Category: 654-98-8

Safety of 5-Chloro-2-(trifluoromethyl)benzoic acidOn March 22, 2007, Wacker, Dean A.; Varnes, Jeffrey G.; Malmstrom, Sarah E.; Cao, Xueying; Hung, Chen-Pin; Ung, Thao; Wu, Ginger; Zhang, Ge; Zuvich, Eva; Thomas, Michael A.; Keim, William J.; Cullen, Mary Jane; Rohrbach, Kenneth W.; Qu, Qinling; Narayanan, Rangaraj; Rossi, Karen; Janovitz, Evan; Lehman-McKeeman, Lois; Malley, Mary F.; Devenny, James; Pelleymounter, Mary Ann; Miller, Keith J.; Robl, Jeffrey A. published an article in Journal of Medicinal Chemistry. The article was 《Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT2C Receptor》. The article mentions the following:

Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. The synthesis and optimization of a class of pyrazinoisoindolone-containing, selective 5-HT2C agonists as antiobesity agents, are described. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of compound I, a 5-HT2C agonist with >300-fold functional selectivity over 5-HT2B and >70-fold functional selectivity over 5-HT2A. Oral dosing of I reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model. In the experimental materials used by the author, we found 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Safety of 5-Chloro-2-(trifluoromethyl)benzoic acid)

5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Safety of 5-Chloro-2-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Schiffler, Matthew A.; Antonysamy, Stephen; Bhattachar, Shobha N.; Campanale, Kristina M.; Chandrasekhar, Srinivasan; Condon, Bradley; Desai, Prashant V.; Fisher, Matthew J.; Groshong, Christopher; Harvey, Anita; Hickey, Michael J.; Hughes, Norman E.; Jones, Scott A.; Kim, Euibong J.; Kuklish, Steven L.; Luz, John G.; Norman, Bryan H.; Rathmell, Richard E.; Rizzo, John R.; Seng, Thomas W.; Thibodeaux, Stefan J.; Woods, Timothy A.; York, Jeremy S.; Yu, Xiao-Peng published an article on January 14 ,2016. The article was titled 《Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors》, and you may find the article in Journal of Medicinal Chemistry.Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid The information in the text is summarized as follows:

As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to improve enzyme potency by over 1000-fold. Addition of an appropriate substituent alleviated time-dependent cytochrome P 450 3A4 (CYP3A4) inhibition. Further structure-activity relationship (SAR) studies led to 8, which had desirable potency (IC50 = 12 nM in an ex vivo human whole blood (HWB) assay) and absorption, distribution, metabolism, and excretion (ADME) properties. Studies on the formulation of 8 identified 8·H3PO4 as suitable for clin. development. Omission of a lipophilic portion of the compound led to 26, a readily orally bioavailable inhibitor with potency in HWB comparable to celecoxib. Furthermore, 26 was selective for mPGES-1 inhibition vs. other mechanisms in the prostanoid pathway. These factors led to the selection of 26 as a second clin. candidate. The results came from multiple reactions, including the reaction of 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid)

5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Application In Synthesis of 5-Chloro-2-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acidOn September 1, 2012 ,《N-1-Alkyl-2-oxo-2-aryl amides as novel antagonists of the TRPA1 receptor》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Vallin, Karl S. A.; Sterky, Karin J.; Nyman, Eva; Bernstroem, Jenny; From, Rebecka; Linde, Christian; Minidis, Alexander B. E.; Nolting, Andreas; Naerhi, Katja; Santangelo, Ellen M.; Sehgelmeble, Fernando W.; Sohn, Daniel; Strindlund, Jennie; Weigelt, Dirk. The article contains the following contents:

A series of potent antagonists of the ion channel transient receptor potential A1 (TRPA1) was developed by modifying lead structure 16 that was discovered by high-throughput screening. Based on lead compound 16, a SAR was established, showing a narrow region at the nitro-aromatic R1 moiety and at the warhead, while the R2 side had a much wider scope including ureas and carbamates. Compound 16 inhibits Ca2+-activated TRPA1 currents reversibly in whole cell patch clamp experiments, indicating that under in vivo conditions, it does not react covalently, despite its potentially electrophilic ketone. The experimental process involved the reaction of 5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid)

5-Chloro-2-(trifluoromethyl)benzoic acid(cas: 654-98-8) belongs to organochlorine compounds. The wide structural variety and divergent chemical properties of organochlorides lead to a broad range of names, applications, and properties. Organochlorine compounds have wide use in many applications, though some are of profound environmental concern, with TCDD being one of the most notorious.Recommanded Product: 5-Chloro-2-(trifluoromethyl)benzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics