Category: 6590-96-1

Exploring ibuprofen derivatives as 伪-glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies was written by Daud, Saima;Abid, Obaid-ur-Rahman;Sardar, Asma;Abdullah, Shawana;Shahid, Wardah;Ashraf, Muhammad;Ejaz, Syeda Abida;Saeed, Amna;Shah, Basit Ali;Niaz, Basit. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2022.Synthetic Route of C7H3Cl2NS This article mentions the following:

This study reports the synthesis of a series of ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4-triazoles 7a-f, and their S-alkylated derivatives 8a-d. All of the newly synthesized derivatives were analyzed using 1H NMR, 13C NMR spectroscopy, and high-resolution mass spectra (electron ionization) spectrometry. These synthetic mols. were examined for their in vitro baking yeast 伪-glucosidase and soybean 15-lipoxygenase (15-LOX) inhibition and cell viability studies. The results revealed that the compounds N-(3,4-dichlorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5f (IC50 3.05 卤 1.23 渭M) and N-(3-fluorophenyl)-5-[1-(4-isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5b (IC50 3.12 卤 1.21 渭M) were the most potent with respect to the 伪-glucosidase enzyme while in case of 15-LOX, the compound 4-(2,4-dichlorophenyl)-1-[2-(4-isobutylphenyl)propanoyl]thiosemicarbazide 4e showed potent inhibition with an IC50 value of 55.41 卤 0.41 渭M. All these compounds were found least toxic by displaying a blood mononuclear cell viability value of 69.2%-97.8% by the MTT assay compared to the standards when assayed at 0.25 mM concentration Mol. docking analyses were conducted to evaluate the inhibition profiles of these derivatives against the said enzymes and the data supported the in vitro profiles. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors was written by Dogan, Hilal;Dogan, Sengul Dilem;Gunduz, Miyase Gozde;Krishna, Vagolu Siva;Lherbet, Christian;Sriram, Dharmarajan;Sahin, Onur;Saripinar, Emin. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 6590-96-1 This article mentions the following:

The rational design and synthesis of eighteen new thiadiazolylhydrazones I [R¹ = H, Me; R² = H, Cl; R³ = H, Me, NO₂, etc.] which were synthesized by intramol. oxidative N-S bond formation reaction of 2-benzylidene-N-(phenylcarbamothioyl)hydrazine-1-carboximidamide derivatives II by phenyliodine(III) bis(trifluoroacetate) (PIFA) under mild conditions were presented. Furthermore, the proposed structure of compounds I [R¹ = Me, R² = H, R³ = MeO] was resolved by single-crystal X-ray anal. The compounds I were evaluated for their in vitro antitubercular activity against M. tuberculosis H37Rv. Among them, some compounds I exhibited remarkable antimycobacterial activity, MIC = 0.78-6.25渭g/mL, with low cytotoxicity. Addnl., the most active compounds were screened for their biol. activities against M. tuberculosis in nutrient starvation model. Enzyme inhibition assays and mol. docking studies revealed enoyl acyl carrier protein reductase (InhA) as the possible target enzyme of compounds to show their antitubercular activities. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Related Products of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents was written by Kong, Xiangkai;Yao, Zeyu;He, Zuopeng;Xu, Wenfang;Yao, Jianwen. And the article was included in MedChemComm in 2015.HPLC of Formula: 6590-96-1 This article mentions the following:

A series of thiourea and nicotinamide-containing sorafenib analogs (7a-n) were designed and synthesized and their antiproliferative activities were tested against HCT116, MDA-MB-231, PC-3 and HepG2 cell lines. Most of the compounds showed potent activities against the four cell lines, compound 7h showed better activities than sorafenib against all four cell lines, and compounds 7a and 7e showed better activities against HCT116 and MDA-MB-231 cell lines. The anti-angiogenic activities of 7e and 7h were also better than that of sorafenib in both in vitro HUVEC tube formation assay and ex vivo rat thoracic aorta ring assay. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II) was written by Altintop, Mehlika Dilek;Ozdemir, Ahmet;Kucukoglu, Kaan;Turan-Zitouni, Gulhan;Nadaroglu, Hayrunnisa;Kaplancikli, Zafer Asim. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2015.Application of 6590-96-1 This article mentions the following:

2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]acetophenone derivatives were designed as human carbonic anhydrase isoenzymes (hCA-I and hCA-II) inhibitor and synthesized. HCA-I and hCA-II were purified from erythrocyte cells by affinity chromatog. The inhibitory effects of 18 newly synthesized acetophenones on hydratase activity of these isoenzymes were studied in vitro. The average IC₅₀ values of the new compounds for hydratase activity ranged from 0.033 to 0.14 渭M for hCA-I and from 0.030 to 0.11 渭M for hCA-II. Among the newly synthesized compounds, 2-[[5-(2,4-dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio]-4′-bromoacetophenone can be considered as a promising hCA-II inhibitor owing to its selective and potent inhibitory effect on hCA-II. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of isothiocyanates by reaction of amines with phenyl chlorothionoformate via one-pot or two-step process was written by Li, Zheng-Yi;Ma, Hong-Zhao;Han, Chen;Xi, Hai-Tao;Meng, Qi;Chen, Xin;Sun, Xiao-Qiang. And the article was included in Synthesis in 2013.Electric Literature of C7H3Cl2NS This article mentions the following:

A facile and efficient synthesis of isothiocyanates from amines is described. This method involves the reaction of amines with Ph chlorothionoformate in the presence of solid NaOH by either a one-pot process or a two-step approach. The one-pot process is useful for preparing alkyl and electron-rich aryl isothiocyanates, whereas the two-step approach is more versatile, working very well not only for alkyl and electron-rich aryl isothiocyanates, but also for highly electron-deficient aryl and heterocyclic isothiocyanates. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Electric Literature of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II was written by Sonmez, Fatih;Bilen, Cigdem;Sumersan, Sinem;Gencer, Nahit;Isik, Semra;Arslan, Oktay;Kucukislamoglu, Mustafa. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2014.HPLC of Formula: 6590-96-1 This article mentions the following:

In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO₂ as a substrate. The results showed that all compounds inhibited the hCA I and hCA II enzyme activities. Among the compounds, 6-(p-tolylthiourenyl) saccharin (6m) was found to be the most active one for hCA I activity (IC₅₀ = 13.67 渭M) and 6-(m-methoxyphenylurenyl) saccharin (6b) was found to be the most active one for hCA II activity (IC₅₀ = 6.54 渭M). Structure-activity relationships (SARs) study showed that, generally, thiourea derivatives (6l-v) inhibited more hCA I and hCA II than urea derivatives (6a-k). All compounds (excluding 6c and 6r) have higher inhibitory activity on hCA II than on hCA I. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface was written by Jiang, Shuangshuang;Tanji, Hiromi;Yin, Kejun;Zhang, Shuting;Sakaniwa, Kentaro;Huang, Jian;Yang, Yi;Li, Jing;Ohto, Umeharu;Shimizu, Toshiyuki;Yin, Hang. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Rational designs of small-mol. inhibitors targeting protein-protein interfaces have met little success. Herein, we have designed a series of triazole derivatives with a novel scaffold to specifically intervene with the interaction of TLR8 homomerization. In multiple assays, TH1027 was identified as a highly potent and specific inhibitor of TLR8. A successful solution of the X-ray crystal structure of TLR8 in complex with TH1027 provided an in-depth mechanistic insight into its binding mode, validating that TH1027 was located between two TLR8 monomers and recognized as an unconventional pocket, thereby preventing TLR8 from activation. Further biol. evaluations showed that TH1027 dose-dependently suppressed the TLR8-mediated inflammatory responses in both human monocyte cell lines, peripheral blood mononuclear cells, and rheumatoid arthritis patient specimens, suggesting a strong therapeutic potential against autoimmune diseases. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface was written by Jiang, Shuangshuang;Tanji, Hiromi;Yin, Kejun;Zhang, Shuting;Sakaniwa, Kentaro;Huang, Jian;Yang, Yi;Li, Jing;Ohto, Umeharu;Shimizu, Toshiyuki;Yin, Hang. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Rational designs of small-mol. inhibitors targeting protein-protein interfaces have met little success. Herein, we have designed a series of triazole derivatives with a novel scaffold to specifically intervene with the interaction of TLR8 homomerization. In multiple assays, TH1027 was identified as a highly potent and specific inhibitor of TLR8. A successful solution of the X-ray crystal structure of TLR8 in complex with TH1027 provided an in-depth mechanistic insight into its binding mode, validating that TH1027 was located between two TLR8 monomers and recognized as an unconventional pocket, thereby preventing TLR8 from activation. Further biol. evaluations showed that TH1027 dose-dependently suppressed the TLR8-mediated inflammatory responses in both human monocyte cell lines, peripheral blood mononuclear cells, and rheumatoid arthritis patient specimens, suggesting a strong therapeutic potential against autoimmune diseases. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, cytotoxic activities and molecular modeling studies of some 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives was written by Yanik, Hulya;Ayan, Sumeyra;Akdemir, Atilla;Erdogan, Omer;Ustundag, Cem Bulent;Cevik;Yilmaz, Ozge Ozgur. And the article was included in Organic Communications in 2020.Computed Properties of C7H3Cl2NS This article mentions the following:

A series of 2-aminonaphtho[2,3-d][1,3]thiazole-4,9-dione derivatives I (R = 4-methylphenyl, 2,4-dichlorophenyl, cyclohexyl, etc.) was synthesized and their structures were verified with spectral anal. In vitro cytotoxic activities of the synthesized compounds I were evaluated by using MTT assay against MKN-45 (Human Gastric cancer), MDA-MB-231 (Human Breast cancer) and HeLa (Human Cervical cancer) cell lines. Among the synthesized compounds, I (R = 4-trifluoromethylphenyl) inhibited MDA-MB-cell proliferation with an IC₅₀ value of 0.276μM. Compound I (R = 4-fluorophenyl) inhibited HeLa and MKN-45 cell proliferation with IC₅₀ values of 0.336μM and 8.769μM, resp. Compound I (R = 4-methoxyphenyl) inhibited HELA cell proliferation with an IC₅₀ value of 0.269μM. Mol. docking results suggest that the ligands may bind to the hDNA TopoIIβ binding pocket and partially exert their effects. These results propose that 2-aminonaphtho[2,3-d]thiazole-4,9-dion core has important biol. effects and further explorations are worthwhile. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Computed Properties of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mild and Efficient Synthesis of 5-(2,2-difluoro-1-phenyl cyclopropyl)-N-substituted-1,3,4-oxadiazol-2-amines via Graphene Oxide as Catalyst under Ultrasonic Irradiation Conditions was written by Reddy, Sirigireddy Sudharsan;Reddy, Bijivemula N.;Reddy, Peddiahgari Vasu Govardhana;Reddy, Gajulapalli Vishwakshan;Sarma, Loka Subramanyam. And the article was included in ChemistrySelect in 2017.Product Details of 6590-96-1 This article mentions the following:

A series of novel 5-(2,2-difluoro-1-phenylcyclopropyl)-N-substituted-1,3,4-oxadiazol-2-amines were synthesized from the reaction of 2,2-difluoro-1-phenylcyclopropane carbohydrazide and various isothiocyanates in the presence of graphene oxide (GO) and 1,8-diazabicyclo [5.4.0]undec-7-ene (DBU) under conventional and ultrasonic irradiation conditions. It was found that the reaction was completed in a short period of time with good to excellent yields by virtue of attributes offered by GO catalyst. Further, the reaction underwent smoothly in ethanol and ionic liquids Noteworthy, GO can be recycled and reused for five cycles without considerable loss in activity. The oxidative activity and morphol. of GO catalyst was confirmed by transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR) and cyclic voltammetry (CV) techniques. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Product Details of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics