Category: 6294-17-3

Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism was written by Kancherla, Rajesh;Muralirajan, Krishnamoorthy;Rueping, Magnus. And the article was included in Chemical Science in 2022.Reference of 6294-17-3 The following contents are mentioned in the article:

The development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides was described. The new methodol. showed broad functional group tolerance and was addnl. be applied in the direct three-component reaction of aldehydes, anilines and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction was proceeded via the inner-sphere electron transfer mechanism. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers was written by Yang, Yu-Zhong;Li, Yang;Lv, Gui-Fen;He, De-Liang;Li, Jin-Heng. And the article was included in Organic Letters in 2022.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biol. relevant mols. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron-Catalyzed Borylation of Alkyl Electrophiles was written by Atack, Thomas C.;Lecker, Rachel M.;Cook, Silas P.. And the article was included in Journal of the American Chemical Society in 2014.Product Details of 6294-17-3 The following contents are mentioned in the article:

The use of low-cost iron(III) acetoacetate (Fe(acac)₃) and tetramethylethylenediamine (TMEDA) enables the direct cross-coupling of alkyl halides with bis(pinacolato)diboron. This approach allows for the borylation of activated or unactivated primary, secondary, and tertiary bromides. Moreover, even the borylation of benzylic or allylic chlorides, tosylates, and mesylates are possible. The reactions proceed under mild conditions at room temperature and show broad functional-group compatibility and “robustness” as measured by a modified Glorius robustness screen. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes was written by Wang, Guang-Zu;Jiang, Jian;Bu, Xiao-Song;Dai, Jian-Jun;Xu, Jun;Fu, Yao;Xu, Hua-Jian. And the article was included in Organic Letters in 2015.Related Products of 6294-17-3 The following contents are mentioned in the article:

The cross-coupling reaction of allyl boron ester with 1°/2°/3°-halogenated alkanes in the presence of copper has been developed for the first time, which provides a mild and efficient method for the construction of saturated C(sp³)-C(sp³) bonds. E.g., in presence of CuI and LiOCMe₃ in DMF, cross-coupling of allylboronic acid pinacol ester with 1-(4-bromobutyl)indole gave 87% I. This protocol shows excellent compatibility with the nonactivated primary, secondary, and even tertiary halogenated alkanes under mild conditions. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors was written by Li, Gudong;Zhang, Wei;Xie, Yuting;Li, Yang;Cao, Rao;Zheng, Guojun;Huang, Niu;Zhou, Yu. And the article was included in Journal of Chemical Information and Modeling in 2020.Product Details of 6294-17-3 The following contents are mentioned in the article:

Pim-1 kinase has been widely regarded as an attractive target for anticancer drugs. Here, we reported our continued efforts in structure-based optimization of compound 10-DEBC, a previously identified micromolar Pim-1 inhibitor. Guided by the Site Identification by Ligand Competitive Saturation (SILCS) method, we quickly obtained a series of 10-DEBC derivatives with significantly improved activity and selectivity. In particular, compound 26 exhibited an IC₅₀ value of 0.9 nM, as well as 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, resp. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Transition Metal Free Stannylation of Alkyl Halides: The Rapid Synthesis of Alkyltrimethylstannanes was written by Li, Songyi;Lian, Chang;Yue, Guanglu;Zhang, Jianning;Qiu, Di;Mo, Fanyang. And the article was included in Journal of Organic Chemistry in 2022.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

A transition metal free stannylation reaction of alkyl bromides and iodides with hexamethyldistannane was developed. This protocol is operationally convenient and features a rapid reaction and good functional group tolerance. A wide range of functionalized primary and secondary alkyl and benzyl tri-Me stannanes were prepared in moderate to excellent yields. The success of the gram-scale procedure and tandem Stille coupling reaction has allowed this protocol to demonstrate potential for application in organic synthesis. Both exptl. and theor. studies reveal the mechanistic details of this stannylation reaction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heat Capacity of α,ω-Bromochloroalkanes and α,ω-Dibromoalkanes: Their Dependence on the Hydrocarbon Chain Length and Temperature (285.15 to 355.15) K was written by Goralski, Pawel;Tkaczyk, Mariola. And the article was included in Journal of Chemical & Engineering Data in 2012.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

The heat capacities at constant pressure of some α,ω-bromochloroalkanes (from C2 to C6) and α,ω-dibromoalkanes (from C2 to C12, without C7 and C10) were measured within the temperature range of (285.15 to 355.15) K. The measurements were performed by means of a Micro DSC III (Setaram) differential scanning calorimeter. The dependence of molar heat capacity on temperature and hydrocarbon chain length was described by the group additivity method. The densities of α,ω-bromochloroalkanes within the temperature range (288.15 to 318.15) K and their volumetric expansion coefficients at 298.15 K were also determined This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions was written by Chen, Haifeng;Yue, Huifeng;Zhu, Chen;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile synthesis of polymerized ionic liquids with high thermal stability was written by Hsieh, Yu-Nung;Kuei, Chun-Hsiung;Chou, Yu-Kai;Liu, Chia-Chyuan;Leu, Kuen-Lin;Yang, Tasi-Hsiu;Wang, Mei-Ying;Ho, Wen-Yueh. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Twelve main-chain-type polymerized ionic liquids that have alkylimidazolium cation units were prepared using simple synthetic processes. The polymers were prepared using the self-polymerization of a single monomer; no polymerization initiators were required. The thermal stability and solvent miscibility of these polymers were studied. Results show that the combined anions greatly influence the solubility and thermal stability of the polymers. Among these polymers, poly-alkylimidazolium bis(trifluoromethyl sulfonyl)imide polymers exhibited the highest thermal stability (> 400°), which makes them candidates for many applications. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Access to 3-alkylselenindoles by multicomponent reaction of indoles, selenium powder and unactivated alkyl halides under transition-metal-free conditions was written by Liu, Huan;Cai, Zhong-Jian;Ji, Shun-Jun. And the article was included in Chinese Chemical Letters in 2022.Product Details of 6294-17-3 The following contents are mentioned in the article:

Herein, a convenient and efficient multicomponent reaction of indoles, selenium powder and unactivated alkyl halides is reported. This protocol provides a practical, and facile approach for the synthesis of 3-alkylselenindole derivatives The advantages of this strategy include mild and transition-metal-free conditions, broad functional group tolerance, the use of simple and easily accessible selenium powder and alkyl halides as coupling partners. More importantly, the reaction proceeded smoothly with a large scale (> 10 g, > 90% yield), which further highlighted the potential application of this selenation strategy. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics