Category: 6249-56-5

Zhu, Jingyi published the artcile^99mTc-Labeled Polyethylenimine-Entrapped Gold Nanoparticles with pH-Responsive Charge Conversion Property for Enhanced Dual Mode SPECT/CT Imaging of Cancer Cells, Application In Synthesis of 6249-56-5, the publication is Langmuir (2019), 35(41), 13405-13412, database is CAplus and MEDLINE.

Development of tumor dual mode contrast agents is still a great challenge due to the relative low accumulation at tumor site, which result in the poor imaging efficiency. In this study, we constructed functional technetium-99m (^99mTc) labeled polyethylenimine (PEI)-entrapped gold nanoparticles (Au PENs) with pH-responsive charge conversion property for enhanced single photon emission computed tomog. (SPECT)/computed tomog. (CT) dual mode imaging of cancer cells. PEI with amine functional groups (PEI.NH₂) was successively modified with monomethyl ether and carboxyl functionalized polyethylene glycol (mPEG-COOH), maleimide and succinimidyl valerate functionalized PEG (MAL-PEG-SVA), diethylenetriaminepentaacetic dianhydride (DTPA), and fluorescein isothiocyanate (FI), and used to entrapped gold nanoparticles inside, followed by conjugation with the alkoxyphenyl acylsulfonamide (APAS) through the PEG maleimide, acetylation of the PEI leftover surface amines and ^99mTc labeling. The created nanosystem with the mean Au core diameter of 3.3 nm and with a narrow size distribution displays an excellent colloidal stability and desired cytocompatibility in the investigated Au concentration range. Due to the fact that the attached APAS moieties are responsive to pH, the functionalized Au PENs with a neutral surface charge can switch to be pos. charged under slightly acidic pH condition, which could improve the cellular uptake by cancer cells. With these properties, the developed functionalized Au PENs could achieve enhanced dual mode SPECT/CT imaging of cancer cells in vitro. The constructed PEI-based nanodevices may be adopted as an excellent dual mode contrast agent for SPECT/CT imaging of cancer cells of different types.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4H6O3, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Leimbacher, Markus published the artcileDiscovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Chemistry – A European Journal (2012), 18(25), 7729-7737, S7729/1-S7729/120, database is CAplus and MEDLINE.

Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions.

Chemistry – A European Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morano, Cain published the artcileMultiple Isotopic Labels for Quantitative Mass Spectrometry, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Analytical Chemistry (Washington, DC, United States) (2008), 80(23), 9298-9309, database is CAplus and MEDLINE.

Quant. mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammonium butyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light form without deuterium). In the present report, two addnl. forms containing three and six deuteriums have been synthesized and tested. These addnl. isotopic tags perform identically to the previously reported tags; peptides labeled with the new TMAB reagents coelute from reversed-phase HPLC columns with peptides labeled with the lighter and heavier TMAB reagents. Altogether, these four tags allow for multivariate anal. in a single liquid chromatog./mass spectrometry anal., with each isotopically tagged peptide differing in mass by 3 Da per tag incorporated. The synthetic scheme is described in simple terms so that a biochemist without specific training in organic chem. can perform the synthesis. The interpretation of tandem mass spectrometry data for the TMAB-labeled peptides is also described in more detail. The addnl. TMAB isotopic reagents described here, together with the addnl. description of the synthesis and anal., should allow these labels to be more widely used for proteomics and peptidomics analyses.

Analytical Chemistry (Washington, DC, United States) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jin, Kunfeng published the artcileFacile Access to Solid-State Carbon Dots with High Luminescence Efficiency and Excellent Formability via Cellulose Derivative Coatings, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(15), 5937-5945, database is CAplus.

Carbon dots (CDs), which are one kind of novel fluorescent materials, exhibit benign biocompatibility, high photobleaching resistance, and easy processing; thus, they have attracted a lot of attention. However, the intrinsic self-aggregation of nanoscale-sized CDs leads to fluorescence quenching, thereby limiting their application in the solid state. In this work, we demonstrate an effective and universal method to obtain solid-state CDs with high luminescence efficiency and excellent formability. Taking advantage of the charged surfaces of most CDs, we utilize two types of eco-friendly cellulose derivatives with pos. or neg. charges to surround the CDs via electrostatic attractions. As a result, the particles of CDs have been isolated and their aggregation-induced quenching phenomenon has been inhibited. The obtained CDs@cellulose derivative powders show bright fluorescence and have a high fluorescence quantum yield (QY); for example, the QY of blue-emitting powder reaches up to 71.5%. Such a simple strategy is available for various CDs. More significantly, the excellent processability and formability of cellulose derivatives enable CDs@cellulose derivatives to be easily processed into films, coatings, and printing inks, providing a huge potential in eco-friendly solid-emitting devices and light-stable anticounterfeiting labels. CDs-based solid fluorescent materials were fabricated by constructing a shell layer with charged cellulose chains via electrostatic attractions.

ACS Sustainable Chemistry & Engineering published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, Kazumi published the artcilePyrolysis reaction of carpronium chloride and its structurally related compounds. 1. Electronic and steric effects on the orientation of the pyrolysis reaction, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Organic Mass Spectrometry (1983), 18(1), 27-33, database is CAplus.

The pyrolysis reaction of carpronium chloride [MeO₂C(CH₂)₃N⁺Me₃ Cl^–] and the structurally related compounds RO₂C(CH₂)_nN⁺Me₃ Cl^– (n = 2, 4, R = Me, Et, CHMe₂; n = 3, R = H, Et, CHMe₂), were studied by gas chromatog.-mass spectroscopy. The reaction modes of these ammonium compounds are dependent on the number of skeletal methylene groups and on the length of the carbon chain of the ester group. These phenomena were interpreted in terms of electronic and steric contributions for the ionic elimination reaction. The electronic and steric effects on the orientation of the reaction were discussed on the basis of the at. population calculated by the CNDO/2 method.

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, Kazumi published the artcileIntermolecular methyl transfer on pyrolysis of carpronium chloride, HPLC of Formula: 6249-56-5, the publication is Organic Mass Spectrometry (1979), 14(2), 61-5, database is CAplus.

Me transfer occurring in the formation of Me₂N(CH₂)₃CO₂Me (I) by pyrolysis of Me₃N⁺(CH₂)₃CO₂R Cl^– (II; R = Me) was examined using pyrolysis gas chromatog.-mass spectrometry of I and II (R = H, Me, Et, CHMe₂) and D labeling studies. Characteristic mol. ion peaks in the mass spectra of I and its deuterated analogs indicated intermol. Me transfer during pyrolysis of II (R = Me) to form I in which the Me group in the methoxycarbonyl group is replaced by an Me from the Me₃N group. The mechanism presented involves the bimol. reaction between zwitterionic intermediates formed by ionic O-demethylation of II (R = Me).

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vega, Beatriz published the artcileCharge-Directed Fiber Surface Modification by Molecular Assemblies of Functional Polysaccharides, Quality Control of 6249-56-5, the publication is Langmuir (2013), 29(44), 13388-13395, database is CAplus and MEDLINE.

Mol. assemblies, namely, polyelectrolyte complexes (PECs) composed of neg. charged xylan-based derivatives and a novel pos. charged cellulose derivative (CN⁺), were used for interfacial modification of wood fibers by charge directed self-assembly. The adsorption process was studied using polyelectrolyte titration and elemental anal. X-ray spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used as advanced techniques for the characterization of the modified fiber surfaces. The measurements revealed an intense interaction between the pulp fibers and PECs, and provided essential information for a better understanding of the adsorption process. The information gathered on this paper might contribute to the basis for the development of new value added products by the use of underutilized biomass.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C10H9IO4, Quality Control of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vega, Beatriz published the artcilePreparation of reactive fiber interfaces using multifunctional cellulose derivatives, Computed Properties of 6249-56-5, the publication is Carbohydrate Polymers (2015), 261-273, database is CAplus and MEDLINE.

Cellulose fibers have poor reactivity and limited potential for surface engineering with advanced chem. functionalization in water. In this work, cellulose fibers were decorated with azide functions by charge-directed self-assembly of a novel water-soluble multifunctional cellulose derivative yielding reactive fibers. Propargylamine and 1-ethynylpyrene were utilized as a proof of concept that alkyne mols. may react with the azide functions of the reactive fibers via copper(I)-catalyzed azide-alkyne Huisgen cycloaddition (CuAAc) reaction in mild conditions. Chem. characterization of the fibers was carried out using classical techniques such as Raman-, fluorescence-, and UV-vis spectroscopy. Among other techniques, time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray spectroscopy (XPS), two-photon microscopy (TPM), and inductively coupled plasma mass spectrometry (ICP-MS) were useful tools for addnl. characterization of the fibers decorated with amino- or photoactive groups. The information gathered in this work might contribute to the basis for the preparation of reactive cellulose-based interfaces with potential application in CuAAc reactions.

Carbohydrate Polymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C44H58NO5PPdS, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grigoray, Olga published the artcileFluorescent Multifunctional Polysaccharides for Sustainable Supramolecular Functionalization of Fibers in Water, Computed Properties of 6249-56-5, the publication is ACS Sustainable Chemistry & Engineering (2017), 5(2), 1794-1803, database is CAplus.

The paper describes the synthesis of multifunctional cellulose derivatives (MCD) containing a fluorescent- and a cationic moiety and their application in the functionalization of pulp fibers. The cellulose derivatives, namely N-(3-propanoic acid)- and N-(4-butanoic acid)-1,8-naphthalimide esters of cellulose, differed in the degree of substitution (DS) and by the aliphatic chain connecting naphtalimide photoactive groups to the polymer backbone. The derivatives were decorated with a cationic moiety, namely (3-carboxypropyl)trimethylammonium chloride. The fluorescent pulp fibers were prepared by direct self-assembly of the water-soluble fluorescent MCDs on the fibers in water at room temperature The results indicated that the adsorption was mainly driven by ion exchange mechanism. UV-vis- and fluorescence spectroscopic studies showed that the adsorption yield of the fluorescent MCDs depended on the length of the aliphatic chain of the photoactive groups. Because of the adsorption, the modified pulp fibers gained fluorescence in the visible part of the spectrum. Under the black light illumination, the modified fibers fluoresced, which made them visually distinguishable from the reference fibers. Thus, the fluorescent pulp fibers prepared in a simple way can be potentially used in fiber-based photoactive materials and authenticity indicators in papers and packaging.

ACS Sustainable Chemistry & Engineering published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Lujie published the artcileDurable antimicrobial cotton fabric fabricated by carboxymethyl chitosan and quaternary ammonium salts, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Cellulose (Dordrecht, Netherlands) (2021), 28(9), 5867-5879, database is CAplus.

In this article, carboxymethyl chitosan (CMC) and (3-carboxypropyl) trimethylammonium chloride (CPTC) were used as raw materials to prepare an antibacterial cotton fabric with excellent laundering durability. CMC was first anchored to the surface of cotton fiber via esterification between the carboxyl groups of CMC and the hydroxyl groups of the cellulose mols. on the cotton fiber surface, and then the CPTC was linked to the CMC chains via amidation to the amino groups of the grafted CMC chains. The antibacterial tests showed that the bacteriostatic reduction rate (BR) of the finished cotton fabric against S. aureus and E. coli was above 99.9%, and the BR value of modified cotton fabric remained above 99.9% even after 120 laundering cycles. The results of cytotoxicity, vapor transmissibility, and tensile strength of the fabric samples, as well as the evaluation of water absorption and flexibility show that the modified cotton fabrics are safe and comfortable.

Cellulose (Dordrecht, Netherlands) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C16H18Br2ClN3O3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics