Category: 66662-48-4

Nakamura, Takumi; Ishikawa, Hiroki; Ban, Kazuma; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published an article on January 31 ,2022. The article was titled 《Attrition-Enhanced Asymmetric Transformation of Axially Chiral Nicotinamides by Dynamic Chiral Salt Formation》, and you may find the article in ChemPlusChem.HPLC of Formula: 66662-48-4 The information in the text is summarized as follows:

Atroposelective resolution for axially chiral nicotinamides was achieved by dynamic chiral salt formation with L-DBTA (dibenzoyl-L-tartaric acid) using six types of nicotinamides that could not be optically resolved by the preferential crystallization method. Kinetic studies of the racemization indicated that the chiral conformation was retained for a significant period of time. Two methods of crystallization-induced asym. transformation were examined by dynamic diastereomeric salt formation: solvent evaporation from a supersaturated solution, and attrition-enhanced asym. transformation. The attrition method was more effective for asym. amplification of diastereomeric salts of axially chiral materials. Attrition of an equimolar amount of the nicotinamide salts with L-DBTA converged to one diastereomeric salt; and the corresponding enantiomers in 87-99% ee were obtained after the chiral acid was removed. Changing the ratio of two of the nicotinamides with L-DBTA to 1:2 inverted the axial chirality. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4HPLC of Formula: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Deracemization of axially chiral nicotinamides by dynamic salt formation with enantiopure dibenzoyltartaric acid (DBTA)》 were Yagishita, Fumitoshi; Kamataki, Norifumi; Okamoto, Kazuma; Kanno, Shota; Mino, Takashi; Masu, Hyuma; Sakamoto, Masami. And the article was published in Molecules in 2013. Category: chlorides-buliding-blocks The author mentioned the following in the article:

The dynamic atroposelective resolution of chiral salts derived from oily racemic nicotinamides (RS)-I (R = pyrrolidino, piperidino, morpholino) and enantiopure dibenzoyltartaric acid (DBTA) was achieved by crystallization The absolute structures of the axially chiral nicotinamides were determined by X-ray structural anal. The chirality could be controlled by the selection of enantiopure DBTA as a chiral auxiliary. The axial chirality generated by dynamic salt formation was retained for a long period after dissolving the chiral salt in solution even after removal of the chiral acid. The rate of racemization of nicotinamides could be controlled based on the temperature and solvent properties, and that of the salts were prolonged compared to free nicotinamides, as the mol. structure of the pyridinium ion in the salts was different from that of acid-free nicotinamides. In the experimental materials used by the author, we found 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Category: chlorides-buliding-blocks)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yagishita, Fumitoshi; Okamoto, Kazuma; Kamataki, Norifumi; Kanno, Shota; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published their research in Chemistry Letters on December 5 ,2013. The article was titled 《Chiral symmetry breaking of axially chiral nicotinamide by crystallization from the melt》.Product Details of 66662-48-4 The article contains the following contents:

One of six 2-alkylamino-4,6-dimethylnicotinamides afforded a conglomerate, and subsequent X-ray crystallog. anal. revealed that the compound crystallized in the monoclinic system, the space group P21. Crystallization of the racemic nicotinamide from the melt led to the chiral breaking of symmetry from 83 to 92% ee. This amide exhibited considerably stable axial chirality (δG ‡ 22.4-23.5 kcal mol-1 at 20 °) due to rotationally restricted scaffolds for the C-C(=O) bond. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Product Details of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 66662-48-4On March 31, 2004, Dyadyuchenko, L. V.; Strelkov, V. D.; Mikhailichenko, S. N.; Zaplishny, V. N. published an article in Chemistry of Heterocyclic Compounds. The article was 《Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact》. The article mentions the following:

Features of electrophilic and nucleophilic substitution under chlorination and nitration reaction conditions have been investigated for 6-hydroxy- and 6-methyl-3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Related Products of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ishikawa, Hiroki; Ban, Kazuma; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published an article on February 24 ,2020. The article was titled 《Attrition-Enhanced Deracemization of Axially Chiral Nicotinamides》, and you may find the article in European Journal of Organic Chemistry.Synthetic Route of C8H8ClNO2 The information in the text is summarized as follows:

Attrition-enhanced deracemization of two axially chiral nicotinamides, crystallizing as a conglomerate of a P21 crystal system, was performed. N,N-Dialkylnicotinamides with substituents on the 2- and 4-positions of the pyridine ring exhibited stable axial chirality due to rotationally restricted scaffolds for the Ar-C(=O)N bond. Crystallization of the racemic mixtures from the melt or attrition-enhanced deracemization led to the chiral breaking of symmetry to give 95-96% ee of enantiomorphic crystals. In the experiment, the researchers used many compounds, for example, 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Synthetic Route of C8H8ClNO2)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C8H8ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 66662-48-4On March 31, 2004, Dyadyuchenko, L. V.; Strelkov, V. D.; Mikhailichenko, S. N.; Zaplishny, V. N. published an article in Chemistry of Heterocyclic Compounds. The article was 《Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact》. The article mentions the following:

Features of electrophilic and nucleophilic substitution under chlorination and nitration reaction conditions have been investigated for 6-hydroxy- and 6-methyl-3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Related Products of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Related Products of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ishikawa, Hiroki; Ban, Kazuma; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami published an article on February 24 ,2020. The article was titled 《Attrition-Enhanced Deracemization of Axially Chiral Nicotinamides》, and you may find the article in European Journal of Organic Chemistry.Synthetic Route of C8H8ClNO2 The information in the text is summarized as follows:

Attrition-enhanced deracemization of two axially chiral nicotinamides, crystallizing as a conglomerate of a P21 crystal system, was performed. N,N-Dialkylnicotinamides with substituents on the 2- and 4-positions of the pyridine ring exhibited stable axial chirality due to rotationally restricted scaffolds for the Ar-C(=O)N bond. Crystallization of the racemic mixtures from the melt or attrition-enhanced deracemization led to the chiral breaking of symmetry to give 95-96% ee of enantiomorphic crystals. In the experiment, the researchers used many compounds, for example, 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Synthetic Route of C8H8ClNO2)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C8H8ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Joshi, Bhuwan C.; Tyagi, R. P.; Dobhal, M.P.; Rawat, Ratna; Chauhan, Madhu published an article in Indian Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis of some new sulfide, sulfone and triazolo derivatives of pyridobenzodiazepines》.Recommanded Product: 66662-48-4 The author mentioned the following in the article:

Synthesis of some new sulfide derivatives of 2,4-dimethyl-5,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-5-thione (2) was carried out by reacting 2 with benzyl chloride and 2-bromobutane, resp. On oxidizing the benzyl sulfide derivative with oxone, the corresponding sulfone was obtained. 3,11,13-Trimethylpyridobenzo[2,3-b]-1,2,4-triazolo[4,3-d][1,4]diazepine was synthesized from 2. In the experiment, the researchers used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In 2004,Bulletin of the Faculty of Pharmacy (Cairo University) included an article by El-Shemy, Khaled; El-Badry, Ossama; Roshdy, Sameha; El-Enany, Mervat. Product Details of 66662-48-4. The article was titled 《Synthesis of certain novel pyridothiopyranoindazoles as potential DNA intercalators in cancer chemotherapy》. The information in the text is summarized as follows:

A series of 5-chloro-8,10-dimethyl-2-(aminoethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole, e.g., I, was obtained by reacting 5-chloro-8,10-dimethyl-2-(2-chloroethyl)pyrido[3′,2′:5,6]thiopyrano[4,3,2-cd]indazole with certain primary or secondary amines. The in vitro cytotoxic effect of selected samples of the synthesized compounds were also achieved. The two synthesized series have structural relationship to certain anthrapyrazoles and benzothiopyranoindazoles which have been reported as potent antitumor agents. The experimental process involved the reaction of 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Product Details of 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Product Details of 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The author of 《Synthesis and biological activity of certain pyridobenzodiazepine derivatives》 were Botros, Samir; El-Gendy, Adel A.; Said, Mohamed M.; Oma, Adel H.. And the article was published in Bulletin of the Faculty of Pharmacy (Cairo University) in 2001. Recommanded Product: 66662-48-4 The author mentioned the following in the article:

The present work comprises the synthesis of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine-5-one derivatives by condensation of 2-chloro-4,6-dimethylnicotinic acid with 1,2-phenylenediamines using 1-butoxyethanol as solvent. Monoalkylation of the products using one equivalent of the appropriate alkyl halide and 30% NaOH in DMSO gave the 6-alkyl derivatives. Some of the prepared compounds were screened for CNS depressant and anticonvulsant activities. After reading the article, we found that the author used 2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4Recommanded Product: 66662-48-4)

2-Chloro-4,6-dimethylnicotinic acid(cas: 66662-48-4) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 66662-48-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics