Category: 6579-54-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, A new synthetic method of this compound is introduced below., Quality Control of 2,6-Dichlorobenzenesulfonyl chloride

2.6-Dichlorobenzenesulfonyl chloride (100 mg, 0.41 mmol) was dissolved in DCM (0.5 mL) and triethylamine (0.11 mL, 0.81 mmol) was added followed by 2-(2- fluorophenyl)ethanamine (0.09 mL, 0.69 mmol). The reaction mixture was stirred for 1.5 hour at room temperature. DCM (10 mL) and brine (10 mL) were added to the mixture. The layers were separated and the organic phase was dried over magnesium sulfate, filtered and the solvent was evaporated. Purification by column chromatography on silica gel with petroleum ether/DCM (60:40 to 40:60) afforded the title compound as white solid (74 mg, 52 %). 1H NMR (400 MHz, CDCfi) d 2.88 (t, J = 6.9 Hz, 2H), 3.36-3.46 (m, 2H), 5.31 (t, J = 5.7 Hz, 1H), 6.95-7.02 (m, 1H), 7.05 (td, J = 7.5, 1.0 Hz, 1H), 7.14 (td, J = 7.5, 1.6 Hz, 1H), 7.17-7.24 (m, 1H), 7.32 (dd, J = 8.7, 7.3 Hz, 1H), 7.43 (s, 1H), 7.45 (d, J = 0.7 Hz, 1H). MS ESI+ m/z 348 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLUCOX BIOTECH AB; WIKSTROeM, Per; WALUM, Erik; (126 pag.)WO2019/215291; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, molecular formula is C6H3Cl3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6579-54-0

fer?-Bu1yl 4-[(7i?)-7-amino-4-methyl-5,6,7,8-tetrahydronaphthalen-l-yl]piperazine-l- carboxylate (87 mg, 0.25 mmol) was dissolved in dichloromethane (2 ml) and DIPEA (52 mul, 0.30 mmol) and 2,6-dichlorobenzenesulfonyl chloride (68 mg, 0.28 mmol) were added. The mixture was stirred for 4 h. The solvent was evaporated and the residue was dissolved in dichloromethane (2 ml) and TFA (0.24 ml) was added. The mixture was stirred at ambient temperature for 15 h. The mixture was concentrated and EtOAc was added. The mixture was washed with aqueous sodium hydroxide (pH 8-9), dried (Na2SO4), filtered and the solvent was evaporated. The residue was purified by preparative HPLC to give a dry film (6.5 mg, 5%).1H NMR (400 MHz, MeOD-^) delta ppm 7.58 (2 H, d) 7.48 (1 H, d) 6.97 (1 H, d) 6.81 (1 H, d) 3.53 – 3.61 (1 H, m) 3.01 – 3.17 (5 H, m) 2.91 – 2.98 (2 H, m) 2.74 – 2.88 (3 H, m) 2.54 – 2.63 (2 H, m) 2.14 (3 H, s) 1.96 – 2.04 (1 H, m) 1.74 – 1.85 (1 H, m); ESI-MS m/z M+H1″ 454, 456, 458.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6579-54-0, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/108742; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthetic Route of 6579-54-0, The chemical industry reduces the impact on the environment during synthesis 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, I believe this compound will play a more active role in future production and life.

General procedure: Benzenesulfonyl chloride (1 mmol) in butanone (5 mL) was heated with stirring to 40C, and cyanamide solution (50%)was added dropwise, then the temperature was raised to 60C and stirring continued for 3 h. The compound 7 (0. 8 mmol)was added and heated to 80C for 3 h. After cooling to 40C, the reaction mixture was poured into cold water while stirring, white crystals or powders were precipitated, filtered,washed with water, and dried. Analytically pure samples were obtained by recrystallization from aqueous ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichlorobenzenesulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Jie; Zheng, Tu-Cai; Jin, Yi; Xu, Jian-Guo; Yu, Jian-Gang; Lv, Yan-Wen; Chemical and Pharmaceutical Bulletin; vol. 66; 1; (2018); p. 55 – 60;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, molecular formula is C6H3Cl3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2,6-Dichlorobenzenesulfonyl chloride

General procedure: Step 3. To the solution of crude product 7 (255 mg, 1 mmol) in dry pyridine (5 mL, Sinopharm), corresponding sulfonyl chloride (1.5 mmol, Energy Chemical, Shanghai, China) was added and the mixture was stirred at room temperature. Then it was added to 10% aqueous HCl (50 mL, Sinopharm) and the suspension was extracted with ethyl acetate (Sinopharm). The organic phase was washed with brine, dried over anhydrous Na2SO4 and filtered. The residue was purified by silica chromatography after removal of ethyl acetate to give compounds 9a-q.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6579-54-0, its application will become more common.

Reference:
Article; Huang, Ke; Jiang, Lulu; Li, Huiti; Ye, Deyong; Zhou, Lu; Molecules; vol. 24; 5; (2019);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6579-54-0, A common heterocyclic compound, 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, molecular formula is C6H3Cl3O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 1,3-Bis(aminomethyl)benzene (100 mg, 0.73 mmol) and 0.25 ml triethylamine in 20 ml dichloromethane was stirred at 0 C. To this solution was slowly added appropriate benzamide or benzenesulfonamide (2.2 mmol) in 20 ml dichloromethane dropwise. After 10 minutes, the reaction mixture was then placed to ambient temperature and stirred for 2 hours. Upon completion, the reaction mixture was concentrated under reduced pressure. Purification by flash chromatography (silica gel, dichloromethane/methanol 40: 1) afforded a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Chen, Yanmei; Liu, Bo; Ouyang, Liang; Pan, Dabo; Xiang, Honggang; Zhang, Jifa; Zhang, Jin; Chinese Chemical Letters; (2020);,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6579-54-0 as follows. Product Details of 6579-54-0

C. 3-(2,6-dichlorophenylsulfonylamino)-4-(2-pyridyl)-5-(3-(4-fluorophenoxy)benzylthio)-(1H)-pyrazole 3-Amino-4-(2-pyridyl)-5-(3-(4-fluorophenoxy)benzylthio)-(1H)-pyrazole (0.39 g, 0.99 mmol) was dissolved in 5 ml of pyridine. Commercial 2,6-dichlorobenzenesulfonyl chloride (0.26 g, 1.04 mmol) was added and the red solution was stirred overnight at room temperature. The reaction mixture was poured into 50 ml of water and was extracted twice with 100 ml portions of ethyl acetate. The organic layers were washed with water and brine, combined, dried over MgSO4 and concentrated. The crude product was slurried in cold ethyl acetate and the solid was filtered off and washed with small portions of cold ethyl acetate and cold diethyl ether and dried under vacuum to afford 0.32 g (53% yield) of the final compound. FD-MS: (M+)600 mp. 164-5 C. Elemental analysis: Calc. C 53.91% H 3.18% N 9.31% S 10.66% Cl 11.79% Found C 54.19% H 3.20% N 9.37% S 9.80% Cl 11.79%

According to the analysis of related databases, 6579-54-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US5972972; (1999); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6579-54-0, Safety of 2,6-Dichlorobenzenesulfonyl chloride

General procedure: To a solution of amine (1 mmol) in 3 mL of pyridine at 0C was slowly added the appropriate benzenesulfonyl chloride (1.1 mmol, 1.1 equiv). The mixture was stirred for 12 h at 25C. The mixture was quenched with 2N HCl, extracted with EtOAc, dried over anhydrous MgSO4, and concentrated in vacuum. The crude product was purified by recrystallization and/or chromatography as noted below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kril, Liliia M.; Vilchez, Valery; Jiang, Jieyun; Turcios, Lilia; Chen, Changguo; Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; Spear, Brett; Watt, David S.; Gedaly, Roberto; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3897 – 3899;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 6579-54-0

Taking 245 mg 2,6-dichlorobenzenesulfonyl chloride dissolved into 20 ml anhydrous methanol, stirring 20 min, add m-phenylenediamine 450 mg and triethylamine 3 ml, in 70 C under stirring 12 h cooling, methanol, water, extracted with ethyl acetate three times, the combined organic phase, water washing, water-free MgSO4Drying, evaporating the solvent, purification with silica gel column chromatography, eluting agent volume ratio: AcOEt: petroleum ether=1:4, to obtain white solid N,N’-bis(2,6-dichlorobenzenesulfonyl)m-phenylenediamine 515 mg, yield 98%.

The synthetic route of 6579-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jishou University; Xiao Zhuping; Ni Weiwei; Fu Zijuan; Yi Juan; Zhou Tianli; (21 pag.)CN109096156; (2018); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride, A new synthetic method of this compound is introduced below., Recommanded Product: 2,6-Dichlorobenzenesulfonyl chloride

General procedure: To a solution of amine (1 mmol) in 3 mL of pyridine at 0C was slowly added the appropriate benzenesulfonyl chloride (1.1 mmol, 1.1 equiv). The mixture was stirred for 12 h at 25C. The mixture was quenched with 2N HCl, extracted with EtOAc, dried over anhydrous MgSO4, and concentrated in vacuum. The crude product was purified by recrystallization and/or chromatography as noted below.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kril, Liliia M.; Vilchez, Valery; Jiang, Jieyun; Turcios, Lilia; Chen, Changguo; Sviripa, Vitaliy M.; Zhang, Wen; Liu, Chunming; Spear, Brett; Watt, David S.; Gedaly, Roberto; Bioorganic and Medicinal Chemistry Letters; vol. 25; 18; (2015); p. 3897 – 3899;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6579-54-0, name is 2,6-Dichlorobenzenesulfonyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks

General procedure: To a solution of 1-(3-Amino-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (1) (0.1 g, 0.373 mmol) in 2.5 mL of dioxane/H2O (50:50) was added methanesulfonyl chloride (0.043 g, 0.372 mmol) over a 20 min period at 0 C followed by 5 h of vigorous stirring at room temperature. The solvent was removed in vacuo, and the resulting solid was purified by silica gel column chromatography (CHCl3/methanol = 95:5).

The synthetic route of 6579-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Park, Chong-Bin; Ahn, Chan Mug; Oh, Sangtae; Kwon, Daeho; Cho, Won-Chul; Shin, Woon-Seob; Cui, Yuan; Um, Ye Sol; Park, Byong-Gon; Lee, Seokjoon; Bioorganic and Medicinal Chemistry; vol. 23; 20; (2015); p. 6673 – 6682;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics