Category: 62593-17-3

Pews, R. Garth published the artcileSynthesis of 2,6-disubstituted and 2,3,6-trisubstituted anilines, Recommanded Product: 2,4-Dichloro-6-(trifluoromethyl)aniline, the main research area is haloaniline regioselective reductive dehalogenation; aniline substituted.

A number of 2,6-disubstituted and 2,3,6-trisubstituted anilines were prepared via the selective para dehalogenation. Modification of the substituents on the amino nitrogen demonstrates that the selectivity is derived from steric rather than electronic effects. The effects of the formate hydrogen donor, Pd catalyst, solvent, and temperature on the efficiency and selectivity of the dehalogenation are discussed. Thus, 3-methyl-2,4,6-trichlorodiacetanilide (I) was hydrogenated over Pd/C in MeCN containing HCO2Na and the resulting diacetanilide hydrolyzed in aqueous HCl-AcOH to give 90% 3,2,6-Me(Cl)2C6H2NH2.

Tetrahedron published new progress about Regiochemistry. 62593-17-3 belongs to class chlorides-buliding-blocks, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, and the molecular formula is C7H4Cl2F3N, Recommanded Product: 2,4-Dichloro-6-(trifluoromethyl)aniline.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62593-17-3, Product Details of 62593-17-3

2,4-Dichloro-6-trifluoromethylphenylacetic acid methyl ester prepared from 2,4-dichloro-6-trifluoromethylaniline; LC-MS (A): tR=0.93 min; 1H NMR ((CD3)2SO) delta: 8.11 (s, 1H), 7.88 (s, 1H), 3.97 (s, 2H), 3.65 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloro-6-(trifluoromethyl)aniline, and friends who are interested can also refer to it.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD.; Hilpert, Kurt; Hubler, Francis; Kimmerlin, Thierry; Renneberg, Dorte; Stamm, Simon; Murphy, Mark; US2014/163035; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C7H4Cl2F3N

Example 62 (General Procedure (D)) 3-Bromo-5-Tert-Butyl-N-(2,4-Dichloro-6-Trifluoromethyl-Phenyl)-6-Hydroxy-2-Methylbenzamide. The title compound was prepared from 3-tert-butyl-5-bromo-6-methylsalicylic acid and 2,4-dichloro-6-trifluoromethylanilin. 1H-NMR: (CDCl3, 400 MHz): delta ppm 1.40 (s, 9 H) 2.69 (s, 3 H) 7.15 (s, 1 H) 7.56 (s, 1 H) 7.68 (s, 1 H) 7.76 (s, 1 H) 9.50 (s, 1 H).); HPLC-MS (Method A): m/z=498, 500, 502 (M+1); Rt=5.9 min.

The synthetic route of 62593-17-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hansen, Birgit Sehested; Hansen, Thomas Kruse; Tullin, Soren; Colding-Jorgensen, Morten; US2004/138301; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 62593-17-3, A common heterocyclic compound, 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, molecular formula is C7H4Cl2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of CuCl2 (3.0 mmol) in 30 mL CH3CN was added tBu-nitrite (4.1 mmol) followed by dropwise addition of 1,1-dichloroethylen (39.1 mmol). A solution of 2,4-dichloro-6-trifluoromethylaniline (2.2 mmol) in 2 mL CH3CN was slowly added. After stirring at RT overnight, the reaction was quenched with 25percent aqueous HCl solution and extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4. After removal of the solvent the crude was redissolved in 3 mL MeOH. After addition of 2.4 mL of a 30percent solution of NaOMe in MeOH the mixture was refluxed for 5 h. Then, 1.8 mL concentrated H2SO4 solution was added at RT and the mixture was heated to reflux for 1 h. After concentrating in vacuo the resulting solid was partitioned between water and DCM. The water phase was extracted 3 times with DCM. The combined organic layers were dried over MgSO4. Purification with CC using Hept/EtOAc (10/1) gives the desired product as yellowish oil. _LC-MS (A): tR=0.93 min; 1H NMR ((CD3)2SO) delta: 8.11 (s, 1H), 7.88 (s, 1H), 3.97 (s, 2H), 3.65 (s, 3H).

The synthetic route of 62593-17-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD.; Hilpert, Kurt; Hubler, Francis; Kimmerlin, Thierry; Renneberg, Dorte; Stamm, Simon; US2015/25075; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 62593-17-3, name is 2,4-Dichloro-6-(trifluoromethyl)aniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 62593-17-3, COA of Formula: C7H4Cl2F3N

A.2.10.1 Synthesis of 2,4-dichloro-6-trifluoromethylphenylacetic acid methyl ester To a suspension of CuCI2 (3.0 mmol) in 30 mL CH3CN was added tBu-nitrite (4.1 mmol) followed by dropwise addition of 1 ,1 -dichloroethylen (39.1 mmol). A solution of 2,4- dichloro-6-trifluoromethylaniline (2.2 mmol) in 2 mL CH3CN was slowly added. After stirring at RT overnight, the reaction was quenched with 25percent aqueous HCI solution and extracted 3 times with EtOAc. The combined organic layers were dried over MgS04. After removal of the solvent the crude was redissolved in 3 mL MeOH. After addition of 2.4 mL of a 30percent solution of NaOMe in MeOH the mixture was refluxed for 5 h. Then, 1.8 mL concentrated H2S04 solution was added at RT and the mixture was heated to reflux for 1 h. After concentrating in vacuo the resulting solid was partitionned between water and DCM. The water phase was extracted 3 times with DCM. The combined organic layers were dried over MgS04. Purification with CC using Hept/EtOAc (10/1 ) gives the desired product as yellowish oil. LC-MS (A): tR = 0.93 min; 1H NMR ((CD3)2SO) delta: 8.1 1 (s, 1 H), 7.88 (s, 1 H), 3.97 (s, 2H), 3.65 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dichloro-6-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; RENNEBERG, Dorte; STAMM, Simon; WO2013/108227; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics