Category: 67747-01-7

Zhang, Jie-long published the artcileGreen synthesis of germicide Prochloraz, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2010), 32(9), 856-858, database is CAplus.

Prochloraz is a broad-spectrum imidazole germicide. The synthesis of the target compound [i.e., N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide, Prochloraz, Mirage, Preclude, Sportake, etc.] was achieved using using 2,4,6-trichlorophenol, 1,2-ethanediol, imidazole and triphosgene as starting materials in an environmentally friendly synthetic sequence (green chem.).

Huaxue Shiji published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C4H7F3O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Qiuguo published the artcileBioaccumulation, Biotransformation, and Synergistic Effects of Binary Fungicide Mixtures in Hyalella azteca and Gammarus pulex: How Different/Similar are the Two Species?, SDS of cas: 67747-01-7, the publication is Environmental Science & Technology (2018), 52(22), 13491-13500, database is CAplus and MEDLINE.

Aquatic organisms are consistently exposed to a mixture of micropollutants that can bioaccumulate, undergo biotransformation, and may exert mixture effects. However, little is known on the underlying mechanisms and species-specificity. Herein the authors investigated bioaccumulation, biotransformation and synergistic effects of azole (i.e., prochloraz) and strobilurin (i.e., azoxystrobin) fungicides in the two aquatic invertebrate species, Hyalella azteca and Gammarus pulex. Bioaccumulation of azoxystrobin was similar, whereas bioaccumulation of prochloraz was slightly different in the two species but was still significantly below the REACH criteria for bioaccumulative substances. Similar biotransformation patterns were observed in both species, and only a few unique biotransformation reactions were detected in H. azteca such as malonyl-glucose and taurine conjugation. Toxicokinetic modeling addnl. indicated that biotransformation is a more important elimination pathway in H. azteca. In mixtures, no-observed-adverse-effect levels of prochloraz decreased the LC50s of azoxystrobin in both species which correlated well with increased internal azoxystrobin concentrations This synergistic effect is partly due to the inhibition of cytochrome P 450 monooxygenases by prochloraz which subsequently triggered the reduced biotransformation of azoxystrobin (lower by 5 folds in H. azteca). The largely similar responses in both species suggest that the easier-to-cultivate H. azteca is a promising representative of invertebrates for toxicity testing.

Environmental Science & Technology published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, SDS of cas: 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Seon Hwa published the artcileDegradation of prochloraz by rice bakanae disease pathogen Fusarium fujikuroi with differing sensitivity: a possible explanation for resistance mechanism, Safety of N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, the publication is Journal of the Korean Society for Applied Biological Chemistry (2010), 53(4), 433-439, database is CAplus.

The fungicide prochloraz was subjected to degradation by the pathogen causing rice Bakanae disease, Fusarium fujikuroi, in order to gain an insight into the mechanisms of sensitivity and resistance to the fungicide. Growth-inhibiting assays of pathogens were conducted on potato dextrose agar (PDA) plates by a paper-disk agar-diffusion method. Significant growth inhibition of the sensitive strain CF106 was observed at the recommended treatment level of prochloraz, whereas negligible growth inhibition of the resistant strain CF245 was observed at the same treatment level. The strain CF245 was shown to be able to grow on PDA with 500 mg/L of the fungicide, which is significantly higher than its recommended treatment level. Growth-inhibiting assays of pathogens were also conducted in potato dextrose broth (PDB) medium supplemented with prochloraz at different concentrations, measuring their biomass weights over the incubation period. Significant growth inhibition was observed in the strain CF106 at a level of 0.5 mg/L, but negligible growth inhibition was observed in the strain CF245 at the same treatment level with the strain CF106. The strain CF245 could grow in PDB supplemented with 1.0 mg/L of prochloraz. The degradation of prochloraz by the 2 strains was evaluated by gas liquid chromatog. and mass spectrometry analyses. The strain CF245 completely degraded 1.0 mg/L prochloraz in 5 days after incubation, whereas no degradation of prochloraz was observed by the strain CF106 at the same treatment level. Liquid chromatog. Q-TOF MS detected N-(2-(2,4,6-trichlorophenoxy)ethyl)propan-1-amine as a major degradation product of prochloraz by the strain CF245. These results indicated that the degradation of prochloraz may account for the reduced sensitivity of the strain CF245 to prochloraz.

Journal of the Korean Society for Applied Biological Chemistry published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, Safety of N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Schaller, Rainer published the artcileSynthesis and fungicidal properties of ethyl phosphorodiamidates, Product Details of C11H14Cl3NO, the publication is Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie (1985), 40B(2), 298-304, database is CAplus.

Secondary amines, HNR₂, especially 2-(aryloxyethyl)propylamines and 4-arylpiperazines were treated with EtOP(O)Cl₂ yielding EtOP(O)(NR₂)Cl. Subsequent substitution of the chloro atom by morpholine derivatives, imidazole or triazole formed new ethylphosphorodiamidates with a broad-spectrum-fungicidal activity. Among the 25 compounds prepared were I and II (X = N, CH).

Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, Product Details of C11H14Cl3NO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Polgar, Laszlo published the artcileRetrospective screening of relevant pesticide metabolites in food using liquid chromatography high resolution mass spectrometry and accurate-mass databases of parent molecules and diagnostic fragment ions, Recommanded Product: N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, the publication is Journal of Chromatography A (2012), 83-91, database is CAplus and MEDLINE.

In recent years, the detection and characterization of relevant pesticide metabolites in food is an important task in order to evaluate their formation, kinetics, stability, and toxicity. In this article, a methodol. for the systematic screening of pesticides and their main metabolites in fruit and vegetable samples is described, using LC-HRMS and accurate-mass database search of parent compounds and their diagnostic fragment ions. The approach is based on (i) search for parent pesticide mols.; (ii) search for their metabolites in the pos. samples, assuming common fragmentation pathways between the metabolites and parent pesticide mols.; and (iii) search for pesticide conjugates using the data from both parent species and diagnostic fragment ions. An accurate-mass database was constructed consisting of 1396 compounds (850 parent compounds, 447 fragment ions and 99 metabolites). The screening process was performed by the software in an automated fashion. The proposed methodol. was evaluated with 29 incurred samples and the output obtained was compared to standard pesticide testing methods (targeted LC-MS/MS). Examples on the application of the proposed approach are shown, including the detection of several pesticide glycosides derivatives, which were found with significantly relevant intensities. Glucose-conjugated forms of parent compounds (e.g., fenhexamid-O-glucoside) and those of metabolites (e.g., despropyl-iprodione-N-glycoside) were detected. Facing the lack of standards for glycosylated pesticides, the study was completed with the synthesis of fenhexamid-O-glucoside for quantification purposes. In some cases the pesticide derivatives were found in a relatively high ratio, drawing the attention to these kinds of metabolites and showing that they should not be neglected in multi-residue methods. The global coverage obtained on the 29 analyzed samples showed the usefulness and benefits of the proposed approach and highlights the practical benefit obtained when the so-called screening methods are used as a complementary tool to standard targeted LC-MS/MS methods.

Journal of Chromatography A published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, Recommanded Product: N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Taylor, Adam C. published the artcileUse of Chemcatcher passive sampler with high-resolution mass spectrometry and multi-variate analysis for targeted screening of emerging pesticides in water, HPLC of Formula: 67747-01-7, the publication is Analytical Methods (2020), 12(32), 4015-4027, database is CAplus and MEDLINE.

Pesticides present at trace concentrations are a common cause of poor water quality. Screening generates large qual. data sets, therefore, there is a need for improved monitoring methods and data interpretation strategies to reduce the need for repetition, and increase the quality of information for end-users. Passive sampling is an in situ time integrative technique, increasingly used for monitoring pesticides in water. Here, we describe a method using the Chemcatcher passive sampler, coupled to targeted screening using liquid chromatog.-quadrupole-time-of-flight mass spectrometry, and a com. available library. Statistical anal. was performed using Agilent Mass Profiler Professional software. Water sampling took place over one year, at three riverine sites in the south of England, UK. Statistical interpretation of time integrative data from passive sampling could distinguish regular and episodic pesticide inputs, and detected compounds neglected by routine monitoring methods. One hundred and eleven pesticides were identified including legacy and current use compounds with diverse origins and uses. Spatial and temporal trends were identified enabling prioritisation of seasonal monitoring at each site. This approach maximises the utility of qual. assessment and may help water quality managers to rationalise pesticide fate in future, providing significant addnl. insight without the need to increase the scope and cost of monitoring.

Analytical Methods published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C15H25BN2O4, HPLC of Formula: 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thurman, E. Michael published the artcileDiscovering metabolites of post-harvest fungicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap tandem mass spectrometry, Quality Control of 67747-01-7, the publication is Journal of Chromatography A (2005), 1082(1), 71-80, database is CAplus and MEDLINE.

In this study, we benefit from the combination of liquid chromatog. (LC)/time-of-flight (TOF) MS accurate mass measurements to generate elemental compositions of ions and LC/ion trap multiple MS (MSⁿ) providing complementary structural information, which is useful for the elucidation of unknown organic compounds at trace levels in complex food extracts We have applied this approach to investigate different citrus fruits extracts, and we have identified two post-harvest fungicides (imazalil and prochloraz), the main degradation product of imazalil ([M + H]⁺, m/z 257) and a non-previously reported prochloraz degradation product ([M + H]⁺, m/z 282). The database-mediated identification of the parent compounds was based on the generated elemental composition obtained from accurate mass measurements and addnl. qual. information from the high resolution chlorine isotopic clusters of both the protonated mols. (imazalil, [M + H]⁺ 297.0556, <0.1 ppm error, 2-Cl; prochloraz, [M + H]⁺ 376.0381, 1.9 ppm error, 3-Cl) and their characteristic fragments ions (imazalil: m/z 255 and 159; prochloraz: m/z 308 and 266). The correlation between the structural information provided by ion trap MS/MS fragmentation pathways of the parent species and the TOF accurate mass elemental composition data of the degradation products were the key to elucidate the structures of the degradation products of both post-harvest fungicides. Finally, where standards were not available (prochloraz), further confirmation was obtained by synthesizing the proposed degradation product by acid hydrolysis of the parent standard and confirmation by LC/TOF-MS.

Journal of Chromatography A published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C5H13Cl2N, Quality Control of 67747-01-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rodriguez-Ortega, Pilar G. published the artcileSynthesis and Structural Characterization of a Ubiquitous Transformation Product (BTS 40348) of Fungicide Prochloraz, COA of Formula: C11H14Cl3NO, the publication is Journal of Agricultural and Food Chemistry (2019), 67(31), 8641-8648, database is CAplus and MEDLINE.

Prochloraz is a widely used imidazole fungicide that has to be analyzed together with its metabolites or transformation products for food safety monitoring purposes in the European Union. Although the focus in food of plant origin has been set on metabolites BTS 44595 and BTS 44596, we consider relevant the study of BTS 40348 metabolite, too, because it has been detected in both raw and processed foods based on citrus fruits in the EU. Metabolite BTS 40348 should be monitored in surface water due to its ecotoxicol. effects. In this work, the synthesis and structural characterization of BTS 40348 metabolite of fungicide prochloraz is presented, because the structure is closely related to the chem. and biol. activity of the substance. Characterization using ¹³C and ¹H NMR, IR, and Raman spectroscopy is detailed, together with confirmation by electrospray mass spectrometry anal.

Journal of Agricultural and Food Chemistry published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C11H14Cl3NO, COA of Formula: C11H14Cl3NO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics