Category: 62936-23-6

Shimada, Kinji published the artcileOrganic compounds in kraft bleaching spent liquors. IV. Toxicity bioassay of organic compounds from beech kraft bleach effluents, COA of Formula: C8H7ClO4, the main research area is bleaching effluent toxicity activated sludge; chloroorg compound toxicity activated sludge; phenolic compound toxicity activated sludge; pulp bleaching effluent toxicity.

The toxicity of organic matter fractionated from the title bleaching effluents of C, E, and D stages to activated sludge decreased in the order of C > E > D. The Et2O-soluble fraction of bleaching effluent was more toxic in pH range 4-6 than in pH range 7-9. The chlorinated low-mol.-weight compounds present in the effluent were primarily responsible for the toxicity. Some of the chlorinated low-mol.-weight compounds were synthesized and tested for toxicity. The results indicated greater toxicity in the acidic region than in the alk. one, and important contribution to toxicity of organically bonded Cl and phenolic OH group.

Mokuzai Gakkaishi published new progress about Bleaching. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, COA of Formula: C8H7ClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shi, Lisheng published the artcileEffect of lignin structure on adsorbable organic halogens formation in chlorine dioxide bleaching, Recommanded Product: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is lignin structure chlorine dioxide bleaching; adsorbable organic halogens; bleaching; chlorine dioxide; lignin model compounds.

Adsorbable organic halogens (AOX) are formed in pulp bleaching as a result of the reaction of residual lignin with chlorine dioxide. The natural structure of lignin is very complex and it tends to be damaged by various extraction methods. All the factors can affect the study about the mechanism of AOX formation in the reaction of lignin with chlorine dioxide. Lignin model compounds, with certain structures, can be used to study the role of different lignin structures on AOX formation. The effect of lignin structure on AOX formation was determined by reacting phenolic and non-phenolic lignin model compound with a chlorine dioxide solution Vanillyl alc. (VA) and veratryl alc. (VE) were selected for the phenolic and non-phenolic lignin model compound, resp. The pattern consumption of lignin model compounds suggests that both VA and VE began reacting with chlorine dioxide within 10 min and then gradually steadied. The volume of AOX produced by VE was significantly higher than that produced by VA for a given initial lignin model compound concentration In a solution containing a combination of VA and VE in chlorine dioxide, VE was the dominant producer of AOX. This result indicates that the non-phenolic lignin structure was more easily chlorinated, while the phenolic lignin structure was mainly oxidized. In addition, AOX content produced in the combined experiments exceeded the total content of the two sep. experiments It suggested that the combination of phenolic and non-phenolic lignin structure can promote AOX formation.

Royal Society Open Science published new progress about Bleaching. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Recommanded Product: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Crawford, R. L. published the artcileDegradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment. Significance to lignin degradation and effect of chloro substituents, Safety of 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is methyl benzoate demethylation Nocardia; lignin degradation actinomycete benzoate derivative; anisate vanillate demethylation Nocardia.

N. corallina A81 from a lignin-rich environment demethylated p-anisic acid to p-hydroxybenzoic acid and isovanillic acid. It dimethylated veratric acid to a mixture of vanillic and isovanillic acids, which were both demethylated to protocatechuic acid which undergoes ring cleavage to muconic acid. An o-chloro substituent on the benzene ring hinders both demethylation and ring opening. o-Hydroxylation of p-methoxybenzoic acid to isovanillic acid was unaffected by a Cl ortho to the Me group. Though N. corallina was able to use various aromatic compounds that are structurally related to lignin, no structural changes in isolated lignin were detected.

Applied Microbiology published new progress about Nocardia. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Safety of 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Clarke, Earl published the artcileDesign and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist, Category: chlorides-buliding-blocks, the main research area is chloroethoxyisopropoxybenzamidomethylbenzoate preparation bioavailability retinoate receptor alpha agonist.

A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 and AGN 193836 was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid (5), which has good selectivity over the RARβ, and RARγ receptors. Anal. of the medicinal chem. parameters of the 3,5-substituents of derivatives of template (5) enabled the authors to design a class of drug-like mols. with lower intrinsic clearance and higher oral bioavailability which led to the novel RARα agonist 4-(3-chloro-4-ethoxy-5-isopropoxybenzamido)-2-methylbenzoic acid (56) that has high RARα potency and excellent selectivity vs. RARβ (2 orders of magnitude) and RARγ (4 orders of magnitude) at both the human and mouse RAR receptors with improved drug-like properties. This RARα specific agonist (56) has high oral bioavailability (>80%) in both mice and dogs with a good PK profile and was shown to be inactive in cytotoxicity and genotoxicity screens.

Bioorganic & Medicinal Chemistry published new progress about Binding energy. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shimada, Kinji published the artcileOrganic compounds in kraft bleaching spent liquors. V. Photodegradation of red-pine chlorinated oxylignin, Formula: C8H7ClO4, the main research area is UV light degradation chlorinated oxylignin; dechlorination chlorinated oxylignin photodegradation; demethoxylation chlorinated oxylignin photodegradation; photodegradation chlorinated lignin model compound.

The degradation of chlorinated oxylignin (I) in NaOH solution with UV light in the presence of O increased with increasing pH and resulted in the formation of low-mol.-weight compounds with accompanying dechlorination, demethoxylation, and cleavage of the aromatic rings and in the reduction of COD of I solutions Upon UV irradiation in the presence of N, no reduction of COD and cleavage of aromatic rings were observed, but Cl and methoxy groups were removed, the color of the I solution became dark, and the I was polymerized slightly. In the methoxy group-containing chlorinated model compounds for lignin, the cleavage of C-Cl bonds in the presence of N promoted a demethoxylation reaction.

Mokuzai Gakkaishi published new progress about Dechlorination. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Formula: C8H7ClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ohi, Nobuhiro published the artcileSemisynthetic β-lactam antibiotics. III. Effect on antibacterial activity and COMT susceptibility of chlorine introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is penicillanic acid antibacterial; catechol methyl transferase metabolism penicillinate.

The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid (I) [81819-61-6] to metabolism by catechol-O-methyl-transferase  [9012-25-3] was increased by introduction of the Cl atom into the catechol moiety. Penicillins having 1 or 2 Cl atoms at the positions adjacent to the OH had greater stability to COMT. This resulted in greater efficiency in vivo in exptl. Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged.

Journal of Antibiotics published new progress about Escherichia coli. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Woo, L. W. Lawrence published the artcileDual Aromatase-Steroid Sulfatase Inhibitors, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is YM511 sulfamate analog preparation structure aromatase steroid sulfatase inhibitor.

By introducing the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent dual aromatase-sulfatase inhibitors (DASIs) were generated. Two best DASIs (I and II) in vitro (JEG-3 cells) had IC50(aromatase) = 0.82 nM; IC50(sulfatase) = 39 nM, and IC50(aromatase) = 0.77 nM; IC50(sulfatase) = 590 nM, resp. X-ray crystallog. of I, and docking studies of selected compounds into an aromatase homol. model and the steroid sulfatase crystal structure are presented. Both I and II inhibit aromatase and sulfatase in PMSG pretreated adult female Wistar rats potently 3 h after a single oral 10 mg/kg dose. Almost complete dual inhibition is observed for I but the levels were reduced to 85% (aromatase) and 72% (sulfatase) after 24 h. DASI I did not inhibit aldosterone synthesis. The development of a potent and selective DASI should allow the therapeutic potential of dual aromatase-sulfatase inhibition in hormone-dependent breast cancer to be assessed.

Journal of Medicinal Chemistry published new progress about Aromatase inhibitors. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kirk, T. Kent published the artcileOxygenation of 4-alkoxyl groups in alkoxybenzoic acids by Polyporus dichrous, Application of 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is alkoxybenzoate oxidation Polyporus; lignin degradation Polyporus.

The degradation of several alkyl ethers of vanillic acid, 3-ethoxy-4-hydroxybenzoic acid, and of syringic acid by the lignin-decomposing fungus P. dichrous included 4-dealkylation, hydroxylation of the 4-alkoxyl groups, and reduction of carboxyl groups. The dealkylations and hydroxylations indicate that the fungus has a relatively nonspecific mechanism for oxygenating various 4-alkoxyl groups of alkoxybenzoic acids; no evidence for oxygenation of 3-alkoxyl groups was obtained. Hydroxylation products were generally degraded further, probably via dealkylation. The vanillic acid and 3-ethoxy-4-hydroxybenzoic acid formed by dealkylations were readily metabolized. Although the isopropyl ether of syringic acid was hydroxylated to 2-(4-carboxyl-2,6-dimethoxyphenoxy)propan-1-ol, neither this compound nor the parent isopropyl ether was dealkylated; syringic acid itself was only slowly and incompletely metabolized. The relation of these results to lignin degradation is discussed.

Applied Microbiology published new progress about Polyporus dichrous. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Application of 3-Chloro-4-hydroxy-5-methoxybenzoic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kersten, Philip published the artcileEnzymic release of halogens or methanol from some substituted protocatechuic acids, Synthetic Route of 62936-23-6, the main research area is protocatechuate metabolism bacteria halogen methanol.

Four strains of gram-neg. bacteria capable of growing at the expense of 5-chlorovanillate were isolated from soil, and the metabolism of 1 strain was studied in particular detail. In the presence of α,α’-bipyridyl, a suspension of 5-chlorovanillate-grown cells accumulated 5-chloroprotocatechuate from 5-chlorovanillate; in the absence of inhibitor these compounds, and various other 5-substituted protocatechuates and vanillates, were oxidized to completion. Cell suspensions of this strain grown on 5-chlorovanillate or vanillate released Cl- quant. from 5-chlorovanillate and released MeOH from syringate. Extracts of cells grown with 4-hydroxybenzoate, vanillate, or syringate possessed high levels of both protocatechuate 4,5-dioxygenase and 2-pyrone-4,6-dicarboxylate hydrolase; extracts from acetate-grown cells did not. Protocatechuate 4,5-dioxygenase, purified from strains that could grow with 5-chlorovanillate, oxidized 5-halogeno-protocatechuates and 3-O-methylgallate with the formation of 2-pyrone-4,6-dicarboxylate. A crude extract converted 5-chloroprotocatechuate into pyruvate plus oxaloacetate. A meta-fission reaction sequence is proposed for the bacterial degradation of vanillate and protocatechuate substituted at C-5 of the benzene ring with halogen or methoxyl.

Journal of Bacteriology published new progress about Comamonas testosteroni. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Synthetic Route of 62936-23-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Genthner, Barbara R. Sharak published the artcileReduction of 3-chlorobenzoate, 3-bromobenzoate, and benzoate to corresponding alcohols by Desulfomicrobium escambiense, isolated from a 3-chlorobenzoate-dechlorinating coculture, Product Details of C8H7ClO4, the main research area is Desulfomicrobium chlorobenzoate bromobenzoate benzoate reduction.

An anaerobic bacterial coculture which dechlorinated 3-chlorobenzoate (3CB) to benzoate was obtained by single-colony isolation from an anaerobic bacterial consortium which completely degraded 3CB in defined medium. Of 29 addnl. halogenated aromatic compounds tested, the coculture removed the meta halogen from 2,3- and 2,5-dichlorobenzoate, 3-bromobenzoate (3BB), 5-chlorovanillate (5CV), and 3-chloro-4-hydroxybenzoate. Dechlorinating activity in the coculture required the presence of pyruvate. 5CV was also O-demethoxylated. The coculture contained two cell types: a short, straight gram-neg. rod and a long, thin, curved gram-pos. rod. The short rod, Desulfomicrobium escambiense, was recently isolated and identified as a new sulfate-reducing bacterial species (B. R. Sharak Genthner, S. D. Friedman, and R. Devereux, Int. J. Syst. Bacteriol. 47:889-892, 1997; B. R. Sharak Genthner, G. Mundfrom, and R. Devereux, Arch. Microbiol. 161:215-219, 1994). D. escambiense did not dehalogenate any of the compounds dehalogenated by the coculture, nor did it O-demethoxylate 5CV or vanillate. However, D. escambiense reduced 3CB, 3BB, and benzoate to their resp. benzyl alcs. Reduction to alcs. required the presence of pyruvate, which was transformed to acetate, lactate, and succinate in the presence or absence of 3CB, 3BB, or benzoate. Alc. formation did not occur in pyruvate-sulfate medium. Under these conditions, sulfate was preferentially reduced. Other electron donors that supported the growth of D. escambiense during sulfate reduction did not support benzoate reduction to benzyl alc.

Applied and Environmental Microbiology published new progress about Desulfomicrobium escambiense. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Product Details of C8H7ClO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics