Category: 63624-28-2

Sulfonylpiperazines based on a flavone as antioxidant and cytotoxic agents was written by Patel, Rahul V.;Mistry, Bhupendra M.;Syed, Riyaz;Parekh, Nikhil M.;Shin, Han-Seung. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

Chrysin-based sulfonylpiperazines 7a-k were synthesized and investigated for their in vitro free radical scavenging potential as well as cytotoxic efficacies against selected cancer cell lines. Cytotoxicity of the new compounds toward noncancer cells was confirmed using the SRB assay against Madin-Darby Canine Kidney cells. Reaction of piperazine with different substituted benzenesulfonyl chlorides in triethylamine furnished sulfonylpiperazines (3a-k), which were then allowed to react with 7-(4-bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one (6) prepared reacting chrysin with 1,4-dibromobutane to give the final derivatives 7a-k. The results concluded that chrysin-sulfonylpiperazines exerted better antioxidant and anticancer efficacies than previously studied chrysin-piperazine precursors. For example, compounds 7h, 7j, and 7k with 4-OCF₃, 4-OCH₃, and 2,4-diOCH₃ groups exhibited the best antioxidant potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. Moreover, halogenated analogs (7b, 7c, 7g, and 7h) demonstrated promising anticancer potential against SK-OV3, HeLa, and HT-29 cell lines, whereas those bearing a methoxy functional group (7j and 7k) had beneficial effects against the cell lines A-549 and HT-29. Thus, it can be confirmed from the bioassay results that the overall structural design as well as proper substitution is crucial to deliver the anticipated biol. effects. Spectroscopic techniques such as FT-IR, ¹H NMR, ¹³C NMR, mass and elemental anal. (CHN) were carried out to confirm the final structures. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and Synthesis of Fsp³-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening was written by Stotani, Silvia;Lorenz, Christoph;Winkler, Matthias;Medda, Federico;Picazo, Edwige;Ortega Martinez, Raquel;Karawajczyk, Anna;Sanchez-Quesada, Jorge;Giordanetto, Fabrizio. And the article was included in ACS Combinatorial Science in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

The exploration of innovative chem. space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biol. relevant metabolites and show attractive features, such as mol. compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available com. reagents and robust chem. transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Direct synthesis of thiophosphates by reaction of diphenylphosphine oxide with sulfonyl chlorides was written by He, Wei;Wang, Zhiming;Li, Xinjin;Yu, Qing;Wang, Zhongwei. And the article was included in Tetrahedron in 2016.Electric Literature of C8H9ClO4S This article mentions the following:

A new method for the synthesis of thiophosphates by reductive coupling reaction of diphenylphosphine oxide and sulfonyl chlorides has been developed. The reaction is metal-free and needs no additives, affording various aryl and alkyl substituted thiophosphates in good to excellent yields under mild conditions. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Electric Literature of C8H9ClO4S).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C8H9ClO4S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of biaryls via intramolecular free radical ipso-substitution reactions was written by Ujjainwalla, Feroze;da Mata, Maria Lucilia E. N.;Pennell, Andrew M. K.;Escolano, Carmen;Motherwell, William B.;Vazquez, Santiago. And the article was included in Tetrahedron in 2015.Application of 63624-28-2 This article mentions the following:

A variety of functionalized biaryls and heterobiaryls are prepared by intramol. free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately positioned substituents on the aromatic acceptor ring. The extension of the process to benzylic sulfonates and their corresponding N-methylsulfonamide alternatives as substrates in potential [1,6]-ipso-substitution reactions leads mainly to the alternative [1,7] addition products. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors was written by Rossi, Cristina;Fincham, Christopher I.;D’Andrea, Piero;Porcelloni, Marina;Ettorre, Alessandro;Mauro, Sandro;Bigioni, Mario;Binaschi, Monica;Maggi, Carlo A.;Nardelli, Federica;Parlani, Massimo;Fattori, Daniela. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Reference of 63624-28-2 This article mentions the following:

A series of N-substituted 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of histone deacetylase (HDAC) inhibitors (zinc binding moiety-linker-capping group) has been previously reported by our group. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells. We report here the second part of the strategy used in our research group to find a new class of HDAC inhibitors, namely the SAR study for the compounds bearing a sulfonyl group on the piperidine nitrogen. In the present work, we have considered both sulfonamides and sulfonyl ureas. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Reference of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New protecting groups for the indole ring of tryptophan in peptide synthesis: 2,4,6-trimethoxybenzenesulfonyl and 4-methoxy-2,3,6-trimethylbenzenesulfonyl groups was written by Fukuda, Tsunehiko;Wakimasu, Mitsuhiro;Kobayashi, Shigeru;Fujino, Masahiko. And the article was included in Chemical & Pharmaceutical Bulletin in 1982.Application of 63624-28-2 This article mentions the following:

The title groups (Mtb and Mtr, resp.) and 2,4-RR¹C₆H₃SO₂ (R = H, R¹ = Me, MeO; R = R¹ = MeO) were introduced at the Nⁱⁿ of tryptophan, and their protective group properties were studied. Thus, Boc-Trp-OCH₂Ph (Boc = Me₃CO₂C) was treated with R²Cl (R² = Mtb, Mtr) to give Boc-Trp(R²)-OCH₂Ph, which was saponified to give Boc-Trp(R²)-OH. Mtb and Mtr were stable to CF₃CO₂H, but they can be removed by HF or MeSO₃H; these groups suppress decomposition and modification of the tryptophan residue during peptide synthesis. The Mtb and Mtr groups were used for the protection of the indole ring in the synthesis of pyro-Glu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂ (bombesin) and LH-releasing hormone analog pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt by solution methods and the preparation of H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH (dynorphin) by the solid-phase method. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Application of 63624-28-2).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 63624-28-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases was written by Rouffet, Matthieu;de Oliveira, Cesar Augusto F.;Udi, Yael;Agrawal, Arpita;Sagi, Irit;McCammon, J. Andrew;Cohen, Seth M.. And the article was included in Journal of the American Chemical Society in 2010.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride This article mentions the following:

Derived from the extensive work in the area of small mol. zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole-sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the chelating group. The findings show that focused chelator libraries are a powerful strategy for the discovery of lead fragments for metalloprotein inhibition. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride).

2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 2,4-Dimethoxybenzene-1-sulfonyl chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics