Category: 6313-54-8

Du, Xiaohui published the artcilePhenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(19), 6218-6223, database is CAplus and MEDLINE.

GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series led to a proof-of-concept compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Mi-hyun published the artcileStructure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Bioorganic & Medicinal Chemistry (2011), 19(6), 1915-1923, database is CAplus and MEDLINE.

The synthesis of a novel series of N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl) amide derivatives 6a-o, 7a-s and their antiproliferative activities against A375P melanoma cell line were described. Most compounds showed competitive antiproliferative activities to sorafenib, the reference standard Among them, N-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl) ureido)-2-methylbenzamide 7c exhibited potent activities (GI₅₀ = 0.27 μM). Especially, 7c was found to be a potent and selective B-Raf V600E and C-Raf inhibitor (IC₅₀ = 0.26 μM, IC₅₀ = 0.11 μM, resp.), showing a possibility as melanoma therapeutics.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jankowiak, Aleksandra published the artcile4-Substituted 1-Acyloxypyridine-2(1 H)-thiones: Experimental and Computational Studies of the Substituent Effect on Electronic Absorption Spectra, SDS of cas: 6313-54-8, the publication is Journal of Organic Chemistry (2009), 74(19), 7441-7448, database is CAplus and MEDLINE.

A series of eight 4-substituted 1-(adamantane-1-carbonyloxy)-4-X-pyridine-2(1H)-thiones (1, X = H, OC₇H₁₅, Me, CF₃, SC₃H₇, CN, COOMe, and Cl) was prepared and characterized by UV-vis spectroscopy in MeCN and cyclohexane. The observed lowest energy transition, designated as π_CS → π*_ring, exhibits a substantial substituent effect and λ_max ranges from 333 (X = OC₇H₁₅) to 415 nm (X = CN). Exptl. λ_max values for all esters except for 1b (X = OC₇H₁₅) correlate with the σ_p^– parameter (ρ = 0.41 ± 0.03, r² = 0.95). In contrast, the energy of the absorption band at about 295 nm, designated as π_CS → π*_CS, is practically substituent independent. Both absorption bands exhibit a modest neg. solvatochromic effect. The exptl. absorption energies correlate better with excitation energies calculated for N-acetyloxy analogs 2 with the ZINDO//DFT than with the TD-DFT//DFT method. Calculations for a series of 12 N-acetates 2 predict the most blue-shifted π → π* transition for the alkoxy substituent and most red-shifted for the NO₂ group relative to the parent 2a (X = H).

Journal of Organic Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, V. published the artcileHeterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2006), 41(9), 1048-1058, database is CAplus and MEDLINE.

Triazolo[3,4-b]thiadiazoles I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are prepared in three steps from the hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) and the carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) via aminomercaptotriazoles II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); the antiinflammatory, analgesic, antibacterial, and antifungal activities of I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) are determined Base-mediated condensation of hydrazides RCONHNH₂ (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carbon disulfide followed by condensation of the potassium arylcarbonylhydrazinocarbodithioate with hydrazine hydrate provides II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl); condensation of II (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl) with carboxylic acids R¹CO₂H (R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂) in phosphorus oxychloride provides I (R = 4-Me₂NC₆H₄, 2-MeHNC₆H₄, 1-naphthylmethyl; R¹ = 2-Ph-4-quinolinyl, 2-Me-4-quinolinyl, 2,6-dihydroxy-4-pyridinyl, 2-chloro-4-pyridinyl, 4-HO-3-MeOC₆H₃CH:CH, 2-H₂N-3,5-Br₂C₆H₂, 2-Me-4-O₂NC₆H₃, 2-ClC₆H₄OCH₂CH₂). The activities of the prepared compounds are lower than those of the standard agents used.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileSynthesis, characterization and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, Quality Control of 6313-54-8, the publication is E-Journal of Chemistry (2007), 4(3), 320-342, database is CAplus.

4-Amino-5-aryl, or heteroaryl, substituted-3-mercapto-1,2,4-triazoles were prepared from the corresponding aromatic carboxylic acids through a multi-step sequence. These compounds were then reacted with various aromaticand hetero aromatic acids and hetero aromatic aldehydes to give 3,6-disubstituted-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles, e.g., I, and 3,6-disubstituted-5,6-dihydro-1,2,4-triazolo [3,4-b]-1,3,4-thiadizoles resp. Elemental anal., IR, ¹H NMR and mass spectral data was elucidated for the structures of all newly synthesized compounds Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

E-Journal of Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathew, Vinod published the artcileStudies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues, SDS of cas: 6313-54-8, the publication is European Journal of Medicinal Chemistry (2007), 42(6), 823-840, database is CAplus and MEDLINE.

Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole, e.g., I (R = H, Me or Ph), and their dihydro analogs were synthesized from hetero aromatic acids and hetero aromatic aldehydes, resp., by microwave-assisted and conventional methods. Synthesized compounds were studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacol. activities.

European Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kuramochi, Takahiro published the artcileDiscovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2005), 13(12), 4022-4036, database is CAplus and MEDLINE.

Ca²⁺ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca²⁺ overload, because NCX inhibitors can directly inhibit the influx of Ca²⁺ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives We have discovered a novel NCX inhibitor (I) with an IC₅₀ value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P 450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of I are discussed.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Asano, Shigehiro published the artcileSuzuki-Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines, Application In Synthesis of 6313-54-8, the publication is Tetrahedron (2012), 68(1), 272-279, database is CAplus.

Suzuki-Miyaura cross-coupling reaction with 2-heteroarylboronic acids is generally challenging due to easy decomposition of these acids. To overcome this problem, we developed a coupling method that uses 2-heteroaryl pinacol boronates in the presence of 1.0 mol % Pd(OAc)₂ and 2.0 mol % S-Phos with 4 equiv amount of LiOH in dioxane and H₂O at 80 °C for 30 min. This developed method allowed for the synthesis of a wide variety of 2-heteroaryl pyrimidines from 2-chloropyrimidyl derivatives in high yields, and is also useful in the preparation of various biaryl derivatives from heteroaryl chlorides.

Tetrahedron published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Application In Synthesis of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Yi published the artcileSynthesis and antifungal activity of novel chiral indole analogues, Name: 2-Chloroisonicotinic acid, the publication is Natural Product Research, database is CAplus and MEDLINE.

Starting from L-tryptophan, 19 new N-substituted chiral indole analogs were synthesized. The prepared compounds were evaluated for biol. activity against Sclerotinia sclerotiorum, Alternaria solani, Verticillium dahliae, Colletotrichum orbiculare, Cytospora juglandis and Curvularia lunata. The preliminary bioassays showed that most of the synthesized compounds exhibited fungicidal activity. Compound in particular exhibited significant antifungal activity against Verticillium dahliae and Sclerotinia sclerotiorum, with the MIC value of 1.95 μg mL-1. Compound also showed excellent activity against six plant pathogen fungi, and was identified as the most active on the biol. assays, and will be studied further.

Natural Product Research published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C20H12N2O2, Name: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Schwarze, Benedikt published the artcile2,2′-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes, Computed Properties of 6313-54-8, the publication is ChemMedChem (2019), 14(24), 2075-2083, database is CAplus and MEDLINE.

Investigations on the antitumor activity of metallacarboranes are sparse in the literature and limited to a handful of ruthena- and molybdacarboranes. In this study, the molybdacarborane fragment [3-(CO)₂-closo-3,1,2-MoC₂B₉H₁₁] was combined with a vector mol., inspired by the well-known drug tamoxifen or 4,4′-dihydroxytamoxifen (TAM-diOH). The molybdacarborane derivative [3,3-{4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine-κ²N,N′}-3-(CO)₂-closo-3,1,2-MoC₂B₉H₁₁] (10), as well as the ligand itself 4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine (6) showed cytotoxic activities in the low micromolar range against breast adenocarcinoma (MDA-MB-231, MDA-MB-361 and MCF-7), human glioblastoma (LN-229) and human glioma (U-251) cell lines. In addition, compounds 6 and 10 were found to induce senescence and cytodestructive autophagy, lower ROS/RNS levels, but only the molybdacarborane 10 induced a strong increase of nitric oxide (NO) concentration in the MCF-7 cells.

ChemMedChem published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C12H13NO3, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics