Category: 6294-17-3

Alkylboronic Esters from Copper-Catalyzed Borylation of Primary and Secondary Alkyl Halides and Pseudohalides was written by Yang, Chu-Ting;Zhang, Zhen-Qi;Tajuddin, Hazmi;Wu, Chen-Cheng;Liang, Jun;Liu, Jing-Hui;Fu, Yao;Czyzewska, Maria;Steel, Patrick G.;Marder, Todd B.;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2012.HPLC of Formula: 6294-17-3 The following contents are mentioned in the article:

Authors have developed an unprecedented copper-catalyzed cross-coupling reaction of unactivated alkyl halides and pseudohalides with diboron reagents. This reaction can be used to prepare primary and secondary alkylboronic esters with diverse structures and functional groups, many of which would be difficult to access by other means. The reaction is efficient, practically simple, and gives easy isolation of the products which can be further enhanced through the use of polymer-supported ligands. It is also reported a mild and practical protocol for the Suzuki-Miyaura coupling of alkylboronic esters with both aryl bromides and chlorides. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3HPLC of Formula: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A MedChem toolbox for cereblon-directed PROTACs was written by Steinebach, Christian;Sosic, Izidor;Lindner, Stefanie;Bricelj, Alesa;Kohl, Franziska;Ng, Yuen Lam Dora;Monschke, Marius;Wagner, Karl G.;Kroenke, Jan;Guetschow, Michael. And the article was included in MedChemComm in 2019.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

A modular chem. toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochem. properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcs., all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists’ PROTAC toolbox towards heterobifunctional mols., e.g. with biotin, fluorescent, hydrophobic and peptide tags. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of new symmetric cyclic and acyclic halocurcumin analogues typical precursors for hybridization was written by Noureddin, Sawsan A.;El-Shishtawy, Reda M.;Al-Footy, Khalid O.. And the article was included in Research on Chemical Intermediates in 2020.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

Starting from vanillin as a naturally occurring compound, several O-haloalkyl derivatives I (n = 3, X = Br; n = 6, X = Cl) have been synthesized and characterized. These derivatives I were subjected to Knoevenagel condensation reaction with cyclohexanone, acetone and acetylacetone to afford the corresponding sym. acyclic and cyclic halocurcumin analogs II, III and IV, resp. The chem. structures of the newly synthesized compounds were confirmed using spectroscopic techniques. These analogs, having primary halogen on both sides, are typical precursors of hybrid curcumin analogs. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of ginger essential oil constituents by simultaneous distillation and solvent extraction combined with GC-MS was written by Luo, Hailin;Lu, Ning. And the article was included in Zhongguo Tiaoweipin in 2010.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Ginger essential oil from hot air dried ginger was extracted by simultaneous distillation and solvent extraction(SDE); qual. anal. and quant. anal. were analyzed by GC-MS. The results showed that ginger essential oil could be extracted effectively by this method; the relative percentages of the constituents were determined by normalization method. The highest content was zingiberene(18.99%), followed by β-sesquiphellandrene(14.35%), α-farnesene(9.95%), α-curcumene(8.77%) and β-bisabolene(5.63%), and this five constituents accounted for 57.69% of the total constituents, initially identified as the main chem. constituents of ginger essential oil. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H₂O: An Expedient Way to Access Alkyl Amides was written by Li, Qiao;Jin, Hongwei;Liu, Yunkui;Zhou, Bingwei. And the article was included in Synthesis in 2020.Application of 6294-17-3 The following contents are mentioned in the article:

Herein, a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanide and water to access alkyl amides I [R = Et, cyclohexyl, CH₂(CH₂)₂Ph, etc.] was described. Bench-stable NiCl₂(dppp) was competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process was proposed based on preliminary experiments and previous literature. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of amine, halide, and pyridinium terminated 2-alkyl-p-tert-butylcalix[4]arenes was written by Hertel, Matthew P.;Behrle, Andrew C.;Williams, Samantha A.;Schmidt, Joseph A. R.;Fantini, Jordan L.. And the article was included in Tetrahedron in 2009.Application of 6294-17-3 The following contents are mentioned in the article:

The synthesis of calix[4]arenes with functional groups tethered to a single methylene bridge has been explored. Mono-lithiated calix[4]arenes react with 1,ω-bromochloroalkanes to give 2-(ω-chloroalkyl)calix[4]arenes, which function as key intermediates in the synthesis of a variety of tether-functionalized calix[4]arenes. Subsequent reactivity of these chloroalkyl species has allowed for successful synthesis of 2-(ω-iodoalkyl)-, 2-(ω-pyridiniumalkyl)-, and 2-(ω-aminoalkyl)-calix[4]arenes. Both alkyl and aryl amines have been incorporated at the end of the tether, and a 2,6-diisopropylaniline derivative has been analyzed by X-ray diffraction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides was written by Cheung, Chi Wai;Hu, Xile. And the article was included in Nature Communications in 2016.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The reductive coupling of nitroarenes RNO₂ (R = 4-OHC₆H₄, OHCH₂CH₂C₆H₄, 1-naphthyl, etc.) with alkyl halides R¹X (R¹ = butan-2-yl, oxolan-3-yl, cyclooctyl, etc.) to yield (hetero)aryl amines, e.g., I has been reported. A simple iron catalyst enables the coupling with numerous primary, secondary and tertiary alkyl halides. Broad scope and high functional group tolerance are demonstrated. Mechanistic study suggests that nitrosoarenes and alkyl radicals are involved as intermediates. This new C-N coupling method provides general and step-economical access to aryl amines. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A new route to functional polymers: Synthesis of functional polymer-supported esters from a weak acid ion exchange resin was written by Hodge, Philip;Houghton, Mark P.;Chakiri, Abdel. And the article was included in Reactive & Functional Polymers in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

Treatment of Amberlite IRC-50, a weak acid cation exchange resin containing methacrylic acid residues, with tetra-n-butylammonium hydroxide or benzyltrimethylammonium hydroxide gives the corresponding polymer-supported quaternary ammonium salts. These react smoothly, in nucleophilic substitution reactions, with a range of alkyl halides or sulfonates to give side chain esters with saturated hydrocarbon groups, with quaternary ammonium or sulfonate salt groups, with halide or alc. groups at the terminus of spacer chains, with 1,2-diol groups, with acetylenic groups or with anthracene residues. These polymer-supported species have a variety of potential applications. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synergetic Effect of Monomer Functional Group Coordination in Catalytic Insertion Polymerization was written by Leicht, Hannes;Goettker-Schnetmann, Inigo;Mecking, Stefan. And the article was included in Journal of the American Chemical Society in 2017.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

PhS- and PhNH-functionalized dienes are copolymerized efficiently with butadiene to stereoregular copolymers by [(mesitylene)Ni(allyl)][BAr^F₄] (Ni-1). Overall polymerization rates and comonomer incorporations depend strongly on the linker length between the diene moiety and functional group, in, e.g., PhS-(CH₂)_xC(=CH₂)-CH=CH₂ (PhS-x-BD, x = 3-7), in particular for certain linker lengths high comonomer reactivity ratios stand out. This effect is related to a favorable binding of the comonomer to the active site comprising coordination of its functional group, which significantly enhances comonomer incorporation in the growing polymer chain. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electron-Deficient Olefin Ligands Enable Generation of Quaternary Carbons by Ni-Catalyzed Cross-Coupling was written by Huang, Chung-Yang;Doyle, Abigail G.. And the article was included in Journal of the American Chemical Society in 2015.Application of 6294-17-3 The following contents are mentioned in the article:

A Ni-catalyzed Negishi cross-coupling with 1,1-disubstituted styrenyl aziridines has been developed. This method delivers valuable β-substituted phenethylamines via a challenging reductive elimination that affords a quaternary carbon. A novel electron-deficient olefin ligand, I (Fro-DO), proved crucial for achieving high rates and chemoselectivity for C-C bond formation over β-H elimination. This ligand is easy to access, is stable, and presents a modular framework for reaction discovery and optimization. We expect that these attributes, combined with the fact that the ligands impart distinct electronic properties to a metal, will support the invention of new transformations not previously possible using established ligands. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics