Category: 6294-17-3

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists was written by Liu, Peng;Xu, Xing;Chen, Lili;Ma, Lei;Shen, Xu;Hu, Lihong. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Name: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Compound I [R = HO] (IC₅₀ = 35.2±7.2 μM), a moderate FXR antagonist was discovered via high-throughput screening. Structure-activity relationship studies indicated that the shape and the lipophilicity of the substituents of the aromatic ring affect the activity dramatically, increasing the shape and the lipophilicity of the substituents of the aromatic ring enhances the potency of FXR antagonists. Especially, when the OH at C2 position of the aromatic ring was replaced by the BnO substituent (analog I [R = PhCH₂O]), its activity could be improved to IC₅₀ = 1.1±0.1 μM. Besides, the length of the linker and the tetrazole structure are essential for retaining the activity. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Name: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Functionalized Phosphonated Half-Cage Molecules as Ligands for Metal Complexes was written by Villemin, Elise;Herent, Marie-France;Marchand-Brynaert, Jacqueline. And the article was included in European Journal of Organic Chemistry in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

Phosphonated mols., featuring a half-cage structure and a N-lateral chain with addnl. metal coordinating groups were designed as ligands of metal cations. These compounds were synthesized by a Diels-Alder (DA) strategy, using 1-diethoxyphosphoryl-1,3-butadiene and a series of N-substituted maleimides as dienophiles. Two cycloadducts, bearing a terminal primary alc. and a terminal iodide, resp., were used as key intermediates for further functionalizations. Metal coordination properties of the ligands equipped with functionalized N-lateral chains were proven by an ESI-HRMS study. The stoichiometry of one selected Eu^III complex with a diphosphonated ligand was determined by photoluminescence spectroscopy in emission mode. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New stable donor-acceptor dyads for molecular electronics was written by Kondratenko, Mykola;Moiseev, Andrey G.;Perepichka, Dmitrii F.. And the article was included in Journal of Materials Chemistry in 2011.Application In Synthesis of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

A series of new donor-bridge-acceptor dyads with high chem., electrochem., thermal and conformational stability were synthesized by Stille coupling of oligo(3,4-ethylenedioxy)thiophenes (nEDOTs) and 1,4,5,8-naphthalenetetracarboxydiimide (NDI) building blocks. The mol. design provides for complete separation of HOMO and LUMO orbitals. A thiol functionality allows for selective anchoring of the dyads to metal electrodes, through either the donor or acceptor sides of the mol. The optoelectronic properties of the dyads, both in solution and in self-assembled monolayers on gold, were characterized by electrochem., spectroelectrochem. and UV-Vis absorption/emission spectroscopy and the results were further supported by DFT calculations This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application In Synthesis of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Manganese-Catalyzed Borylation of Unactivated Alkyl Chlorides was written by Atack, Thomas C.;Cook, Silas P.. And the article was included in Journal of the American Chemical Society in 2016.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

The use of low-cost manganese(II) bromide (MnBr₂) and tetramethylethylenediamine (TMEDA) catalyzes the cross coupling of (bis)pinacolatodiboron with a wide range of alkyl halides, demonstrating the first manganese-catalyzed coupling with alkyl electrophiles. This method allows access to primary, secondary, and tertiary boronic esters from the parent chlorides, which were previously inaccessible as coupling partners. The reaction proceeds in high yield with as little as 1000 ppm catalyst loading, while 5 mol % can provide high yields in as little as 30 min. Finally, radical-clock experiments revealed that at 0 °C direct borylation outcompetes alternative radical processes, thereby providing synthetically useful, temperature-controlled reaction outcomes. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile Regioselective Synthesis of Novel bis-Thiazole Derivatives and Their Antimicrobial Activity was written by Mahmoodi, Nosrat O.;Parvizi, Jafar;Sharifzadeh, Bahman;Rassa, Mehdi. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2013.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The design and synthesis of several new bis[thiazole] derivatives serving as bis[drug] dimers in comparison with mono-heterocyclic analogs are described. These bis-drugs present superior medicinal and pharmacol. activities against both Gram-neg. (Pseudomonas aeruginosa and Escherichia coli) and Gram-pos. (Micrococcus luteus and Bacillus subtilis) bacteria, which are in general more sensitive to compounds with higher hydrophobicity. Compounds with higher hydrophobicity exhibited some activity against Gram-neg. bacteria. The synthesis of the target compounds was achieved by a cyclization of thiourea with (phenyl)ethanone dimer derivatives The title compounds thus formed included a thiazolamine dimer compound (I) and related substances. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organozinc Chemistry Enabled by Micellar Catalysis. Palladium-Catalyzed Cross-Couplings between Alkyl and Aryl Bromides in Water at Room Temperature was written by Duplais, Christophe;Krasovskiy, Arkady;Lipshutz, Bruce H.. And the article was included in Organometallics in 2011.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

Negishi-like cross-couplings between (functionalized) alkyl and aryl bromides are described. Despite the fact that organozinc reagents are intolerant of water, their formation as well as their use in an aqueous micellar environment is discussed herein. Each component of this complex series of events leading up to C-C bond formation has an important role which has been determined insofar as the type of zinc, amine ligand, surfactant, and palladium catalyst are concerned. In particular, the nature of the surfactant has been found to be crucial in order to obtain synthetically useful results involving highly reactive, moisture-sensitive organometallics. Neither organic solvent nor heat is required for these cross-couplings to occur; just add water. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Construction and investigation of photo-switch property of azobenzene-bridged pillar[5]arene-based [3]rotaxanes was written by Chong, Hui;Nie, Cuiyun;Wang, Lihong;Wang, Sicong;Han, Ying;Wang, Yang;Wang, Chengyin;Yan, Chaoguo. And the article was included in Chinese Chemical Letters in 2021.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

Series of azobenzene-bridged pillar[5]arene-based [3]rotaxanes with different alkyl chain length of guest mols. were constructed by threading-endcapping method with alkylenetriazole as axile and tetrahydrochromene as endcapping group. The encapsulation of pillar[5]arenes were proved by high-resolution mass, ¹H NMR and NOESY spectra. The photo-responsive property were examined by irradiation of the synthesized [3]rotaxanes with 365 nm and blue light LED, which caused trans to cis and cis to trans isomerization, resp. Irradiation of corresponding model guest compounds without pillar[5]arene encapsulation resulted in near completely trans to cis and cis to trans isomerization, indicating the existence of pillar[5]arenes is the determining factor for the comprised photo isomerization efficiency. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Enamides by Ruthenium-Catalyzed Reaction of Alkyl Azides with Acid Anhydrides in Ionic Liquid was written by Pak, Han Kyu;Han, Junghoon;Jeon, Mina;Kim, Yongjin;Kwon, Yearang;Park, Jin Yong;Rhee, Young Ho;Park, Jaiwook. And the article was included in ChemCatChem in 2015.Related Products of 6294-17-3 The following contents are mentioned in the article:

Enamides were synthesized by a ruthenium-catalyzed one-pot, one-step procedure from alkyl azides and acid anhydrides. The substrate scope includes not only secondary azides, but also primary aliphatic ones to give a wide range of enamides containing various functional groups. This one-step procedure was based on the newly discovered activity of Severin’s diruthenium complex ([CpR̂uCl₂]₂: Cp=̂η⁵-1-methoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl) for the transformation of alkyl azides into the corresponding N-H imine intermediates in ionic liquids The formation of ruthenium tetrazene complexes was observed in the stoichiometric reaction of Severin’s complex with alkyl azides, which acted as the catalyst for the formation of N-H imine intermediates. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides was written by Wang, Fei;Rao, Weidong;Wang, Shun-Yi. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The cross-electrophile coupling between unactivated alkyl bromides RBr [R = 2-phenylethyl, but-3-en-1-yl, 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, etc.] with arenesulfonyl cyanides R¹S(O)₂CN (R¹ = 4-CH₃C₆H₄, C₆H₅, 4-CH₃OC₆H₄, 4-ClC₆H₄) catalyzed by Ni(acac)₂ under reductive conditions to form unsym. sulfides is developed. This approach for sulfide synthesis is practical, relies on available, unfunctionalized materials such as alkyl (pseudo)halides, and is scalable. This catalytic strategy provides a complementary method for the preparation of unsym. alkyl-aryl sulfides under mild conditions with good functional group tolerance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Promoted Reactions of Organostibines with Alkynes and Organic Halides to Give Chalcogenated (Z)-Olefins and Ethers was written by Le, Liyuan;Li, Shuangshuang;Zhang, Dejiang;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Organic Letters in 2022.Quality Control of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Herein, with air-stable chalcogenated stibines (Sb-ER) as organometallic chalcogenating reagents, base-promoted (Z)-hydrochalcogenation of alkynes with DMSO/DMSO-d₆ as hydrogen/deuterium sources, giving chalcogenated (Z)-olefins in good yields and with excellent regioselectivity was developed. These reagents, easily synthesized from halostibines with in situ generated [Zn(ER)₂] at room temperature within a few minutes, was also used in the base-promoted C(sp³)-S(Se) cross-coupling with C(sp³)-X and copper-catalyzed C(sp²)-S(Se) cross-coupling with C(sp²)-X (X = F, CI, Br, I) under mild conditions. This protocol was also be simply extended to organobismuth complexes (Bi-ER) with good functional tolerance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Quality Control of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics