Category: 6276-54-6

Reference of 6276-54-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6276-54-6 name is 3-Chloropropan-1-amine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

DIPEA (105 muL, 0.604 mmol) was added to asolution of 19 (88 mg, 0.10 mmol)and HATU (96 mg, 0.25 mmol) in DMF (1 mL). The solution was stirred for 30 min then cooled to 0C. 3-Chloropropan-1-amine hydrochloride (39 mg, 0.30 mmol) was added to the reaction mixture, and the solution was stirred for 1 h. The dark brown reaction mixture was added to water (5 mL) and extracted with ethyl acetate (3 × 5 mL). The combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified by flash column chromatography (Biotage SP4, 12+S column, eluting with hexanes/ethyl acetate,0-70% gradient) to give a brown solid (72 mg, 75% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropropan-1-amine hydrochloride, and friends who are interested can also refer to it.

Reference:
Article; Evison, Benjamin J.; Actis, Marcelo L.; Wu, Sean Z.; Shao, Youming; Heath, Richard J.; Yang, Lei; Fujii, Naoaki; Bioorganic and Medicinal Chemistry; vol. 22; 22; (2014); p. 6333 – 6343;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6276-54-6, A common heterocyclic compound, 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To the 3 mL of dichloromethane was added the compound of Example 5 (65 mg, 0.12 mmol)After dissolving 3-chloropropylamine hydrochloride (33 mg, 0.24 mmol) and triethylamine (0.05 mL, 0.37 mmol)And the mixture was stirred at room temperature under a nitrogen atmosphere for 5 hours.After completion of the reaction, Dichloromethane and purified water were added and stirred,The organic layer and the water layer were separated,The water layer was extracted three times with dichloromethane to collect all organic layers.After the water remaining in the organic was removed with magnesium sulfate, Concentrated and purified by silica gel column chromatography (eluent: 5% MeOH-CH2Cl2) to obtain the desired compound as a white solid. (49 mg, 78.6%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BioActs Co., Ltd.; Park, Jin Woo; Choi, Jae-Ho; Kim, Ki Won; Kim, Jinju; (29 pag.)KR2017/60859; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 6276-54-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6276-54-6 as follows.

[0086] Under stirring, a solution of di-tert-butyl di-carbonate (23.79 g, 110 mmol) in chloroform (50 mL) is slowly addedinto a solution of 3-chloropropylamine hydrochloride (11.0 g, 110 mmol) and triethylamine (18.42 mL, 130 mmol) inchloroform (50 mL). After stirring overnight at room temperature, a brown oil is obtained as a crude product. Thencompound (8-2) (22 g, 95%) as a colorless solid is produced by Kugelrohr distillation at a temperatures of less than 48 C.

According to the analysis of related databases, 6276-54-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hangzhou Bensheng Pharmaceutical Co., Ltd.; XU, Rongzhen; XIE, Fuwen; LAI, Hongxi; RONG, Frank; EP2615092; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 6276-54-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6276-54-6 as follows.

To a solution of phenol A4 (80 mg, 0.22 mmol, 1.0 equiv) indry CH3CN (4 mL) was added tetrabutylammonium hydrogen sulfate (16.0 mg, 0.05 mmol, 0.21 equiv) and powdered NaOH (32 mg, 0.80 mmol, 3.6 equiv). This mixture was then allowed to stir at room temperature for 30 minutes, at which point 1-Amino-3-chloropropane hydrochloride (58 mg, 0.45 mmol, 2.0 equiv) was added to the solution. The mixture was then placed in an oil bath that had been preheated to 55 C, and was allowed to stir at this temperature for 14 hours.Following determination of reaction completion by TLC and LCMS analysis, the solution was then removed from the oil bath and allowed to cool to room temperature. Upon cooling, the mixture was diluted with EtOAc (20 mL) prior to the addition of H20 (10 mL), which served to dissolve all of the inorganic solids present. Following separation of the layers, the aqueous layer was extracted with EtOAc (20 mL). The organic layer was then washed with brine (10 mL), dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was then purified through flash column chromatography (12 g silica gel cartridge, 0-100% EtOAc/Hexanes, followed by 0-20% MeOHICH2C12, and desired product eluted during 20%MeOH, to yield the desired product (65.0 mg, 70%) as a yellow solid. ?H NIVIR (400 MHz,CHLOROFORM-d) 7.13 (d, J= 8.52 Hz, 2H), 6.85 (d, J = 8.52 Hz, 2H), 3.96-4.13 (m, 2H),2.94 (t, J = 6.70 Hz, 2H), 2.67-2.89 (m, 1H), 2.20 -2.28 (m, 2H), 2.09 -2.15 (m, 1H), 1.91 -2.04 (m, 8H), 1.66 – 1.86 (m, 12H), 1.50 – 1.66 (m, 1H), 1.22 – 1.49 (m, 2H); 13C NMR (100IVIHz, CHLOROFORIVI-d) 157.4, 138.1, 127.8, 114.5, 111.5, 109.3, 76.8, 66.0, 42.5, 41.2,39.3, 36.9, 36.6, 36.5, 35.0, 35.0, 34.9, 34.9, 34.3, 33.2, 32.7, 27.0, 26.6, 23.7; MS (ESI)calculated for C25H36N04 [M + H] m/z 414.26, found 414.17

According to the analysis of related databases, 6276-54-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; TALUKDER, Poulami; RENSLO, Adam, Robert; BLANK, Brian, Richard; MUIR, Ryan, Keith; EVANS, Michael, John; (270 pag.)WO2019/5977; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 6276-54-6, The chemical industry reduces the impact on the environment during synthesis 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, I believe this compound will play a more active role in future production and life.

3-Chloropropylamine hydrochloride (1.85g, 14.2mmol) is suspended in toluene (20mL). 1.0mL of 37w% formaldehyde solution (13.4mmol) is added, then once the solids have dissolved KOH (930mg, 14.1mmol based on 85% purity) is also added. The mixture is stirred for 5h. The clear toluene phase is taken from the white paste and filtered through MgSO4. The solids are extracted with a further 1mL of toluene. The combined solutions are pumped down and the residue is dried under high vacuum for 1hr to leave a colourless oil (1.298g, 4.1mmol, 93%) which turns cloudy within a few hours. 1H NMR (m-PhF set to 7.072): delta=3.39 (6H, t, J=6.4, -CH2Cl), 3.12 (6H, s, NCH2N), 2.38 (6H, t, J=6.6, TACCH2-), 1.64 (6H, quintet, J=6.5, -CH2CH2Cl). 13C NMR – 1H-coupled, (m-PhF set to 130.476): delta=74.6 (t of quintets, J=143/4.6, NCH2N), 49.6 (t, J=133, TAC-CH2-), 43.3 (t of quintets, J=151/4.2, -CH2Cl), 31.1 (t of t, J=128/2.8, -CH2CH2Cl).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropropan-1-amine hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Koehn, Randolf D.; Coxon, Alexander G.N.; Hawkins, Christopher R.; Smith, David; Mihan, Shahram; Schuhen, Katrin; Schiendorfer, Michael; Kociok-Koehn, Gabriele; Polyhedron; vol. 84; (2014); p. 3 – 13;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Du, Qiwei, once mentioned the application of 6276-54-6, Name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, molecular weight is 130.02, MDL number is MFCD00012913, category is chlorides-buliding-blocks. Now introduce a scientific discovery about this category, Category: chlorides-buliding-blocks.

In this study, the effect of calcium ions (Ca2+) on the heat stability and rheology of high-calorie (>1.0 kcal/mL) whey protein emulsion (HCWPE) was investigated. The mass fractions of carbohydrate, lipid and protein in the emulsions were 20, 6, and 6 wt%, respectively. It was found that there was little difference in stability and rheology between emulsions (unheated) of different concentrations of Ca2+. However, after high-temperature sterilization (121 degrees C for 15 min), Ca2+ had a significant effect on the stability of HCWPE. The particle size and flocculation degree increased rapidly when the Ca2+ concentration was above 1.5 mM, and absolute.-potential decreased. The change of 3-week particle size and backscattering showed that the emulsion had better storage stability when the Ca2+ concentration was below 1.5 mM. Another interesting result was that after the high temperature sterilization, the rheological behavior of HCWPE changed from shear-thickening to shearthinning with increase in Ca2+ concentration. It could be explained that free Ca2+ continued to bind with protein during the shearing process. The present study would provide a theoretical reference for calcium fortified functional drinks.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 6276-54-6, Category: chlorides-buliding-blocks.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 6276-54-6, Name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, belongs to chlorides-buliding-blocks compound, is a common compound. In a patnet, author is Salama, Ahmed, once mentioned the new application about 6276-54-6, Application In Synthesis of 3-Chloropropan-1-amine hydrochloride.

Cellulose and silk fibroin were dissolved in 1-Butyl-3-methylimidazolium chloride [Bmim][Cl] and regenerated with ethanol to form homogenous blend of regenerated cellulose/silk fibroin. The bioactivity of regenerated cellulose/silk matrix to assist calcium phosphate mineralization was studied in the current article. Cellulose/silk fibroin/calcium phosphate biocomposite was investigated by different characterization methods such as FT-IR, XRD, TGA, SEM and EDX. The potential of the prepared composite for removal of organic dyes, such as methylene blue (MB), was calculated. The prepared biocomposite exhibited high removal efficiency for MB (172.4 mg/g) compared to regenerated cellulose/silk fibrin blend which is 120.4 mg/g. The kinetic study and the isotherm results for the examined materials followed pseudo second order and Langmuir models, respectively. The regenerated cellulose/silk/calcium phosphate biocomposite, thus providing prospects for further research and application in the remediation of water from dye pollution. (C) 2020 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6276-54-6. The above is the message from the blog manager. Application In Synthesis of 3-Chloropropan-1-amine hydrochloride.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Application of 6276-54-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6276-54-6, Name is 3-Chloropropan-1-amine hydrochloride, SMILES is NCCCCl.[H]Cl, belongs to chlorides-buliding-blocks compound. In a article, author is Okesola, Mary Abiola, introduce new discover of the category.

Ginger rhizomes have been reportedly used in folk medicine for the management of various ailments. This study, therefore, investigates the ameliorative effect of the ethanolic extract of ginger (Zingiber officinale) rhizomes against DNA damage in rats induced with different carcinogens. Fifteen Wistar rats grouped into 3 of 5 rats per group were used for the study. The first set of blood samples was first collected before the animals were orally treated with heavy metals. After 14 days of induction, the second set of blood was collected. The third phase of blood collection was done after administering an ethanolic extract of Z. officinale for 14 days. The UV wavelength absorption spectrum and conventional PCR analysis were carried out on DNA extracts of all the animals. Cluster analysis of optical density (OD) and PCR data were carried out as well as genomic instability, similarity, and diversity using the best 3 Random Amplified Polymorphic DNA (RAPD) primers. The PCR -DNA concentration analysis showed the Z. officinale extract’s ameliorative effect against lead acetate, cadmium chloride, and arsenic trioxide- induced DNA damage with a significant (p < 0.05) reduction in DNA concentration of the treated rats when compared with induced rats. The cluster analysis of optical density values revealed close similarity between the control animals' DNA, a slight similarity with treated animals' DNA, and a significant difference with the induced animal DNA. These results indicated the ameliorative properties of Z. officinale against these heavy metals induced DNA damage in rats. (C) 2020 by the authors. Application of 6276-54-6, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 6276-54-6 is helpful to your research.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 6276-54-6, Name is 3-Chloropropan-1-amine hydrochloride, SMILES is NCCCCl.[H]Cl, in an article , author is Gang, Li, once mentioned of 6276-54-6, Product Details of 6276-54-6.

A Promoted Mesoporous Silica-Based Material for SO2 Adsorption

Mesoporous materials have been widely used in the adsorption of air pollutants because of their uniform pore structure and large specific surface area. In this study, hexadecyltrimethylammonium chloride and tetramethylammonium hydroxide pentahydrate were used as structure-directing agents, silica as a silicon source, and tetramethylammonium silicate as a functional group to prepare a mesoporous silica-based material (MSBM) by a designed hydrothermal reaction. The synthetic materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunner-Emmet-Teller (BET), Fourier-transform infrared spectroscopy (FITR), and thermogravimetric analysis (TGA). The adsorption efficiency of MSBM for SO2 in simulated flue gas under different conditions was studied. The results showed that the structure of the MSBM was the hexagonally ordered MCM-41 structure. It had the characteristics of uniform appearance, large specific surface area, rich surface groups, and strong thermal stability. The static activity of SO2 in flue gas could reach 32.1 mg/g under optimal conditions, which was slightly inferior to activated carbon. Therefore, MSBM has great practical application potential in the treatment of SO2 in flue gas.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 6276-54-6, you can contact me at any time and look forward to more communication. Product Details of 6276-54-6.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 6276-54-6, Name is 3-Chloropropan-1-amine hydrochloride, molecular formula is C3H9Cl2N, belongs to chlorides-buliding-blocks compound, is a common compound. In a patnet, author is Holtz, Arne, once mentioned the new application about 6276-54-6, Category: chlorides-buliding-blocks.

Automated measurement of pH-dependent solid-liquid equilibria of itaconic acid and protocatechuic acid

Crystallization is a highly selective unit operation capable of separating target molecules from complex media. Its design requires precise solid-liquid equilibrium (SLE) data. The SLE of platform chemicals like carboxylic acids in complex aqueous media depends on temperature, pH value as well as on present side components, but predominantly, only the solubility for different temperatures is reported. This work presents a novel automated method for the determination of the pH- and temperature-dependent SLE in complex media using readily available laboratory equipment. Taking the example of itaconic acid, the pH-dependent solubility for different temperatures is measured and validated with results obtained from the classic excess solid method along with literature data. Using the automated setup, the influence of different loadings of sodium chloride on the SLE of itaconic acid is investigated and a correlation between solubility and concentration of the electrolyte is derived. The SLE data acquired for protocatechuic acid in fermentation medium demonstrates the applicability of the method for the determination of comprehensive SLE in multicomponent mixtures without the requirement of specific analytical methods for the target compound. The resulting SLE data can be used for a more precise design and techno-economic evaluation of crystallization processes in biotechnological production routes. (C) 2020 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 6276-54-6. The above is the message from the blog manager. Category: chlorides-buliding-blocks.