Category: 67421-02-7

Sahoo, Manoj Kumar; Pradhan, Sourav; Kim, Dongwook; Park, Jung-Woo; Chang, Sukbok published the artcile< Head-to-Head Homocoupling of Ynamides via a Dual Activation Mode of Triple Bonds by Half-Sandwich Metal Complexes>, SDS of cas: 67421-02-7, the main research area is rhodium mediated cyclometalation homocoupling terminal ynamide amidosulfonyl compound; dienyl amidosulfonyl rhodacyclic complex preparation electrochem optimized geometry DFT; crystal structure dienyl amidosulfonyl rhodacyclic iridacyclic complex; mol structure dienyl amidosulfonyl rhodacyclic iridacyclic complex.

Reported herein is the half-sandwich Rh-mediated head-to-head homocoupling of terminal ynamides to furnish dienyl bisamido rhodacyclic complexes, where the Rh-vinyl bond was formed selectively at the α-C to the N atom. This transformation was extended to include piano-stool Ru and Ir complexes to display an analogous homocoupling reactivity. Based on d. functional theory studies, the reaction probably proceeds via a dual activation mode of the ynamide triple bonds: (i) generation of a zwitterionic keteniminyl metal species to induce an intramol. chloride transfer and (ii) syn-carbometalation of the 2nd coordinated alkynes by the alkenyl metal intermediate. An oxidative transformation of the homocoupled metal complexes gave multifunctional dienyl bisamide compounds

Organometallics published new progress about Crystal structure. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, SDS of cas: 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pettinari, Claudio; Pettinari, Riccardo; Xhaferai, Nertil; Giambastiani, Giuliano; Rossin, Andrea; Bonfili, Laura; Maria Eleuteri, Anna; Cuccioloni, Massimiliano published the artcile< Binuclear 3,3',5,5'-tetramethyl-1H,H-4,4'-bipyrazole Ruthenium(II) complexes: Synthesis, characterization and biological studies>, Reference of 67421-02-7, the main research area is binuclear arene tetramethylbipyrazole ruthenium preparation crystal mol structure antitumor; DNA interaction binuclear arene tetramethylbipyrazole ruthenium complex.

Organometallic Ru(II) arene complexes have emerged as potential alternative to platinum anti-tumor drugs due to their stability in solution and in the solid state, significant biol. activity and reduced toxicity and hydrophobicity of their ancillary arene groups. Authors report here a series of Ru(II)-arene dinuclear complexes prepared from 3,3′,5,5′-tetramethyl-1H,H-4,4′-bipyrazole and [(η6-arene)RuCl2] dimers. The new compounds were spectroscopically (FT-IR, 1H, 13C, ESI-MS) and structurally characterized. These complexes were found to adopt the piano stool coordination geometry around the Ru(II) ions, with the bipyrazole ligand bridging two metal centers through its pyridinic nitrogen. Their in vitro cytotoxicity was paralleled in human epithelial normal, cancerous and cisplatin-resistant cancerous cells. Ultimately, two possible mechanisms of drug biochem. action underlying the observed effects (DNA targeting and proteasome inhibitory abilities) were explored.

Inorganica Chimica Acta published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Reference of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Jian; Li, Shuang; Wang, Xinyi; Xu, Gang; Gou, Shaohua published the artcile< Dinuclear Organoruthenium Complexes Exhibiting Antiproliferative Activity through DNA Damage and a Reactive-Oxygen-Species-Mediated Endoplasmic Reticulum Stress Pathway>, Synthetic Route of 67421-02-7, the main research area is dinuclear organoruthenium complex preparation cancer DNA.

Subtle ligand modifications on ruthenium arene complexes can lead to different mechanisms of action and result in significant changes in the anticancer efficacy. Herein, four novel dinuclear ruthenium(II) arene complexes were designed and prepared In vitro tests indicated that complexes 1-3 displayed moderate antiproliferative activity against the tested cancer cells, while the cytotoxicity of complex 4 is superior or comparable to that of cisplatin. Further studies indicated that complexes 1-4 induce cell death through DNA interaction and a reactive-oxygen-species-mediated endoplasmic reticulum (ER) stress pathway, which is the first example of an organometallic ruthenium(II) arene complex to induce ER stress as well as DNA interaction. This kind of dinuclear ruthenium(II) arene complex has unique biol. characteristics and is a promising model for new anticancer drug development.

Inorganic Chemistry published new progress about Antiproliferative agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kalsin, Alexander M.; Peganova, Tatyana A.; Sinopalnikova, Iana S.; Fedyanin, Ivan V.; Belkova, Natalia V.; Deydier, Eric; Poli, Rinaldo published the artcile< Mechanistic diversity in acetophenone transfer hydrogenation catalyzed by ruthenium iminophosphonamide complexes>, Reference of 67421-02-7, the main research area is mechanism DFT acetophenone transfer hydrogenation ruthenium iminophosphonamide catalyst kinetics; crystal structure mol optimized ruthenium arene iminophosphonamide complex preparation.

A series of arene ruthenium iminophosphonamide complexes, [(Arene)RuCl{R2P(NR’)2}] (1), bearing various arenes and R,R’ substituents on the NPN ligand have been investigated as precatalysts in acetophenone transfer hydrogenation in basic and base-free isopropanol. The results clearly demonstrate the presence of two distinct reaction mechanisms, which are controlled by the basicity of the N-atoms. Complexes 1 in which both R’ substituents are aryl groups are only active once the neutral hydride complex [(Arene)RuH{R2P(NR’)2}] (2) is generated in basic isopropanol, the latter being able to reduce a ketone via a stepwise hydride and proton transfer. On the other hand, complexes in which at least one R’ group is Me readily catalyze the reaction in the absence of base. In the latter case, the results of kinetic studies and DFT calculations support an outer-sphere concerted asynchronous hydride and proton transfer assisted by the basic N-atom of the NPN ligand, which promotes catalysis via precoordination of an alc. mol. by hydrogen bonding.

Dalton Transactions published new progress about Activation enthalpy. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Reference of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shu, Liwei; Ren, Lulu; Wang, Yuchen; Fang, Tao; Ye, Zhijian; Han, Weidong; Chen, Chao; Wang, Hangxiang published the artcile< Niacin-ligated platinum(IV)-ruthenium(II) chimeric complexes synergistically suppress tumor metastasis and growth with potentially reduced toxicity in vivo>, SDS of cas: 67421-02-7, the main research area is antitumor niacin platinum ruthenium chimeric complexes synergy metastasis proliferation.

Niacin-ligated platinum(IV)-ruthenium(II) chimeric complexes have been synthesized and evaluated for their antitumor performance. The water-soluble optimal complex was shown to be a chimeric prodrug that not only potently inhibits the metastasis and proliferation of tumor cells but also has an unexpectedly higher safety margin in animals compared with the traditionally-used, clin. approved drug cisplatin.

Chemical Communications (Cambridge, United Kingdom) published new progress about Antitumor agents. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, SDS of cas: 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rahman, A. K. Fazlur; Bennett, Martin A. published the artcile< Protonation of Group 9 Metal (Co, Rh, Ir) Coordinated Bicyclo-[2.2.1]-hepta-2,5-diene and Bicyclo[2.2.2]octa-2,5-diene complexes: Facile Activation of Carbon-Carbon Bond in Bicyclo-[2.2.1]hepta-2,5-diene via M-H or M-H-C interactions>, Related Products of 67421-02-7, the main research area is protonation norbornadiene bicyclooctadiene Group 9 half sandwich bond activation; carbon carbon bond activation protonation cyclopentadienyl cobalt rhodium iridium; crystal mol structure norbornadiene bicyclooctadiene cyclopentadienyl complex.

The activation of C-C bond in coordinated M (η4-bicyclo[2.2.1]heptadiene) (NBD) via protonation for 3d, 4d and 5d transition metals have been examined Monoprotonation of the diolefin complexes [M(η5-C5R5)(η4-NBD)] (R = H, Me; M = Co, Rh), with CF3COOH or CF3SO3H forms transient agostic metal hydrides (M-H-C) at -80°. Similar reaction with HPF6 (60% aqueous), the Ir analogs give terminal hydrides [IrH(η5-C5Me4R)(η4-NBD)][PF6] (R = Me, or Et) as isolable solids at room temperature All these hydride complexes coordinated to NBD subsequently undergo ligand migration to give stable η2-vinyl η3-cyclopentenyl cations [M(η5-C5R5)(C7H9)]+ (M = Co, Rh, Ir). Protonation of the cobalt and rhodium coordinated bicyclo[2.2.2]octa-2,5-diene (BCOD) gives unstable M-H-C ground state structures at -80°, which decompose upon warming to room temperature Protonation reactions of the BCOD complexes of Ir also give terminal hydrides [IrH(η5-C5Me5)(η4-BCOD)][PF6] as solids. Thermolysis of [IrH(η5-C5Me5)(η4-BCOD)][PF6] did not give the expected, isomerized or C-C bond activated product, probably because BCOD is less strained than NBD. Coupling constant [JCH] and stretching frequency [ν M-H] data indicate the electron d. donation from the Me groups in the Cp ring favors agostic structures. The C-C bond activation in the coordinated norbornadiene, via hydride migration is slower for the terminal hydride, M-H (M = Ir) compared to agostic hydrides for (M = Co, Rh) compounds The vinyl cyclopentenyl cations of Rh, Ir undergo further isomerization in CF3COOH to give corresponding η6-toluene cations [M(η5-C5R5)(η6-C6H5CH3)]+. At 50° in vacuo the salt [(η5-C5Me5)Ir(H)(η4-NBD)][PF6] forms a neutral tetramethylfulvenyliridium complex [(η5-C5Me4:CH2)Ir(η4-NBD)] by C-H activation of a Me group in the C5Me5 ring.

Journal of Organometallic Chemistry published new progress about Agostic bond. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Related Products of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Chao; Irshad, Faisal; Luo, Maowei; Zhao, Yujun; Ma, Xinbin; Wang, Shengping published the artcile< Ruthenium Complexes Immobilized on an Azolium Based Metal Organic Framework for Highly Efficient Conversion of CO2 into Formic Acid>, Application of C24H36Cl4Ru2, the main research area is ruthenium complex metal organic framework catalyst carbon dioxide hydrogenation; formic acid carbon dioxide hydrogenation catalyst.

A series of efficient heterogenized ruthenium catalysts designated as Rux-NHC-MOF (x=1, 2, 3; NHC=N-heterocyclic carbene; MOF=metal organic framework) were successfully synthesized by the immobilization of different ruthenium complexes RuCl3, [RuCp*Cl2]2 (Cp*=pentamethylcyclopentadienyl) and [Ru(C6Me6)Cl2]2 (C6Me6=hexamethylbenzene) on an azolium based MOF through post-synthetic metalation. The heterogenized catalysts were subsequently accessed for the catalytic hydrogenation of CO2 to formic acid. The resulting Ru3-NHC-MOF catalyst exhibited the highest activity because of its stronger electron-donating ability of C6Me6 ligand of [Ru(C6Me6)Cl2]2 complex, which is favorable for CO2 hydrogenation reaction. A high turnover number (TON) value up to 3803 was obtained at 120° under a total pressure of 8 MPa (H2/CO2=1) for 2 h with K2CO3 additive in N,N-Dimethylformamide (DMF) solvent. Furthermore, the heterogenized Ru3-NHC-MOF catalyst was effectively recovered through filtration without significant loss of catalytic activity.

ChemCatChem published new progress about Crystallinity. 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Application of C24H36Cl4Ru2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matveevskaya, Vladislava V.; Pavlov, Dmitry I.; Samsonenko, Denis G.; Bonfili, Laura; Cuccioloni, Massimiliano; Benassi, Enrico; Pettinari, Riccardo; Potapov, Andrei S. published the artcile< Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells>, Synthetic Route of 67421-02-7, the main research area is ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex preparation antitumor; crystal structure ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex.

Six new arene-ruthenium(II) complexes containing two different η6-arene ligands – benzene and hexamethylbenzene, with indenoquinoxalinone oxime analogs (11H-indeno[1,2-b]quinoxalin-11-one oxime, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one oxime and 6-(hydroxyimino)indolo[2,1-b]quinazolin-12(6H)-one oxime (tryptanthrin-6-oxime)) as N,N’- chelating ligands are reported. The complexes were characterized by elemental anal., IR, UV-VIS, 1H and 13C NMR spectroscopy and by single-crystal X-ray structure anal. Complexes adopt a half-sandwich <> geometry with oxime ligands in anionic form, the ruthenium(II) center coordinates one arene, one N,N-bidentate oximate and one chloride ligand. The computational anal. of non-covalent intermol. interactions revealed weak attraction between the oxime oxygen atoms and the nearest hydrogen atoms of the oxime and the arene ligands. The cytotoxic activity of the complexes was evaluated against human breast cancer cell line MCF-7 and cisplatin-resistant human breast cancer cell line MCF-7CR as well as non-cancerous human breast epithelial cell line MCF10A. The cytotoxicity tests show micromolar IC50 values and tryptanthrin-6-oxime hexamethylbenzene-ruthenium(II) complex was found to exhibit the best antiproliferative activity among the studied compounds against the MCF-7 and MCF-7CR cell lines (IC50 9.0 ± 4.4 and 8.9 ± 1.5μM, resp.).

Inorganica Chimica Acta published new progress about Antitumor agents (mammary gland). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics