Category: 6249-56-5

Wood, Gordon W. published the artcileMethyl transfer in field desorption mass spectrometry of ammonioalkanecarboxylate hydrochloride salts, COA of Formula: C7H16ClNO2, the publication is Organic Mass Spectrometry (1983), 18(1), 42-5, database is CAplus.

Field desorption mass spectra of simple N,N,N-trimethylammoniocarboxylate hydrochloride salts and their N,N,N-perdeuteriotrimethylammonium analogs are reported in which Me transfer was observed Mechanisms for this and other fragmentation and rearrangement processes are dependent on anode heating current. Addition of the protonating agent p-MeC₆H₄SO₃H suppressed most ions except the protonated mol. ion.

Organic Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C18H35NO, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haberfield, Paul published the artcileProximate charge effects. 8. Ion pair formation as an assembly process in ester aminolysis, Computed Properties of 6249-56-5, the publication is Journal of Organic Chemistry (1990), 55(4), 1334-8, database is CAplus.

The rate of aminolysis of p-nitrophenyl hexanoate by benzylamine in 95.3 mol % dioxane-water was compared to the rate of this reaction when the n-pentyl group in the ester was replaced by a Me₃N⁺(CH₂)₃ group, and the benzyl group in the amine by a ^–O₃SCH₂CH₂ group. The second-order rate constant of the first reaction was 4.21 × 10^-3 L mol^-1 s^-1, the first-order rate constant for the reacting ion pair was 1.88 × 10^-2 s^-1, yielding an effective molarity of 4.47 mol L^-1 as the measure of the rate acceleration caused by this preassembly of the reactants by electrostatic attraction. Further evidence for the intermediacy of an ion pair in the reaction between the oppositely charged reactants was the observation of a special salt effect, the addition of an inert salt causing a decrease in the aminolysis rate.

Journal of Organic Chemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wall, Joseph S. published the artcileSpectrophotometric determination of betaines and other quaternary compounds as their periodides, HPLC of Formula: 6249-56-5, the publication is Anal. Chem. (1960), 870-4, database is CAplus.

The method of Appleton, et al. (CA 48, 3437a), for the determination of choline, through the absorbance of its periodide at 365 mμ, was modified for the determination of other quaternary N compounds (e.g. betaine, trigonelline, carnitine, stachydrine, and γ-butyrobetaine) as each was separated from an extract of corn grain by ion-exchange chromatography (cf. following abstract). Certain N compounds (such as nicotinic acid, histidine, adenine, and thiamine), which give precipitates with I, may occur in some eluates but they do not interfere in this method. As many as 50 tubes of anal. samples containing 10-100 γ of a compound can be handled. The roles of pH, I concentration, temperature, time, and presence of chloride ions on the yield of the isolated periodide were studied.

Anal. Chem. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Ho-Taek published the artcileSurface Modulation of Magnetic Nanocrystals in the Development of Highly Efficient Magnetic Resonance Probes for Intracellular Labeling, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of the American Chemical Society (2005), 127(28), 9992-9993, database is CAplus and MEDLINE.

High-quality biocompatible magnetic iron oxide (Fe₃O₄) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic mols. By simple modulation of the nanocrystal surface ligand charge properties, the authors have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for addnl. transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.

Journal of the American Chemical Society published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C2H3N3, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hsu, Li-Na published the artcileCentral action of drugs for treatment of hypertension. I. Effect of reserpine on the conditioned response and blood pressure of normal dogs, Category: chlorides-buliding-blocks, the publication is Shengli Xuebao (1961), 24(3-4), 151-60, database is CAplus.

In 7 normal dogs given reserpine orally at 0.005-0.03 mg./kg. for 4-15 days, the positive conditioned response decreased and the reinforcement relation changed, sometimes with change in phase. The effect on the delayed conditioned response depends on dosage. A large dose (0.25 mg./kg.) seriously upset the equilibrium in stimulation-depression mechanisms to cause a nervous condition. With a daily dose of 0.005 or 0.01 mg./kg., no change in blood pressure was observed, but a change in conditioned response was quite distinct. This indicates that the cerebral cortex is more sensitive to resperine than the midbrain. It also indicates that the change in response is not induced by the action of resperine on the vasomotor center.

Shengli Xuebao published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hodgson, Ernest published the artcileNutrition and metabolism of methyl donors and related compounds in the blowfly Phormia regina, Application In Synthesis of 6249-56-5, the publication is Archives of Biochemistry and Biophysics (1960), 48-54, database is CAplus and MEDLINE.

In the nutrition of P. regina (CA 51, 6894i), γ-butyrobetaine (I) or O-acetylcarnitine served as replacements for choline (II) (quant. data given), while 2-monomethylaminoethanol was a partial replacement. The relative effectiveness of the various compounds is discussed. Ethanolamine, β-hydroxybutyrate, γ-aminobutyrate, β-hydroxy-γ-aminobutyrate, trimethylamine, and sarcosine did not serve as replacements in promoting growth, even when supplemented by other metabolites (named). The II-inhibitor 2-amino-2-methylpropanol inhibited growth, but its effects could be reversed by II and compounds which could replace II. Phospholipides containing serine, ethanolamine, and II were found to be normal constituents of 3rd instar larvae. Formate was not utilized in the biosynthesis of Me groups in II synthesis, but was metabolized with liberation of CO₂, both by the living larvae and their homogenates. Biosynthesis of II from ethanolamine either did not occur or was of little importance. The effectiveness of I as a replacement for II was of interest, since I has been described as a carnitine inhibitor in other organisms. Possible mechanisms of utilization are discussed. Metabolic differences in different spp. of insects are interpreted in relation to dietary requirements. 33 references.

Archives of Biochemistry and Biophysics published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hudson, Sian R. published the artcileEvaluation of a Solid-Supported Tagging Strategy for Mass Spectrometric Analysis of Peptides, Related Products of chlorides-buliding-blocks, the publication is ACS Combinatorial Science (2012), 14(2), 97-100, database is CAplus and MEDLINE.

The authors have explored two divinylbenzene cross-linked polystyrene supports for use in a solid-supported N-terminal peptide tagging strategy. Resin-bound tags designed to be cleaved in a single step at the N-terminus of peptides have been devised and explored as peptide N-terminal tagging reagents (constructs) for subsequent mass spectrometric anal. While the brominated tagging approach shows promise, the use of these specific solid supports has drawbacks, in terms of tagging reaction scale, for real applications in proteomics.

ACS Combinatorial Science published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cavallaro, Gennara published the artcileReversibly stable thiopolyplexes for intracellular delivery of genes, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Controlled Release (2006), 115(3), 322-334, database is CAplus and MEDLINE.

Novel polyaspartamide non-viral carriers for gene therapy were synthesized by introducing, on the same polymer backbone, pos. charged groups, for electrostatic interactions with DNA, and thiol groups for the formation of disulfide bridges between polymer chains. The introduction of thiols was aimed to have a vector with low redox potential sensitivity: disulfide crosslinking in fact, being stable in extracellular environment, allowed either to have stable complexes in plasma, that can protect DNA from metabolism, or to be reduced inside the cell, where the excess of glutathion in reduced form maintains a low redox potential. The consequent destabilization of the complex after disulfide cleavage can release DNA selectively inside the cells. α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) was used as starting polymer being a highly water-soluble synthetic polymer, already proposed with success as therapeutic carrier by our group. In this study, PHEA was firstly functionalized with ethylendiamine, obtaining a well defined copolymer with pendant primary amine groups (PHEA-EDA), to which N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) were linked in two subsequent steps, allowing the introduction of thiol and cationic groups resp. Finally DTT treatment lead to the final PHEA-EDA-SH-CPTA thiopolycation, named PESC. The present work describes the synthesis and characterization of the thiopolycation PESC. ¹H NMR spectroscopy detected the derivatization molar degrees in SPDP and CPTA; the formation of DNA complexes (thiopolyplexes), their stability in the presence of polyanions and the ability to release DNA under reductive conditions were studied by agarose gel electrophoresis. DNase II degradation study was carried out to detect the ability of thiopolyplex to stabilize DNA towards enzymic metabolism Thiopolyplexes were then characterized by Dynamic Light Scattering (DLS) and Zeta Potential anal. Finally, in vitro toxicity profile (MTT) and gene transfer efficiency (Luciferase assay) were carried out to evaluate thiopolyplex biocompatibility, safety and efficacy to be used as gene delivery system.

Journal of Controlled Release published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Licciardi, Mariano published the artcileNovel cationic polyaspartamide with covalently linked carboxypropyl-trimethyl ammonium chloride as a candidate vector for gene delivery, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is European Polymer Journal (2006), 42(4), 823-834, database is CAplus.

The non-viral gene vector properties of a protein-like polymer, the α,β-poly(N-2-hydroxyethyl)-,-aspartamide (PHEA) were investigated after its derivatization with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) as mol. bearing cationic groups, in order to obtain stable polycations able to condense DNA. PHEA was firstly functionalized with hydrazide pendant groups by reaction with hydrazine monohydrate (HYD), obtaining the polyhydrazide α,β-poly(N-2-hydroxyethyl/carbazate)-,-aspartamide (PHEA-HYD). In this paper we reported that polymer functionalization degree can be easily modulated by varying reaction conditions, so allowing us to produce two PHEA derivatives at different molar percentage of hydrazide groups. Subsequently, condensation reaction of PHEA-HYD copolymers with CPTA yielded α,β-poly(N-2-hydroxyethyl)-N-carbazate[N’-(3-trimethylammonium chloride)propylhydrazide]-,-aspartamide (PHEA-HYD-CPTA) polycation derivatives In vitro studies were carried out to evaluate polycations ability to complex DNA and to protect it from nuclease degradation Obtained results demonstrated the good efficiency of our new PHEA-polycations derivatives, PHEA-HYD-CPTA, to complex and condense genomic material even at very low polycation/DNA weight ratio.

European Polymer Journal published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Licciardi, Mariano published the artcileSynthesis and characterization of polyaminoacidic polycations for gene delivery, Related Products of chlorides-buliding-blocks, the publication is Biomaterials (2006), 27(9), 2066-2075, database is CAplus and MEDLINE.

The properties as non viral gene vector of a protein-like polymer, the α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) were exploited after its derivatization with 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) as mol. bearing a cationic group, in order to obtain stable polycations able to condense DNA. PHEA was firstly functionalized with aminic pendant groups by reaction with ethylenediamine (EDA) obtaining the α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PHEA-EDA) copolymer. We demonstrated that polymer functionalization degree is easily modulable by varying reaction conditions, so allowing to produce two PHEA-EDA derivatives at different molar percentage of amine groups. Subsequently, the condensation reaction of PHEA-EDA copolymers with CPTA yielded α,β-poly(N-2-hydroxyethyl)(2-[3-(trimethylammonium chloride)propylamide]-amidoethylcarbamate)-D,L-aspartamide (PHEA-EDA-CPTA) polycation derivatives In vitro studies were carried out to evaluate polycations ability to complex DNA and to protect it from nuclease degradation Obtained results demonstrated the good ability of our new PHEA polycationic derivatives, PHEA-EDA-CPTA, to complex and condense genomic material, neutralizing its anionic charge even at very low polycation/DNA weight ratio. Finally, PHEA-EDA-CPTA polycations were characterized by in vitro cytotoxicity studies to evaluate their effects on the viability of HuH-6 human hepatocellular carcinoma cells by MTS assay. No cytotoxicity was evidenced by both polycationic derivatives after 48 h of incubation at all tested concentrations

Biomaterials published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics