Category: 6313-54-8

Selvakumari, S. published the artcileDonor acceptor groups effect, polar protic solvents influence on electronic properties and reactivity of 2-Chloropyridine-4-carboxylic acid, Quality Control of 6313-54-8, the publication is Journal of the Indian Chemical Society (2022), 99(6), 100478, database is CAplus.

The computational reckoning of 2-Chloropyridine-4-carboxylic acid (2CP4CA) was accomplished employing DFT/B3LYP with the root set as 6-311++G(d, p). The impact of polar protic solvents which are eco-friendly solvents (water, methanol, ethanol, 1-propanol) on 2CP4CA were analyzed. To examine the solvent effect, vibrational investigations and NLO reports of 2CP4CA in dissimilar solvents were executed. Geometrical properties were also established in gas phase for 2CP4CA. Exercising VEDA program, the entire vibrational assignment was accomplished. Donor-acceptor exchanges were ascertained utilizing NBO scrutiny technique. Thermodn. properties of 2CP4CA were analyzed at different temperatures By applying TD – DFT approach, theoretic UV-Vis absorption spectrum was procured in different solvents. In order to evaluate the complete electron concentration and sensitive spots of 2CP4CA, MEP coupled with FMO analyzes were employed. HOMO along with LUMO orbitals and energy band gap were acquired for 2CP4CA employing dissimilar polar protic solvents. Addnl., ELF, LOL and charge transfer studies were also executed. RDG anal. has been exercised for revealing non-covalent interactions.

Journal of the Indian Chemical Society published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C14H31NO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Campagnol, Nicolo published the artcileOn the electrochemical deposition of metal-organic frameworks, Product Details of C6H4ClNO2, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2016), 4(10), 3914-3925, database is CAplus.

The electrochem. deposition of Metal-Organic Frameworks (MOFs) is an interesting technique to synthesize adherent, microporous layers on top of conductive substrates. The technique can be subdivided in two approaches: anodic and cathodic deposition. While the mechanism of the cathodic approach has already been well studied, at least for MOF-5 not much is known about the anodic approach. A four-step mechanism is proposed to better understand the anodic deposition, and the same MOF used for the study, HKUST-1, is also deposited cathodically to compare the two approaches. This study focuses on how nucleation starts and proceeds, on the influence of the potential applied, the stresses in the growing layers, and the origin of defects like delamination and MOF detachment. The study is followed by critical considerations on the methods and on the technique, together with suggestions and guidelines to synthesize new MOF layers.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fukunaga, Kenji published the artcile2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; A new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors, HPLC of Formula: 6313-54-8, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(24), 6933-6937, database is CAplus and MEDLINE.

A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found compounds I (R = 4-F (II), 2,6-di-OMe, 2-F-6-Cl) to possess potent in vitro GSK-3β inhibitory activity with good in vitro PK profiles. Compound II demonstrated significant decrease of tau phosphorylation after oral administration in mice and excellent PK profiles.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, HPLC of Formula: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jitchati, R. published the artcileThree synthetic routes to a commercial N3 dye, Category: chlorides-buliding-blocks, the publication is International Journal of Applied Physics and Mathematics (2012), 2(2), 107-110, database is CAplus.

We present the synthesis and characterization of a com. standard ruthenium dye namely, N3, by cheap and easily prepared starting materials from three synthetic routes: the Gratzel’s protocol and the other two new methods designed in our laboratory, i.e., the one-pot reaction and via the reaction of cymene complex.

International Journal of Applied Physics and Mathematics published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Barnash, Kimberly D. published the artcileDiscovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2, Computed Properties of 6313-54-8, the publication is ACS Combinatorial Science (2017), 19(3), 161-172, database is CAplus and MEDLINE.

The function of EED within Polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. Allosteric activation of PRC2 by binding of methylated proteins to EED’s aromatic cage is essential for full catalytic activity, but details of this regulation are not fully understood. EED’s recognition of the product of PRC2 activity, histone H3 lysine 27 trimethylation (H3K27me3), stimulates PRC2 methyltransferase activity at adjacent nucleosomes leading to H3K27me3 propagation and, ultimately, gene repression. By coupling combinatorial chem. and structure-based design, we optimized a low affinity methylated Jarid2 peptide to a smaller, more potent peptidomimetic ligand (Kd = 1.14 ± 0.14 μM) of the aromatic cage of EED. Our strategy illustrates the effectiveness of applying combinatorial chem. to achieve both ligand potency and property optimization. Furthermore, the resulting ligands, UNC5114 and UNC5115, demonstrate that targeted disruption of EED’s reader function can lead to allosteric inhibition of PRC2 catalytic activity.

ACS Combinatorial Science published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ishizuka, Tomoya published the artcileProton-Coupled Electron Shuttling in a Covalently Linked Ruthenium-Copper Heterodinuclear Complex, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of the American Chemical Society (2011), 133(46), 18570-18573, database is CAplus and MEDLINE.

A heterodinuclear complex (I) based on a Ru^II-TPA [TPA = tris(2-pyridylmethyl)amine] complex having a peripheral Cu^II(bpy)₂ (bpy = 2,2′-bipyridine) group bonded through an amide linkage displayed reversible intramol. electron transfer between the Ru and Cu complex units that can be controlled by protonation and deprotonation of the bridging amide moiety.

Journal of the American Chemical Society published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Greguric, Ivan published the artcileDiscovery of [¹⁸F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of Medicinal Chemistry (2009), 52(17), 5299-5302, database is CAplus and MEDLINE.

The high melanoma uptake and rapid body clearance displayed by our series of [¹²³I]iodonicotinamides prompted the development of [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide, a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [¹⁸F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclin. studies for progression into clin. trials to assess the responsiveness of therapeutic agents.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reeves, Jonathan T. published the artcileDevelopment of an Enantioselective Hydrogenation Route to (S)-1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine, COA of Formula: C6H4ClNO2, the publication is Organic Process Research & Development (2014), 18(7), 904-911, database is CAplus.

A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl Et ketone, a simple enamide synthesis by direct condensation of propionamide with a ketone, catalytic asym. enamide hydrogenation employing the inhouse-developed ligand MeO-BIBOP, and a mild epimerization-free deprotection of a propionamide using Koenig’s procedure.

Organic Process Research & Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Taisaku published the artcileDiscovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design, Name: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry (2013), 21(14), 4233-4249, database is CAplus and MEDLINE.

A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones were explored as human chymase inhibitors using structure-based drug design according to the x-ray cocrystal structure of chymase and SUN13834. The optimization focused on the prime site led to the attainment of compounds that showed potent inhibitory activity, and among them, 6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-N-{(1R)-1-[(1H-tetrazol-5-ylamino)carbonyl]propyl}-1,4-diazepan-1-carboxamide shows a novel interaction mode.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C8H6ClF3, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Jong Yeon published the artcileOptimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei, COA of Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(14), 4127-4131, database is CAplus and MEDLINE.

We previously reported the phenylchloronitrobenzamides (PCNBs), a novel class of compounds active against the species of trypanosomes that cause Human African Trypanosomiasis (HAT). Herein, we explored the potential to adjust the reactivity of the electrophilic chloronitrobenzamide core. These studies identified compound 7d that potently inhibited the growth of trypanosomes (EC₅₀ = 120 nM for Trypanosoma b. brucei, 18 nM for Trypanosoma b. rhodesiense, and 38 nM for Trypanosoma b. gambiense) without significant cytotoxicity against mammalian cell lines (EC₅₀ > 25 μM for HepG2, HEK293, Raji, and BJ cell lines) and also had good stability in microsomal models (t_1/2 > 4 h in both human and mouse). Overall these properties indicate the compound 7d and its analogs are worth further exploration as potential leads for HAT.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics