Category: 627-42-9

627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 627-42-9

A mixed solution of 1500 g of 1-naphthol, 1032 g of 2-methoxyethyl chloride, 460 g of sodium hydroxide, 78 g of sodium iodide and 3000 g of ethanol was heated and stirred at 80 C for 37 hours under a nitrogen atmosphere.After cooling, 3000 g of water and 5000 g of toluene were added to separate the organic layer, and the mixture was washed five times with 1800 g of a 5 mass% aqueous sodium hydroxide solution. Subsequently, the solution was washed four times with 1800 g of water, and then the organic layer was concentrated to obtain 1835 g of an oily product. This was distilled under reduced pressure (110 C / 13 Pa) to obtain 1637 g (yield: 77%) of the target compound

Statistics shows that 627-42-9 is playing an increasingly important role. we look forward to future research findings about 2-Methoxyethyl chloride.

Reference:
Patent; Shin-Etsu Chemical Industry Co., Ltd.; Ohashi, Masaki; Kobayashi, Tomohiro; Seki, Akihiro; Sagehasi, Masayoshi; Fukushima, Masahiro; (42 pag.)KR101695054; (2017); B1;,
Chloride – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 627-42-9, name is 2-Methoxyethyl chloride, This compound has unique chemical properties. The synthetic route is as follows., 627-42-9

146.5 g (1.2 mol) of 4-hydroxybenzaldehyde are dissolved in DMF, and 2O g (0.12 mol) of potassium iodide, 134.6 g (1.2 mol) of potassium tert-butoxide and 170.2 g (1.8 mol) of 2- chloroethyl methyl ether are added. The reaction mixture is stirred at 800C for 16 h. For work-up, the reaction mixture is concentrated under reduced pressure. The residue is taken up in 1 1 of ethyl acetate and extracted with 0.5 1 of IN aqueous sodium hydroxide solution. The ethyl acetate phase is dried using magnesium sulphate and concentrated under reduced pressure. The residue obtained after concentration is distilled under high vacuum (b.p. = 1000C at 0.45 mbar). This gives 184.2 g (85% of theory) of product.MS (ESIpos): m/z = 181 (M+H)+1H-NMR (300 MHz, CDCl3): delta = 3.5 (s, 3H); 3.8 (tr, 2H); 4.2 (tr, 2H); 7.0 (d, 2H); 7.8 (d, IH); 9.9 (s, IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BAYER HEALTHCARE AG; WO2007/73855; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9. 627-42-9

the 121g (leq) ELTA 1200ml and dimethylformamide (DMF) was stirred clear solution; sequentially added 323g (4eq) 2- chloroethyl methyl ether, 944g (8eq) of anhydrous potassium carbonate and 23.6gTetrabutylammonium bromide; purged with nitrogen three times,Under nitrogen, the reaction was heated to 105~110 C 13~14h; the filter cake was rinsed DCM until the filtrate was colorless; the combined filtrate was concentrated under reduced pressure to a fraction distilled off; the residue was added DCM, cooled to room temperature , washed with 3Nu K0H, the DCM phase was separated, washed with water, brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to 45 C to give 210g oil ELTB, yield 96.4%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Methoxyethyl chloride.

Reference:
Patent; Chongqing Peng Wei Pharmaceutical Co., Ltd.; Yan, Weiwei; Ren, Yanrong; Liu, Zeyan; Han, Gongchao; (9 pag.)CN105566233; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A common compound: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 627-42-9

(Ph2SiH)2 (0.10g, 0.27mmol) and B(C6F5)3 (0.015g, 0.029mmol) were combined with toluene (1mL) in a Schlenk flask. 2-Chloroethyl methyl ether (0.050mL, 0.55mmol) was added dropwise with stirring, and the resulting mixture was stirred under N2 (open to the nujol bubbler) for 16h, by which time it was cloudy white. The toluene was removed under vacuum and cold pentane (2mL) was added, giving a white precipitate. The precipitate was collected by filtration, washed with cold pentane (4mL), and dried under vacuum, giving a white powdery solid (0.094g, 65%). 1H NMR (300MHz, C6D6) delta 3.17 (t, 3JHH=6Hz, 4H, OCH2CH2Cl), 3.77 (t, 4H, OCH2CH2Cl), 7.14 (m, 12H, Hm/p-SiPh2), 7.75 (m, 8H, Ho-SiPh2); 13C NMR (75MHz, C6D6) delta 45.1 (OCH2CH2Cl), 64.8 (OCH2CH2Cl), 128.2 (Cm-SiPh2), 130.3 (Cp-SiPh2), 135.4 (Co-SiPh2). 29Si NMR (99MHz, C6D6) delta-7.7. M.p. 138-140C. Anal. (calcd for 93% C28H28O2Cl2Si2 (18) and 7% C2H6OSi (grease)): C 63.28 (63.23) H 5.17 (5.36).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 627-42-9, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lee, Peter T.K.; Rosenberg, Lisa; Journal of Organometallic Chemistry; vol. 809; (2016); p. 86 – 93;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-42-9 name is 2-Methoxyethyl chloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 627-42-9

General procedure: The 7-alkoxy-1-methyl-beta-carbolines (3a-o) were synthesized according to a previously reported procedure.13 The appropriate alkyl halide (by portion) or 1-tosyl-4,4,4-trifluorobutane (for compound 3e) and cesium carbonate were added to harmol (2) dissolved in anhydrous dimethylformamide (DMF). Then, the reaction mixture was stirred at room temperature or heated for several hours. At the end of the reaction, the mixture was cooled and diluted with dichloromethane, washed once with water and three times with brine. The organic layer was dried over MgSO4 and concentrated. The crude product was purified by liquid chromatography.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methoxyethyl chloride, and friends who are interested can also refer to it.

Reference:
Article; Reniers; Robert; Frederick; Masereel; Vincent; Wouters; Bioorganic and Medicinal Chemistry; vol. 19; 1; (2011); p. 134 – 144;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

627-42-9, A common compound: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

The ether-functionalized ionic liquids 1-(2-methoxyethyl)-3-methylimidazolium threonine ([C1OC2Mim][Thr]) and 1-(2-ethoxyethyl)-3-methylimidazolium threonine ([C2OC2Mim][Thr]) were prepared according to the method as described in the literatures [32]. Under the protection of nitrogen, 2-chloroethyl methyl ether (122 ml, 1.1 mol) was added to N-methylimidazole (85 ml,1.0 mol) with a constant pressure funnel in round-bottom flaskwas stirred at 353.15 K for 48 h. After the reaction, extraction with ethyl acetate (3 ¡Á 60 mL) and drying under vacuum at 353.15 K for48 h to obtain pale yellow liquid [C1OC2Mim][Cl]. Next,[C1OC2Mim][OH] was synthesized from [C1OC2mim][Cl] by the useof activated anion-exchange resin. Then aqueous [C1OC2Mim][OH] was added to a slightly excess threonine aqueous solution and stirred for 48 h. Finally, excess water was evaporated under reduced pressure. To this reaction mixture was added the mixed solvent ethanol/acetonitrile (volumetric ratio = 9/1), and it was stirred befittingly. The mixture was then filtered to remove excess threonine.The product was dried under vacuum at 353.15 K for 48 h to obtain the target ionic liquid [C1OC2Mim][Thr]. Similarly, [C2OC2Mim] [Thr] was also synthesized according to the above method. Fig. 1 shows the synthetic route of the ionic liquids [C1OC2Mim][Thr] and [C2OC2Mim][Thr]. Based on the mass loss of product, the yields were estimated approximately 80%. The ether groups are abbreviated as CmOCn-, where m stands for the number of carbon atoms inthe alkyl tail and n stands for the number of carbon atoms of the spacer between the cationic nitrogen atom and the ether oxygen atom. The 3-methylimidazolium and the threonine are abbreviated as Mim and Thr, respectively.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Duo; Li, Biao; Hong, Mei; Kong, Yu-Xia; Tong, Jing; Xu, Wei-Guo; Journal of Molecular Liquids; vol. 304; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

627-42-9, A common heterocyclic compound, 627-42-9, name is 2-Methoxyethyl chloride, molecular formula is C3H7ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

p-Acetylphenol (20.0 g, 147 mmol) was dissolved in DMF (200 mL). While cooling on ice, sodium hydride (6.46 g, 0.16 mol, 60% in oil) and then chloromethyl methylether (16.7 mL, 220 mmol) were added to the solution, and the mixture was stirred for 2 hours at the same temperature. The reaction solution was added with ice and saturated aqueous sodium hydrogencarbonate, and extracted with ethyl acetate. After the organic layer was washed with saturated brine, the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was,purified by silica gel column chromatography (n-hexane/ethyl acetate = 9/1), and 4-(methoxymethoxy)acetophenone (23.7 g, 89% yield) was obtained. FAB -MS m/z: [M+H]+ 181.1H-NMR (CDCl3) delta (ppm): 2.56 (s, 3H), 3.48 (s, 3H), 5.23 (s, 2H), 7.07 (d, J = 9.1 Hz, 2H), 7.93 (d, J = 9.1 Hz, 2H).

The synthetic route of 627-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd; EP1431280; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

627-42-9, Adding some certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9.

Adding 76.1 g (0.5 mol) of methyl salicylate to 250 ml of N-methylpyrrolidone,2-chloromethyl ethyl ether 56.7 g (0.6 mol),Potassium iodide 8.3g (0.05mol),Potassium carbonate 82.9g (0.6mol),It was stirred at 120 C for 16 hours.After cooling the reaction solution, 300 ml of water was added,Extracted with 300 ml of ethyl acetate,After washing the ethyl acetate solution with saturated brine,The solvent was distilled off. Thereafter, 40 g of a 50% aqueous NaOH solution, 40 ml of water, and 40 ml of ethanol were added.It was stirred at 100 C for 1 hour.After the reaction is completed, hydrochloric acid water is added for neutralization.Ethyl acetate was added for extraction.The ethyl acetate solution is washed with saturated brine.The solvent was distilled off. Thereafter,Purification by ruthenium column chromatographyAnd get 59g(yield 60%)Intermediate 4.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 627-42-9.

Reference:
Patent; Fujifilm Corporation; Takasaki, Yuta; Sasaki, Daisuke; Ishizaka, Soji; (141 pag.)TWI626233; (2018); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics