Category: 6313-54-8

Hu, Chongbo published the artcileSynthesis and insecticidal activities of N-(tert-butyl)-N’-(fluorobenzoyl)pyridinecarboxylic acid hydrazide derivatives, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Youji Huaxue (2016), 36(5), 1051-1059, database is CAplus.

In order to find novel diacylhydrazine derivatives which possessed high activities against pests, 20 novel N-(tert-butyl)-N’-(fluorobenzoyl)pyridinecarboxylic acid hydrazide derivatives of formula I [Py = substituted pyridine; R = H, F] were synthesized by introducing fluoro-contained Ph and pyridine into the basic structure of diacylhydrazines. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. The bioassay results indicated that most of the compounds exhibited more than 80 % mortality against Mythimna separata at the concentration of 500 mg/L. Among these compounds, N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2-chloronicotinohydrazine and N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2,5-dichloronicotinohydrazine exhibited 100 % and 80 % mortality against Mythimna separata at 10 mg/L, resp. The LC₅₀ of compound N-(tert-butyl)-N’-(2,6-difluorobenzoyl)-N-2-chloronicotinohydrazine against Mythimna separata was 8.77 mg/L, and it showed about 0.51 times of toxicity against Mythimna separata than tebufenozide and had 1.5 times of toxicity against Plutella xylostella than tebufenozide.

Youji Huaxue published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zeng, Jing published the artcileSelective Co/Ti Cooperatively Catalyzed Biaryl Couplings of Aryl Halides with Aryl Metal Reagents, HPLC of Formula: 6313-54-8, the publication is Organic Letters (2013), 15(20), 5342-5345, database is CAplus and MEDLINE.

Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO₂NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol% CoCl₂/15 mol% PBu₃ and substoichiometric Ti(OEt)₄ (40 mol% to ArM) at room temperature in high yields with high chemo- and regioselectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yin, Xue-Song published the artcileCopper(II)-catalyzed methoxylation of unactivated (hetero)aryl C-H bonds using a removable bidentate auxiliary, Related Products of chlorides-buliding-blocks, the publication is Organic Chemistry Frontiers (2015), 2(2), 119-123, database is CAplus.

A copper(II)-catalyzed methoxylation of unactivated (hetero)aryl C-H bonds directed by newly developed PIP directing group with methanol has been achieved. This protocol occurs efficiently with a catalytic amount of copper (5 mol%), is a simple and environmentally benign reaction system, has a broad substrate scope and high functional group tolerance.

Organic Chemistry Frontiers published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C24H20Ge, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Fa-Jie published the artcileCu(II)-Mediated C-S/N-S Bond Formation via C-H Activation: Access to Benzoisothiazolones Using Elemental Sulfur, Synthetic Route of 6313-54-8, the publication is Organic Letters (2014), 16(21), 5644-5647, database is CAplus and MEDLINE.

A copper-mediated C-S/N-S bond-forming reaction via C-H activation that uses elemental sulfur has been developed. The addition of TBAI was found to be crucial for the success of this transformation. The method is scalable, shows excellent functional group tolerance, and is compatible with heterocycle substrates, providing efficient and practical access to benzoisothiazolones. E.g., in presence of TBAI, Cu(OAc)₂, Ag₂O, and S₈, reaction of benzamide substrate (I) gave 89% benzoisothiazolone derivative (II). The direct diversification of the benzoisothiazolone products into a variety of sulfur-containing compounds is also demonstrated.

Organic Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qin, Zhaohai published the artcileStudies on pyridine derivatives (IV): Synthesis and R. solani inhibiting activities of 4-aryl(alkyl)-3-[(2-chloropyrid)-4-yl]-1,2,4-triazoline-5-thiones, Related Products of chlorides-buliding-blocks, the publication is Nongyaoxue Xuebao (1999), 1(3), 85-87, database is CAplus.

Twelve 4-aryl(alkyl)-3-[(2-chloropyrid)-4-yl]-1,2,4-triazoline-5-thiones I (R = alkyl or aryl) were synthesized. Nine of them were good inhibitors for R. Solani (EC₅₀ were within 10.5âˆ?8.8 μg·mL^-1). Their ¹HNMR was also assigned.

Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jianping published the artcileSynthesis and herbicidal activity of α-benzylcyclododecanone oxime esters, Synthetic Route of 6313-54-8, the publication is Nongyaoxue Xuebao (2008), 10(2), 161-165, database is CAplus.

Several α-(benzyl)cyclododecanone oxime esters were synthesized by a reaction of α-(benzyl)cyclododecanone oxime with carboxylic acid derivatives Product structures were determined by NMR, elemental anal., IR. A preliminary bioassay indicated that one compound possessed an an inhibition rate 72.70% and 54.98% against Digitaria sanguinalis and 85.04% and 81.91% against Abutilon theophrasti at a concentration of 100 and 1 mg/L. The IC₅₀ value for Digitaria sanguinalis and IC₉₀ value for Abutilon theophrasti of that compound was was 0.49 and 1.90 mg/L, resp.

Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Synthetic Route of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lim, Chae Jo published the artcile4-Heteroaryl phthalazin-1(2H)-one derivatives as potent melanin concentrating hormone receptor 1 (MCH-R1) antagonists, Related Products of chlorides-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2012), 33(7), 2389-2392, database is CAplus.

The target compounds, 4-heteroaryl-2-{3-[4-(3-acetamidophenyl)piperidin-1-yl]propyl}phthalazin-1(2H)-ones, were prepared starting from 2-BrC₆H₄CO₂H in 4 steps starting via Li-halo exchange using excess BuLi, followed by acylation with appropriate heteroaroyl esters to give the corresponding 2-heteroaroylbenzoates. The key 4-heteroarylphthalazin-1(2H)-one intermediates were then generated by condensation with N₂H₄. Subsequent N-alkylation with Cl(CH₂)₃I using NaH base afforded 2-(3-chloropropyl)4-heteroarylphthalazin-1 (2H)-ones, which were transformed to the target compounds through coupling with N-[3-(4-piperidinyl)phenyl]acetamide in the presence of Na₂CO₃. The title compounds proved to be potent MCH-R1 antagonists. An extensive SAR study carried out with substances in this family containing C(4) pyridyl and 5-membered heteroaryl groups led to the identification of a 5-chlorothien-2-yl derivative as a highly potent MCH-R1 antagonist. This substance displayed good metabolic stability, no inhibition of CYP450 enzymes, and low hERG binding activity.

Bulletin of the Korean Chemical Society published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Poplawski, Sarah E. published the artcileIdentification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase, Formula: C6H4ClNO2, the publication is Journal of Medicinal Chemistry (2013), 56(9), 3467-3477, database is CAplus and MEDLINE.

Fibroblast activation protein (FAP) is a serine protease selectively expressed on reactive stromal fibroblasts of epithelial carcinomas. It is widely believed to play a role in tumor invasion and metastasis and therefore to represent a potential new drug target for cancer. Investigation into its biol. function, however, has been hampered by the current unavailability of selective inhibitors. The challenge has been in identifying inhibitors that are selective for FAP over both the dipeptidyl peptidases (DPPs), with which it shares exopeptidase specificity, and prolyl oligopeptidase (PREP), with which it shares endopeptidase specificity. Here, we report the first potent FAP inhibitor with selectivity over both the DPPs and PREP, N-(pyridine-4-carbonyl)-d-Ala-boroPro (ARI-3099, I). We also report a similarly potent and selective PREP inhibitor, N-(pyridine-3-carbonyl)-Val-boroPro (ARI-3531, II). Both are boronic acid based inhibitors, demonstrating that high selectivity can be achieved using this electrophile. The inhibitors are stable, easy to synthesize, and should prove to be useful in helping to elucidate the biol. functions of these two unique and interesting enzymes, as well as their potential as drug targets.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karpina, V. R. published the artcileThe synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8, SDS of cas: 6313-54-8, the publication is Zhurnal Organichnoi ta Farmatsevtichnoi Khimii (2019), 17(1), 28-35, database is CAplus.

A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of ¹H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives

Zhurnal Organichnoi ta Farmatsevtichnoi Khimii published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Makane, Vitthal B. published the artcileSynthesis and evaluation of α-aminoacyl amides as antitubercular agents effective on drug resistant tuberculosis, Name: 2-Chloroisonicotinic acid, the publication is European Journal of Medicinal Chemistry (2019), 665-677, database is CAplus and MEDLINE.

Synthesis, SAR and evaluation of α-aminoacyl amides R¹C(O)N(R²)CH(R³)C(O)NHR⁴ [R¹ = 2-pyrrolyl, 2-furyl, 2-thienyl, etc.; R² = Ph, 4-MeC₆H₄, 2-HOC₆H₄, etc.; R³ = Ph, 3-ClC₆H₄, 4-MeOC₆H₄, etc.; R⁴ = t-Bu, cyclohexyl, Bn, 2-naphthyl] as antitubercular agents were reported via Ugi reaction of benzaldehydes, isocyanides, anilines and carboxylic acids. The systematic medicinal chem. approach led to identification of optimal substitutions required for the activity. Compound R¹C(O)N(R²)CH(R³)C(O)NHR⁴ [R¹ = 2,4-di-methylthiazol-5-yl; R² = 2,4-di-MeC₆H₃; R³ = 3-pyridyl; R⁴ = cyclohexyl] was identified as antitubercular lead with drug like properties. Further, R¹C(O)N(R²)CH(R³)C(O)NHR⁴ [R¹ = 2,4-di-methylthiazol-5-yl; R² = 2,4-di-MeC₆H₃; R³ = 3-pyridyl; R⁴ = cyclohexyl] selectively inhibited M. tuberculosis H37Rv with MIC value of 0.78 μM and was found to be non-toxic to CHO-K1 cells. The lead compound inhibited multi drug resistant and Pre-Extensively drug resistant strains of Mycobacterium at 2 μg/mL and 8 μg/mL resp.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics