Category: 6294-17-3

Tuning the effects of N1 substituents on the 2-methylimidazolium functionalized polynorbornene alkaline anion exchange membranes was written by Huang, Shengmei;He, Xiaohui;Guo, Yan;Chen, Defu. And the article was included in Polymer in 2020.Related Products of 6294-17-3 The following contents are mentioned in the article:

The N1-substituted (Me, iso-Pr, Bu, benzyl or dodecyl) 2-methylimidazolium functionalized polynorbornene (rPNB-RMIm-30) AEMs are prepared and the effects of substituents are studied. The N1-Bu or isopropyl-substituted 2-methylimidzolium (rPNB-BuMIm-30 or rPNB-iPrMIm-30) anion exchange membrane (AEM) reveals much better alk. durability than that of Me, benzyl and dodecyl-substituted 2-methylimidazolium-based AEMs, reflected by the almost unaltered FT-IR spectra and TGA curves after being subjected to 1 M NaOH for 720 h at 60°C, with a conductivity degradation of 17% and 14% resp. Furthermore, a highest hydroxide conductivity (51.5 mS cm^-1, 80°C) is achieved of the rPNB-BuMIm-30 AEM, attributing to its well-defined phase-separated structure, as evidenced by results of at. force microscope (AFM) and X-ray scattering (SAXS). Membrane electrode assembly (MEA) with rPNB-BuMIm-30 AEM exhibits a peak power d. of 205 mWcm^-2 at 60°C. This study paves the way of N1-Substituented 2-methylimidazolium-based AEM for fuel cells practical application. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optogenetic control of kinetochore function was written by Zhang, Huaiying;Aonbangkhen, Chanat;Tarasovetc, Ekaterina V.;Ballister, Edward R.;Chenoweth, David M.;Lampson, Michael A.. And the article was included in Nature Chemical Biology in 2017.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

Kinetochores act as hubs for multiple activities during cell division, including microtubule interactions and spindle checkpoint signaling. Each kinetochore can act autonomously, and activities change rapidly as proteins are recruited to, or removed from, kinetochores. Understanding this dynamic system requires tools that can manipulate kinetochores on biol. relevant temporal and spatial scales. Optogenetic approaches have the potential to provide temporal and spatial control with mol. specificity. Here we report new chem. inducers of protein dimerization that allow us to both recruit proteins to and release them from kinetochores using light. We use these dimerizers to manipulate checkpoint signaling and mol. motor activity. Our findings demonstrate specialized properties of the CENP-E (kinesin-7) motor for directional chromosome transport to the spindle equator and for maintenance of metaphase alignment. This work establishes a foundation for optogenetic control of kinetochore function, which is broadly applicable to exptl. probing of other dynamic cellular processes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes was written by Westphal, Matthias V.;Sarott, Roman C.;Zirwes, Elisabeth A.;Osterwald, Anja;Guba, Wolfgang;Ullmer, Christoph;Grether, Uwe;Carreira, Erick M.. And the article was included in Chemistry – A European Journal in 2020.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The endocannabinoid (eCB) system is implied in various human diseases ranging from central nervous system to autoimmune disorders. Cannabinoid receptor 2 (CB₂R) is an integral component of the eCB system. Yet, the downstream effects elicited by this G protein-coupled receptor upon binding of endogenous or synthetic ligands are insufficiently understood-likely due to the limited arsenal of reliable biol. and chem. tools. Herein, we report the design and synthesis of CB₂R-selective cannabinoids along with their in vitro pharmacol. characterization (binding and functional studies). They combine structural features of HU-308 and AM841 to give chimeric ligands that emerge as potent CB₂R agonists with high selectivity over the closely related cannabinoid receptor 1 (CB₁R). The synthesis work includes convenient preparation of substituted resorcinols often found in cannabinoids. The utility of the synthetic cannabinoids in this study is showcased by preparation of the most selective high-affinity fluorescent probe for CB₂R to date. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bis-imidazolium functionalized self-crosslinking block polynorbornene anion exchange membrane was written by Zhang, Feng;He, Xiaohui;Cheng, Changwen;Huang, Shengmei;Duan, Yapeng;Zhu, Chuanyi;Guo, Yan;Wang, Kai;Chen, Defu. And the article was included in International Journal of Hydrogen Energy in 2020.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

Anion exchange membranes (AEMs) are widely studied as an important component of fuel cells. In this paper, series self-crosslinking AEMs are obtained by copolymerization of the prepared bis-imidazolium functionalized ionic liquids The block copolymer shows excellent thermal stability with a decomposition temperature (Td) of 300°C. And the mech. properties of AEMs in OH^– are significantly improved due to the crosslinking of epoxy groups. The transmission electron microscopy (TEM) test results show a good microscopic phase separation structure and form ion channels in the membranes, which is benefited to ions conductivity The OH^– conductivity of AEMs is measured as above 2410^-3Scm^-1 and 9510^-3Scm^-1 at 30°C and 80°C, resp. In addition, the AEMs also exhibits excellent swelling performance, the highest is only 20.86% at 80°C. And the conductivity of all AEMs remained above 90% after being immersed in 1MNaOH aqueous at 60°C for 250 h. The peak power d. of the AEMs reaches 207.95 mW cm^-2 at c.d. of 403 mA cm^-2. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase was written by Zhao, Quanju;Ren, Chaowei;Liu, Linyi;Chen, Jinju;Shao, Yubao;Sun, Ning;Sun, Renhong;Kong, Ying;Ding, Xinyu;Zhang, Xianfang;Xu, Youwei;Yang, Bei;Yin, Qianqian;Yang, Xiaobao;Jiang, Biao. And the article was included in Journal of Medicinal Chemistry in 2019.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

The oncogenic fusion protein BCR-ABL is the driving force of leukemogenesis in chronic myeloid leukemia (CML). Despite great progress for CML treatment through application of tyrosine kinase inhibitors (TKIs) against BCR-ABL, long-term drug administration and clin. resistance continue to be an issue. Herein, we described the design, synthesis, and evaluation of novel proteolysis-targeting chimeric (PROTAC) small mols. targeting BCR-ABL which connect dasatinib and VHL E3 ubiquitin ligase ligand by extensive optimization of linkers. Our efforts have yielded SIAIS178 (19), which induces proper interaction between BCR-ABL and VHL ligase leading to effective degradation of BCR-ABL protein, achieves significant growth inhibition of BCR-ABL⁺ leukemic cells in vitro, and induces substantial tumor regression against K562 xenograft tumors in vivo. In addition, SIAIS178 also degrades several clin. relevant resistance-conferring mutations. Our data indicate that SIAIS178 as efficacious BCR-ABL degrader warrants extensive further investigation for the treatment of BCR-ABL⁺ leukemia. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and extraction results of new halide terminated 2-alkyl-p-tert-butylcalix[4]arenes bearing phosphine oxides or ketones on the narrow rim was written by Menon, Sreejit R.;Schmidt, Joseph A. R.. And the article was included in Tetrahedron in 2016.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

The synthesis of lower rim tetraphosphorylated and tetraketone calix[4]arenes with haloalkyl groups tethered to a single methylene bridge and their utilization as extraction agents for rare earth elements are reported. Synthesis of these new functionalized calix[4]arene species were achieved in good to modest yields, and extraction of nine lanthanide nitrates were explored using these calix[4]arene species. The tetraphosphorylated calix[4]arenes show better lanthanide extraction efficiency than their ketone counterparts, especially for europium(III). These experiments demonstrate that inclusion of a substituent tethered to the methylene bridge does not significantly reduce the extraction efficiency of these new calix[4]arene ligands as compared to similar unsubstituted ligands in the literature, making them important precursors in the development of functionalized stationary phases for separation of lanthanides. Development of similar CMPO-bearing narrow rims and new solid-phase extraction materials for the solid-liquid separation of lanthanides remains the subject of future work. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Designed PEG-Dicationic Imidazolium-Based Ionic Liquids as Effective Plasticizers for Sustainable Polylactide was written by Zuo, Huijie;Chen, Xiangjian;Ding, Yingli;Cui, Liang;Fan, Baomin;Pan, Li;Zhang, Kunyu. And the article was included in Chinese Journal of Chemistry in 2021.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

A series of novel polyethylene glycol-dicationic imidazolium-based ionic liquids (mPEG-ILs) were synthesized by facile quaternization reaction from various elaborately designed di-imidazoles and PEG, which were then studied as green plasticizers for sustainable polylactide (PLA) material. The influences of the chain structure, content, and mol. weight of the mPEG-ILs on the plasticizing effect were systematically investigated by characterization of a series of PLA/mPEG-ILs blending systems. FTIR results show there is combination of ion-dipole interaction and hydrogen bonds interaction between PLA and mPEG-ILs, which is beneficial for the compatibility. Thermal behaviors indicate that mPEG-ILs have a significant plasticizing effect on PLA. Particularly, mPEG400-amide-IM can remarkably improve the mobility of PLA chain, leading to decreased glass transition temperature (T_g) and cold crystallization temperature (T_cc) of PLA. Tensile test results show that the ductility of plasticized PLA is greatly enhanced, and its elongation at break reaches 249.4%, which is 22 times that of neat PLA. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Insertion of Diazo Esters into C-F Bonds toward Diastereoselective One-carbon Elongation of Benzylic Fluorides: Unprecedented BF₃ Catalysis with C-F Bond Cleavage and Reformation was written by Wang, Fei;Nishimoto, Yoshihiro;Yasuda, Makoto. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

Herein the BF₃ -catalyzed formal insertion of diazo esters RC(=N₂)C(O)OR¹ (R = 2-methylphenyl, 4-chlorophenyl, 4-phenylphenyl, etc.; R¹ = Me, prop-2-en-1-yl, 2-chloroethyl, adamantan-1-yl) and 4-diazoisochroman-3-one as one-carbon-atom sources into C-F bonds to accomplish one-carbon elongation of benzylic fluorides ArCH(F)R² (Ar = Ph, 4-fluorophenyl, naphthalen-2-yl, etc.; R² = Me, Pr, tetradecyl, 6-chlorohexyl) was reported. A DFT calculation study revealed that the BF₃ catalyst could contribute to both C-F bond cleavage and re-formation. This elongation provided α-fluoro-α,β-diaryl esters (2R,3R)/(2R,3S)-ArCH(R²)C(F)(R)C(O)OR¹ and (2R,3R)/(2R,3S)-4-(1-(4-chlorophenyl)ethyl)-4-fluoroisochroman-3-one with a high level of diastereoselectivity. Various benzylic fluorides and diazo esters were applicable. The synthetic utility of this method was demonstrated by the synthesis of a fluoro analog of a compound I that is used as a transient receptor and potential canonical channel inhibitor. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Irradiation-Induced Heck Reaction of Unactivated Alkyl Halides at Room Temperature was written by Wang, Guang-Zu;Shang, Rui;Cheng, Wan-Min;Fu, Yao. And the article was included in Journal of the American Chemical Society in 2017.Related Products of 6294-17-3 The following contents are mentioned in the article:

The palladium-catalyzed Mizoroki-Heck reaction is arguably one of the most significant carbon-carbon bond-construction reactions to be discovered in the last 50 years, with a tremendous number of applications in the production of chems. This Nobel-Prize-winning transformation has yet to overcome the obstacle of its general application in a range of alkyl electrophiles, especially tertiary alkyl halides that possess eliminable β-hydrogen atoms. Whereas most palladium-catalyzed cross-coupling reactions utilize the ground-state reactivity of palladium complexes under thermal conditions and generally apply a single ligand system, authors report that the palladium-catalyzed Heck reaction proceeds smoothly at room temperature with a variety of tertiary, secondary, and primary alkyl bromides upon irradiation with blue light-emitting diodes in the presence of a dual phosphine ligand system. Also rationalized that this unprecedented transformation is achieved by utilizing the photoexcited-state reactivity of the palladium complex to enhance oxidative addition and suppress undesired β-hydride elimination. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site was written by Karuturi, Rajesh;Al-Horani, Rami A.;Mehta, Shrenik C.;Gailani, David;Desai, Umesh R.. And the article was included in Journal of Medicinal Chemistry in 2013.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

To discover promising sulfated allosteric modulators (SAMs) of glycosaminoglycan-binding proteins (GBPs), such as human factor XIa (FXIa), we screened a library of 26 synthetic, sulfated quinazolin-4(3H)-ones (QAOs) resulting in the identification of six mols. that reduced the V_max of substrate hydrolysis without influencing the K_M. Mutagenesis of residues of the heparin-binding site (HBS) of FXIa introduced a nearly 5-fold loss in inhibition potency supporting recognition of an allosteric site. Fluorescence studies showed a sigmoidal binding profile indicating highly cooperative binding. Competition with a pos. charged, heparin-binding polymer did not fully nullify inhibition suggesting importance of hydrophobic forces to binding. This discovery suggests the operation of a dual-element recognition process, which relies on an initial Coulombic attraction of anionic SAMs to the cationic HBS of FXIa that forms a locked complex through tight interaction with an adjacent hydrophobic patch. The dual-element strategy may be widely applicable for discovering SAMs of other GBPs. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics