Discovery of 2-Methoxyethyl chloride

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Recommanded Product: 627-42-9

Example 23. 3-[4-tert-Butyl-2-(2-methoxy-ethoxy)-phenyl]-N-(3-fluoro-4- methanesulfonylamino-5-vinyl-benzyl)-acrylamideStep 1 : 4-tert-Butyl-1-iodo-2-(2-methoxyethoxy)benzeneNaH (21.0mg, 0.5250mmol, 60% disp.oil , 5eq) and tert-Butyl-2-iodo-phenol (29.0 mg, 0.105 mmol, 1eq) were added DMF. Chloroethyl methyl ether (23.96^, 0.26mmol, 2.5eq) was added into the mixture. The reaction mixture was stirred overnight at 90 C. The reaction mixture was quenched by adding H2O. After DMF was removed in vacuo, the residue was extracted with EtOAc. A combined organic layer was washed by H2O and brine, dried with Na2SO4, and then concentrated in vacuo. The residue was purified with column chromatography (n-Hexane :EtOAc = 20:1 ) to give liquid (32.0mg, 91.2%).1H NMR (400MHz, CDCI3) : delta 7.58(d, J=8.4Hz, 1H), 6.82(d, J=2.0Hz, 1H), 6.69(dd, J=8.4, 2.4Hz, 1H), 4.10(t, J=4.8Hz, 2H), 3.75(dd, J=4.8, 4.4Hz, 2H), 3.43(s, 3H), 1.22(s, EPO 9H); IR(NaCI Neat, crtau1) : 2960, 2871 , 1713, 1628, 1607, 1165.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMOREPACIFIC CORPORATION; WO2006/101318; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., name: 2-Methoxyethyl chloride

2,5-Di-tert-butylhydroquinone (0.2 mmol) was dissolved in anhydrous THF (20 ml). Sodium hydride (0.6 mmol) and 2-chloroethylethylether (0.4 mmol) was then added to the solution. The reaction mixture was then stirred at room temperature overnight. After removal of the solvent, the residue was partitioned between dichloromethane and aqueous NaHCO3 (0.1M). The organic portion was separated and dried over Na2SO4. After solvent removal in vacuo, the crude product was chromatographed (silica, hexanes/DCM from 5:1 to 1:1) to afford 1,4-bis(2-methoxyethoxy)-2,5-di-tert-butyl-benzene in an 81% yield. The product was characterized by 1H NMR (300 MHz, CDCl3, delta/ppm): 7.14 (s, 2H), 4.11 (t, J=4.5 Hz, 4H), 3.80 (t, J=4.5 Hz, 4H), 3.45 (s, 6H), 1.37 (s, 18H).

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhang, Zhengcheng; Zhang, Lu; Amine, Khalil; US2011/294003; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The important role of 627-42-9

Statistics shows that 2-Methoxyethyl chloride is playing an increasingly important role. we look forward to future research findings about 627-42-9.

Reference of 627-42-9, These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 3,4-dihydroxybenzoate (1.7 g, 9.3 mmol) was placed in a reaction flask and 8 mL of DMF was added to dissolve it. Potassium tert-butoxide (2.0 g, 17.8 mmol) and potassium iodide (1.0 g, 6.0 mmol), and the temperature was raised to 100 C. 2-Chloroethyl methyl ether (3.52 g, 37.2 mmol) was added dropwise and the reaction was continued for 12 h after completion of the dropwise addition. Cooled to room temperature, ice water (200 mL) was added, and extracted three times with ethyl acetate (3 x 200 mL). The organic phase was combined, washed three times with distilled water, three times with saturated brine, dried over anhydrous sodium sulfate overnight, filtered, and the filtrate was evaporated to dryness under reduced pressure to give an oil. The elution system was petroleum ether / ethyl acetate = 1) Ethyl 3,4-bis (2-methoxyethoxy) benzoate.

Statistics shows that 2-Methoxyethyl chloride is playing an increasingly important role. we look forward to future research findings about 627-42-9.

Reference:
Patent; Shandong University; Shandong Yikang Pharmaceutical Co., Ltd.; Zhao Guisen; Li Pengzhan; Shi Yongqiang; Yin Yanzhen; Wang Yongtao; (11 pag.)CN104725327; (2017); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New learning discoveries about 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., Computed Properties of C3H7ClO

Methyl 4-hydroxy-3-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acetamido)benzoate (1.0 equiv), anhydrous potassium carbonate (3.0 equiv) and 1-chloro-2-methoxyethane (2.0 equiv) were mixed in DMF, the resulting mixture was stirred overnight at room temperature and concentrated under reduced pressure, and the obtained residue was diluted with EtOAc and washed with sodium bicarbonate, water and brine. An organic layer was collected and dehydrated with anhydrous MgSO4, and concentrated under reduced pressure. The concentrate was purified by silica gel column chromatography, thereby obtaining methyl 4-(2-methoxyethoxy)-3-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acetamido)benzoate (white solid, 0.10 g, 87.7% yield). 1H-NMR (400 MHz, CDCl3) delta 9.15 (s, 1H), 9.06 (s, 1H), 7.83-7.80 (m, 1H), 7.32 (d, J=8.0 Hz, 2H), 6.94-6.90 (m, 3H), 4.62 (s, 2H), 4.23 (t, J=4.0 Hz, 2H), 3.89 (s, 3H), 3.78 (t, J=4.0 Hz, 2H), 3.44 (s, 3H), 1.71 (s, 2H), 1.34 (s, 6H), 0.70 (s, 9H); 13C-NMR (100 MHz, CDCl3) delta 166.7, 166.4, 154.8, 151.0, 144.0, 127.4, 126.9, 126.6, 123.4, 121.0, 114.0, 110.7, 70.7, 68.4, 67.0, 59.2, 57.0, 52.0, 38.1, 32.3, 31.8, 31.6; HRMS [M+H] calcd [C27H38NO6]: 472.2699, Found: 472.2699; Purity: 100% (as determined by RP-HPLC, method A, tR=27.57 min).

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DONGGUK UNIVERSITY GYEONGJU CAMPUS INDUSTRY-ACADEMY COOPERATION FOUNDATION; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; Lee, Kyeong; Won, Mi Sun; Ban, Hyun Seung; Kim, Minkyoung; Kim, Bo Kyung; (40 pag.)US2020/31764; (2020); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Share a compound : C3H7ClO

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Application of 627-42-9, These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

From the vacuum dryer D0201 out of 3,4-dihydroxybenzonitrile into the reactor R0301,Into the solvent acetone, the raw material 3,4-dihydroxybenzonitrile was dissolved under sufficient stirring,Then followed by adding potassium iodide and anhydrous potassium carbonate, the reaction was heated 9h after reflux, sample sampling by the sampling port 03001,The reaction was stopped completely after the reaction of the raw material, the reaction liquid through the material pump P0301 into the filter F0301,Remove the solid anhydrous potassium carbonate, the filtrate into the vacuum dryer D0301,After vacuum drying solvent acetone recovery, the acetone recovered into the acetone recovery tank V0301,After the acetone is recovered, the product 3,4-bis (2-methoxyethoxy) benzeneacetonitrile is obtained,The product 3,4-bis (2-methoxyethoxy) benzeneacetonitrile exits vacuum dryer D0301.

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yancheng Normal College; Nanjing Tech University; Han Qing; Gu Huiwen; Sui Jingjiao; Yin Zijian; Sun Yaquan; (13 pag.)CN106957274; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Share a compound : 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Electric Literature of 627-42-9, These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

An excess of n-BuLi (2.5 M in n-hexane; 1.0 mL, correct stoichiometric amount corresponding to 0.50 mL, 1.24 mmol) was added via cannula through a rubber septum to a flask containing N,N-bis(2-phosphinoethyl)methoxyethylamine (5′) (60 mg, 0.31 mmol) in freshly distilled THF (10 mL) at 0 C. The solution became dark (black-violet coloured). Still at 0 C., under stirring, 2-chloroethyl methylether (236 mg, 2.48 mmol) dissolved in distilled THF (5 mL) was added dropwise. The mixture was left to reach room temperature overnight becoming yellow-gold coloured. It was then reduced to one third of the initial volume by a gentle stream of dinitrogen. Distilled diethylether (20 mL) was added. The flask was cooled again with an ice bath and degassed water (5 mL) was added dropwise. Two phases were formed: the upper organic phase was yellow-gold coloured, whereas the aqueous phase was almost colourless. Degassed diethylether (20 mL) was added, and the mixture was transferred in a separatory funnel (previously fluxed with dinitrogen) via cannula to avoid the contact with the atmosphere. Always under a dinitrogen atmosphere the lower aqueous phase was recovered in another separatory funnel and treated with additional diethylether (2×10 mL). Then the aqueous phase was discharged and the combined ethereal phases were placed in a 100 mL round bottom flask containing anhydrous Na2SO4 (ca. 500 mg). The solid was filtered off under dinitrogen and washed with additional anhydrous diethylether (2×10 ml). The combined ethereal phases were concentrated under dinitrogen and then under vacuum (yield ca. 60%).1H NMR (CDCl3): delta(ppm)=3.57-3.47 (10H); 3.33 (s, 12H); 3.32 (s, 3H); 2.66 (m, 6H); 1.78 (t, 8H); 1.65 (m, 4H).13C NMR (CDCl3): delta(ppm)=71.02 (s); 70.39 (d); 58.86 (s); 52.48 (s); 52.52 (s); 50.83 (d); 27.96 (d); 24.75 (d).31P{1H} (CDCl3): delta(ppm)=-39.0.

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIHON MED-PHYSICS CO., LTD.; US2010/160615; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of C3H7ClO

According to the analysis of related databases, 627-42-9, the application of this compound in the production field has become more and more popular.

Electric Literature of 627-42-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 627-42-9 as follows.

Step 1. Synthesis of sodium 2-methoxyethanesulfonate A solution of 2-chloroethyl methyl ether (1.01 g, 10.7 mmol) and Na2SO3 (1.42 g, 11.2 mmol) in H2O (5.0 mL) was stirred at reflux for 20 h. The solution was cooled to room temperature and concentrated to give sodium 2-methoxyethanesulfonate (2.33 g, quantitative yield) as a white solid. 1H NMR (DMSO-d6, 400 MHz) delta 3.53 (t, 2H), 3.37 (s, 3H), 2.70 (t, 2H).

According to the analysis of related databases, 627-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; National Health Research Institutes; Ueng, Shau-Hua; Yeh, Shiu-Hwa; Lin, Shu-Yu; Shih, Chuan; (329 pag.)US2017/253569; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Extended knowledge of 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference of 627-42-9, These common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 3 4-(2-Methoxyethoxy)-benzaldehyde 219.8 g of 4-hydroxybenzaldehyde were stirred with 270 g of potassium carbonate and 1134 g of 2-chloroethyl methyl ether in a 3 l autoclave for 12 hours at 150 C. Filtration, washing with 46.1 g of 2-chloroethyl methyl ether and removal by distillation of the excess 2-chloroethyl methyl ether as in Example 1, gave 319.9 g of crude product as red-brown liquid and 819.2 g of 2-chloroethyl methyl ether with a purity of 99.4% (GC).

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Giffels, Guido; Dreisbach, Claus; US2001/14697; (2001); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The origin of a common compound about C3H7ClO

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethyl chloride, its application will become more common.

Synthetic Route of 627-42-9,Some common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium iodide (0.191 g, 1.273 mmol) was added to a stirred suspension of 5-fluoro-2- nitrophenol (4 g, 25.5 mmol), potassium carbonate (10.56 g, 76 mmol) and l-chloro-2- methoxyethane (5.1O mL, 56.0 mmol) in DMF (102 mL) at room temperature. The reaction mixture was allowed to stir at 800C overnight. Further l-chloro-2-methoxyethane (6.38 mL, 70.0 mmol) was added and the reaction mixture was allowed to stir at 800C for 4 h. Water and ethyl acetate were added and the organic layer was separated. The aqueous layer was neutralised with 1 N hydrochloric acid and extracted with ethyl acetate. The combined organic layers were washed with water, dried (MgSO4), filtered and evaporated to give a yellow oil. Column chromatography (petroleum ether/ethyl acetate 6:1) gave 4-fluoro-2-(2-methoxyethoxy)-l -nitrobenzene as a clear oil (2.26g, 39%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methoxyethyl chloride, its application will become more common.

Reference:
Patent; BIAL-PORTELA & COMPANHIA, S.A.; WO2009/84970; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analyzing the synthesis route of 627-42-9

The synthetic route of 2-Methoxyethyl chloride has been constantly updated, and we look forward to future research findings.

Application of 627-42-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-42-9, name is 2-Methoxyethyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example A67 1-(2-Methoxy-ethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 2-Chloroethyl methyl ether (0.050 ml, 0.63 mmol) was added to a stirred solution of 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (5.0 g, 25.77 mmol) and cesium carbonate (12.59 g, 38.65 mmol) in DMF (27 ml). The mixture was stirred at 160 C. for 30 min. under microwave irradiation and then the solvent was evaporated in vacuo. The crude product was purified by flash column chromatography (silica; MeOH in DCM 2/98). The desired fractions were collected and evaporated in vacuo to yield intermediate 67 (4.6 g, 72%) as a pale yellow oil.

The synthetic route of 2-Methoxyethyl chloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica NV; US2012/329792; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics