Category: 6313-54-8

Makane, Vitthal B.; Krishna, Vagolu Siva; Krishna, E. Vamshi; Shukla, Manjulika; Mahizhaveni, B.; Misra, Sunil; Chopra, Sidharth; Sriram, Dharmarajan; Dusthackeer, V. N. Azger; Rode, Haridas B. published an article on February 15 ,2019. The article was titled 《Synthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis》, and you may find the article in European Journal of Medicinal Chemistry.Reference of 2-Chloroisonicotinic acid The information in the text is summarized as follows:

Synthesis, SAR and evaluation of α-aminoacyl amides R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2-pyrrolyl, 2-furyl, 2-thienyl, etc.; R2 = Ph, 4-MeC6H4, 2-HOC6H4, etc.; R3 = Ph, 3-ClC6H4, 4-MeOC6H4, etc.; R4 = t-Bu, cyclohexyl, Bn, 2-naphthyl] as antitubercular agents were reported via Ugi reaction of benzaldehydes, isocyanides, anilines and carboxylic acids. The systematic medicinal chem. approach led to identification of optimal substitutions required for the activity. Compound R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2,4-di-methylthiazol-5-yl; R2 = 2,4-di-MeC6H3; R3 = 3-pyridyl; R4 = cyclohexyl] was identified as antitubercular lead with drug like properties. Further, R1C(O)N(R2)CH(R3)C(O)NHR4 [R1 = 2,4-di-methylthiazol-5-yl; R2 = 2,4-di-MeC6H3; R3 = 3-pyridyl; R4 = cyclohexyl] selectively inhibited M. tuberculosis H37Rv with MIC value of 0.78 μM and was found to be non-toxic to CHO-K1 cells. The lead compound inhibited multi drug resistant and Pre-Extensively drug resistant strains of Mycobacterium at 2 μg/mL and 8 μg/mL resp. In the experiment, the researchers used 2-Chloroisonicotinic acid(cas: 6313-54-8Reference of 2-Chloroisonicotinic acid)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Reference of 2-Chloroisonicotinic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8》 were Karpina, V. R.; Kovalenko, S. S.; Kovalenko, S. M.; Zaremba, O. V.; Silin, O. V.; Langer, T.. And the article was published in Zhurnal Organichnoi ta Farmatsevtichnoi Khimii in 2019. SDS of cas: 6313-54-8 The author mentioned the following in the article:

A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives2-Chloroisonicotinic acid(cas: 6313-54-8SDS of cas: 6313-54-8) was used in this study.

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 6313-54-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

《Synthesis, characterization and antioxidant activity of 2-aryl benzimidazole derivatives》 was published in Asian Journal of Pharmaceutical Research and Development in 2020. These research results belong to Vineet Kumar Singh, Amrita Parle. Category: chlorides-buliding-blocks The article mentions the following:

In the present study 19 benzimidazole derivatives were synthesized by reacting O-phenylenediamine as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatog. technique, and the newly synthesized derivatives were characterized by ATIR and 1HNMR techniques. The antioxidant assay was performed using ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] method and DPPH [2,2-diphenyl-1-picrylhydrazyl] method. The experimental process involved the reaction of 2-Chloroisonicotinic acid(cas: 6313-54-8Category: chlorides-buliding-blocks)

2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics