Reddy, Guda Mallikarjuna et al. published their research in Bioorganic Chemistry in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 638-07-3

Pyranopyrazoles as efficient antimicrobial agents: Green, one pot and multicomponent approach was written by Reddy, Guda Mallikarjuna;Garcia, Jarem Raul;Zyryanov, Grigory V.;Sravya, Gundala;Reddy, Nemallapudi Bakthavatchala. And the article was included in Bioorganic Chemistry in 2019.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

Innovative therapeutic heterocycles having precisely thiadiazolyl-pyranopyrazole fragments were prepared by using the ecofriendly synthetic route. Entire compounds formed in quant. yields. All the composites tested for their antimicrobial effectiveness against four microbial, two beneficial fungi’s and accurately measured the min. inhibitory concentrations (MIC and MBC/MFC), along with some initial structure activity relationships (SARs) also discussed. From the biol. outcomes, the motif 6f provided an outstanding activity against all six pathogens. The possible presence of a nitro substituent on this composite may undoubtedly enhance the activity. In addition, amalgams 6d, 6g and 6l displayed promising antimicrobial results. This may be justified to the presence of electron capture group attached to the benzene ring, while the combinations 6j and 6k were zero effect towards all bacterial strains. The other compounds were excellent to low antimicrobial efficiency. The intriguing point was observed that all the active compounds had in common immense antibacterial effectiveness on Gram-neg. bacteria than Gram-pos. one and more antifungal activity on A. niger compare to other fungus. All things considered and suggested that this outstanding green synthetic approach is used to develop biol. active compounds On top of that, biol. results confirmed that these biol. energetic motifs suitable for addnl. preclin. examine with the aim of standing novel innovative drugs. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chavan, Abhijit P. et al. published their research in Medicinal Chemistry Research in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Synthesis of new 1,3,4-oxadiazole and benzothiazolylthioether derivatives of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-one as potential antimycobacterial agents was written by Chavan, Abhijit P.;Deshpande, Rujuta R.;Borade, Nandkumar A.;Shinde, Abhijit;Mhaske, Pravin C.;Sarkar, Dhiman;Bobade, Vivek D.. And the article was included in Medicinal Chemistry Research in 2019.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

A new series of 4-[(substituted benzylidene)-3-[(5-(pyridine-4-yl)-1,3,4-oxadiazole-2-ylthio)-methyl]]isoxazol-5(4H)-one and 4-(substituted benzylidene)-3-((benzo[d]thiazol-2-ylthio)methyl)isoxazol-5(4H)-one I and II [Ar = Ar1 = 4-methylphenyl, 4-hydroxyphenyl, 3-indolyl, etc.], resp. was synthesized. All the synthesized compounds I and II were screened for antitubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis BCG (ATCC 35743) and antibacterial activity against Escherichia coli (NCIM 2576), Pseudomonas flurescence (NCIM 2059), Staphylococcus aureus (NCIM 2602), Bacillus subtilis (NCIM 2162). Amongst the synthesized 1,3,4-oxadiazole and benzothiazoyl thioether derivatives, compounds I and II [Ar = Ar1 = 4-methoxyphenyl] showed excellent antimycobacterial activity and compounds I [Ar = 4-methoxyphenyl], II [Ar1 = 4-methylphenyl, 4-hydroxyphenyl, 4-methoxyphenyl] showed excellent antibacterial activity against all tested antibacterial strains. The synthesized compounds I and II were further evaluated for their cytotoxic activity against the HCT 116 and HeLa cancer cell lines. The 1,3,4-oxadiazole and benzothiazoyl thioether derivatives I and II did not showed cytotoxicity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Naghiyev, Farid et al. published their research in ChemistrySelect in 2022 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 638-07-3

Synthesis and Biological Activity of Functionally Substituted Pyrimidine and Pyran Derivatives on the Basis of Isatylidene Malononitriles was written by Naghiyev, Farid;Mamedov, Ibrahim;Askerov, Rizvan;Taslimi, Parham;Poustforoosh, Alireza. And the article was included in ChemistrySelect in 2022.Product Details of 638-07-3 The following contents are mentioned in the article:

In this study, it was shown that pyrimidine and imidazopyridine derivatives were obtained from the multicomponent reaction of isatylidene malononitriles with malononitrile and diamines at room temperature Also, the interaction of 2-(5-bromo-2-oxoindoline-3-ylidene)with malononitrile and benzoyl acetone (or ethyl-4-chlorine-acetoacetate) was carried out and the formation of the corresponding pyran derivatives was observed The acetylcholinesterase (AChE) inhibitor compounds recorded as important therapeutic drugs for the therapy of Alzheimer’s disease. Also, novel complexes effectively inhibited AChE enzyme, with Ki values in the range of 4.56 to 8.21μM. For this enzyme, it was obtained with IC50 values in the range of 4.04 to 9.85μM. For α-glycosidase enzyme the most effective Ki values were for I and II compounds with Ki values of 31.48 and 32.63μM, resp. The mol. docking study was employed to investigate of chem. activities and interaction of synthesized compounds with low Ki in the presence of AChE, butyrylcholinesterase, and α-Glycosidase. The results revealed that some of the compounds, like compound III have a good binding affinity to AChE with a docking score of -6.243 (kcal/mol). This compound can affect the enzyme activity by attachment to essential residues of the catalytic domain of the enzyme. The ADME/T anal. was also performed and revealed that compounds have the potential to be utilized as medicine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Product Details of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Product Details of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Garrepalli, Sailaja et al. published their research in Journal of Molecular Structure in 2023 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 638-07-3

Synthesis and characterization of two known and one new impurities of dolutegravir: In silico evaluation of certain intermediates against SARS CoV-2 O-ribose methyltransferase (OMTase) was written by Garrepalli, Sailaja;Gudipati, Ramesh;Kapavarapu, Ravikumar;Ravindhranath, Kunta;Pal, Manojit. And the article was included in Journal of Molecular Structure in 2023.Recommanded Product: 638-07-3 The following contents are mentioned in the article:

Besides its use against HIV infection the marketed anti-retroviral drug dolutegravir attracted attention as a potential agent against COVID-19 in multiple AI (artificial intelligence) based studies. The synthesis of O-Me ent-dolutegravir was accomplished in three-steps the first one involved the construction of fused 1,3-oxazinane ring. The cleavage of -OEt ether moiety followed by methylation afforded the target compound The second impurity i.e. N-(2,4-difluorobenzyl)-4-methoxy-3-oxobutanamide was synthesized via a multi-step method involving sequentially the keto group protection, ester hydrolysis, acid chloride formation followed by the reaction with amine and finally keto group deprotection. The synthesis of new or dimer impurity was carried out via another multi-step method similar to the previous one starting from Et 4-chloro acetoacetate. The methodol. involved preparation of ether derivative, keto group protection, ester hydrolysis, preparation of amide derivative via acid chloride formation in situ and then keto group deprotection for a longer duration. The last step afforded the target compound for which a plausible reaction mechanism has been proposed. The in silico evaluation of three selected synthesized intermediates e.g. I, II and III (structurally similar to dolutegravir) against SARS CoV-2 O-ribose methyltransferase (OMTase) (PDB: 3R24) indicated that compound I could be of interest as a possible inhibitor of this protein. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hu, Chun-Fang et al. published their research in Bioorganic Chemistry in 2020 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus was written by Hu, Chun-Fang;Zhang, Peng-Li;Sui, Yan-Fei;Lv, Jing-Song;Ansari, Mohammad Fawad;Battini, Narsaiah;Li, Shuo;Zhou, Cheng-He;Geng, Rong-Xia. And the article was included in Bioorganic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Ethylenic conjugated coumarin thiazolidinediones as potential multi-targeting new antimicrobial compounds I [R1 = H, Me; R2 = H, Et, CH2HC=CH2, 4-FC6H4CH2, etc.; R3 = H, CH2HC=CH2, CH2C≡CH] were synthesized through convenient procedures from com. available resorcinol and were evaluated for their antimicrobial potency. Bioactive evaluation revealed that some of the prepared compounds I showed strong antimicrobial activities toward the tested microorganisms including clin. drug-resistant strains. Especially, propargyl derivative I [R1 = Me; R2 = CH2C≡CH; R3 = H] exhibited effective anti-MRSA potency with MIC value of 0.006μmol/mL, which was highly advantageous over clin. antibacterial drug norfloxacin. Compound I [R1 = Me; R2 = CH2C≡CH; R3 = H] showed rapid killing effect, low toxicity against hepatocyte LO2 cell line and no obvious drug resistance development against MRSA. Preliminary exploration of action mechanism manifested that compd I [R1 = Me; R2 = CH2C≡CH; R3 = H] acted upon MRSA through forming stable supramol. complex with bacterial DNA which might impede DNA replication. Mol. docking showed that compound I [R1 = Me; R2 = CH2C≡CH; R3 = H] could bind with DNA-gyrase through hydrogen bonds. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Natal, Carolina M. et al. published their research in RSC Advances in 2021 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C6H9ClO3

New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation was written by Natal, Carolina M.;Fernandes, Maria Jose G.;Pinto, Nuno F. S.;Pereira, Renato B.;Vieira, Tatiana F.;Rodrigues, Ana Rita O.;Pereira, David M.;Sousa, Sergio F.;Fortes, A. Gil;Castanheira, Elisabete M. S.;T. Goncalves, M. Sameiro. And the article was included in RSC Advances in 2021.Electric Literature of C6H9ClO3 The following contents are mentioned in the article:

New compounds with potential insecticide activity were synthesized by structural modifications performed in the monoterpenoid phenolic moieties of carvacrol and thymol, resulting in a set of derivatives with the ether function containing the Pr, chloropropyl or hydroxypropyl chains, as well as a bicyclic ether with an unsaturated chain containing a carboxylic acid terminal. In addition, an analog of carvacrol and thymol isomers bearing methoxyl, 1-hydroxyethyl and (3-chlorobenzoyl)oxy, instead of the three original Me groups, was also synthesized. Several structural changes that resulted in diminished insecticide activity have been identified, but two significantly active mols. have been synthesized, one of them being less toxic to human cells than the naturally-derived starting materials. Structure-based inverted virtual screening and mol. dynamics simulations demonstrate that these active mols. likely target the insect odorant binding proteins and/or acetylcholinesterase and are able to form stable complexes. For the most promising compounds, nanoencapsulation assays were carried out in liposomes of egg phosphatidylcholine/cholesterol (7 : 3) prepared by both thin film hydration and ethanolic injection methods. The compound-loaded liposomes were generally monodisperse and with sizes smaller than or around 200 nm. The thin film hydration method allowed high encapsulation efficiencies (above 85%) for both compounds and a delayed release, while for the systems prepared by ethanolic injection the encapsulation efficiency is lower than 50%, but the release is almost complete in two days. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Electric Literature of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coskun, Kubra A. et al. published their research in Anti-Cancer Agents in Medicinal Chemistry in 2021 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 638-07-3

Designing Specific HSP70 Substrate Binding Domain Inhibitor for Perturbing Protein Folding Pathways to Inhibit Cancer Mechanism was written by Coskun, Kubra A.;Koca, Irfan;Gumus, Mehmet;Tutar, Yusuf. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2021.Recommanded Product: 638-07-3 The following contents are mentioned in the article:

HSP70 is a survival factor for tumor cells in transformation and in tumor progression as well as in anti-apoptotic response. Several inhibitors targeting HSP70 ATPase function displayed off-target effects, but PES, which targets the HSP70 substrate binding domain, prevents tumor cell survival prominently. However, PES may not bind HSP70 in the absence of nucleotide. This research aimed to design a unique inhibitor mol. that works both in the presence and absence of nucleotides to amplify inhibition. A set of chimeric coumarine-pyrazole derivatives were determined by in silico techniques and synthesized to elucidate their inhibitory effects. Cell viability experiments displayed KBR1307 as the most efficient inhibitor. A set of characterization experiments were performed, and the results were compared to that of PES agent. Binding constant, ATP hydrolysis rate, and percent aggregation were determined in the presence and absence of inhibitors. In silico docking experiments showed that only KBR1307 binds the HSP70 substrate binding domain and interacts with cochaperone interface. Binding experiments indicated that KBR1307 binds HSP70 both in the presence and absence of nucleotides, but PES does not. Both inhibitors significantly lower HSP70 ATPase activity and substrate protein disaggregation activity. However, KBR1307 displays a lower IC50 value at the MCF-7 cell line compared to PES. Both inhibitors do not alter HSP70 secondary structure composition and overall stability. KBR1307 effectively inhibits HSP70 compared to PES and provides a promising template for novel anticancer drug development. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Zeyu et al. published their research in Catalysis Science & Technology in 2020 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C6H9ClO3

Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system was written by Yang, Zeyu;Fu, Hengwei;Ye, Wenjie;Xie, Youyu;Liu, Qinghai;Wang, Hualei;Wei, Dongzhi. And the article was included in Catalysis Science & Technology in 2020.Formula: C6H9ClO3 The following contents are mentioned in the article:

Alc. dehydrogenases (ADHs) together with the economical substrate-coupled cofactor regeneration system play a pivotal role in the asym. synthesis of chiral alcs.; however, severe challenges concerning the poor tolerance of enzymes to 2-propanol and the adverse effects of the byproduct, acetone, limit its applications, causing this strategy to lapse. Herein, a novel ADH gene smadh2 was identified from Stenotrophomonas maltophilia by traditional genome mining technol. The gene was cloned into Escherichia coli cells and then expressed to yield SmADH2. SmADH2 has a broad substrate spectrum and exhibits excellent tolerance and superb activity to 2-propanol even at 10.5 M (80%, volume/volume) concentration Moreover, a new thermostatic bubble column reactor (TBCR) system is successfully designed to alleviate the inhibition of the byproduct acetone by gas flow and continuously supplement 2-propanol. The organic waste can be simultaneously recovered for the purpose of green synthesis. In the sustainable system, structurally diverse chiral alcs. are synthesized at a high substrate loading (>150 g L-1) without adding external coenzymes. Among these, about 780 g L-1 (6 M) Et acetoacetate is completely converted into Et (R)-3-hydroxybutyrate in only 2.5 h with 99.9% ee and 7488 g L-1 d-1 space-time yield. Mol. dynamics simulation results shed light on the high catalytic activity toward the substrate. Therefore, the high 2-propanol tolerance SmADH2 with the TBCR system proves to be a potent biocatalytic strategy for the synthesis of chiral alcs. on an industrial scale. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Munikrishnappa, Chandrashekar S. et al. published their research in Arabian Journal of Chemistry in 2021 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 638-07-3

Design, synthesis, and biological evaluation of novel bromo-pyrimidine analogues as tyrosine kinase inhibitors was written by Munikrishnappa, Chandrashekar S.;Suresh Kumar, G. V.;Bhandare, Richie R.;Shaik, Afzal B.. And the article was included in Arabian Journal of Chemistry in 2021.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

In the present investigation a novel series of bromo-pyrimidine analogs I (R = Ph, 2-furyl, 3-ClC6H4, etc.; R1 = H, Me), II (R = Ph, 4-F3CC6H4, 4-FC6H4, etc.) and III (R = Ph, 4-ClC6H4, 3-pyridinyl, etc.) are designed, synthesized and evaluated as anticancer agents. The compounds were characterized using spectroscopic studies and elemental anal. and screened for their in vitro cytotoxic activity by MTT assay against four cancer cell lines including HCT116 (human colon cancer cell line), A549 (human lung cancer cell line), K562 (human chronic myeloid leukemia cell line), U937 (human acute monocytic myeloid leukemia cell line) as well as the normal human liver cell line, L02. Most of the compounds showed potent activity on K562 cells. Considering this, the compounds were evaluated for Bcr/Abl tyrosine kinase inhibitory activity by ADP-Glo assay. Dasatinib was used as standard drug for both cytotoxicity and tyrosine kinase inhibition studies. The compounds, I (R = 4-F3CC6H4; R1 = H), I (R = 4-F3CC6H4; R1 = Me), II (R = 4-F3CC6H4), and III (R = 4-F3CC6H4) emerged as potent Bcr/Abl kinase inhibitors. Hence, the potent compounds that arose out of this investigation are potential lead mols. to develop as an alternative to existing dasatinib therapy. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Thacker, Pavitra S. et al. published their research in Bioorganic Chemistry in 2020 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C6H9ClO3

Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors was written by Thacker, Pavitra S.;Sridhar Goud, Nerella;Argulwar, Omkar S.;Soman, Jyothsna;Angeli, Andrea;Alvala, Mallika;Arifuddin, Mohammed;Supuran, Claudiu T.. And the article was included in Bioorganic Chemistry in 2020.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

Two series, coumarin-linked to thiazolidinone via a pyrazole linker I [R = H, 3-Me, 4-Cl, etc.] and coumarin-linked 1,2,3-triazoles II [R1 = H, 4-MeO, 3-Cl, etc.] were synthesized and were subjected for evaluation against the four physiol. and pharmacol. relevant hCA isoforms, hCA I, II, IX and XII. The results indicated selective inhibition of tumor-associated isoforms hCA IX and XII over the off-target isoforms, hCA I and II. The compounds I exhibited better hCA IX inhibition compared to hCA XII, with compounds I [R = 3-Me, 3-F3C, 4-Me, 4-MeO] exhibited notable Ki values of less than 100 nM. Among all the compounds, compound I [R = 3-Me] showed the best inhibition with a Ki value of 61.5 nM. Among the compounds of II, compounds II [R1 = H, 4-O2N, 2,5-di-Cl, 4-CN, 4-Me, 3-Cl] exhibited notable hCA IX inhibition. Compound II [R1 = 4-CN] showed the best inhibition with a Ki value of 32.7 nM. In the case of hCA XII, compound II [R1 = 4-MeO] showed the best inhibition with a Ki value of 84.2 nM. Hence, compound I [R = 3-Me] and II [R1 = 4-CN] could be taken as lead compounds for the further development of selective and potent hCA IX inhibitors, whereas the compound II [R1 = 4-MeO] can be explored further for the design of selective and potent hCA XII inhibitors. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics