Category: 6294-17-3

Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors was written by Jadhavar, Pradeep S.;Ramachandran, Sreekanth A.;Riquelme, Eduardo;Gupta, Ashu;Quinn, Kevin P.;Shivakumar, Devleena;Ray, Soumya;Zende, Dnyaneshwar;Nayak, Anjan K.;Miglani, Sandeep K.;Sathe, Balaji D.;Raja, Mohd.;Farias, Olivia;Alfaro, Ivan;Belmar, Sebastian;Guerrero, Javier;Bernales, Sebastian;Chakravarty, Sarvajit;Hung, David T.;Lindquist, Jeffrey N.;Rai, Roopa. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Synthetic Route of C6H12BrCl The following contents are mentioned in the article:

While enzalutamide and abiraterone are approved for treatment of metastatic castration-resistant prostate cancer (mCRPC), approx. 20-40% of patients have no response to these agents. It has been stipulated that the lack of response and the development of secondary resistance to these drugs may be due to the presence of AR splice variants. HDAC6 has a role in regulating the androgen receptor (AR) by modulating heat shock protein 90 (Hsp90) acetylation, which controls the nuclear localization and activation of the AR in androgen-dependent and independent scenarios. With dual-acting AR-HDAC6 inhibitors it should be possible to target patients who don’t respond to enzalutamide. Herein, the authors describe the design, synthesis and biol. evaluation of dual-acting compounds which target AR and are also specific towards HDAC6. The efforts led to compound I which was found to have potent dual activity (HDAC6 IC₅₀ = 0.0356 μM and AR binding IC₅₀ = <0.03 μM). Compound I was further evaluated for antagonist and other cell-based activities, in vitro stability and pharmacokinetics. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Synthetic Route of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comb-Like Poly(Ether-Sulfone) Membranes Derived from Planar 6,12-Diaryl-5,11-Dihydroindolo[3,2-b]Carbazole Monomer for Alkaline Fuel Cells was written by Zuo, Peipei;Su, Yumiao;Li, Wenmu. And the article was included in Macromolecular Rapid Communications in 2016.Application of 6294-17-3 The following contents are mentioned in the article:

Highly conductive anion exchange membranes (AEMs), along with the ability to suppress swelling, are critical but challenging requirements for alk. fuel cell applications. To achieve this criterion, a series of poly(ether sulfone)s (PESFs) with flexible alkyl imidazolium pendants attached directly on large planar 6,12-bis(4-hydroxyphenyl)-5,11-dihydroindolo[3,2-b]carbazole (DCP) units is reported. The planar DCP units stabilize the hydrophobic phase through strong π-π interactions and also facilitate the formation of ionic conducting channels through self assembly of hydrophilic pendants. The AEM prepared here, based on rational design, has a relatively low ion exchange capacity (IEC) of 1.86 × 10^-3 mol g^-1 and exhibits high hydroxide ion (OH^–) conductivity of 101 × 10^-3 S cm^-1, a low swelling ratio of 9.3% and a water uptake of 39.6%. Furthermore, the AEMs reported in this paper have excellent stability in 1 M NaOH solution at 80°C over 500 h. Therefore, the synthesized polymers offer a new insight into the design of high performance materials for AEMs. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coupling reaction of enol derivatives with silyl ketene acetals catalyzed by gallium trihalides was written by Nishimoto, Yoshihiro;Kita, Yuji;Ueda, Hiroki;Imaoka, Hiroto;Chiba, Kouji;Yasuda, Makoto;Baba, Akio. And the article was included in Chemistry – A European Journal in 2016.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

A cross-coupling reaction between enol derivatives and silyl ketene acetals catalyzed by GaBr₃ took place to give the corresponding α-alkenyl esters. GaBr₃ showed the most effective catalytic ability, whereas other metal salts such as BF₃·OEt₂, AlCl₃, PdCl₂, and lanthanide triflates were not effective. Various types of enol ethers and vinyl carboxylates as enol derivatives are amenable to this coupling. The scope of the reaction with silyl ketene acetals was also broad. We successfully observed an alkylgallium intermediate by using NMR spectroscopy, suggesting a mechanism involving anti-carbogallation among GaBr₃, an enol derivative, and a silyl ketene acetal, followed by syn-β-alkoxy elimination from the alkylgallium. Based on kinetic studies, the turnover-limiting step of the reaction using a vinyl ether and a vinyl carboxylate involved syn-β-alkoxy elimination and anti-carbogallation, resp. Therefore, the leaving group had a significant effect on the progress of the reaction. Theor. calculations anal. suggest that the moderate Lewis acidity of gallium would contribute to a flexible conformational change of the alkylgallium intermediate and to the cleavage of the carbon-oxygen bond in the β-alkoxy elimination process, which is the turnover-limiting step in the reaction between a vinyl ether and a silyl ketene acetal. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation was written by Zhou, Li;Chen, Wenming;Cao, Chenyang;Shi, Yonghui;Ye, Wenchong;Hu, Jiliang;Wang, Ling Li;Zhou, Wen. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

Extrahepatic cytochrome P 450 1B1 (CYP1B1), which is highly expressed in various tumors, is an attractive and potential target for cancer prevention, therapy, and reversal of drug resistance. CYP1B1 inhibition is the current predominant therapeutic paradigm to treating CYP1B1-mediated malignancy, but therapeutic effect has little success. Herein, we reported CYP1B1 degradation in place of CYP1B1 inhibition for reversing drug resistance toward docetaxel in CYP1B1-overexpressing prostate cancer cell line DU145 using a PROTAC strategy. Replacing chlorine atom of a CYP1B1 selective inhibitor we found previously with ethynyl, we got the resulting α-naphthoflavone derivative 5 which kept strong inhibition against CYP1B1 (IC₅₀ = 0.4±0.2 nM) and high selectivity. Coupling of 5 with thalidomide derivatives of varying chain lengths afforded conjugates 6A-6D via click reaction. In vitro cell-based assay indicated that 6C was more effective in eliminating drug resistance of CYP1B1-overexpressed DU145 cells compared with other analogs. Western blotting anal. showed CYP1B1 degradation was one main reason for the reversal of drug resistance to docetaxel and the effect was obtained in a concentration-dependent manner. This work is the first attempt to overcome CYP1B1-mediated drug resistance via CYP1B1 degradation instead of CYP1B1 inhibition, which could provide a new direction toward eliminating drug resistance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Effects of accelerator alkyl chain length on the microvia filling performance in copper superconformal electroplating was written by Luo, Jiye;Li, Zhen;Shi, Minghao;Chen, Jiajia;Hao, Zhifeng;He, Jun. And the article was included in Journal of the Electrochemical Society in 2019.Synthetic Route of C6H12BrCl The following contents are mentioned in the article:

In addition to the commercialized accelerator bis-(sodium sulfopropyl)-disulfide (SPS), the authors designed and synthesized two other disulfide compounds, namely, bis-(sodium sulfohexyl)-disulfide (SHS) and bis-(sodium sulfoethyl)-disulfide (SES), to study the effect of their alkyl chain lengths on the microvia filling performance. The galvanostatic measurements show that the addition of Cl^– to different accelerator-containing solutions leads to the same synergistic effects at a c.d. of 20 mA/cm², indicating that the interactions between accelerators and Cl^– are independent of their alkyl chain lengths. However, when both Cl^– and a suppressor are present, the alkyl chain length in accelerators strongly impacts their anti-suppressor strength, which increases with the growth of the alkyl chain length, reaches a maximum (SPS) and then decreases. A possible adsorption and interaction model is proposed to explain the difference of anti-suppressor effects, and microvia filling plating experiments were carried out to evaluate the effects on the filling performance. Both SES and SPS, which have appropriate mol. lengths and relatively strong antagonistic effects against polyethylene glycol (PEG) and Cl^– ensemble, achieved complete microvia filling. For SHS, due to the overlong alkyl chain and weak antagonistic effect against PEG and Cl^–, no microvia was completely filled. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Synthetic Route of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

sp³ C-H Arylation and Alkylation Enabled by the Synergy of Triplet Excited Ketones and Nickel Catalysts was written by Shen, Yangyang;Gu, Yiting;Martin, Ruben. And the article was included in Journal of the American Chemical Society in 2018.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Triplet ketone sensitizers are of central importance within the realm of photochem. transformations. Although the radical-type character of triplet excited states of diaryl ketones suggests the viability for triggering hydrogen-atom transfer (HAT) and single-electron transfer (SET) processes, among others, their use as multifaceted catalysts in C-C bond-formation via sp³ C-H functionalization of alkane feedstocks still remains rather unexplored. Herein, we unlock a modular photochem. platform for forging C(sp³)-C(sp²) and C(sp³)-C(sp³) linkages from abundant alkane sp³ C-H bonds as functional handles using the synergy between nickel catalysts and simple, cheap and modular diaryl ketones. This method is distinguished by its wide scope that is obtained from cheap catalysts and starting precursors, thus complementing existing inner-sphere C-H functionalization protocols or recent photoredox scenarios based on iridium polypyridyl complexes. Addnl., such a platform provides a new strategy for streamlining the synthesis of complex mols. with high levels of predictable site-selectivity and preparative utility. Mechanistic experiments suggest that sp³ C-H abstraction occurs via HAT from the ketone triplet excited state. We believe this study will contribute to a more systematic utilization of triplet excited ketones as catalysts in metallaphotoredox scenarios. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 was written by Rizzo, Stefano;Bartolini, Manuela;Ceccarini, Luisa;Piazzi, Lorna;Gobbi, Silvia;Cavalli, Andrea;Recanatini, Maurizio;Andrisano, Vincenza;Rampa, Angela. And the article was included in Bioorganic & Medicinal Chemistry in 2010.Formula: C6H12BrCl The following contents are mentioned in the article:

We report on a series of hybrid compounds structurally derived from donepezil and AP2238. This study was aimed at improving the activities of the reference compounds, donepezil and AP2238, and at broadening the range of activities of new derivatives as, due to the multifactorial nature of AD, mols. that modulate the activity of a single protein target are unable to significantly modify the progression of the disease. In particular, the indanone core from donepezil was linked to the phenyl-N-methylbenzylamino moiety from AP2238, through a double bond that was kept to evaluate the role of a lower flexibility in the biol. activities. Moreover, SAR studies were performed to evaluate the role of different substituents in position 5 or 6 of the indanone ring in the interaction with the PAS, introducing also alkyl chains of different lengths carrying different amines at one end. Derivatives 21 and 22 proved to be the most active within the series and their potencies against AChE were in the same order of magnitude of the reference compounds Compounds 15, 21-22, with a 5-carbon alkyl chain bearing an amino moiety at one end, better contacting the PAS, remarkably improved the inhibition of AChE-induced Aβ aggregation with respect to the reference compounds They also showed activity against self-aggregation of Aβ₄₂ peptide, the most amyloidogenic form of amyloid produced in AD brains, while the reference compounds resulted completely ineffective. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Ratiometric and Targetable Fluorescent Sensor for Quantification of Mitochondrial Zinc Ions was written by Xue, Lin;Li, Guoping;Yu, Cailan;Jiang, Hua. And the article was included in Chemistry – A European Journal in 2012.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The authors designed a fluorescent sensor, DQZn2 (I), for ratiometric detection of mitochondrial Zn²⁺. 2-Picolylamine (DPA) was employed as an ion chelator that was installed on the 2-position of a quinoline platform to achieve high selectivity for Zn²⁺ over biol. Na⁺, K⁺, Ca²⁺, and Mg²⁺ with 1:1 stoichiometry and high affinity with nanomolar or lower K_a values. To increase basicity of the sensor, the stronger electron donating nitrogen atom replaced the oxygen atom on 4-position of quinoline. The authors anticipated that this sensor could be protonated under neutral or even weakly basic media, and consequently would yield a resonance between quinolinium and onium resonant structures as observed for DQCd1. The resonance would lead to charge delocalization, which is more pronounced in the excited state of the mol., due to occurrence of intramol. charge transfer (ICT) in polar media. The authors envisioned that Zn²⁺ coordination would induce the deprotonation of the sensor and consequent inhibition of the resonance. The ratiometric measurements with distinct emission maxima shift can thus be established. Mitochondria are known to be one of sites that take up Zn²⁺ in living cells. The triphenylphosphonium salt (TPP), an effective mitochondrial targeting group, was thus chosen and attached to the sensor. This ratiometric approach was used for quantification of the mitochondrial free Zn²⁺ concentration in NIH3T3 cells. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Modification of nano-clays with ionic liquids for the removal of Cd (II) ion from aqueous phase was written by Naderi, Arman;Delavar, Mohmmad Amir;Ghorbani, Yousef;Kaboudin, Babak;Hosseini, Mehdi. And the article was included in Applied Clay Science in 2018.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The present study attempts to synthesize nano-modified clays of Na-bentonite (Bent) and montmorillonite (MT), using three imidazolium-based ionic liquids (ILs) including 3,3′-(hexyl)bis(3-methylimidazolium) bromide chloride (H(mim)₂[Br][Cl]), 1-hexyl-3-methylimidazolium chloride ([Hmim][Cl]) and 1-octyl-3-methylimidazolium chloride ([Omim][Cl]). X-ray diffraction (XRD), Fourier transformed IR spectroscopy (FT-IR), carbon, hydrogen and nitrogen elemental anal. (CHN), scanning electron microscope (SEM) and sp. surface area (SSA) (using N₂-BET) techniques provided evidence of successful modification of the guest clays. Removal of Cd (II) from aqueous phase was investigated using the modified clays under different exptl. conditions of reaction time, pH and adsorbent dosage. Detailed isotherms and kinetic studies showed that the modified clays have much higher Cd (II) adsorption capacity compared to those of the starting clay minerals. The maximum Cd (II) absorption capacities of 87.46 and 94.6mg g^-1 were observed in [H(mim)₂]-MT and [H(mim)₂]-Bent with d-values of 35.4Å and 28.3Å resp. The [Omim]-clays had the highest adsorption affinities of Cd (II) in initial concentrations of Cd (II). This study shows that ILs could enhance the clay capacity and tendency for Cd (II) absorption with different trends based on the ILs structures. The modified clays using ILs are green and eco-friendly adsorbents and due to substantial increase in their capacity for the removal of heavy metals, they could have pos. economic and environmental impacts. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Automated iterative Csp³-C bond formation was written by Blair, Daniel J.;Chitti, Sriyankari;Trobe, Melanie;Kostyra, David M.;Haley, Hannah M. S.;Hansen, Richard L.;Ballmer, Steve G.;Woods, Toby J.;Wang, Wesley;Mubayi, Vikram;Schmidt, Michael J.;Pipal, Robert W.;Morehouse, Greg. F.;Palazzolo Ray, Andrea M. E.;Gray, Danielle L.;Gill, Adrian L.;Burke, Martin D.. And the article was included in Nature (London, United Kingdom) in 2022.Application of 6294-17-3 The following contents are mentioned in the article:

Fully automated synthetic chem. would substantially change the field by providing broad on-demand access to small mols. However, the reactions that can be run autonomously are still limited. Automating the stereospecific assembly of Csp³-C bonds would expand access to many important types of functional organic mols.¹. Previously, methyliminodiacetic acid (MIDA) boronates were used to orchestrate the formation of Csp²-Csp² bonds and were effective building blocks for automating the synthesis of many small mols., but they are incompatible with stereospecific Csp³-Csp² and Csp³-Csp³ bond-forming reactions. Here authors report that hyperconjugative and steric tuning provide a new class of tetra-Me N-methyliminodiacetic acid (TIDA) boronates that are stable to these conditions. Charge d. anal. revealed that redistribution of electron d. increases covalency of the N-B bond and thereby attenuates its hydrolysis. Complementary steric shielding of carbonyl π-faces decreases reactivity towards nucleophilic reagents. The unique features of the iminodiacetic acid cage, which are essential for generalized automated synthesis, are retained by TIDA boronates. This enabled Csp³ boronate building blocks to be assembled using automated synthesis, including the preparation of natural products through automated stereospecific Csp³-Csp² and Csp³-Csp³ bond formation. These findings will enable increasingly complex Csp³-rich small mols. to be accessed via automated assembly. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics