Category: 6276-54-6

Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C3H9Cl2N

General procedure: Toa suspension of lawsone (0.87 g, 5.0 mmol) in ethanol(10 mL) were added sequentially: i) the corresponding amine (5.5 mmol) – andtriethylamine (5.0 mmol, 0.7 mL) in the case of 3-(chloropropyl)aminehydrochloride – and ii) the respective aldehyde (6.0 mmol). The reactionmixture was stirred at RT, in the dark for 12h, after which time the orangeprecipitate was filtered, washed with ethanol, diethyl ether and dried undervacuum.Forthe syntheses of 6a, 6b, 6e, 6f, 6g and 6h, which are more soluble than the other products, the reactionswere carried out in the same amount of ethanol, but using 10.0 mmol of lawsone,10.0 mmol of heptylamine and 12.0 mmol of aldehydes.Compounds4a, 5a, 8a, 4b, 5b, 4c, 5c, 4d, 5d, 6d, 7d, 8d, 9e, 5g, 4h and 5h were synthesized as describedpreviously.3-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6276-54-6, its application will become more common.

Reference:
Article; da Silva, Gustavo B.; Neves, Amanda P.; Vargas, Maria D.; Marinho-Filho, Jose D.B.; Costa-Lotufo, Leticia V.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3537 – 3542;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6276-54-6,Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-5,6,7,8- tetrahydropyrimido[4,5-(i]pyrimidin-4-yl]-4-methyl-N-propylbenzamide (206 mg, 0.4 mmol) in DMF (4 mL) was added (3-chloropropyl)amine hydrochloride (78 mg, 0.6 mmol) and triethylamine (112 uL, 0.8 mmol). The mixture was heated with microwave at 600C for 2 hrs. The mixture was separated by flash chromatography to afford the title compound (100 mg, 47%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropropan-1-amine hydrochloride, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/147109; (2007); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: chlorides-buliding-blocks

Triethylamine (51.0 g) was added dropwise to a solution of di-tert-butyl dicarbonate (100.0 g) and 3-chloropropylamine hydrochloride (71.5 g) in methanol (400 mL) at 0 C., and the mixture was then stirred at the same temperature for 16 hours. Thereafter, toluene (400 mL) and water (400 mL) were added to the reaction solution for liquid separation, and the organic layer was then washed with water. 400 mL of toluene was added to the organic layer, and the mixed solution was concentrated to 300 mL under reduced pressure. After that, N,N-dimethylacetamide (210 mL) was added, and the mixed solution was concentrated to 300 mL under reduced pressure. Thereafter, to this solution, potassium carbonate (126.66 g), tetrabutylammonium bromide (44.32 g), dimethyl malonate (90.82 g) and N,N-dimethylacetamide (100 mL) were added, and the mixed solution was then stirred at 55 C. for 20 hours. Thereafter, toluene (400 mL) and water (700 mL) were added to the reaction solution for liquid separation. The organic layer was successively washed with water, a 1 M aqueous sodium hydroxide solution and water, and was then concentrated to 150 mL under reduced pressure. To this solution, methanol (1870 mL) and a 1 M aqueous sodium hydroxide solution (430.8 mL) were added, and the mixed solution was then stirred at 0 C. for 27.5 hours. Subsequently, concentrated hydrochloric acid (2.5 mL) was added to the reaction solution, so that the pH of the solution was adjusted to pH 7-9, and the solution was then concentrated to 375 mL under reduced pressure. Ethyl acetate (500 mL) was added to the reaction solution, and concentrated hydrochloric acid (35.1 mL) was then added to the mixed solution, so that the pH of the solution was adjusted to pH 2.2-2.5, followed by liquid separation. The water layer was extracted with ethyl acetate (500 mL), the organic layer was then mixed therewith. The mixed solution was dehydrated and concentrated under reduced pressure to prepare an ethyl acetate (250 mL) solution. To the obtained solution, ethyl acetate (500 mL) and morpholine (37.5 g) were added, and the obtained mixture was stirred overnight. Thereafter, the precipitated crystals were filtrated, were then washed with ethyl acetate, and were then dried under reduced pressure to obtain the title compound (136.1 g, yield: 81.9%). (0118) 1H-NMR (DMSO-d6) delta: 6.79 (1H, t, J=5.5 Hz), 3.61 (4H, t, J=4.9 Hz), 3.58 (3H, s), 3.14 (1H, t, J=7.8 Hz), 2.90-2.80 (6H, m), 1.74-1.59 (2H, m), 1.37 (9H, s), 1.34-1.25 (2H, m) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6276-54-6, its application will become more common.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; HAYASHI, Masaki; UKAI, Kazutoshi; (16 pag.)US2018/29993; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6276-54-6, Quality Control of 3-Chloropropan-1-amine hydrochloride

Step 1: Synthesis of 1-azido-3-aminopropane 1 Synthesis is carried out according to the following reaction scheme: This compound was obtained according to a synthesis previously described by Carboni, B. et al. (Macromolecules, Vol. 40, No. 16, 2007/Carboni, B.; Benanlil, A.: Vaultier, M. J. Org. Chem. 1993, 58, 3736). An aqueous solution (30 mL) of 3-chloropropylamine hydrochloride (4 g; 30.8 mmol) and of sodium nitride (6 g; 92.3 mmol, 3 equiv) is heated at 80 C. for 17 h. After evaporation of the water, the reaction mixture is put in an ice bath. 50 mL of diethyl ether and 4 g of potassium hydroxide are added. The phases are separated. The product is extracted from the aqueous phase with 2*20 ml, of diethyl ether. The organic phase is then dried over magnesium sulfate and filtered. After evaporation, the oil obtained is purified by distillation at reduced pressure. (2.46 g; yield: 80%; colorless oil) 1H NMR (300 MHz, CDCl3), delta (ppm): 3.33 (t, 2H, CH2N3); 2.55 (t, 2H, Cl2NH2); 2.34 (s, 2H, NH2); 1.55 (q, 2H, CH2CH2CH2). FT-IR (ATR, cm-1): 2100 (N3)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Centre National de la Recherche Scientifique; Coudane, Jean; Darcos, Vincent; El Habnouni, Sarah; Garric, Xavier; Lemaire, Laurent; Nottelet, Benjamin; US2014/302324; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3-Chloropropan-1-amine hydrochloride

Step-3: Synthesis of Compound 4 (0140) (0141) To a stirred suspension of crude (2R,3R,4S)-2,3,4,6-tetrakis(benzyloxy)-5-oxohexanal 3 (20 g, 37.13 mmol) in MeOH (400 mL) were added 3-chloro propylamine (47 g, 743 mmol) at 0 C. and activated molecular sieves (100 g) and the reaction mixture was stirred at room temperature for 20 min. Then the reaction mixture was cooled to 0 C. and solid NaBH3CN (9.33 g, 148.5 mmol) was added to the reaction mixture and stirred at same temperature for 1 h. Then the reaction mixture was stirred at room temperature for 20 h. After removal of the molecular sieves through celite pad, the filtrate was concentrated under reduced pressure. The crude mass was dissolved in ethyl acetate (250 mL) and organic part was washed with saturated solution of NaHCO3 (100 mL), dried over Na2SO4 and concentrated under reduced pressure to get crude which was purified by column chromatography using 100-200 mesh silica gel and eluting with 8% EtOAc/hexane to afford (2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-[(benzyloxy)methyl]-1-(3-chloropropyl)piperidine 4 (8.0 g, 36%) as white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6276-54-6, its application will become more common.

Reference:
Patent; CELLIX BIO PRIVATE LIMITED; Kandula, Mahesh; US9150557; (2015); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Chloropropan-1-amine hydrochloride

3-Chloropropylamine hydrochloride (12 mg, 0.093 mmol), 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDC, 17 mg, 0.089 mmol), 4,4-dimethylaminopyridine (DMAP, 1 mg 0.008 mmol) and Et3N (50 muL, 0.359 mmol) were added to a solution of 1-pyreneacetic acid (20 mg, 0.077 mmol) in anhydrous CH2Cl2 (1 mL) under an argon atmosphere. The reaction mixture was stirred at room temperature for 7 h, quenched with aqueous saturated NH4Cl solution, and extracted with AcOEt. The organic layer was washed with brine, dried over Na2SO4 and evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (CH2Cl2) to give 6 as a pale yellow solid (13 mg, 50%). 1H-NMR (400 MHz, CDCl3) delta (ppm) 8.20 (2H, d, J = 7.6 Hz), 8.15 (3H, d, J = 7.9 Hz), 8.08 (1H, d, J = 9.2 Hz), 8.04 (1H, d, J = 9.2 Hz), 8.02 (1H, t, J = 7.9 Hz), 7.88 (1H, d, J = 7.9 Hz), 4.28 (2H, s), 3.31 (2H, t, J = 6.4 Hz), 3.25 (2H, q, J = 6.4 Hz), 1.78 (2H, quin, J = 6.4 Hz). 13C-NMR (125 MHz, CDCl3) delta (ppm) 171.23, 131.28, 131.16, 130.76, 129.53, 128.50, 128.16, 127.69, 127.27, 126.28, 125.60, 125.48, 125.20, 125.12, 124.62, 122.76, 42.22, 42.08, 37.28, 31.86. IR (cm-1): 3293, 1646, 1544. HR ESI-MS (m/z): calcd. for [C21H19ClNO]+, 336.1150 ([M+H]+); found 336.1161.

The synthetic route of 6276-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fuchi, Yasufumi; Obayashi, Hideto; Sasaki, Shigeki; Molecules; vol. 20; 1; (2015); p. 1078 – 1087;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6276-54-6, category: chlorides-buliding-blocks

To a solution of 3-chloropropan-1-amine hydrochloride salt (1.00 g, 7.69 mmol) in water (4ml) was added NaN3 (1.49 g, 22.7 mmol) and the reaction was heated at 80 C for 15 h. Thesolution was basified with KOH (1.10 g, 19.2 mmol) and extracted with diethyl ether (3 × 5 ml). Thecombined organics were dried over anhydrous Na2SO4, filtered and the solvent was removed (almost todryness) in vacuo to give 3-azidopropan-1-amine as a colourless oil (0.761 g, quant.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropropan-1-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hanna, Jill R.; Allan, Christopher; Lawrence, Charlotte; Meyer, Odile; Wilson, Neil D.; Hulme, Alison N.; Molecules; vol. 22; 5; (2017);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reference of 6276-54-6, A common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 750 g of dimethyl sulfoxide to the reaction flask.420 g (2.196 mol) of compound 1 (prepared in Example 3) are added,Add 340g (8.5mol) of sodium hydroxide, heat, raise the temperature to about 90 C, add 14g of potassium iodide,Under stirring, 340 g (2.615 mol) of 3-chloropropylamine hydrochloride was added in portions, and the reaction was incubated at 100-110 C. for 20 hr.After confirmation of the reaction, 1000 g of water was added, pH=10~11 was adjusted with concentrated hydrochloric acid, and the mixture was stirred for about 1.5 hr. The mixture was allowed to stand for liquid separation. The aqueous phase was extracted once with 800 g of toluene. The organic phase was combined and used 50 kg of sodium chloride. The aqueous solution was washed once, and the liquid was separated. The organic solvent was concentrated and the solvent was weighed to obtain 500 g of an oil (theoretical amount: 545.38 g). Yield: 91.7%.

The synthetic route of 6276-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Inner Mongolia Jingdong Pharmaceutical Co., LTD.; Guo, Rong Yao; Wang, Xiao Feng; Inner Mongolia Jingdong Pharmaceutical Co., Ltd.; Guo Rongyao; Wang Xiaofeng; (11 pag.)CN107698538; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 6276-54-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2-Chlorobenzylamine (14.2 g, 0.10 mol), 4-chlorobenzylamine (14.2 g, 0.10 mol), and2,4-dichlorobenzylamine (17.6 g, 0.10 mol) were each dissolved in water (100 cm3),together with phosphorous acid (16.5 g, 0.20 mol), and concentrated hydrochloric acid (d1.18) (100 cm3) was added. The mixture was heated under reflux on a water bath (100C)and formalin (37% aqueous formaldehyde) (0.20 mol) was added portionwise. After 1 hwater was removed by evaporation until crystals appeared. The solution was then cooledand the product was filtered off and recrystallized three times from water to give theproduct as a white crystalline solid, as follows.

The chemical industry reduces the impact on the environment during synthesis 3-Chloropropan-1-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Reference:
Article; Hudson, Harry R.; Koroma, Sia N.; Ojo, Isaac A. O.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 12; (2015); p. 2187 – 2193;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, A new synthetic method of this compound is introduced below., Safety of 3-Chloropropan-1-amine hydrochloride

General procedure: Toa suspension of lawsone (0.87 g, 5.0 mmol) in ethanol(10 mL) were added sequentially: i) the corresponding amine (5.5 mmol) – andtriethylamine (5.0 mmol, 0.7 mL) in the case of 3-(chloropropyl)aminehydrochloride – and ii) the respective aldehyde (6.0 mmol). The reactionmixture was stirred at RT, in the dark for 12h, after which time the orangeprecipitate was filtered, washed with ethanol, diethyl ether and dried undervacuum.Forthe syntheses of 6a, 6b, 6e, 6f, 6g and 6h, which are more soluble than the other products, the reactionswere carried out in the same amount of ethanol, but using 10.0 mmol of lawsone,10.0 mmol of heptylamine and 12.0 mmol of aldehydes.Compounds4a, 5a, 8a, 4b, 5b, 4c, 5c, 4d, 5d, 6d, 7d, 8d, 9e, 5g, 4h and 5h were synthesized as describedpreviously.3-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; da Silva, Gustavo B.; Neves, Amanda P.; Vargas, Maria D.; Marinho-Filho, Jose D.B.; Costa-Lotufo, Leticia V.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3537 – 3542;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics