Reference of 6480-66-6,Some common heterocyclic compound, 6480-66-6, name is 2,6-Dichloro-4-methoxyaniline, molecular formula is C7H7Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Trichloromethyl carbonochloridic acid ester (0.0065 mol) was added to the solution of 2,6-dichloro-4-methoxybenzenamine (0.001 mol) and Et3N (0.4 ml) in dry toluene (16 ml). The reaction mixture was stirred for 2 hours at 6O0C till the starting aniline reacted completely (control by TLC). Then, a solution of intermediate 24 (prepared according to A8.c) in DCM (4 ml) was added to the reaction mixture at 6O0C at stirring. Formation of precipitate was observed. The stirring was continued at 60-70C for 1 hour. Then, the reaction mixture was concentrated in vacuum. The formed sediment was treated with water and filtered off. Then, it was washed with water, ethyl acetate, ether, and dried on the air. Yield: 0.360 g of compound 15 (66 %).
The synthetic route of 6480-66-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/148868; (2008); A1;,
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