Category: 638-07-3

Cerium(IV) based oxidative free radical cyclization of active methylene compounds with some cyclic alkenes: A useful annulation method for terpene functionalization was written by Svetlik, Jan;Turecek, Frantisek;Hartwich, Katarzyna;Koziel, Krzysztof;Pakulski, Pawel;Palasz, Aleksandra;Kalinowska-Tluscik, Justyna;Ciez, Dariusz. And the article was included in Tetrahedron in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Ceric ammonium nitrate-mediated oxidative cyclizations of CH-acids with terpenes and terpene-like substrates were investigated. Dimedone, acetylacetone, and Me nitroacetate were condensed with pinene, norbornene, nopol, camphene, and carvone and the reaction stereoselectivity was examined Condensation with endocyclic double bonds in pinene and nopol displayed stereoselectivity, resulting in the formation of pure enantiomers. Condensation with exocyclic double bonds in camphene and carvone produced enantiomer mixtures The mechanism of the intramol. annulation in a nopol derivative is discussed with the help of DFT and ab initio calculations This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient and metal-free synthesis of 5,7-dimethylcyclopentenon[2,3-c]coumarin was written by Yerramreddy, Thirupathi Reddy;Yiannikouris, Alexandros. And the article was included in Journal of Chemical Research in 2021.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

A synthesis of 5,7-dimethylcyclopentenon[2,3-c]coumarin I from 3,5-dimethoxyphenol via a Pechmann condensation involved five steps and represented an alternative com. viable approach over existing synthetic protocols in the literature. Operational simplicity, inexpensive key raw materials, short reaction times, and excellent yields were remarkable features of this approach. The aflatoxin template was provided in 55%-67% overall yield from 3,5-dimethoxyphenol with >99% purity, evaluated by high-performance liquid chromatog., ¹H NMR, ¹³C NMR, high-resolution mass spectrometry, and liquid chromatog.-mass spectrometry. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers was written by Yoritate, Makoto;Londregan, Allyn T.;Lian, Yajing;Hartwig, John F.. And the article was included in Journal of Organic Chemistry in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, author report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Functionalised Chromonyl-pyrimidines and Their Potential as Antimycobacterial Agents was written by Santoso, Kristiana T.;Brett, Matthew W.;Cheung, Chen-Yi;Cook, Gregory M.;Stocker, Bridget L.;Timmer, Mattie S. M.. And the article was included in ChemistrySelect in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:

Herein, the development of chromonyl-pyrimidines I [R¹ = Me, CH₂Cl, CH₂OMe, Ph, 4-FC₆H₄; R² = H, C(O)Ph; R³ = CO₂H, CO₂Et, Ph, 4-NH₂C₆H₄, 4-O₂NC₆H₄] as a new tuberculosis (TB) drug scaffold was presented. A library of chromonyl-pyrimidines was synthesized, from which lead compounds I [R¹ = Me, R² = H, Ph R³ = Ph; R¹ = Me, R² = R³ = Ph] was identified. From this work, the potential of chromonyl-pyrimidines as therapeutics for TB was demonstrated. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An unusual synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones from ethyl 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate via benzopyran ring opening was written by Kavitha, Kotthireddy;Srikrishna, Devulapally;Sridhar, Balasubramanian;Aparna, Pasula. And the article was included in Molecular Diversity in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

An unusual and unexpected synthesis of 3-(2-(arylamino)thiazol-4-yl)-2H-chromen-2-ones was observed by the reaction of Et 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylate with various arylthioureas in ethanol under mild reaction conditions with excellent yields. The ambiguity in the structure of the obtained products was solved by recording its single-crystal X-ray anal. This protocol was found to be a novel approach for the preparation of title compounds via benzopyran ring opening. A systematic plausible mechanism was proposed for the formation of the product. Also, an efficient one-pot three-component method was demonstrated for the formation of title compounds starting from salicylaldehyde. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Category: chlorides-buliding-blocks).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines was written by Ostrovskii, Vladimir A.;Danagulyan, Gevorg G.;Nesterova, Olga M.;Pavlyukova, Yulia N.;Tolstyakov, Vladimir V.;Zarubina, Olga S.;Slepukhin, Pavel A.;Esaulkova, Yana L.;Muryleva, Anna A.;Zarubaev, Vladimir V.;Trifonov, Rostislav E.. And the article was included in Chemistry of Heterocyclic Compounds in 2021.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments were separated by hydrazinocarbonylmethyl I [R = H, Me], methylpyrazolyl II, groups or a sulfur atom III [R¹ = Ph; R² = H; R¹ = CH₂CO₂H, R² = Me] were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which had very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient ultrasonic-assisted synthesis of enol carbamates via oxidative coupling of formamides with 1,3-dicarbonyl compounds was written by Akbari, Jafar;Meyestani, Alireza Akbari. And the article was included in Letters in Organic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Sonochem. oxidative-coupling of N,N-dimethyl/diethylformamide with 1,3-dicarbonyl compounds RC(O)CH(R¹)C(O)OR² (R = Me, chloromethyl, Ph, propyl; R¹ = H, Cl; R² = Me, Bn, prop-2-en-1-yl, etc.) in the corresponding carbamates R²OC(O)C(R¹)=C(R)OC(O)N(R³)(R⁴) (R³ = R⁴ = Me, Et) by CuO nanoparticles as a catalyst and tert-Bu hydroperoxide (TBHP) as an oxidant has been reported. Various derivatives of enol carbamates were synthesized with good to high yields under the optimized reaction conditions. Compared with conventional methods, the main advantage of this method is mild conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Polyacrylonitrile fiber with strongly acidic electrostatic microenvironment: Highly efficient and recyclable heterogeneous catalyst for the synthesis of heterocyclic compounds was written by Xiao, Jian;Xu, Gang;Wang, Lu;Li, Pengyu;Zhang, Wenqin;Ma, Ning;Tao, Minli. And the article was included in Journal of Industrial and Engineering Chemistry in 2019.SDS of cas: 638-07-3 The following contents are mentioned in the article:

Four categories of sulfonic acid functionalized fiber catalysts with different surface microenvironments were synthesized by covalent grafting using polyacrylonitrile fiber (PANF) as the support. After the effect of acid structure on catalytic activity was investigated by Friedlander reaction, PANEOSF was chosen for the synthesis of quinolines and coumarin derivatives with high yields and extensive substrate scope (51 examples) in ethanol or water. The effect of electrostatic microenvironment and solvent was discussed and a “release-catch-release-catch” catalytic pattern was proposed accordingly. PANEOSF can be easily recycled for 20 times without any decrease of catalytic activity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Realizing the Trifunctional Potential of Alkyl 4-Chloro-2-diazo-3-oxobutanoates: Convenient Assembly of 6,7-Dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazine Core was written by Dar’in, Dmitry;Khoroshilova, Olesya;Kantin, Grigory;Krasavin, Mikhail. And the article was included in Synthesis in 2020.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The first example of exploiting the trifunctional character of alkyl 4-chloro-2-diazo-3-oxobutanoates in the reactions with vicinal N,S-bis-nucleophiles led to the formation of bicyclic 6,7-dihydro-4H-[1,2,3]triazolo[5,1-c][1,4]thiazines was presented. The key to the successful realization of the atom-economical synthetic strategy was the initial SN₂ event, which facilitated the subsequent domino 1,2,3-triazole formation via the Wolff reaction. Equally important was the choice of sodium acetate as the base: acetic acid formed in the course of the initial nucleophilic substitution acted as an efficient catalyst for the Wolff reaction, which suppressed the competing, unwanted fragmentation path (observed when other bases were used). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An expedient one-pot tandem method for the synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones under green conditions was written by Kavitha, K.;Srikrishna, D.;Dubey, Pramod Kumar;Aparna, P.. And the article was included in Journal of the Iranian Chemical Society in 2019.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

This paper describes a facile pathway for the one-pot three-component synthesis of 3-(2-(phenylamino)thiazol-4-yl)-2H-chromen-2-ones starting from ethyl-4-chloroacetoacetate by treating it with equimolar amounts of various phenylthioureas and salicylaldehyde. Use of biosynthetically prepared L-proline as an efficient catalyst and naturally extracted renewable polyethylene glycol-600 (PEG-600) as an effective green reaction media are the added advantages of this method. Alternatively, tandem, stepwise methods have been proposed to isolate the intermediate and to study the possible reaction mechanism. These reactions are very simple, rapid, cost effective, industrially viable, which would be applied for various biomass conversions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics