Category: 6294-17-3

Cooperative veratryle and nitroindoline cages for two-photon uncaging in the NIR was written by Cueto Diaz, Eduardo;Picard, Sebastien;Klausen, Maxime;Hugues, Vincent;Pagano, Paolo;Genin, Emilie;Blanchard-Desce, Mireille. And the article was included in Chemistry – A European Journal in 2016.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Tandem uncaging systems in which a two-photon absorbing module and a cage moiety, linked via a phosphorous clip, that act together by Foerster resonance energy transfer (FRET) have been developed. A library of these compounds, using different linkers and cages (7-nitroindolinyl or nitroveratryl) has been synthesized. The investigation of their uncaging and two-photon absorption properties demonstrates the scope and versatility of the engineering strategy towards efficient two-photon cages and reveals surprising cooperative and topol. effects. The interactions between the 2PA module and the caging moiety are found to promote cooperative effects on the 2PA response while addnl. processes that enhance the uncaging efficiency are operative in well-oriented nitroindoline-derived dyads. These synergic effects combine to lead to record two-photon uncaging cross-section values (i.e., up to 20 GM) for uncaging of carboxylic acids. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif was written by Williams, Leslie K.;Zhang, Xiaohua;Caner, Sami;Tysoe, Christina;Nguyen, Nham T.;Wicki, Jacqueline;Williams, David E.;Coleman, John;McNeill, John H.;Yuen, Violet;Andersen, Raymond J.;Withers, Stephen G.;Brayer, Gary D.. And the article was included in Nature Chemical Biology in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The complex plant flavonol glycoside montbretin A (MbA) is a potent (K_i = 8 nM) and specific inhibitor of human pancreatic α-amylase (HPA) with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inhibition analyses, identified an essential high-affinity core structure comprising the myricetin and caffeic acid moieties linked via a disaccharide. X-ray structural analyses of the montbretin A complex with human α-amylase confirmed the importance of this core structure and revealed a novel mode of glycosidase inhibition, wherein internal π-stacking interactions between the myricetin and caffeic acid moieties organize their ring hydroxyls for optimal hydrogen bonding to the α-amylase catalytic residues D197 and E233. This novel inhibitory motif can be reproduced in a greatly simplified analog, offering potential for new strategies for glycosidase inhibition and therapeutic development. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Hantzsch adducts as cholinesterases and calcium flux inhibitors, antioxidants and neuroprotectives was written by Angona, Irene Pachon;Martin, Helene;Daniel, Solene;Moraleda, Ignacio;Bonet, Alexandre;Wnorowski, Artur;Maj, Maciej;Jozwiak, Krzysztof;Iriepa, Isabel;Refouvelet, Bernard;Marco-Contelles, Jose;Ismaili, Lhassane. And the article was included in International Journal of Molecular Sciences in 2020.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

We report herein the design, synthesis, biol. evaluation, and mol. modeling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((5-aminoalkyl)oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3a-p, have been obtained via Hantzsch reaction from appropriate and com. available precursors. Pertinent biol. anal. has prompted us to identify MTDL 3h [dimethyl-4-(4-((5-(4-benzylpiperidin-1-yl)pentyl)oxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine3,5-dicarboxylate] as an attractive inhibitor of AChE (1.8μM) and BuChE (2μM), Ca+2 channel antagonist (47.72% at 10μM), and antioxidant (2.54 TE) agent, showing significant neuroprotection 28.68% and 38.29% against H2O2, and O/R, resp., at 0.3μM, thus being considered a hit-compound for further investigation in our search for anti-Alzheimer’s disease agents. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL was written by Lai, Ashton C.;Toure, Momar;Hellerschmied, Doris;Salami, Jemilat;Jaime-Figueroa, Saul;Ko, Eunhwa;Hines, John;Crews, Craig M.. And the article was included in Angewandte Chemie, International Edition in 2016.Application In Synthesis of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Proteolysis Targeting Chimera (PROTAC) technol. is a rapidly emerging alternative therapeutic strategy with the potential to address many of the challenges currently faced in modern drug development programs. PROTAC technol. employs small mols. that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. During the course of their development, the authors discovered that the capacity of a PROTAC to induce degradation involves more than just target binding: the identity of the inhibitor warhead and the recruited E3 ligase largely determine the degradation profiles of the compounds; thus, as a starting point for PROTAC development, both the target ligand and the recruited E3 ligase should be varied to rapidly generate a PROTAC with the desired degradation profile. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application In Synthesis of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif was written by Williams, Leslie K.;Zhang, Xiaohua;Caner, Sami;Tysoe, Christina;Nguyen, Nham T.;Wicki, Jacqueline;Williams, David E.;Coleman, John;McNeill, John H.;Yuen, Violet;Andersen, Raymond J.;Withers, Stephen G.;Brayer, Gary D.. And the article was included in Nature Chemical Biology in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The complex plant flavonol glycoside montbretin A (MbA) is a potent (K_i = 8 nM) and specific inhibitor of human pancreatic α-amylase (HPA) with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inhibition analyses, identified an essential high-affinity core structure comprising the myricetin and caffeic acid moieties linked via a disaccharide. X-ray structural analyses of the montbretin A complex with human α-amylase confirmed the importance of this core structure and revealed a novel mode of glycosidase inhibition, wherein internal π-stacking interactions between the myricetin and caffeic acid moieties organize their ring hydroxyls for optimal hydrogen bonding to the α-amylase catalytic residues D197 and E233. This novel inhibitory motif can be reproduced in a greatly simplified analog, offering potential for new strategies for glycosidase inhibition and therapeutic development. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, Catalytic Activity and Comparative Leaching Studies of Calix[8]arene-Supported Pd-NHC Complexes for Suzuki-Miyaura Cross-Couplings was written by Abi Fayssal, Sandra;Naret, Timothee;Buendia, Julien;Labattut, Axel;Huc, Vincent;Martini, Cyril;Schulz, Emmanuelle. And the article was included in Advanced Synthesis & Catalysis in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A rapid and scalable synthesis of supported NHC-Pd(II)-pyridine complexes on a benzyloxycalix[8]arene macrocycle is reported. Their subsequent use in Suzuki-Miyaura benchmark reactions led to the optimization of the nature of the ligands around the metal center, delivering two very active precatalysts. They both promote the cross-coupling of challenging API precursors at low catalytic loadings, when used as insoluble species in EtOH as a green reaction solvent. Moreover, their activity has been shown to be comparable or even superior to that of more conventional homogeneous catalysts. Of main importance, a simple filtration of the insoluble supported catalysts after reaction afforded the lowest Pd contamination values in the target products, in some cases directly approaching the levels authorized by the industrial regulations. Offering furthermore the possibility of easy palladium recovery in the current context of its overconsumption, we are convinced that these calixarene-supported NHC-PEPPSI Pd complexes are valuable tools for the fine chem. industry, to prepare metal-free functionalized biaryl compounds in high yields, ranging from 76 to 94%. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Influence of acetylene-containing peripheral chains on the mesomorphic properties of triphenylene-based liquid crystals was written by Stackhouse, Philip J.;Hird, Michael. And the article was included in Liquid Crystals in 2009.Application In Synthesis of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Three series of acetylene-containing triphenylene-based liquid crystals have been prepared One class of material is sym. with the acetylenic unit located at the terminus of a peripheral alkynyloxy chain in a peripheral position at the terminus of an alkoxy chain. These sym. hexa-substituted materials possess high m.ps. which renders mesomorphism monotropic. A second class comprises materials where only one of the six peripheral units contains a terminal alkyne chain. The asymmetry confers relatively low m.ps. and an enantiotropic hexagonal columnar mesophase is exhibited for all materials, albeit to a lower temperature than the known parent systems. The third series of materials also comprises unsym. structures, here containing one acetylenic unit conjugated with the triphenylene core and five alkoxy chains. This third series of materials show enhanced π-π interactions and enhanced space-filling effects of the acetylenic unit close to the core which enhance mesophase stability markedly over the hexaalkoxy analogs. This result shows that rigidity of peripheral chains, as opposed to mol. symmetry, is the significant factor for the reduction of mesophase stabilities. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application In Synthesis of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron-Catalyzed C(sp²)-H Alkylation of Indolines and Benzo[h]quinoline with Unactivated Alkyl Chlorides through Chelation Assistance was written by Jagtap, Rahul A.;Samal, Pragnya Paramita;Vinod, C. P.;Krishnamurty, Sailaja;Punji, Benudhar. And the article was included in ACS Catalysis in 2020.Application In Synthesis of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Regioselective C-H bond alkylation of indolines and benzo[h]quinoline with a wide range of unactivated and highly demanded primary and secondary alkyl chlorides is accomplished using a low-cost iron catalyst. This reaction tolerates diverse functionalities, such as C(sp²)-Cl, fluoro, alkenyl, silyl, ether, thioether, pyrrolyl, and carbazolyl groups including cyclic and acyclic alkyls as well as alkyl-bearing fatty-alc. and polycyclic-steroid moieties. The demonstrated iron-catalyzed protocol proceeded via either a five-membered or a six-membered metallacycle. Intriguingly, the C-7-alkylated indolines can be readily functionalized into free-NH indolines/indoles and tryptamine derivatives A detailed mechanistic investigation highlights the participation of an active Fe(I) catalyst and the involvement of a halogen-atom transfer process via a single-electron-based mechanism. Deuterium labeling and kinetics anal. indicate that the C-H metalation of indoline is the probable turnover-limiting step. Overall, the exptl. and theor. studies supported an Fe(I)/Fe(III) pathway for the alkylation reaction comprising the two-step, one-electron oxidative addition of alkyl chloride. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application In Synthesis of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effects of link chain length on oxidation of cyclohexylbenzene catalyzed by immobilized N-hydroxyphthalimide on crosslinked polystyrene was written by Sun, Tingting;Shan, Yuhua;Wang, Jiyuan;Chen, Shaohui;Huang, Chao. And the article was included in Shiyou Xuebao, Shiyou Jiagong in 2020.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

To solve the drawbacks of difficult recovery and reuse of N-hydroxyphthalimide (NHPI), the crosslinked polystyrene (CPS) immobilized NHPI (CPS-NHPI-C_n) catalysts with different link chain lengths were prepared by chem. immobilization of NHPI on the surface of CPS microsphere using different chain lengths of halogenated hydrocarbons as alkylation agents. The synthesized CPS-NHPI-C_n catalysts were characterized by XPS, FT-IR, BET and SEM, and evaluated by cyclohexylbenzene oxidation The effects of link chain length (C₁-C₉) in CPS-NHPI-C_n and reaction conditions on the catalytic performance were investigated. Results indicate that the link chain length affects the catalytic performance of CPS-NHPI-C_n obviously, and the catalytic activity increases with the link chain number from 1 to 6. Using CPS-NHP-C₆ as catalyst, at 95°C and 1 MPa O₂ partial pressure for 8 h, the cyclohexylbenzene conversion is 28.4%, with the selectivity of cyclohexanone and phenol is 90.7% and 87.6%, resp. After the CPS-NHP-C₆ catalyst has been reused for 10 times, the catalytic performance is still as high as that of fresh one. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed Alkyl-Alkyl Cross-Coupling Reactions Using Hydrocarbon Additives: Efficiency of Catalyst and Roles of Additives was written by Iwasaki, Takanori;Imanishi, Reiko;Shimizu, Ryohei;Kuniyasu, Hitoshi;Terao, Jun;Kambe, Nobuaki. And the article was included in Journal of Organic Chemistry in 2014.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

Cross-coupling of alkyl halides with alkyl Grignard reagents proceeds with extremely high TONs of up to 1230000 using a Cu/unsaturated hydrocarbon catalytic system. Alkyl fluorides, chlorides, bromides, and tosylates are all suitable electrophiles, and a TOF as high as 31200 h^-1 was attained using an alkyl iodide. Side reactions of this catalytic system, i.e., reduction, dehydrohalogenation (elimination), and the homocoupling of alkyl halides, occur in the absence of additives. It appears that the reaction involves the β-hydrogen elimination of alkylcopper intermediates, giving rise to olefins and Cu-H species, and that this process triggers both side reactions and the degradation of the Cu catalyst. The formed Cu-H promotes the reduction of alkyl halides to give alkanes and Cu-X or the generation of Cu(0), probably by disproportionation, which can oxidatively add to alkyl halides to yield olefins and, in some cases, homocoupling products. Unsaturated hydrocarbon additives such as 1,3-butadiene and phenylpropyne play important roles in achieving highly efficient cross-coupling by suppressing β-hydrogen elimination, which inhibits both the degradation of the Cu catalyst and undesirable side reactions. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics