Brief introduction of 627-42-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Electric Literature of 627-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-42-9 name is 2-Methoxyethyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6 (3.4 g, 20 mmol) in N,N?-dimethylformamide (DMF), K2CO3 (5.5 g, 40 mmol) was added at room temperature. After the mixture was stirred at 90 oC for 10 minutes, the DMF solution (2 mL) of 1-chloro-2-methoxyethane (3.8 g, 40 mmol) was slowly added over the course of 30 min at this temperature. The mixture was stirred at 90 oC for 12 h. After completion of the reaction, the mixture was poured into ice water (60 mL), followed by extraction with ethyl acetate (60 ¡Á 3 mL). The combined organic solvent phase was then washed by water (60 ¡Á 3 mL) and saturated sodium chloride (60 ¡Á 3 mL), dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to afford an oil, which was purified by column chromatography with petroleum ether/ethyl acetate (10 : 1) to obtain 7. Methyl 2-hydroxy-4-(2-methoxyethoxy)benzoate (7) White solid, yield 91%; mp: 136-138 oC; 1H NMR (CDCl3, 600 MHz): delta = 7.73 (1H, d, J = 8.4 Hz, H-6), 6.48 (1H, dd, J = 1.8, 8.4 Hz, H-5), 6.46 (1H, d, J = 1.8 Hz, H-3), 4.82 (1H, br, ArOH), 4.13 (2H, t, J = 4.8 Hz, ArOCH2), 3.91 (3H, s, COOCH3), 3.75 (2H, t, J = 4.8 Hz, CH3OCH2), 3.45 (3H, s, CH3OCH2); HRMS (ESI) m/z calcd. for C11H14O5 ([M+H]+): 227.0914, found: 227.0913.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Reference:
Article; Liu, Yang; Li, Yijing; Liu, Jianzhen; Yang, Limin; Li, Pengzhan; Zhao, Guisen; Letters in drug design and discovery; vol. 13; 4; (2016); p. 314 – 323;,
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Brief introduction of 627-42-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627-42-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-42-9, name is 2-Methoxyethyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 627-42-9

1-chloro-2-methoxyethane (0.48 mol) was added to the mixture ofmethyl 2-hydroxybenzoate (0.40 mol), K2CO3 (0.80 mol), KI(0.04 mol) and DMF (150 mL). The mixture was heated for 6 h at150 C. The solution was cooled and filtered, and the solvent wasevaporated under reduced pressure. The residue was dissolved inCHCl3 and extracted with water and 10% NaOH. The organic phasewas dried over anhydrous MgSO4 and filtered, and the solvent wasevaporated under reduced pressure. Yield: 96%, RF: 0.78 (EtOAc/petroleum ether 1:1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627-42-9.

Reference:
Article; Vettorazzi, Marcela; Angelina, Emilio; Lima, Santiago; Gonec, Tomas; Otevrel, Jan; Marvanova, Pavlina; Padrtova, Tereza; Mokry, Petr; Bobal, Pavel; Acosta, Lina M.; Palma, Alirio; Cobo, Justo; Bobalova, Janette; Csollei, Jozef; Malik, Ivan; Alvarez, Sergio; Spiegel, Sarah; Jampilek, Josef; Enriz, Ricardo D.; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 461 – 481;,
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Extended knowledge of 627-42-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Formula: C3H7ClO

1) according to the amount of substance, the 2 portions N-methyl imidazole is added to the round-bottom flask, then adding normal heptane, magnetic stirring, the stirring speed is 500 revolutions/minutes, until the reaction is complete;(2) for the shares N-methyl imidazole 1.1 times of chloroethyl methyl ether is added to the above-mentioned solution; nitrogen protection, the water bath temperature control, magnetic stirring, at a temperature of 80 C reaction under 48 hours;(3) to the upper layer solution retrodisplacement reaction is ended, the lower layer solution is extracted with ethyl acetate 3 times, vacuum distillation to obtain intermediate 1-methyl, 3-methyl ether chloride ion ionic liquid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; Huanghuai College; Feng, Xiantao; Wei, Yu; Zhang, Jingxun; (6 pag.)CN105399679; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Research on new synthetic routes about 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

Step (i) N-methoxyethyl-N-methylpyrrolidinium chloride, PYR1(2O1)Cl, was synthesized by reacting N-methylpyrrolidine with the appropriate amount of 2-chloroethyl methyl ether. The reagents were firstly dissolved in ethyl acetate and, then, mixed in a reactor. The reaction temperature was set at 70 C forachieving a yield approaching 100% (determined by weighting the obtained precursor after vacuum drying at 100 C overnight) upon 5-6 days heating due to the low kinetics of the reaction (1) [15,17].A white, solid precipitate of PYR1(2O1)Cl was obtained whereas the yellowish liquid phase (e.g., containing impurities generally very soluble in ethyl acetate) was removed by vacuum filtering (paper filter membrane). Finally, the precursor was rinsed 5 times with ethyl acetate.

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Moreno; Montanino; Carewska; Appetecchi; Jeremias; Passerini; Electrochimica Acta; vol. 99; (2013); p. 108 – 116;,
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Extracurricular laboratory: Synthetic route of 627-42-9

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Methoxyethyl chloride

K2CO3 (24.8 g, 180 mmol), KI (0.75 g, 4.5 mmol) and 1-chloro-2-methoxyethane (17.0 g, 180 mmol) were added successively to a solution of the compound 9 (20 g, 90.0 mmol) in DMF (120 mL) and the mixture was stirred at 70 C for 5 h. The mixture was poured to water (500 mL) and the aqueous phase was extracted with AcOEt (3 * 400 mL). The organic solution was washed with water follow by saturated aqueous NaCl solution, dried over anhydrous Na2SO4, and evaporated to afford the compound 10 (24.0 g, yield, 95%), which was used to the next reaction without further purification. Mp: 187-189 C; 1H NMR (500 MHz, CDCl3) delta: 7.52 (1H, s), 6.51 (1H, s), 5.77 (2H, bs), 4.35 (2H, q, J = 7.1 Hz), 3.94 (2H, t, J = 5.4 Hz), 3.69 (2H, t, J = 5.4 Hz), 3.36 (3H, s), 1.40 (3H, t, J = 7.1 Hz); IR (film, cm-1): 3468, 3358, 2987, 2891, 1780, 1691, 1584, 1489, 1432, 1370, 1328, 1280, 1226, 1111, 1064, 954, 832, 789, 746, 660.

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yin, Siyuan; Zhou, Liliang; Lin, Jinsheng; Xue, Lingjing; Zhang, Can; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 462 – 475;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 627-42-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., SDS of cas: 627-42-9

Starting Material Synthetic Example 106 4-Hydroxybenzaldehyde (300 g) and 2-chloroethyl methyl ether (279 g) were dissolved in DMF (3 L) and potassium carbonate (408 g) was added. The mixture was stirred with heating at 60 C. for 16 hr. After the reaction, the reaction mixture was poured into water and liberated oil was extracted with ethyl acetate. The organic layer was washed with 1N aqueous sodium hydroxide solution and washed with saturated brine. The organic layer was dried over anhydrous magnesium sulfate. After drying, the residue was concentrated under reduced pressure to give 4-(2-methoxyethoxy)benzaldehyde as an oil (212 g). 1H-NMR 270 MHz (CDCl3, ppm) delta: 9.87(1H, s), 7.82(2H, d), 7.02(2H, d), 4.18(2H, m), 3.77(2H, m), 3.44(3H, s).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Welfide Corporation; US6288061; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simple exploration of 627-42-9

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Quality Control of 2-Methoxyethyl chloride

KOH (1.12 g, 20 mmol) was added to a flask equipped with benzimidazole (2.36 g, 20 mmol) and acetonitrile (20 mL). The mixture was then stirred at room temperature for 1 h before adding 2- chloroethyl methyl ether (1.90 g, 20 mmol) slowly. The mixture was then heated at 76 C for 17 h. The reaction mixture was cooled to room temperature. All volatiles were removed by vacuum. The residue was added with water (20 mL). The aqueous solution was extracted by chloroform (3 x 30 mL). The organic layers were collected, washed by water (2 x 20 mL) and dried by MgS04. The solvent was removed by vacuum to obtain ligh-yellow oil (2.80 g, 80%). The characterization data were identical to those literature values (Ozdemir, I.; Sahin, N.; Gok, Y.; Demir, S.; Cetinkaya, B. J. Mol Catal. A: Chem. 2005, 234, 181. and Denton, J. R. Synthesis 2010, 775-782).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; THE GOVERNING COUNCIL OF UNIVERSITY OF TORONTO; LANXESS Deutschland GmbH; MUELLER, Julia Maria; STEPHEN, Douglas; LUND, Clinton; SGRO, Michael; ONG, Christopher; CARIOU, Renan; WO2013/24119; (2013); A1;,
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Share a compound : 627-42-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627-42-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-42-9, name is 2-Methoxyethyl chloride, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 627-42-9

A mixture of 4-iodo-1H-pyrazole (10.00 g, 51.553 mmol), 1-chloro-2-methoxyethane (14.62 g, 154.64 mmol), potassium hydroxide (5.78 g, 103.02 mmol), and KBr (610 mg, 5.12 mmol) in ethanol (200 mL) was heated at 100 C. After 16 h, the mixture was concentrated under vacuum, and the resulting residue was purified by silica gel chromatography (95:5 dichloromethane/methanol) to afford 4-iodo-1-(2-methoxyethyl)-1H-pyrazole (12 g, 92%) as a yellow oil. LCMS (ESI): [M+H]+=292.95.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627-42-9.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Daniels, Blake; Drobnick, Joy; Gazzard, Lewis; Heffron, Timothy; Huestis, Malcolm; Liang, Jun; Malhotra, Sushant; Mendonca, Rohan; Rajapaksa, Naomi; Siu, Michael; Stivala, Craig; Tellis, John; Wang, Weiru; Wei, BinQing; Zhou, Aihe; Cartwright, Matthew W.; Gancia, Emanuela; Jones, Graham; Lainchbury, Michael; Madin, Andrew; Seward, Eileen; Favor, David; Fong, Kin Chiu; Good, Andrew; Hu, Yonghan; Hu, Baihua; Lu, Aijun; US2018/282328; (2018); A1;,
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Share a compound : 627-42-9

The chemical industry reduces the impact on the environment during synthesis 627-42-9. I believe this compound will play a more active role in future production and life.

The chemical industry reduces the impact on the environment during synthesis 627-42-9, name is 2-Methoxyethyl chloride, I believe this compound will play a more active role in future production and life. 627-42-9

To a solution of 3,4-dihydroxybenzaldehyde (10 g, 72.5 mmol) (Aldrich) in DMF (200 mL) was added 2-chloroethyl methyl ether (16.5 mL, 181.2 mmol) (Aldrich), potassium carbonate (50 g, 362.3 mmol) and a catalytic amount of potassium iodide (Aldrich). The reaction mixture was heated at 85 C. for 14 hours. The reaction mixture was cooled down, diluted with EtOAc and washed with brine. The organic phase was dried over anhydrous sodium sulfate, evaporated to afford 3,4-bis-(2-methoxy-ethoxy)-benzaldehyde as an oil and was used in the next step without further purification. (Yield 11 g, 70%).

The chemical industry reduces the impact on the environment during synthesis 627-42-9. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Dominique, Romyr; Luk, Kin-Chun; Qiao, Qi; Rossman, Pamela Loreen; US2012/184548; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Introduction of a new synthetic route about 2-Methoxyethyl chloride

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-42-9, name is 2-Methoxyethyl chloride, A new synthetic method of this compound is introduced below., 627-42-9

General procedure: NaBH4 (23 mg, 0.60 mmol, 3.0 eq.) was portionwise added to a solution of 4,4′-diselanediyldibenzenesulfonamide 1 (94 mg, 0.20 mmol, 1.0 eq.) in EtOH (2 mL) at 0 C under inert atmosphere (N2). After 30 min, the halo-alkyl 2a-f (0.36 mmol, 2.1 eq.) was slowly added and the reaction mixture was stirred at reflux for 3 h, until complete consumption of the starting material was observed by TLC. The reaction was quenched by addition of saturated aq. NH4Cl (2 mL) and diluted with EtOAc (5 mL). The layers were separated and the aqueous layer was extracted with EtOAc (2 x 5 mL), dried over Na2SO4, filtered and concentrated under vacuum. The crude material was purified by flash chromatography to yield selenides (3a-f) bearing benzenesulfonamide moiety.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Angeli, Andrea; di Cesare Mannelli, Lorenzo; Lucarini, Elena; Peat, Thomas S.; Ghelardini, Carla; Supuran, Claudiu T.; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 210 – 219;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics