Category: 6590-96-1

Synthesis of novel thiosemicarbazone derivatives as antidiabetic agents with enzyme kinetic studies and antioxidant activity was written by Tok, Fatih;Kucukal, Bahar;Baltas, Nimet;Tatar Yilmaz, Gizem;Kocyigit-Kaymakcioglu, Bedia. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Novel thiosemicarbazone derivatives I [R = H, 4-F, 2,6-Cl₂, etc.] were synthesized via condensation reactions between the corresponding thiosemicarbazides and 4-(methylsulfonyl)acetophenone. The chem. structures of all compounds were elucidated by IR, ¹H-NMR and ¹³C-NMR spectroscopy and mass spectrometry. Antioxidant studies of I were performed by using CUPRAC, FRAP, DPPH methods. I [R = H] (II) possessed good antioxidant activity with an SC₅₀ value of 15.70 μM which also is higher than standard drug ascorbic acid. All compounds were evaluated for their antidiabetic properties as α-glycosidase and α-amylase inhibitors. Compound II was found to be the most active compound against α-glucosidase and α-amylase with IC₅₀ values of 1.58 μM and 3.24 μM, resp. The enzyme kinetic studies demonstrated that II [R = H] had a competitive mode of binding. Furthermore, mol. docking studies had elucidated the binding mechanism at the mol. level by examining the mol. interactions between II and these enzymes. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, cytotoxic activity, and 2D- and 3D-QSAR studies of 19-carboxyl-modified novel isosteviol derivatives as potential anticancer agents was written by Liu, Cong-Jun;Zhang, Tao;Yu, Shu-Ling;Dai, Xing-Jie;Wu, Ya;Tao, Jing-Chao. And the article was included in Chemical Biology & Drug Design in 2017.HPLC of Formula: 6590-96-1 This article mentions the following:

Two series of novel acylthiosemicarbazide and oxadiazole fused-isosteviol derivatives were synthesized based on the 19-carboxyl modification. The target compounds were evaluated for their cytotoxicities against three cancer cell lines (HCT-116, HGC-27, and JEKO-1) using an MTT assay. Lead compounds from the acylthiosemicarbazides (4) showed IC₅₀ values in the lower micromolar range. For example, compounds (4i, 4l, 4m, 4r, and 4s) exhibited significant inhibitory activities against the three cell lines with IC₅₀ values of 0.95-3.36 μm. Furthermore, 2D-HQSAR and 3D-topomer CoMFA analyses were established, which could be used to develop second generation of isosteviol derivatives as anticancer agents. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1HPLC of Formula: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design and syntheses of some new pyrazolo[3,4-d]-8-(phenyl)-1,2,4-(8H)-triazolo-[2,3-a]-pyrimidin-4(1H)-one derivatives as potent anti-inflammatory agent was written by Kawade, D. P.;Khedekar, P. B.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2014.Safety of 2,4-Dichlorophenylisothiocyanate This article mentions the following:

Pyrazolo[3,4-d](aryl)-1,2,4-triazolopyrimidinones I [R = 2-Me, 4-Me, 2-Cl, 4-Cl, 2-O₂N, 4-O₂N, etc.] were synthesized from 5-amino-6-arylamino-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones which were obtained by the reaction of ethyl-5-amino-1H-pyrazole-4-carboxylate and appropriate phenylisothiocyanate in the presence of toluene followed by cyclization reaction with hydrazine hydrate in absolute ethanol. The most active compounds I [R = 2-O₂N, 4-O₂N] were evaluated for its ulcerogenicity. The results of anti-inflammatory activity (in-vivo) indicated that the compounds I [R = 2-O₂N, 4-O₂N] possessed significant anti-inflammatory activity as compared to standard drug, Indomethacin. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Safety of 2,4-Dichlorophenylisothiocyanate).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 2,4-Dichlorophenylisothiocyanate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and tyrosinase inhibitory properties of novel isoquinoline urea/thiourea derivatives was written by Genc, Hayriye;Zengin, Mustafa;Yavuz, Emre;Gencer, Nahit;Arslan, Oktay. And the article was included in Artificial Cells, Nanomedicine, and Biotechnology in 2014.Synthetic Route of C7H3Cl2NS This article mentions the following:

A new series of isoquinoline urea/thiourea derivatives I (X = O, S; R = Ph, n-Bu, i-Pr, n-Pr, n-Hexyl, etc.) were synthesized, and their inhibitory effects on tyrosinase were evaluated. Isoquinoline urea/thiourea derivatives were obtained as a result of the reaction of 5-aminoisoquinoline with isocyanates or isothiocyanates. The result showed that all the synthesized compounds inhibited the tyrosinase enzyme activity. Among the compounds synthesized, 1-(4-chlorophenyl)-3-(isoquinolin-5-yl)thiourea was found to be the most active one (Ki = 119.22 μM), and the inhibition kinetics analyzed using Lineweaver-Burk double reciprocal plots revealed that compound I (X= S; R = 4-ClPh) was a competitive inhibitor. HOMO-LUMO energy levels for selected synthesized compounds were calculated using Gaussian software. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Synthetic Route of C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antitumor activity of (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-1,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazide was written by Bhole, Ritesh P.;Bhusari, Kishore P.. And the article was included in Medicinal Chemistry Research in 2011.Reference of 6590-96-1 This article mentions the following:

To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl-2-thioxo-1,3,4-thiadiazol-3-yl]methanones e.g., I and [-(3,4-disubstituted)-1,3-thiazol-2-ylidene]-4-hydroxybenzohydrazides e.g., II were synthesized using appropriate synthetic route. The newly prepared compounds, e.g., I and II demonstrated inhibitory effects on the growth of a wide range of cancer cell lines especially on leukemia (HL-60), non-small lung cancer (HOP-92), renal cancer (ACHN) at the range of GI₅₀ -4.23 to -7.23. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and antimicrobial activity of new urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine was written by Vedavathi, Pandreti;Sudhamani, Hasti;Raju, Chamarthi Naga. And the article was included in Research on Chemical Intermediates in 2017.Recommanded Product: 6590-96-1 This article mentions the following:

Synthesis of a series of novel urea and thiourea derivatives of (2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methanamine (valsartan intermediate) was accomplished by its reaction with various substituted aryl isocyanates and aryl isothiocyanates in presence of N,N-dimethylpiperazine (DMP). All synthesized compounds were evaluated for their antibacterial and antifungal activities and their min. inhibitory concentration (MIC) values determined A few of the title compounds showed good in-vitro antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. The title compounds also exhibited high antifungal activity. The title compounds were characterized by IR, ¹H and ¹³C NMR and mass spectral data. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, synthesis, structural optimization, SAR, in silico prediction of physicochemical properties and pharmacological evaluation of novel & potent thiazolo[4,5-d]pyrimidine corticotropin releasing factor (CRF) receptor antagonists was written by Islam, Rabiul Md;Teleb, Mohamed;Karageorgos, Vlasios;Sakellaris, Stelios;Papadopoulos, Minas;Pirmettis, Ioannis;Fronczek, Frank R.;Liapakis, George;Fahmy, Hesham. And the article was included in European Journal of Pharmaceutical Sciences in 2022.Reference of 6590-96-1 This article mentions the following:

Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide secreted from the hypothalamus and is the main regulator of the hypothalamus-pituitary-adrenocortical (HPA) axis. CRF is the master hormone which modulates physiol. and behavioral responses to stress. Many disorders including anxiety, depression, addictive disorders and others are related to over activation of the CRF system. This suggests that new mols. which can interfere with CRF binding to its receptors may be potential candidates for neuropsychiatric drugs to treat stress-related disorders. Previously, three series of pyrimidine and fused pyrimidine CRF1 receptor antagonists were synthesized by our group and specific binding assays, competitive binding studies and determination of the ability to antagonize the agonist-stimulated accumulation of cAMP (the second messenger for CRF receptors) were reported. In continuation of our efforts in this direction, in the current manuscript, we report the synthesis & biol. evaluation of a new series of CRF1 receptor antagonists. Seven compounds showed promising binding affinity with the best two compounds (compounds 6 & 43) displaying a superior binding affinity to all of our previous compounds Compounds 6 & 43 have only 4 times and 2 times less binding affinity than the standard CRF antagonist antalarmin, resp. Thus, our two best lead compounds (compound 6 & 43) can be considered potent CRF receptor antagonists with binding affinity of 41.0 & 19.2 nM vs. 9.7 nM for antalarmin. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Reference of 6590-96-1).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 6590-96-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

One-pot regio- and chemo-selective synthesis of thiaazatricyclododecane was written by Alizadeh, Abdolali;Bagherinejad, Akram;Bayat, Fahimeh;Zhu, Long-Guan. And the article was included in Tetrahedron in 2016.Formula: C7H3Cl2NS This article mentions the following:

A highly regio- and chemo-selective heteroannulation protocol for the synthesis of unreported polysubstituted thiaazatricyclododecanes I (R¹ = H, Br, Cl, OCH₃; R² = H, Cl; R³ = H, Br; R⁴ = H, Cl, F) has been developed by a sequential four-component reaction of isoquinoline, 2-bromoacetophenones R¹C₆H₄C(O)CH₂Br, aryl isothiocyanates 2-R²-3-R³-4-R⁴-C6H2NCS, and Me 4-chloro-3-oxobutanoate under mild conditions in CH₃CN. The method features formation of various C-N, C-S, and C-C bonds, low-cost and readily available substrates, as well as simple one-pot operation, which makes this process highly profitable. This synthesis serves as a nice addition to chem. in which purification via chromatog. and recrystallization can be avoided, and the pure products were obtained simply by washing the crude products with hexane-Et acetate (10:1). In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics