Category: 6313-54-8

Vineet Kumar Singh, Amrita Parle published the artcileSynthesis, characterization and antioxidant activity of 2-aryl benzimidazole derivatives, Synthetic Route of 6313-54-8, the publication is Asian Journal of Pharmaceutical Research and Development (2020), 8(2), 35-44, database is CAplus.

In the present study 19 benzimidazole derivatives were synthesized by reacting O-phenylenediamine as the primary reactant with different aromatic aldehydes and benzoic acids. Reactions were monitored using thin layer chromatog. technique, and the newly synthesized derivatives were characterized by ATIR and ¹HNMR techniques. The antioxidant assay was performed using ABTS [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] method and DPPH [2,2-diphenyl-1-picrylhydrazyl] method.

Asian Journal of Pharmaceutical Research and Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C7H13NO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ren, Jing-Ling published the artcileLimonoids containing a C₁-O-C₂₉ moiety: isolation, structural modification, and antiviral activity, Quality Control of 6313-54-8, the publication is Marine Drugs (2018), 16(11), 434, database is CAplus and MEDLINE.

Five new limonoids named thaigranatins A-E (1-5), containing a C1-O-C29 moiety, were isolated from seeds of the Thai Xylocarpus granatum, collected at the mangrove swamp of Trang Province, together with the known limonoid, granatumin L (6). The structures of these compounds were established by HR-ESIMS and extensive NMR spectroscopic data. The absolute configuration of 1 was unequivocally determined by single-crystal X-ray diffraction anal., conducted with Cu Kα radiation; whereas that of 2 or 6 was established to be the same as that of 1 by the similarity of their electronic CD (ECD) spectra. In view of the marked antiviral activity of 6, its structure was modified via hydrolysis with alk. KOH, esterification with diazomethane and various organic acids, and oximization with hydroxyamine. Finally, 18 derivatives, viz. 7-10, 8a-8i, 9a-9b, and 10a-10c, were obtained. In vitro antiviral activities of these derivatives against human immunodeficiency virus 1 (HIV-1) and influenza A virus (IAV) were evaluated. Most notably, 8i exhibited marked inhibitory activity against HIV-1 with an IC50 value of 15.98 ± 6.87 μM and a CC50 value greater than 100.0 μM; whereas 10b showed significant inhibitory activity against IAV with an IC50 value of 14.02 ± 3.54 μM and a CC50 value greater than 100.0 μM.

Marine Drugs published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Bang-Chang published the artcilep-Arsanilic acid stabilizing titanium-oxo clusters with various core structures and light absorption behaviours, Related Products of chlorides-buliding-blocks, the publication is Inorganic Chemistry Communications (2017), 14-17, database is CAplus.

P-Arsanilic acid stabilizing polyoxo-titanium clusters (PTCs) were successfully synthesized through solvothermal method, which present {Ti₄}, {Ti₅} and {Ti₆} cores functionalized by different carboxylic acid ligands. PTC-111 displays a {Ti₄} core structure which is stabilized by glycolic acid and esterified p-arsanilic acid. PTC-112, PTC-113 and PTC-114 have isostructural {Ti₆} structures, functionalized by isonicotinic acid, 2-chloroisonicotinic acid and HOBz, resp. The {Ti₅} core of PTC-115 is functionalized by m-nitrobenzoic acid. It is interesting that the light absorption behaviors of these PTCs are dependent on their core structures and the functionalizing ligands.

Inorganic Chemistry Communications published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C15H15OP, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xiaoqing published the artcileA series of luminescent Ln^III-based coordination polymers: Syntheses, structures and luminescent properties, Related Products of chlorides-buliding-blocks, the publication is Inorganica Chimica Acta (2020), 119459, database is CAplus.

A series of lanthanide coordination polymers (Ln-CPs), with the formula of {[Ln(L)₃(CH₃OH)(H₂O)]_n} (Ln = Sm (1), Eu (2), HL = 2-chloroisonicotinic acid) and {[Ln(L)₃(H₂O)₂]_n} (Ln = Dy (3), Tb (4)), were synthesized under solvothermal condition. This series display two different 1D chains due to the lanthanide contraction: complexes 1 and 2, based on light Sm and Eu, resp., consist of paddle-wheel [Ln₂(COO)₄] dimmers through double μ₂-COO bridges, and complexes 3 and 4 with heavy Dy and Tb, resp., show 1D [Ln(COO)₂]_n chains. The luminescent measurements indicate the typical emissions of corresponding Ln³⁺ ions in complexes 1–4. Furthermore, complexes 2 and 4 display significant luminescent response for Fe³⁺ ions with high quenching constant Complexes 2 and 4 can act as luminescent probes for Fe³⁺ ions with relatively high sensitivity and selectivity.

Inorganica Chimica Acta published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H13BO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qin, Yaoguo published the artcileDesign, synthesis and biological activity of novel aphid alarm pheromone analogues containing isonicotinic acid, Name: 2-Chloroisonicotinic acid, the publication is Gaodeng Xuexiao Huaxue Xuebao (2016), 37(11), 1977-1986, database is CAplus.

A series of new aphid alarm pheromone [(E)-β-farnesene, EBF] analogs containing isonicotinic acid was designed based on the principles of connecting sub-structure and bioisosterism. With EBF as a lead compound, 20 EBF analogs were prepared via four steps starting from geraniol. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. The preliminary bioassay suggested that all the analogs showed repellent and aphicidal activities against Myzus persicae (Sulzer). Among them, compounds 7d, 8f and 8n showed good repellent activity with the repellent rate of 62.6%, 62.0% and 61.0% resp.; and the analogs 8a, 8b and 8d exhibited better aphicidal mortality of 73.6%, 81.1% and 70.2% than lead EBF. The primary structure-activity relationship (SAR) anal. indicated that introducing of ester group was favorable to repellent activity while introducing amide was conducive to aphicidal activity. Moreover, N-substituted carbon chain length, number of branched chain as well as aromaticity played roles in repellent activity. This study provides useful clues for further development of novel aphid control agent.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Schutter, Joris W. published the artcileNovel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase, Safety of 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(19), 5781-5786, database is CAplus and MEDLINE.

A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Safety of 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jia, Xiaojuan published the artcileSulfur-silicon bond activation catalyzed by Cl/Br ions: waste-free synthesis of unsymmetrical thioethers by replacing fluoride catalysis and fluorinated substrates in S_NAr reactions, Application of 2-Chloroisonicotinic acid, the publication is Green Chemistry (2014), 16(7), 3444-3449, database is CAplus.

In contrast to conventional activation of Nu-SiR₃ reagents by F ion attributed to the strong affinity of Si to F, S-Si activation can now be achieved using Cl/Br ions of TBAX as catalysts via formation of weaker X-Si bonds and Me₃Si-X. This led to a waste-free synthesis of unsym. thioethers via F-free S_NAr reactions of activated (hetero)aryl halides and RS-SiMe₃, with recovery of the useful Me₃Si-X reagent in high yields.

Green Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Application of 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Matthew published the artcileA very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Tetrahedron (2006), 62(6), 1110-1115, database is CAplus.

A very concise synthesis of a potent KDR kinase inhibitor I is described. The synthesis features an exceedingly efficient one-pot preparation of 2-aminothiazole-5-carbonitrile, followed by Pd-Xantphos catalyzed cross-coupling with 2-chloro-4-pyridinecarboxaldehyde. Reductive amination of the resulting aldehyde 2-(4-formylpyridin-2-ylamino)thiazole-5-carbonitrile with N-methyl-1-piperazinecarboxamide afforded the final product I.

Tetrahedron published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C10H18O4, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Ming-Chuan published the artcileSynthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety, Name: 2-Chloroisonicotinic acid, the publication is European Journal of Medicinal Chemistry (2012), 128-135, database is CAplus and MEDLINE.

This study designed and synthesized a series of novel ursolic acid derivatives in an attempt to develop potent antitumor agents. Their structures were confirmed using MS, IR, ¹H NMR and ¹³C NMR. The inhibitory activities of the title compounds against the MGC-803 (gastric cancer cell) and Bcap-37 (breast cancer cell) human cancer cell lines were evaluated using standard MTT assay in vitro. The pharmacol. results showed that some of the compounds displayed moderate to high levels of antitumor activities against the tested cancer cell lines and that most exhibited more potent inhibitory activities compared with ursolic acid. The mechanism of 2-(4-(2,6-dichlorobenzoyl)piperazin-1-yl)ethyl 3β-hydroxyurs-12-en-28-oate was preliminarily investigated by acridine orange/ethidium bromide staining, Hoechst 33258 staining, TUNEL assay and flow cytometry, which revealed that the compound can induce cell apoptosis in MGC-803 cells.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Shengtao published the artcileA Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway, Application In Synthesis of 6313-54-8, the publication is Journal of Medicinal Chemistry (2017), 60(4), 1449-1468, database is CAplus and MEDLINE.

The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, the application of oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series of oridonin A-ring modified analogs, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized and evaluated for anticancer efficacy. Some of the derivatives were significantly more potent than oridonin against both drug-sensitive and drug-resistant cancer cells. The most potent compound, I, was 200-fold more efficacious than oridonin in MCF-7 cancer cells. Furthermore, I induced apoptosis and cell cycle arrest at the G2/M phase. A decrease in mitochondrial membrane potential and increased Bax/Bcl-2 ratio, accompanied by activated caspase-3 cleavage, were observed in MCF-7 cells after treatment with I, suggesting that the mitochondrial pathway was involved in the I-mediated apoptosis. Moreover, I significantly inhibited tumor growth in mouse xenograft models and had no observable toxic effect.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C5H7FO2, Application In Synthesis of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics