Category: 627-42-9

Related Products of 627-42-9, These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3 4-(2-Methoxyethoxy)-benzaldehyde 219.8 g of 4-hydroxybenzaldehyde were stirred with 270 g of potassium carbonate and 1134 g of 2-chloroethyl methyl ether in a 3 l autoclave for 12 hours at 150 C. Filtration, washing with 46.1 g of 2-chloroethyl methyl ether and removal by distillation of the excess 2-chloroethyl methyl ether as in Example 1, gave 319.9 g of crude product as red-brown liquid and 819.2 g of 2-chloroethyl methyl ether with a purity of 99.4% (GC).

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Giffels, Guido; Dreisbach, Claus; US2001/14697; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., 627-42-9

General procedure: NaBH4 (23 mg, 0.60 mmol, 3.0 eq.) was portionwise added to a solution of 4,4′-diselanediyldibenzenesulfonamide 1 (94 mg, 0.20 mmol, 1.0 eq.) in EtOH (2 mL) at 0 C under inert atmosphere (N2). After 30 min, the halo-alkyl 2a-f (0.36 mmol, 2.1 eq.) was slowly added and the reaction mixture was stirred at reflux for 3 h, until complete consumption of the starting material was observed by TLC. The reaction was quenched by addition of saturated aq. NH4Cl (2 mL) and diluted with EtOAc (5 mL). The layers were separated and the aqueous layer was extracted with EtOAc (2 x 5 mL), dried over Na2SO4, filtered and concentrated under vacuum. The crude material was purified by flash chromatography to yield selenides (3a-f) bearing benzenesulfonamide moiety.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Angeli, Andrea; di Cesare Mannelli, Lorenzo; Lucarini, Elena; Peat, Thomas S.; Ghelardini, Carla; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 210 – 219;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 627-42-9,Some common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium iodide (0.191 g, 1.273 mmol) was added to a stirred suspension of 5-fluoro-2- nitrophenol (4 g, 25.5 mmol), potassium carbonate (10.56 g, 76 mmol) and l-chloro-2- methoxyethane (5.1O mL, 56.0 mmol) in DMF (102 mL) at room temperature. The reaction mixture was allowed to stir at 800C overnight. Further l-chloro-2-methoxyethane (6.38 mL, 70.0 mmol) was added and the reaction mixture was allowed to stir at 800C for 4 h. Water and ethyl acetate were added and the organic layer was separated. The aqueous layer was neutralised with 1 N hydrochloric acid and extracted with ethyl acetate. The combined organic layers were washed with water, dried (MgSO4), filtered and evaporated to give a yellow oil. Column chromatography (petroleum ether/ethyl acetate 6:1) gave 4-fluoro-2-(2-methoxyethoxy)-l -nitrobenzene as a clear oil (2.26g, 39%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethyl chloride, its application will become more common.

Reference:
Patent; BIAL-PORTELA & COMPANHIA, S.A.; WO2009/84970; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 627-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-42-9 name is 2-Methoxyethyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a typical run, the appropriate volumes of the reagents (see Table 1 ) were charged into PTFE-coated stainless-steel reactor and heated at 110C for 6h under constant stirring and pressure (N2, 10bar). After cooling to room temperature and removal of acetonitrile, the IL (as chloride; (IL-Cl- IL-Cl- )) was purified by vigorously stirring with cold ethyl acetate (three times, 75mL each time); separated (lower layer) and dried at 40C under reduced pressure over P4O10 for 72h. The IL-OAc- IL-OAc- was obtained by anion exchange (IL-Cl- IL-Cl- ? IL-OH- IL-OH- ; methanol solvent), followed by neutralization of the IL-OH- IL-OH- with acetic acid. The completeness of the (Cl-/OH-) ion-exchange was assured by testing a dilute aqueous solution of the IL-OH- IL-OH- with AgNO3/HNO3 solution. After neutralization, methanol was evaporated under reduced pressure and the IL was dried at 40C under reduced pressure over P4O10 for 96h. The final yield for each IL is shown in Table 1. The structure of the IL was confirmed by 1H NMR spectroscopy

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Reference:
Article; Ferreira, Daniela C.; Oliveira, Mayara L.; Bioni, Thais A.; Nawaz, Haq; King, Alistair W.T.; Kilpelaeinen, Ilkka; Hummel, Michael; Sixta, Herbert; El Seoud, Omar A.; Carbohydrate Polymers; vol. 212; (2019); p. 206 – 214;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C3H7ClO

4-( 4,4,5,5-Tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1H-pyrazole (1 00 mg, 0.52mmol), 1-chloro-2-methoxyethane (0.056 mL, 0.62 mmol) and cesium carbonate (252mg, 0.73 mmol) in DMF (1 mL) were heated in microwave reactor at 160 C for 30 min.The reaction mixture was concentrated under reduced pressure and purified by silica gelchromatography (ISCO, hexanes/ethyl acetate 0-100% over 15 min) to isolate CompoundB162a (130 mg, 100% yield). HPLC: RT = 1.0 min (LCMS Method M). MS (ES): m/z= 253.0 [M+H( 1H NMR (500MHz, CHLOROFORM-d) 8 8.04 (s, 1H), 7.83 (d,J=18.4 Hz, 1H), 4.37 (t, J=5.2 Hz, 1H), 3.78 (t, J=5.2 Hz, 1H), 3.38-3.31 (m, 2H), 2.98(s, 3H), 2.90 (s, 3H), 1.34 (s, 6H), 1.26 (s, 3H).

The synthetic route of 2-Methoxyethyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FINLAY, Heather; JIANG, Ji; KIM, Soong-Hoon; PARKHURST, Brandon; QIAO, Jennifer X.; WANG, Tammy C.; PI, Zulan; TORA, George O.; LLOYD, John; JOHNSON, James A.; WO2014/15088; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 627-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-42-9 name is 2-Methoxyethyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(6-Bromo-2-(ethoxymethoxy)quinolin-3-yl)boronic acid (82). To a solution of 81 (1.55 g, 5.85 mmol) in DMF(30 mL, anhydrous) at 0 C, DIPEA was added (3.06 mL, 17.5 mmol). 1-Chloro-2-methoxyethane(1.38 g, 14.6 mmol) was then added, and the resultant mixture stirred at r.t. for 48 h. The reaction wasdiluted with brine (50 mL) and extracted with EtOAc (3 20 mL). The combined organic layers washedwith brine (50 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to obtain ayellow solid. Crude product was triturated with hexanes:Et2O (1:1) mixture and filtered and collectedto give 82 as a white solid (1.31 g, 69%) which was pure enough to be used for the next step. 1H NMR(DMSO, 400 MHz) 8.69 (s, 2H), 8.42 (s, 1H), 8.12 (d, J = 2.4 Hz, 1H), 7.83 (dd, J = 9.1, 2.4 Hz, 1H), 7.56(d, J = 9.1 Hz, 1H), 5.73 (s, 2H), 3.55 (q, J = 7.1 Hz, 2H), 1.07 (t, J = 7.0 Hz, 3H). Found: [M + H OH +MeOH OH + MeOH] = 356.1. HRMS: calculated for C12H13BBrNO4: 325.0121; found: 325.0126.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Reference:
Article; Choi, Peter J.; Conole, Daniel; Sutherland, Hamish S.; Blaser, Adrian; Tong, Amy S.T.; Cooper, Christopher B.; Upton, Anna M.; Palmer, Brian D.; Denny, William A.; Molecules; vol. 25; 6; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-42-9, name is 2-Methoxyethyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H7ClO

Compound 5 (4.1 mL, 44.7 mmol) was added to and mixed with a first mixture including isovanillin (4.0 g, 26.3 mmol), potassium carbonate (6.5 g, 47.3 mmol), and dimethylformamide (DMF, 30 mL) to obtain a second mixture. The second mixture was then stirred at a temperature ranging from 85 C. to 90 C. for 20 hours, cooled to room temperature, and filtered via Buechner funnel, and the residue was washed with EtOAc. The EtOAc filtrate was washed with a sodium hydroxide aqueous solution (2N), water, and brine, and then dried over MgSO4, and concentrated to obtain a yellow oil (5.3 g, 97% yield). The spectrum analysis for the yellow oil obtained by the above procedures is: 1H NMR (400 MHz, CDCl3), delta (ppm): 9.83 (s, 1H), 7.47-7.42 (m, 2H), 6.97-6.95 (d, J=8.2 Hz, 1H), 4.23-4.21 (m, 2H), 3.93 (s, 3H), 3.81-3.79 (m, 2H), 3.44 (s, 3H); 13C NMR (100.6 MHz, CDCl3), delta (ppm): 190.7, 154.9, 148.8, 129.9, 126.8, 110.8, 110.7, 70.6, 68.2, 59.0, 56.0; LRMS-EI+ (m/z): 211 ([M+H]+, 13), 210 ([M]+, 100), 152(67), 123(4), 95(3), 77 (5), 59 (67); HRMS-TOF-ES+ (m/z): [M+H]+ calculated for C11H15O4, 211.0970, found: 211.0971. The yellow oil obtained was confirmed to be Compound 6 (4-methoxy-3-(2-methoxyethoxy)benzaldehyde).

According to the analysis of related databases, 627-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; National Chiao Tung University; Chao, Jui-I; Chen, Chin-Piao; Liu, Kuang-Kai; (16 pag.)US10251886; (2019); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Methoxyethyl chloride

A pressure glass vessel charged with 1-(4-hydroxy-2,6-dimethylphenyl)ethanone (500 mg, 3.1 mmol, 1.0 equiv) and 1-chloro-2-methoxyethane (0.28 nL, 3.1 mmol, 1.0 equiv) in 50% aqueous NaOH solution (5.0 mL) was heated at 140 C for 16 h. The residue was diluted with H2O (20 mL) and extracted with EtOAc (3 X 30 mL). The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to give 1-(4-(2-methoxyethoxy)-2,6-dimethylphenyl)ethanone (430.9 mg, 1.9 mmol) as yellow oil in 64% yield: 1H NMR (CDCl3, 500 MHz) delta 6.58 (s, 2 H), 4.09-4.10 (m, 2 H), 3.72-3.74 (m, 2 H), .44 (s, 3 H), 2.45 (s, 3 H), 2.23 (s, 6 H); ESI-MS: m/z 223.6 (M + H)+.

The synthetic route of 2-Methoxyethyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson; WO2013/82324; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 627-42-9,Some common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2a, b (2 mmol) in dry DMF (15 mL) was added K2CO3(0.276 g, 2 mmol) and the mixture was stirred at room temperature for 1 h. 2-(2-Chloroethoxyethanol), 1-chloro-2-methoxyethane or 3-chloropropane-1,2-diol (2 mmol)was added and stirring was continued for 8-10 h (TLC) at 70C. The solvent wasremoved under reduced pressure and the residue was triturated with a mixture ofdiethyl ether:petroleum ether (40-60) [50:50]. The resulting solid was filtered off andrecrystallized from ethanol to give the desired products

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; El-Sayed, Wael A.; Ali, Omar M.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 1; (2014); p. 88 – 97;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 627-42-9,Some common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2a, b (2 mmol) in dry DMF (15 mL) was added K2CO3(0.276 g, 2 mmol) and the mixture was stirred at room temperature for 1 h. 2-(2-Chloroethoxyethanol), 1-chloro-2-methoxyethane or 3-chloropropane-1,2-diol (2 mmol)was added and stirring was continued for 8-10 h (TLC) at 70C. The solvent wasremoved under reduced pressure and the residue was triturated with a mixture ofdiethyl ether:petroleum ether (40-60) [50:50]. The resulting solid was filtered off andrecrystallized from ethanol to give the desired products

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; El-Sayed, Wael A.; Ali, Omar M.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; 1; (2014); p. 88 – 97;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics