Category: 638-07-3

Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers was written by Irie, Takayuki;Asami, Tokiko;Sawa, Ayako;Uno, Yuko;Taniyama, Chika;Funakoshi, Yoko;Masai, Hisao;Sawa, Masaaki. And the article was included in Journal of Medicinal Chemistry in 2021.Formula: C6H9ClO3 The following contents are mentioned in the article:

CDC7, a serine-threonine kinase, plays conserved and important roles in regulation of DNA replication and has been recognized as a potential anticancer target. We report here the optimization of a series of furanone analogs starting from compound 1 with a focus on ADME properties suitable for clin. development. By replacing the 2-chlorobenzene moiety in 1 with various aliphatic groups, we identified compound 24 as a potent CDC7 inhibitor with excellent kinase selectivity and favorable oral bioavailability in multiple species. Oral administration of 24 demonstrated robust in vivo antitumor efficacy in a colorectal cancer xenograft model. Compound 24 (AS-0141) is currently in phase I clin. trials for the treatment of solid cancers. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective Construction of Diverse Polycyclic Spirooxindoles via a Three-Component Reaction of Cyclic Mercapto-Substituted β-Enamino Esters, Isatins, and Cyclic 1,3-Diketones was written by Sun, Quan-Shun;Sun, Jing;Pan, Liu-Na;Yan, Chao-Guo. And the article was included in Journal of Organic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The three-component reaction of alkyl 2-(benzo[b][1,4]thiazin-3-ylidene)acetates, isatins, and 1,3-indanedione (1,3-cyclopentanedione) in ethanol in the presence of acetic acid conveniently afforded spiro[indeno[1,2-b]phenothiazine-6,3′-indolines] or spiro[cyclopenta[b]phenothiazine-4,3′-indolines] in good yields and with high diastereoselectivity. More interestingly, a similar three-component reaction with 4-hydroxychromen-2-one resulted in the unexpected polycyclic spiro[benzo[b]chromeno[3′,4′:5,6]pyrano[2,3-e][1,4]thiazine-7,3′-indolines] in satisfactory yields. A plausible reaction mechanism was rationally proposed for formation of different kinds of the spiro compounds, and the stereochemistries of the various spiro compounds were clearly elucidated. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

B(C₆F₅)₃-catalyzed synthesis of coumarins via Pechmann condensation under solvent-free conditions was written by Prajapti, Santosh Kumar;Rao, S. Prakash. And the article was included in Monatshefte fuer Chemie in 2021.Formula: C6H9ClO3 The following contents are mentioned in the article:

Tris(pentafluorophenyl)borane [B(C₆F₅)₃] catalyzed simple, efficient and environmentally benign protocol has been developed for the Pechmann condensation using variety of phenols and β-ketoesters under solvent-free conditions to afford coumarin derivatives The present protocol displayed significant advantages such as low catalyst loading, short reaction time, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups. In addition, it is a convenient, clean, and fast alternative approach for synthesizing variety of coumarin derivatives Moreover, the applicability of this method towards large-scale synthesis demonstrated its suitability for the industrial application. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Theoretical and experimental investigation of NMR, IR and UV-visible spectra of hydroxyl-substituted-4-chloromethylcoumarin derivatives was written by Loarueng, Chutipapha;Boekfa, Bundet;Jarussophon, Suwatchai;Pongwan, Pawinee;Kaewchangwat, Narongpol;Suttisintong, Khomson;Jarussophon, Nongpanga. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2019.Electric Literature of C6H9ClO3 The following contents are mentioned in the article:

UV-Visible, FTIR and NMR exptl. and theor. spectral results have been compared for five substituted-4-chloromethylcoumarin derivatives (6-OH, 7-OH, 6,7-di-OH, 7,8-di-OH and 5,7-di-OH-substituted-4-chloromethylcoumarins). The theor. investigation was conducted using d. functional theory (DFT), namely the M06-2X functional form with 6-311 + G(2df,2p) basis set. The ¹³C-NMR and ¹H-NMR chem. shifts, vibrational spectra and MOs of the excited states were calculated based on their optimized geometries. The calculated values were found to have close agreement with the exptl. values. The theor. data are useful and could be important in the proper selection of compounds as intermediates for different chem. applications and modifications. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Electric Literature of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Electric Literature of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antibacterial Evaluation of Thiouracil Derivatives Containing 1,2,4-Triazolo[1,5-a]Pyrimidine was written by Cui, Penglei;Zhang, Di;Guo, Xiumin;Ji, Shujing;Jiang, Qingmei. And the article was included in Letters in Organic Chemistry in 2021.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

A series of new thiouracil compounds containing 1,2,4-triazolo[1,5-a]pyrimidines I (R¹ = 4-Cl, 3,4-Cl₂, 3,4,5-Cl₃; R² = H, 2-Cl, 4-Cl, 4-Ph, 2,4-Cl₂) was designed and synthesized. The in vitro antibacterial activities of the new compounds I against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis were tested. The results showed that some of the new compounds had strong inhibitory activities against the tested bacteria. At the concentration of 50μg/mL, the compound I (R¹ = 4-Cl, R² = 2,4-Cl₂) had broad and highest inhibitory activity with the 100% inhibition against the three tested strains, the same as norfloxacin which was used as the control. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Semi-Industrial Fluorination of β-Keto Esters with SF₄ : Safety vs Efficacy was written by Trofymchuk, Serhii A.;Kliukovskyi, Denys V.;Semenov, Sergey V.;Khairulin, Andrii R.;Shevchenko, Valerii O.;Bugera, Maksym Y.;Tarasenko, Karen V.;Volochnyuk, Dmitriy M.;Ryabukhin, Sergey V.. And the article was included in Synlett in 2020.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The possibility of deoxofluorination of β-keto esters using SF₄ was investigated. The scope and limitation of the reaction were determined The efficient method for the synthesis of β,β-difluorocarboxylic acids was elaborated based on the reaction. The set of mentioned acids, being the perspective building blocks for medicinal chem., were synthesized on multigram scale. The safety of SF₄ use was discussed. The described method does not improve upon the safety of using SF₄, but practical recommendations for working with the reagent were proposed. Despite the hazards of using toxic SF₄, a significant increase of efficacy in the synthesis of medicinal-chem.-relevant building blocks, based on the reaction, in comparison with earlier described approaches was shown. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Efficient nicotinamide adenine dinucleotide phosphate [NADP(H)] recycling in closed-loop continuous flow biocatalysis was written by Baumer, Benedikt;Classen, Thomas;Pohl, Martina;Pietruszka, Joerg. And the article was included in Advanced Synthesis & Catalysis in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Biocatalytic redox reactions regularly depend on expensive cofactors that require recycling. For continuous conversions in flow chem., this is often an obstacle since the cofactor is washed away. Here, we present a quasi-stationary recycling system for NADP utilizing an immobilized alc. dehydrogenase. Four model substrates were reduced with high enantioselectivity as a proof of concept. The two-phase system enables continuous production as well as quick substrate changes. This setup may serve as a general cofactor regeneration module for continuous biocatalytic devices employing (co-)substrates being miscible in organic solvent. The system resulted in space-time yields up to 117 g L^-1 h^-1 and total turnover numbers for NADP higher than 12,000 mol/mol are possible. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An unexpected synthesis and application of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate was written by Li, Yang;Dong, Shiyu;Tang, Bingyue;Zou, Hongtao;Jiang, Wenting. And the article was included in Research on Chemical Intermediates in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:

An unexpected and direct synthesis of Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate from the chlorotrimethylsilane-promoted Friedlander reaction between 1-(2-amino-5-iodophenyl)ethanone and Et 4-chloro-3-oxobutanoate has been disclosed. As a versatile and attractive building block, a synthetic application of the Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate in the successive Williamson ether synthesis with various phenols 2-R-3-R¹-4-R²-C₆H₂OH (R = H, Me, Cl, t-Bu, etc.; R¹ = H, Br; R² = H, Me, Cl, Br, t-Bu) and in situ ester hydrolysis reaction has been achieved and the corresponding 2,4-bis(aroxymethyl)quinoline-3-carboxylic acids I were obtained in good yields of 71-86%. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The structure-based optimization of δ-sultone-fused pyrazoles as selective BuChE inhibitors was written by Zhang, Ziwen;Min, Jingli;Chen, Mengdie;Jiang, Xia;Xu, Yingying;Qin, Huali;Tang, Wenjian. And the article was included in European Journal of Medicinal Chemistry in 2020.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

Structure-based optimization was conducted to improve the potency and selectivity of BuChE inhibitors with δ-sulfonolactone-fused pyrazole scaffold. By mimicking the hydrophobic interactions of donepezil at PAS, the introduction of a tertiary benzylamine at 5-position can significantly increase BuChE inhibitory activity. Compounds C4 and C6 were identified as high selective nanomolar BuChE inhibitors (IC₅₀ = 8.3 and 7.7 nM, resp.), which exhibited mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity. Kinetic studies showed that BuChE inhibition of compound C6 was mixed-type against BuChE (K_i = 24 nM) and >2000-fold selectivity for BuChE over AChE. The proposed binding mode of new inhibitors was consistent with the results of structure-activity relationship anal. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions was written by Mukherjee, Herschel;Blain, J. Craig;Vandivier, Lee E.;Chin, Donovan N.;Friedman, Jessica E.;Liu, Fei;Maillet, Ashley;Fang, Chao;Kaplan, Jenifer B.;Li, Jinxing;Chenoweth, David M.;Christensen, Allan Beck;Petersen, Lars Kolster;Hansen, Nils Jakob Vest;Barrera, Luis;Kubica, Neil;Kumaravel, Gnanasambandam;Petter, Jennifer C.. And the article was included in ACS Chemical Biology in 2020.Related Products of 638-07-3 The following contents are mentioned in the article:

RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small mols., however, has been hampered by the relative lack of methods for the anal. of small mol.-RNA interactions. Here, the authors present the authors’ efforts to develop such a platform using photoaffinity labeling. This technique, termed Photoaffinity Evaluation of RNA Ligation-Sequencing (PEARL-seq), enables the rapid identification of small mol. binding locations within their RNA targets and can provide information on ligand selectivity across multiple different RNAs. These data, when supplemented with small mol. SAR data and RNA probing data enable the construction of a computational model of the RNA-ligand structure, thereby enabling the rational design of novel RNA-targeted ligands. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics