Category: 6249-56-5

Shelly, Kevin P. published the artcileGeneral acid catalysis in the enolization of acetone, Application In Synthesis of 6249-56-5, the publication is Canadian Journal of Chemistry (1989), 67(8), 1274-82, database is CAplus.

Iodometry was used to study the enolization of acetone in water catalyzed by HCl, MeSO₃H, 24 aliphatic monocarboxylic acids, nine aromatic monocarboxylic acids, eight aliphatic dicarboxylic acids, and 20 monoanions of dicarboxylic acids. The log k-pK profile for unbuffered solutions of strong and moderately strong acids shows a maximum near pK â‰?0. The Broensted α value for a set of eight aliphatic monocarboxylic acids in which effects of bulk, charge, and polarizability are at a min. is 0.56. Steric effects, probably augmented by polarizability effects in some cases, cause pos. deviations form the Broensted line drawn with respect to these standard acids. Anionic carboxylic acids are also more reactive than would be predicted from their equilibrium acid strengthens, whereas cationic acids tend to be less reactive. Using D₂O as solvent has only a small effect on the rate of carboxylic acid catalysis. Using acetone-d₆ gives values of k_H/k_D in the range of 7.0-8.0 at 25°, values consistent with a proton or deuteron being transferred between two bases of comparable strength, the carboxylate anion and the enol form of acetone.

Canadian Journal of Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C8H5F3O3, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Takahashi, Hidehiko published the artcileRelation between pharmacological actions on the mammalian ileum and chemical structure of γ-aminobutyric acid (GABA), Computed Properties of 6249-56-5, the publication is Japan J. Physiol. (1961), 229-37, database is CAplus.

The effects of GABA, its derivatives and related compounds on the isolated ileum of the guinea-pig, rabbit, and cat were investigated. GABA caused sustained tone-increasing, or relaxing or transient tone-increasing one followed by relaxation, whereas other ω-amino-acids, such as glycine, δ-aminovaleric acid, and ε-aminocaproic acid had no effect; β-alanine (10^-2M) sometimes produced a slight relaxation. α-Aminobutyric acid and β-aminoisobutyric acid had no effect. 4-Aminobutanol and N-methyl-4-aminobutanol at very high concentrations had a slight stimulant action, although BuOH had none. N-Substitution by Ac, Ph, Bu, or M group reduced the relaxing activity of GABA. Methyl esterification of GABA increased its stimulant activity, but these stimulant effects were antagonized by atropine. As the chem. structure of GABA became more like that of acetylcholine (Ach) its stimulant activity increased; however, even N,N,N-trimethyl-GABA methyl ester, the strongest methyl ester stimulant, was far weaker than Ach. N-Ethylation and N-butylation lessened the stimulant effect of GABA methyl ester and N-phenylation reversed it to a relaxing effect. N-Methyl-GABA ethyl ester had less stimulant effect than N-methyl-GABA methyl ester. N-Methyl-GABA butyl ester and N-methyl-GABA benzyl ester had a marked relaxing effect. N-Methyl-GABA ethyl ester had a weak relaxing action in lower concentrations but a stimulant effect in higher concentrations On the contrary, N-methyl-GABA butyl ester had a weak stimulant effect in lower concentration, but a strong relaxing one in higher concentrations The effects of the β-hydroxy derivative of GABA (GABOB) and its Me ester were similar to that of GABA and its methyl ester but were weaker. Nicotinic acid, isonicotinic acid, and their methyl esters produced a slight relaxation. The rabbit ileum and cat ileum responded in similar manner, but were less sensitive than the guinea-pig ileum.

Japan J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H43NP2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, K. published the artcileThin-layer chromatography of methyl N-trimethyl-γ-aminobutyrate chloride and related compounds, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Chromatography (1974), 90(1), 230-2, database is CAplus.

The best separation of trimethylaminobutyrate derivatives[Me3N+(CH2)3CO2RCl-] came when a plate was heated for 1 hr at 120°. Sharp spots free from tailing were found in the solvent system EtOAc-HCO2H-water. Increasing the HCO2H concentration gave higher Rf values, but did not improve separation The Rst values were applied using crystal violet as the standard and the results were better in terms of reproducibility.

Journal of Chromatography published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Adamiak, Lisa published the artcilePeptide Brush Polymers and Nanoparticles with Enzyme-Regulated Structure and Charge for Inducing or Evading Macrophage Cell Uptake, SDS of cas: 6249-56-5, the publication is ACS Nano (2017), 11(10), 9877-9888, database is CAplus and MEDLINE.

Cellular uptake by macrophages and ensuing clearance by the mononuclear phagocyte system stands as a significant biol. barrier for nanoparticle therapeutics. While there is a growing body of work investigating the design principles essential for imparting nanomaterials with long-circulating characteristics and macrophage evasion, there is still a widespread need for examining stimuli-responsive systems, particularly well-characterized soft materials, which differ in their physiochem. properties prior to and after an applied stimulus. In this work, we describe the synthesis and formulation of polymeric nanoparticles (NPs) and soluble homopolymers (Ps) encoded with multiple copies of a peptide substrate for proteases. We examined the macrophage cell uptake of these materials, which vary in their peptide charge and conjugation (via the N- or C-terminus). Following treatment with a model protease, thermolysin, the NPs and Ps undergo changes in their morphol. and charge. After proteolysis, zwitterionic NPs showed significant cellular uptake, with the C-terminus NP displaying higher internalization than its N-terminus analog. Enzyme-cleaved homopolymers generally avoided assembly and uptake, though at higher concentrations, enzyme-cleaved N-terminus homopolymers assembled into discrete cylindrical structures, whereas C-terminus homopolymers remained dispersed. Overall, these studies highlight that maintaining control over NP and polymer design parameters can lead to well-defined biol. responses.

ACS Nano published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, SDS of cas: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jia, Ruonan published the artcileSunlight-Driven Wearable and Robust Antibacterial Coatings with Water-Soluble Cellulose-Based Photosensitizers, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Advanced Healthcare Materials (2019), 8(5), n/a, database is CAplus and MEDLINE.

Herein, a simple, effective, and general strategy is demonstrated to obtain a water-soluble and nontoxic cellulose-based photosensitizer (CPS) with enhanced photodynamic antibacterial activity through introducing protoporphyrin IX (PpIX) and quaternary ammonium salt (QAS) groups onto the cellulose backbone. The synergistic effect of the anchoring and diluting effect of the cellulose backbone and the electrostatic repulsion between QAS groups effectively inhibit the π-π stacking of PpIX groups, thus the as-prepared CPS exhibits markedly enhanced reactive oxygen species (ROS) yield. Meanwhile, the pos. charged QAS groups endow the CPS with water-solubility and a strong attractive force to bacteria. As a result, the CPS can rapidly and efficiently kill drug-resistant bacteria strains, including E. coli and S. aureus, with a low light dose (2.4 J cm-2) and low concentration of PpIX groups (0.35 × 10-6M). Benefiting from the excellent processability and formability, the CPS is readily applied as a sunlight-driven wearable and robust antibacterial coating by a spray coating and later crosslinking procedure.

Advanced Healthcare Materials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tsuei, Michael published the artcileInterfacial Polyelectrolyte-Surfactant Complexes Regulate Escape of Microdroplets Elastically Trapped in Thermotropic Liquid Crystals, Name: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Langmuir (2022), 38(1), 332-342, database is CAplus and MEDLINE.

Polyelectrolytes adsorbed at soft interfaces are used in contexts such as materials synthesis, stabilization of emulsions, and control of rheol. Here, we explore how polyelectrolyte adsorption to aqueous interfaces of thermotropic liquid crystals (LCs) influences surfactant-stabilized aqueous microdroplets that are elastically trapped within the LC. We find that adsorption of poly(diallyldimethylammonium chloride) (PDDA) to the interface of a nematic phase of 4-cyano-4�pentylbiphenyl (5CB) triggers the ejection of microdroplets decorated with sodium dodecylsulfate (SDS), consistent with an attractive elec. double layer interaction between the microdroplets and LC interface. The concentration of PDDA that triggers release of the microdroplets (millimolar), however, is three orders of magnitude higher than that which saturates the LC interfacial charge (micromolar). Observation of a transient reorientation of the LC during escape of microdroplets leads us to conclude that complexes of PDDA and SDS form at the LC interface and thereby regulate interfacial charge and microdroplet escape. Poly(sodium 4-styrenesulfonate) (PSS) also triggers escape of dodecyltrimethylammonium bromide (DTAB)-decorated aqueous microdroplets from 5CB with dynamics consistent with the formation of interfacial polyelectrolyte-surfactant complexes. In contrast to PDDA-SDS, however, we do not observe a transient reorientation of the LC when using PSS-DTAB, reflecting weak association of DTAB and PSS and slow kinetics of formation of PSS-DTAB complexes. Our results reveal the central role of polyelectrolyte-surfactant dynamics in regulating the escape of the microdroplets and, more broadly, that LCs offer the basis of a novel probe of the structure and properties of polyelectrolyte-surfactant complexes at interfaces. We demonstrate the utility of these new insights by triggering the ejection of microdroplets from LCs using peptide-polymer amphiphiles that switch their net charge upon being processed by enzymes. Overall, our results provide fresh insight into the formation of polyelectrolyte-surfactant complexes at aqueous-LC interfaces and new principles for the design of responsive soft matter.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H6Cl2O, Name: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

van der Maaden, Koen published the artcileFluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK_a Determination of Self-Assembled Monolayers on Silicon Surfaces, Related Products of chlorides-buliding-blocks, the publication is Langmuir (2012), 28(7), 3403-3411, database is CAplus and MEDLINE.

Since the computer industry enables one to generate smaller and smaller structures, silicon surface chem. is becoming increasingly important for (bio-)anal. and biol. applications. For controlling the binding of charged biomacromols. such as DNA and proteins on modified silicon surfaces, the surface pK_a is an important factor. Here the authors present a fluorescent nanoparticle adhesion assay as a novel method to determine the surface pK_a of silicon surfaces modified with weak acids or bases. This method is based upon electrostatic interactions between the modified silicon surface and fluorescent nanoparticles with an opposite charge. Silicon slides were modified with 3-aminopropyltriethoxysilane (APTES) and were further derivatized with succinic anhydride. Layer thickness of these surfaces was determined by ellipsometry. After incubating the surfaces with an amine-reactive fluorescent dye, fluorescence microscopy revealed that the silicon surfaces were successfully modified with amine- and carboxyl-groups. Two surface pK_a values were found for APTES surfaces by the fluorescent nanoparticle adhesion assay. The 1st surface pK_a (6.55 ± 0.73) was comparable with the surface pK_a obtained by contact angle titration (7.3 ± 0.8), and the 2nd surface pK_a (9.94 ± 0.19) was only found by using the fluorescent nanoparticle adhesion assay. The surface pK_a of the carboxyl-modified surface by the fluorescent nanoparticle adhesion assay (4.37 ± 0.59) did not significantly differ from that found by contact angle titration (5.7 ± 1.4). In conclusion, the authors have developed a novel method to determine the surface pK_a of modified silicon surfaces: the fluorescent nanoparticle adhesion assay. This method may provide a useful tool for designing pH-dependent electrostatic protein and particle binding/release and to design surfaces with a pH-dependent surface charge for (bio-)anal. lab-on-a-chip devices or drug delivery purposes.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H28N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morita, Hirokazu published the artcileDifferential thermographic features of some crystalline biopolymers, HPLC of Formula: 6249-56-5, the publication is Biopolymers (1966), 4(2), 215-22, database is CAplus.

Thermograms are shown for globular, serum, and blood plasma proteins, calf thymus DNA, sodium triticonucleate, sodium thermonucleate, sperm DNA, yeast RNA, adenosine 3′-phosphate, adenosine 5′-phosphate, disodium adenosine triphospate, adenosine, and deoxyadenosine. A pronounced effect of moisture on the differential thermal properties of DNA was observed. Solid-state denaturation may be one of the prominent thermal effects recorded by the differential thermal analysis of proteins and nucleic acids.

Biopolymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mistryukov, E. A. published the artcileSynthesis and steric structure of some 1-methyl-4-phenyl-4-piperidinols, COA of Formula: C7H16ClNO2, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 623-6, database is CAplus.

cf. CA 52, 20159b. PhLi from 17 g. Li treated in Et₂O with 127.6 g. 1-methylperhydro-4-pyrindone gave, after refluxing 4 h. and treating with aqueous HCl, followed by NaOH, 44% 1-methyl-4-phenylperhydro-4-pyrindole (I), b_0.3 136-46°, m. 45.5-6.5° (HCl salt m. 221-2°), along with a small amount of a base, C₂₃H₂₉NO, m. 71-2°; the mother liquors gave a base, m. 4850° (picrate decomposed at 199-200°; propionate HCl salt m. 206-7°), whose structure was not determined I formed a picrate, m. 157-7.5°. PhLi and 1-methyldecahydro-4-quinolone gave 63.7% isomeric alcs. in 62:24:14 ratio: α-form of 1-methyl-4-phenyldecahydro-4-quinolol, m. 126.5-7°; β-form, m. 112-13° (HCl salt m. 216-19°); and γ-form, m. 148-50°. Heating (CCMe₂OH)₂ with p-MeC₆H₄SO₃H in the presence of pyrogallol at 100°/100 mm. 1 h. gave H₂O and CO₂ and a residue of 2,5-dimethyl-1,5-hexadien-3-yne, b₄₀ 46-9°, and 2,5-dimethyl-5-hexen-3-yn-2-ol, b₁₃ 64-7°. Treatment of 2,5-dimethyl-1,4-hexadien-3-one and its MeOH adducts (crude mixture, Nazarov and Bukhmutskaya, CA 42, 7733e) with 39% aqueous MeNH₂ 2 days at room temperature gave, after treatment with H₂O and aqueous HCl, followed by NaOH, 40% 1,2,2,5-tetramethyl-4-piperidone, b₁₅ 90-3°, n²⁰_D 1.4620 (HCl salt m. 195.5°; picrate m. 180-80.5°). This and PhLi gave only 1 isomer of 1,2,2,5-tetramethyl-4-phenyl-4-piperidinol, m. 81-2°; HCl salt m. 201° (hydrate m. 152-3°). This piperidinol probably had equatorial Ph and Me groups at C-5. Only I showed evidence of internal H-bonding in the IR spectrum.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herbain, Maurice published the artcileA biologic test of antilipemic heparin derivatives, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Clinica Chimica Acta (1960), 204-7, database is CAplus and MEDLINE.

cf. Velluz, et al., CA 53, 10555g, 19898g. Rabbits were fed a diet containing saturated fats and 200 mg./kg./day cholesterol for a period of 30 days. Those animals in which serum total cholesterol levels reached 8 g./l. or more were selected for testing. The ratio of β-lipoprotein lipide/total lipide exceeded 0.70 compared to a control value of 0.35. After removal of cholesterol from the diet for 24 hrs., 5 mg./kg. heparin or other antilipemic agent was injected intravenously and total and β-lipoprotein lipides (the latter were precipitated with dextran) were estimated at 6, 10, and 14 hrs. When the test was carried out with N-dimethylbenzoyl-N-desulfoheparin, its antilipemic activity was found to be slower but more intense than that of heparin.

Clinica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics