Category: 67421-02-7

Han, Tianyu; Wu, Yuying; Han, Weinan; Yan, Kaiwen; Zhao, Jian; Sun, Yanyan published the artcile< Antitumor Effect of Organometallic Half-Sandwich Ru(II)-Arene Complexes Bearing a Glutathione S-Transferase Inhibitor>, Formula: C24H36Cl4Ru2, the main research area is antitumor human ruthenium half sandwich glutathione transferase inhibitor preparation; mol structure optimized ruthenium half sandwich glutathione transferase inhibitor; hydrolysis kinetics DFT ruthenium half sandwich glutathione transferase inhibitor.

The facile modification of the ligands in organometallic Ru(II)-arene complexes offers more opportunities to optimize their pharmacol. profiles. Herein, three Ru(II)-arene complexes containing a glutathione S-transferase (GST) inhibitor (NBDHEX) in chelate ligand have been designed and synthesized in this study. In vitro results indicated that the ligation with NBDHEX significantly increased the activities and selectivities of the organometallic Ru(II)-arene complexes against tumor cells, especially complex 3, which was the most active compound among the tested compounds DFT calculations and hydrolysis results demonstrated that complex 3 with more alkyl groups in the arene ligand has increased electron d. at the Ru(II) center as compared with complexes 1 and 2, thus resulting in the improved hydrolysis rate, which may be responsible for its higher anticancer activity. Further studies showed that complexes 1-3 can cause the loss of the mitochondrial membrane potential and upregulate the expression of Bcl-2 and Bax in A549 cells, suggesting that complexes 1-3 induced cell death may be mediated via the mitochondrial apoptotic pathway. Thus, these findings suggested that simultaneous modification of the chelate ligands and arene rings in the organometallic Ru(II) arene complexes is an effective way to improve their pharmacol. properties.

Inorganic Chemistry published new progress about Antitumor agents (breast, lung). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fazlur-Rahman, A. K.; Bennett, Martin A. published the artcile< Activation of carbon-carbon bonds in d9 (Co, Rh, Ir) and d8 (Ru) metal coordinated bicyclo[3.2.1]octa-2,6-diene via agostic M-H-C and M-H interactions>, Formula: C24H36Cl4Ru2, the main research area is bicyclooctadiene Group 9 element ruthenium complex preparation protonation rearrangement; crystal mol structure bicyclooctadiene Group 9 element ruthenium complex.

This contribution reveals the first synthesis, protonation reactions and skeletal rearrangements of a series of Group 9 element complexes [M(η5-C5R5)(bcod)] (bcod = η2:η2-bicyclo[3.2.1]octa-2,6-diene; M = Co, Rh, Ir; R = H, Me) (1-3) and ruthenium complexes [Ru(η6-arene)(bcod)] (4, arene = C6Me6, C6Me4H2, C6H3Me3). Monoprotonation of these coordinated bcod complexes, 1, 3, 4 with super acids such as HPF6 (60% aqueous), HBF4·Et2O or CF3SO3H at low temperature (-80° to -20°) forms agostic M-H-C structures for [Rh(μ-H)(η5-C5R5)(η2:η2-2,6-bcod)]+ (5), [CpCo(μ-H)(η2:η2-bcod)]+ (6) and [Ru(μ-H)(η6-arene)(η2:η2-bcod)]+ (7). Similar reactions of iridium complexes 2a,b gave terminal hydride complexes [Cp*Ir(H)(η2:η2-bcod)][PF6] (8a,b) as isolable salts at room temperature Initial products of all these monoprotonated cationic salts 5-8, undergo isomerization via hydride migration and subsequent cleavage of carbon-carbon bonds to the corresponding η2-vinyl η3-cyclohexenyl cations (9-12), independent of the non-coordinating anions. All metal coordinated η2-vinyl, η3-cyclohexenyl cations were isolated and characterized by 1H and 13C NMR spectroscopic methods. The structure of 9b was solved by x-ray crystallog. anal. Nucleophilic addition of H- to the [Ru(η6-C6Me6)(η2-vinyl-η3-cyclohexenyl)]PF6 cation (12c) resulted in the formation of 5-ethyl-η4-1,3-cyclohexadiene complex (14c) as the isomerized product.

Journal of Organometallic Chemistry published new progress about Agostic bond. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Formula: C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tang, Haiming; Saunders, Graham C.; Raymond, Onyekachi; Ma, Xiaochuan; Henderson, William published the artcile< Pyrrole thioamide complexes of organo-rhodium(III), -iridium(III) and -ruthenium(II)>, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is pyrrole thioamide organo rhodium iridium ruthenium preparation antitumor activity; crystal structure pyrrole thioamide iridium complex.

Reactions of the pentamethylcyclopentadienyl complexes [(η5-Cp*)MCl2]2 (M = Rh, Ir) and the ruthenium arene complex [(η6-C6Me6)RuCl2]2 with pyrrole-2-thioamide ligands (containing various substituents on the pyrrole ring) and triethylamine base were investigated. A set of new dinuclear complexes were obtained in which the pyrrole thioamide ligand bonds as a dianion, through the deprotonated pyrrole, and the sulfur atom bridging the two metal centers, as confirmed by a x-ray structure determination on an iridium derivative When triphenylphosphine was included in the reaction mixture, mononuclear complexes were obtained, with the pyrrole thioamide dianion ligand coordinating through sulfur and the pyrrole nitrogen, forming a five-membered chelate ring. The complexes were characterized by NMR and IR spectroscopies, and ESI mass spectrometry. A preliminary investigation of the activity of a selection of compounds towards A549 (adenocarcinomic human alveolar basal epithelial) cells was also carried out.

Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jeans, Rebekah J.; Chan, Antony P. Y.; Riley, Laura E.; Taylor, James; Rosair, Georgina M.; Welch, Alan J.; Sivaev, Igor B. published the artcile< Arene-Ruthenium Complexes of 1,1'-Bis(ortho-carborane): Synthesis, Characterization, and Catalysis>, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is areneruthenium complex ortho carborane preparation catalyst Diels Alder reaction; crystal structure arene ruthenium complex ortho carborane; mol structure arene ruthenium complex ortho carborane.

Deprotonation of 1,1′-bis(ortho-carborane) with BuLi in THF followed by reaction with [RuCl2(p-cymene)]2 affords, in addition to [Ru(κ3-2,2′,3′-{1-(1′-closo-1′,2′-C2B10H10)-closo-1,2-C2B10H10})(p-cymene)] (I), a small amount of a new species, [Ru(κ3-2,2′,11′-{1-(7′-nido-7′,8′-C2B9H11)-closo-1,2-C2B10H10})(p-cymene)] (1a), with two B-agostic B-H⇀Ru bonds, making the bis(carborane) unit a closo-nido-X(C)L2 ligand, a previously unreported bonding mode. Similar species were also formed with arene = benzene (1b), mesitylene (1c), and hexamethylbenzene (1d), although in the last two cases the metallacarborane-carborane species [1-(1′-closo-1′,2′-C2B10H11)-3-(arene)-closo-3,1,2-RuC2B9H10], 2c and 2d, were also isolated. With the bis(ortho-carborane) transfer reagent [Mg(κ2-2,2′-{1-(1′-closo-1′,2′-C2B10H10)-closo-1,2-C2B10H10})(DME)2], the target compounds [Ru(κ3-2,2′,3′-{1-(1′-closo-1′,2′-C2B10H10)-closo-1,2-C2B10H10})(arene)], 4b and 4d, were prepared in reasonable-to-good yields, although for arene = benzene and mesitylene small amounts of the unique paramagnetic species [{Ru(arene)}2(μ-Cl)(μ-κ4-2,2′,3,3′-{1-(1′-closo-1′,2′-C2B10H9)-closo-1,2-C2B10H9})], 3b and 3c, were also formed. In compounds 3, the bis(carborane) acts as a closo-closo-X4(C,C’,B,B’) ligand to the Ru2 unit. In I, 4b, and 4d, the B-agostic B-H⇀Ru bond is readily cleaved by MeCN, affording compounds [Ru(κ2-2,2′-{1-(1′-closo-1′,2′-C2B10H10)-closo-1,2-C2B10H10})(arene)(NCMe)] (5a, 5b, and 5d) and suggesting that I, 4b, and 4d could act as Lewis acid catalysts, which is subsequently shown to be the case for the Diels-Alder cycloaddition reactions between cyclopentadiene and methacrolein, ethylacrolein and E-crotonaldehyde. All new species were characterized by multinuclear NMR spectroscopy and 1a, 1c, 1d, 2c, 2d, 3b, 3c, 4b, 4d, 5a, 5b, and 5d were also characterized crystallog.

Inorganic Chemistry published new progress about Bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (alkenyl). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Name: (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

P. K., Anuja; Paira, Priyankar published the artcile< Luminescent anticancer Ru(II)-arenebipyridine and phenanthroline complexes: Synthesis, characterization, DFT studies, biological interactions and cellular imaging application>, Product Details of C24H36Cl4Ru2, the main research area is luminescent anticancer ruthenium arene bipyridine phenanthroline preparation DFT imaging; crystal mol cymene ruthenium phenanthroline complex; phosphaadamantane arene ruthenium phenanthroline preparation anticancer; BSA binding; Cellular imaging; DFT; DNA binding; Gel electrophoresis; Ru(II)-arene.

A series of ruthenium(II)-arene complexes of several bipyridine and phenanthroline derivatives have been synthesized by employing a green and efficient protocol involving water as a solvent under sonication. The structures of all the complexes were elucidated by the spectroscopic anal. The geometry of the chlorido and PTA (1,3,5-Triaza-7-phosphaadamantane) complexes were further confirmed by DFT and single crystal XRD. The stability study in various solvents, specifically in the intracellular one was conducted. Most of the compounds exhibited significant potency and selectivity against MCF7 and HeLa cell lines with respect to normal HEK-293 cells compared to cisplatin and RAPTA-C (Ruthenium(II)-arene PTA complex). Complex [(η6-hexamethylbenzene)RuCl(κ2-N,N-4,4′-di-n-nonyl-2,2′-bpy)]Cl (3e) presented best anticancer profiles against all the human cancer cells. Interestingly, few complexes turned up to be highly fluorescent depicted by the quantum yield values. Remarkably, [(η6-p-cymene)RuCl(κ2-N,N-bpy)]Cl (3i) was identified as most significant anticancer theranostic agent interms of potency, selectivity and fluorescence quantum yield. This complex also represented itself as significant cellular imaging agent in live U-87 MG cells which was monitored by confocal microscope. Absorption and emission spectral studies of bypyridine and phenanthroline complex series revealed that the complexes interacted with calf thymus DNA through groove binding as well as intercalative mode. In addition to this, strong binding efficacy of these scaffolds wish BSA (Bovin Serum Albumin) also enhanced their transportation property inside the cells.

Journal of Inorganic Biochemistry published new progress about Absorption. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Product Details of C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dub, Pavel A.; Matsunami, Asuka; Kuwata, Shigeki; Kayaki, Yoshihito published the artcile< Cleavage of N-H Bond of Ammonia via Metal-Ligand Cooperation Enables Rational Design of a Conceptually New Noyori-Ikariya Catalyst>, SDS of cas: 67421-02-7, the main research area is ammonia bond cleavage metal ligand cooperation; ionic ruthenium iridium metallacycle Noyori Ikariya precatalyst asym catalysis.

The asym. transfer hydrogenation (ATH) of ketones/imines with Noyori-Ikariya catalyst represents an important reaction in both academia and fine chem. industry. The method allows for the preparation of chiral secondary alcs./amines with very good to excellent optical purities. Remarkably, the same chiral Noyori-Ikariya complex is also a precatalyst for a wide range of other chemo- and stereoselective reductive and oxidative transformations. Among them are enantioselective sulfonamidation of acrylates (intramol. aza-Michael reaction) and carboxylation of indoles with CO2. Development of these catalytic reactions has been inspired by the realized cleavage of the N-H bond of sulfonamides and indoles by the 16e- amido derivative of the 18e- precatalyst via metal-ligand cooperation (MLC). This paper summarizes our efforts to investigate N-H bond cleavage of gaseous ammonia in solution via MLC and reports the serendipitous discovery of a new class of chiral tridentate κ3[N,N’,N”] Ru and Ir metallacycles, derivatives of the famous M-FsDPEN catalysts (M = Ru, Ir). The protonation of these metallacycles by strong acids containing weakly coordinating (chiral) anions generates ionic complexes, which were identified as conceptually novel Noyori-Ikariya precatalysts. For example, the ATH of aromatic ketones with some of these complexes proceeds with up to 99% ee.

Journal of the American Chemical Society published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, SDS of cas: 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jeans, Rebekah J.; Chan, Antony P. Y.; Murrell, Ashton H.; Chouman, Heather A.; Rosair, Georgina M.; Welch, Alan J. published the artcile< Metalation of Bis(meta-carborane)>, Application In Synthesis of 67421-02-7, the main research area is bicarborane metalation preparation metallacarborane ruthenium cobalt sandwich complex; crystal structure ruthenium cobalt sandwich bicarborane arene cyclopentadienyl complex; mol structure ruthenium cobalt sandwich bicarborane arene cyclopentadienyl complex.

The first metallacarborane derivatives of 1,1′-bis(meta-carborane) I [vertex = BH; 2, M = Ru(p-cymene), Z = H; 3, M = Ru(p-cymene), Z = OEt; 4, M = Ru(C6Me6), Z = H; 5, M = Ru(C6Me6), Z = OEt; 6, M = CoCp, Z = H; 7, M = Co(C5Me5), Z = H], have been prepared by deboronation of one cage and subrogation of the {BH} fragment removed by an isolobal {Ru(arene)}, {CoCp} or {CoCp*} fragment. In the case of the Ru(arene) species, attack on the products 2 and 4 by EtO- resulted in derivatives 3 and 5, resp., in which an OEt group is attached to B6 of the metallacarborane cage. All products were characterised by multinuclear NMR spectroscopy and single-crystal X-ray diffraction. All are of the form the 2,1,7-MC2B9-1′,7′-C2B10, and even though the structural studies reveal clear evidence of steric crowding between the arene or Cp/Cp* ligand on the metal and the pendant carborane cage, no isomerization of the metallacarborane to either 2,1,8-MC2B9 or 2,1,12-MC2B9 occurs, even on heating to reflux in toluene.

Journal of Organometallic Chemistry published new progress about Carboranes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Application In Synthesis of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Skoczynska, Anna; Pasternak, Beata; Malecka, Magdalena; Krajewska, Urszula; Mirowski, Marek; Merecz-Sadowska, Anna; Karwowski, Boleslaw T.; Kusz, Joachim; Budzisz, Elzbieta published the artcile< The cytotoxic effect of Ru(II) complexes with 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid methyl ester: Synthesis, X-ray structure and DNA damage potential>, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is hydroxyphenyl pyridylpyrazole carboxylate ruthenium arene complex preparation DNA damage; antitumor activity hydroxyphenyl pyridylpyrazole carboxylate ruthenium arene complex; crystal mol structure cymeneruthenium hydroxyphenyl pyridylpyrazole carboxylate complex.

A series of arene ruthenium(II) complexes, 1a-3a, with the general formula [(η6-arene)Ru(L)Cl2] (where arene = p-cymene, hexamethylbenzene and benzene, resp., and L = 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid Me ester) were synthesized and characterized by elemental anal., MS, IR and 1H NMR spectroscopy. The stability of selected complexes was assessed by UV-Vis spectroscopy over 24 and 48 h periods. The synthesized complexes were evaluated for in vitro experiments using HL-60, NALM-6, WM-115 and COLO-205, and they showed low cytotoxic activity. The most active compound, 2a, possesses IC50 = 41.17 ± 3.68 μM, which is comparable to the reference compound quercetin. X-ray crystallog. anal. of compound 1a found that the ruthenium complex adopts a piano-stool type of geometry, with crystal packing stabilized by a 3-D net of O-H…Cl and C-H…Cl type hydrogen bonds, the latter forming dimers in the crystal lattice. The most active complexes in the cytotoxicity experiments were selected for evaluation of the damage percentage in NALM-6 cells by a comet assay: the extent of DNA fragmentation in the lymphoblastic leukemia cells indicated that the analyzed ruthenium(II) complexes triggered DNA damage.

Polyhedron published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pettinari, Riccardo; Marchetti, Fabio; Tombesi, Alessia; Di Nicola, Corrado; Pettinari, Claudio; Guo, Chuanpan; Zhang, Zhihong; Galindo, Agustin; Fadaei-Tirani, Farzaneh; Hadiji, Mouna; Dyson, Paul J. published the artcile< Arene-ruthenium(II) complexes with pyrazole-based ligands bearing a pyridine moiety: Synthesis, structure, DFT calculations, and cytotoxicity>, Recommanded Product: (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is arene ruthenium pyridinylpyrazolone pyridinyltrifluoroacetylpyrazolone preparation ruthenium complexation; crystal mol structure cytotoxicity arene ruthenium pyridinylpyrazolone pyridinyltrifluoroacetylpyrazolone complex.

Two pyrazole-based ligands bearing a pyridine moiety, 3-methyl-1-(pyridin-2-yl)-5-pyrazolone (HLpy), and 3-methyl-1-(pyridin-2-yl)-4-trifluoroacetyl-5-pyrazolone (HQpy,CF3), were prepared and fully characterized in the solid-state and the tautomerism of both ligands in solution was also rationalized by using D. Functional Theory. Neutral ruthenium(II) arene complexes of composition [Ru(arene)(Lpy)Cl] and [Ru(arene)(Qpy,CF3)Cl] [arene = p-cymene (cym) or hexamethylbenzene (hmb)] were synthesized and characterized by IR, 1H, 13C, 15N and 19F NMR spectroscopy, elemental anal. and ESI mass spectrometry. The structures of complexes [Ru(hmb)(Lpy)Cl] and [Ru(hmb)(Qpy,CF3)Cl] were determined by x-ray crystallog., showing κ2-N,N’-coordination not only for Lpy but also for Qpy,CF3 ligand. DFT studies confirm that κ2O,O’-coordination, generally observed in metal complexes with 4-acyl-5-pyrazolone ligands, is not favored in this case. The cytotoxicity of ligands and complexes was evaluated against human ovarian carcinoma cells (A2780 and A2780cisR, cisplatin sensitive and cisplatin-resistant, resp.), and non-tumorous human embryonic kidney SV40 transformed (HEK293T) cells to reveal essentially equivalent activity in the cisplatin sensitive and cisplatin-resistant ovarian carcinoma cells.

Inorganica Chimica Acta published new progress about Antitumor agents (kidney, and ovarian). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Recommanded Product: (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Phearman, Alexander S.; Moore, Jewelianna M.; Bhagwandin, Dayanni D.; Goldberg, Jonathan M.; Heinekey, D. Michael; Goldberg, Karen I. published the artcile< (Hexamethylbenzene)Ru catalysts for the Aldehyde-Water Shift reaction>, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer, the main research area is crystal structure mol hexamethylbenzene ruthenium complex preparation green chem; hexamethylbenzene ruthenium catalyst aldehyde water shift occupational safety green.

The Aldehyde-Water Shift (AWS) reaction uses H2O as a benign oxidant to convert aldehydes to carboxylic acids, producing H2, a valuable reagent and fuel, as its sole byproduct. (Hexamethylbenzene)RuII complexes are demonstrated to have higher activity and selectivity (up to 95%) for AWS over disproportionation than previously reported catalysts.

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Safety of (Hexamethylbenzene)ruthenium(II) dichloride dimer.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics