Category: 638-07-3

Heterogeneously Catalyzed Pechmann Condensation Employing the HFe(SO₄)₂.4H₂O-Chitosan Nano-Composite: Ultrasound-Accelerated Green Synthesis of Coumarins was written by Zarei, Forough;Soleimani-Amiri, Somayeh;Azizi, Zahra. And the article was included in Polycyclic Aromatic Compounds in 2022.Product Details of 638-07-3 The following contents are mentioned in the article:

A heterogeneous magnetic HFe(SO₄)₂.4H₂O-chitosan nano-composite (HFe(SO₄)₂.4H₂O-Ch NCs) was designed and synthesized through a facile and economical two-steps procedure. The synthesized was identified by XRD, EDX, FT-IR, VSM, SEM, TEM, and TGA techniques. The resulting HFe(SO₄)₂.4H₂O-Ch NCs was applied as an efficient nano-catalyst in the green synthesis of coumarin derivatives through Pechmann condensation under solvent-free conditions at 100 °C, and also with ultrasonic-assisted at 70 °C. High yields of the products, short reaction times, and mild reaction conditions were perceived in both methods. The ability of detachment, recycling, and reuse of the nano-catalyst was investigated under reaction conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Product Details of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

A Visible Light Ru-Catalyzed Photoredox Access to Substituted Dihydrofurans was written by Victoria-Miguel, Jorge;Garcia-Santos, William H.;Cordero-Vargas, Alejandro. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

An efficient, visible light Ru(bpy)₃Cl₂-catalyzed method for the preparation of 2,3-dihydrofurans I [R¹ = CH₂Cl, Ph, 2-thienyl, etc.; R² = Me, Et, TBS; R³ = H, Me, Ph] and II [X = a bond, CH₂] was reported. This approach employed 2-bromoketoesters as radical precursors and alkyl enol ethers as acceptors. The photoredox cycle furnished an oxonium ion that was captured by an internal nucleophile to render the corresponding dihydrofurans. Moreover, the obtained products contained a versatile acetal moiety at C-2, allowing its transformation into a diverse variety of heteroaromatic and nonaromatic compounds This method could served as an important tool in the synthesis of complex tetrahydro- and dihydrofurans as well as heteroaromatic structures. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers was written by He, Yingfang;Whitehead, David M.;Briard, Emmanuelle;Numao, Shin;Mu, Linjing;Schibli, Roger;Ametamey, Simon M.;Auberson, Yves P.. And the article was included in ChemMedChem in 2020.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The authors describe their efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-α]pyrimidin-5-one scaffold. The metabolic stability and overall properties were optimized satisfactorily, although binding affinities remained a limiting factor for in vivo imaging. The authors identified [¹⁸F]pyrimidinone I as a radioligand providing good-quality images in autoradiog. studies, as well as [³H₂]pyrimidinylcyclopropanecarbonitrile II, which was used for the successful development of a radioligand binding assay. These are valuable new tools for the study of GluN2A-containing NMDA receptors, and for the optimization of allosteric modulators binding to the pharmacophore located at the dimer interface of the GluN1-GluN2A ligand-binding domain. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines was written by Lin, Yu;Li, Zhanhui;Ma, Haikuo;Wang, Yujie;Wang, Xu;Song, Shiwei;Zhao, Li;Wu, Shuwei;Tian, Sheng;Fu, Chunyan;Luo, Lusong;Zhu, Fang;He, Sudan;Zheng, Jiyue;Zhang, Xiaohu. And the article was included in ChemMedChem in 2020.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Chemokine receptor CXCR4 and its natural ligand CXCL12 (also known as stromal cell-derived factor-1, or SDF-1) regulate a broad range of physiol. functions. Dysregulation of the CXCL12/CXCR4 axis is involved in numerous pathol. conditions such as HIV infection, inflammation and cancer. Herein, we report the design, synthesis, and characterization of novel CXCR4 antagonists based on cyclic amine scaffolds. Compound 24(I) was identified as a potent CXCR4 receptor antagonist (competitive inhibition of 12G5 binding, IC₅₀=24 nM; functional inhibition of CXCL12-induced cytosolic calcium increase, IC₅₀=0.1 nM). In addition, compound 24 potently inhibited cell migration in CXCR4/CXCL12-mediated chemotaxis in a matrigel invasion assay. The absolute configuration of compound 24 was elucidated by X-ray crystallog. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis was written by Moraes, Maiara C.;Lenardao, Eder J.;Barcellos, Thiago. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2021.Electric Literature of C6H9ClO3 The following contents are mentioned in the article:

A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Bronsted acid catalyst. Fifteen examples were prepared with moderate to excellent yields (50% to 90%) using 10 mol % of the catalyst. Furthermore, it was possible from the proposed methodol. to scale up the synthesis of coumarins to obtain up to 11 g of product. This work also provides a preliminary insight into the reaction mechanism using high-resolution mass spectrometry anal. The key cinnamic acid derivative intermediate was detected, implying that under the evaluated conditions, the mechanistic pathway starts with an aromatic electrophilic substitution followed by dehydration reaction and intramol. transesterification. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Electric Literature of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 2-arylhydrazono-4-chloro-3-oxobutanoates existing as (E)/(Z)-hydrazone isomers in solution: Correlation between equilibrium constants and substituent constants was written by Kawamura, Chihaya;Yoshida, Kiminari;Yamazaki, Naoki;Sato, Noriko;Nagai, Kenichiro;Kaji, Eisuke;Kurasawa, Yoshihisa. And the article was included in Journal of Molecular Structure in 2020.Application of 638-07-3 The following contents are mentioned in the article:

Various 2-arylhydrazono-4-chloro-3-oxobutanoates ClCH₂COC(:NNHR)CO₂Et (R = 4-R¹C₆H₄; R¹ = O₂N, NC, MeCO, Cl, Br, F, H, Me, MeO) (I) were prepared by the reactions of Et 4-chloro-3-oxobutanoate with benzenediazonium chlorides (prepared from the corresponding anilines); the stereochemistries of the hydrazones in DMSO-d₆ were determined and the equilibrium constants for stereoisomerization correlated to the Hammett substituent constants for the para substituents. The preponderance of the (Z)-hydrazone isomers in I was assumed to be directed by the 4-chloro substituent; the equlilibrium constants for stereoisomerization of I decreased with decreasing Hammett substituent constants and increasing temperature This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions was written by Ghorbani, Fatemeh;Kiyani, Hamzeh;Pourmousavi, Seied Ali. And the article was included in Research on Chemical Intermediates in 2020.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

It was found that nano-SiO₂-H₂SO₄ was catalyzed the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride and β-ketoesters toward the synthesis of α,β-unsaturated isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allowed the synthesis of several α,β-unsaturated isoxazol-5(4H)-ones using this method. Some new derivatives of isoxazolones were also synthesized and characterized. It was efficient, clean, simple, safe and ecol. friendly. This straightforward method was cost-effective and required no preparation of reactants. The three-component annulation was performed without using energy sources, for example heat, ultrasound wave, and microwave irradiation This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives was written by Biernasiuk, Anna;Kawczynska, Magdalena;Berecka-Rycerz, Anna;Rosada, Beata;Gumieniczek, Anna;Malm, Anna;Dzitko, Katarzyna;Laczkowski, Krzysztof Z.. And the article was included in Medicinal Chemistry Research in 2019.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Synthesis and investigation of antimicrobial activity of fifteen novel thiazoles containing cyclohexene moiety are presented. Among the derivatives, compounds 3a-3d, 3f, 3n, and 3o showed very strong activity against the reference Candida spp. strains with MIC = 0.015-3.91μg/mL. The activity of these compounds is similar and even higher than the activity of nystatin used as pos. control. Compounds 3d, 3f, 3n, 3o showed the highest activity with very strong effect towards most of yeasts isolated from clin. materials with MIC = 0.015-7.81μg/mL. The cytotoxicity studies for the most active compounds showed that Candida spp. growth was inhibited at noncytotoxic concentrations for the mammalian L929 fibroblast. In addition, a good correlation was obtained between lipophilicity of compounds determined using reversed phase thin-layer chromatog. and their antifungal activity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Category: chlorides-buliding-blocks).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL) was written by Mayer, Nicole;Schweiger, Martina;Fuchs, Elisabeth;Migglautsch, Anna K.;Doler, Carina;Grabner, Gernot F.;Romauch, Matthias;Melcher, Michaela-Christina;Zechner, Rudolf;Zimmermann, Robert;Breinbauer, Rolf. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alc. fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure-activity relationship (SAR) studies of small mol. inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Biosynthesis of α-Substituted β-Ketoesters via the Tandem Knoevenagel Condensation-Reduction Reaction Using a Single Enzyme was written by Liu, Xiaolong;Li, Xiangjie;Wang, Zhelun;Zhou, Jinlong;Fan, Xinjiong;Fu, Yao. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:

Saturated α-substituted β ketoesters are important building blocks in synthesis of pharmaceuticals and agrochems. Herein, we report a one-pot biosynthesis of α-substituted β-ketoesters via Knoevenagel condensation and reduction of received unsaturated alkenes in situ, catalyzed by single ene-reductase (NerA). A series of inexpensive and readily available aldehydes and 1,3-diketones were condensed and reduced by NerA in aqueous solution at room temperature We also note that low loadings (3 mg/mL) of NerA are sufficient to facilitate the cascade process, both E and Z isomeric intermediates can be reduced effectively and improved the overall yield up to 95%. Meanwhile, the method can be applied in preparative-scale synthesis of pharmaceutical intermediate. This process conforms to the concepts of green chem. and shows advantages for synthesis of high value saturated α-substituted β ketoesters. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Computed Properties of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics