethyl-2,5-hexanediol (10 g, 68.5 mmol) in a 500 mL flask was added reagent grade concentrated HCl (150 mL) and the solution was stirred at ambient temperature for 1 h. Water (100 mL) and CH2Cl2 (100 mL) were then added slowly and the layers were separated. The aqueous layer was washed with additional CH2Cl2 (100 mL). The combined organic layers were dried over MgSO4 and filtered thru silica gel pad. The solvent was removed to yield 10.9g (87%) of 2,5-dichloro-2,5-dimethylhexane. The dichloride was dissolved in 150 mL Of CH2Cl2 and 9.6 mL of toluene (90 mmol) was added. AlCl3 (390 mg, 2.9 mol) was added in portions over 5 min at ambient temperature. HCl is evolved and the solution turns dark red. The reaction was placed in an ice-bath and quenched with deionized water (120 mL). Hexane (150 mL) was added and the organic layer was removed. The aqueous layer was washed with additional hexane (150 mL). The combined organic layers were washed with water (200 mL) and brine (100 mL) and dried over MgSO4. The solvent was removed in vacuo to give l,l,4,4,6-pentamethyl-l,2,3,4- tetrahydronaphthalene as a colorless oil that crystallized after storage at -2O0C.[0155] Yield: 12 g (91%); low melting white solid; Rf = 0.7 in 100% hexane.[0156] 1H-NMR (CDCl3, 300 MHz) delta 1.32 (s, 12H), 1.7 (s, 4H), 2.34 (s, 3H), 6.85 (dd, IH), 7.14 (d, IH), 7.22 (d, IH)[0157] 13C-NMR (CDCl3, 75 MHz) delta 21.54, 32.26, 32.32, 34.29, 34.51, 35.57, 35.63, 126.64, 126.75, 127.21, 134.93, 142.00, 144.83.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2007/22437; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H16Cl2

(1) Synthesis of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-methylnaphthalene (b) The synthesis process is as set forth in the chemical reaction formula below. Into anhydrous toluene (10 mL) were added aluminum chloride (200 mg, 1.5 mmol), 2,5-dichloro-2,5-dimethylhexane (4.70 g, 25.7 mmol) followed by stirring at room temperature for 24 hours. The reaction solution was poured into cold water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution, and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The yield was 4.90 g (94%). 1H-NMR (500 MHz, CDCl3) delta 7.20 (d, 1H, J=8.0 Hz), 7.10 (d, 1H, J=1.2 Hz), 6.95 (dd, 1H, J=6.5, 1.2 Hz), 2.29 (s, 3H), 1.67 (s, 4H), 1.28 (s, 6H), 1.26 (s, 6H).

The synthetic route of 6223-78-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Baba, Masanori; Hashimoto, Yuichi; US2011/172185; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6223-78-5, A common heterocyclic compound, 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, molecular formula is C8H16Cl2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphtalene 4: To a solution of 2,5 dichloro-2,5 dimethylhexane 2 (10 g, 54.7 mmol) in toluene (270 Ml, 0.2 M) is slowly added aluminum trichloride (5.47 g, 41 mmol) as a solid over a 15-minute period. The reaction is complete after 10 minutes as assayed by tlc in hexanes. The unreacted aluminum trichloride is quenched slowly with water over 10 minutes. Additional toluene (250 mL) is added to extract the product from the aqueous layer. The organic layer is passed through a pad of silica gel (40 g) and eluted with toluene. The organic layer is evaporated in vacuo to dryness to yield 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphtalene 4 (11 g, 97% yield). NMR 1.29 (s, 6H), 1.28 (s, 6H), 1.69 (s, 4H), 2.32 (s, 3H), 7.22 (d, 1H), 7.12 (s, 1H), 6.97 (dd, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Pfizer Inc.; US2004/10033; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, molecular formula is C8H16Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6223-78-5

(c) 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene (2): To a 1000 mLround-bottomed flask fitted with water condenser were added compound 1(30.0 g, 165 mmol), toluene (35.1 mL, 330 mmol) and CH2Cl2 (150 mL). To thisvigorously stirred solution was added aluminum chloride (1.92 g, 1.4 mmol)slowly in portionwise, which resulted in rapid evolution of gaseoushydrochloride acid. The reaction mixture was stirred at RT for 30 minfollowed by additional aluminum chloride (400 mg). After the reactionmixture was stirred and heated to reflux for 15 min, it was cooled in an icebath and quenched with 20% HCl aqueous solution (150 mL). The mixture wasextracted with hexanes; the combined organic layers were washed with waterand brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo.The crude product was purified by column chromatography with hexanes toafford 2 as a white solid (28.3 g, 85%), mp 34-35 C (lit.2 34-36 C). 1H NMR(CDCl3): d 7.40 (d, J = 8.0 Hz, 1H), 7.31 (s, 1H), 7.14 (d, J = 8.0 Hz, 1H), 2.49 (s,3H), 1.87 (s, 4H), 1.48(s, 6H), 1.47 (s, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6223-78-5, its application will become more common.

Reference:
Article; Wang, Min; Davis, Toni; Gao, Mingzhang; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2015); p. 1742 – 1747;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 6223-78-5

Into a 100-mL round-bottom flask, was placed methylbenzene (60 ml_), 2, 5- dichloro-2, 5-dimethylhexane (5 g, 27.30 mmol, 1.00 eq.). This was followed by the addition of AICI3 (2.7 g, 20.48 mmol, 0.75 eq.) in several portions at 0C. The resulting solution was stirred for 1 h at room temperature. The reaction mixture was cooled to 0 C. The reaction was then quenched by the addition of 30 ml_ of water. The resulting solution was extracted with 2×50 ml_ of ethyl acetate and the organic layers combined. The resulting mixture was washed with 1 x50 ml_ of brine and dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with EtOAc/petroleum ether (1/5). This resulted in 6.6 g (crude) of 1 , 1 ,4,4,6-pentamethyl-1 ,2,3,4-tetrahydronaphthalene as light yellow oil.

The synthetic route of 6223-78-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAWN SCIENTIFIC PHARMACEUTICALS, LLC; TSAI, Donald; KAELIN, David; (60 pag.)WO2019/169270; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 6223-78-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 1000 mL round-bottomed flask fitted with water condenser were added compound 1 (30.0 g, 165 mmol), toluene (35.1 mL, 330 mmol) and CH2Cl2 (150 mL). To this vigorously stirred solution was added aluminum chloride (1.92 g, 1.4 mmol) slowly in portionwise, which resulted in rapid evolution of gaseous hydrochloride acid. The reaction mixture was stirred at RT for 30min followed by additional aluminum chloride (400 mg). After the reaction mixture was stirred and heated to reflux for 15 min, it was cooled in an ice bath and quenched with 20% HCl aqueous solution (150mL). The mixture was extracted with hexanes; the combined organic layers were washed with water and brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography with hexanes to afford 2 as a white solid (28.3g, 85%), mp 34-35C (lit.2 34-36C). 1H NMR (CDCl3): delta 7.40 (d, J=8.0Hz, 1H), 7.31 (s, 1H), 7.14 (d, J=8.0Hz, 1H), 2.49 (s, 3H), 1.87 (s, 4H), 1.48(s, 6H), 1.47 (s, 6H).

The synthetic route of 2,5-Dichloro-2,5-dimethylhexane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Min; Davis, Toni; Gao, Mingzhang; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1742 – 1747;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H16Cl2

For comparison in the biological evaluation (Fig. 1 and 2) of compounds 1 – 3, [8 and 9] and 30-32, [8b and 9b] an authentic sample of bexarotene and its ketone analog (33a) were synthesized, following the reported route (Boehm, et al. “Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids.” J. Med. Chem. 1994, 37, 2930-2941 ): a seven step, convergent synthesis that gave a 29% overall yield of bexarotene. The first sequence of steps to bexarotene concerned the SN1 conversion of 2,5-dimethyl-2,5-hexanediol (33b) to 2,5-dichloro-2,5- dimthylhexane (34) by HCI, and the subsequent aluminum trichloride catalyzed Friedel-Crafts alkylation of toluene to give 1 ,2,3,4-tetrahydro-l .l A4,6-pentamethylnapthalene (35) in 68% yield over two steps (Scheme 1 ).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6223-78-5.

Reference:
Patent; ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan; WO2011/103321; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,5-Dichloro-2,5-dimethylhexane

10351] A flame-dried 50-mE pressure vessel, equipped with a Teflon stir bar, was charged with phenol SO (2 g, 21.25 mmol, 1 equiv.), 2,5-dichloro-2,5-dimethylhexane (4.28 g, 23.38 mmol, 1.1 eqiuv.) and CH2C12 (20 mE). Aluminum trichloride (2.83 g, 21.25 mmol, 1 equiv.) was added to this reaction mixture and the reaction was stirred at 500 C. for 12 h. The reaction mixture was quenched by the addition of distilled H20 (20 mE), and the phases were separated. The aqueous phase was washed with CH2C12 (3×20 mE). The combined organic fractions were dried over Mg504, filtered and concentrated in vacuo to afford a crude residue, which was purified using flash column chromatography (silica gel with 15% EtOAc in hexanes as eluant) to afford Si as white powder in 70% isolated yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY; LUMB, JEAN-PHILIP; ESGUERRA, KENNETH V.N.; (118 pag.)US2017/66711; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6223-78-5, name is 2,5-Dichloro-2,5-dimethylhexane, A new synthetic method of this compound is introduced below., Computed Properties of C8H16Cl2

To 2,5-dimethyl-2,5-hexanediol (10 g, 68.5 mmol) in a 500 mL flask was added reagent grade concentrated HCl (150 mL) and the solution was stirred at ambient temperature for 1 h. Water (100 mL) and CH2Cl2 (100 mL) were then added slowly and the layers were separated. The aqueous layer was washed with additional CH2Cl2 (100 mL). The combined organic layers were dried over MgSO4 and filtered thru silica gel pad. The solvent was removed to yield 10.9g (87%) of 2,5-dichloro-2,5-dimethylhexane. The dichloride was dissolved in 150 mL Of CH2Cl2 and 9.6 mL of toluene (90 mmol) was added. AlCl3 (390 mg, 2.9 mol) was added in portions over 5 min at ambient temperature. HCl is evolved and the solution turns dark red. The reaction was placed in an ice-bath and quenched with deionized water (120 mL). Hexane (150 mL) was added and the organic layer was removed. The aqueous layer was washed with additional hexane (150 mL). The combined organic layers were washed with water (200 mL) and brine (100 mL) and dried over MgSO4. The solvent was removed in vacuo to give l,l,4,4,6-pentamethyl-l,2,3,4- tetrahydronaphthalene as a colorless oil that crystallized after storage at -2O0C.[0155] Yield: 12 g (91%); low melting white solid; Rf = 0.7 in 100% hexane.[0156] 1H-NMR (CDCl3, 300 MHz) delta 1.32 (s, 12H), 1.7 (s, 4H), 2.34 (s, 3H), 6.85 (dd, IH), 7.14 (d, IH), 7.22 (d, IH)[0157] 13C-NMR (CDCl3, 75 MHz) delta 21.54, 32.26, 32.32, 34.29, 34.51, 35.57, 35.63, 126.64, 126.75, 127.21, 134.93, 142.00, 144.83.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2007/22437; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6223-78-5 as follows. 6223-78-5

In a 250 ml_ round-bottomed flask was weighed T-1 (1.8 g, 10 mmol). Dry DCE (20 ml_) was added followed by dry toluene (921 mg, 10 mmol, 1 equiv). Then AICI3 (133 mg, 1 mmol, 10 mol%) was added in portions. The resulting mixture was stirred under argon for 16 h. The mixture was cooled to room temperature, and then poured on ice-water (50 ml_). The organic layer was separated and the aqueous layer was extracted with Et2Patent; QUEEN’S UNIVERSITY AT KINGSTON; CAMERON, Donald Andrew; PETKOVICH, Martin; RANTANEN, Toni Kristian; SNIECKUS, Victor; BOARD, Johnathan; SINGH, Suneel; MAHETA, Ashishkumar Jayantilal; (76 pag.)WO2018/107289; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics