Category: 67952-93-6

Synthetic Route of 67952-93-6,Some common heterocyclic compound, 67952-93-6, name is 3-Chloro-4-methylbenzylamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dichlorophthalazine-6-carbonitrile and 3-chloro-4-methylbenzylamine were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby the title compound was obtained as a less polar compound. 1H-NMR (400 MHz, DMSO-d6) delta; 2.29 (3H, s), 4.73 (2H, d, J=5.2 Hz), 7.28-7.32 (2H, m), 7.45 (1H, d, J=0.8 Hz), 8.20 (1H, dd, J=8.4, 0.4 Hz), 8.34 (1H, d, J=8.4, 1.6 Hz), 8.52 (1H, t, J=5.2 Hz), 9.00 (1H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-methylbenzylamine, its application will become more common.

Reference:
Patent; Eisai Co., Ltd.; US6498159; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 67952-93-6, name is 3-Chloro-4-methylbenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 67952-93-6

General procedure: A mixture of 2-amino-3-nitrobenzoic acid (5.0 mmol), EDCI (6.0 mmol),and HOBt (0.6 mmol) in DCM (30 mL) was stirred at room temperature for 5 mins. Then, amines (6.0 mmol) were added and the reaction was stirred at room temperature overnight. After completion, the mixture was diluted with DCM, washed with water twice, dried over anhydrous Na2SO4, evaporated, and chromatographed (EtOAc – petroleum ether) to afford the compounds 2a-k.

The synthetic route of 3-Chloro-4-methylbenzylamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Yinbo; Le, Vanminh; Xu, Xiaoyong; Shao, Xusheng; Liu, Jianwen; Li, Zhong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 3948 – 3951;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 67952-93-6, name is 3-Chloro-4-methylbenzylamine, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 67952-93-6

General procedure: Under an Ar atmosphere, to a solution of benzylamine 1a (0.55 mL, 5 mmol) in 20 mL of CH2Cl2, FeCl3 (811 mg, 5.0 mmol) and m-CPBA (2.2 g, 10.5 mmol, 85%) were added successively at 0 C. The reaction mixture was stirred at 0 C for 3h (TLC monitoring) and quenched with saturated aqueous Na2S2O3 (10 mL). Then, 10% NaOH solution (15 mL) and H2O (15 mL) were added and the mixture wasextracted with CH2Cl2. The combined extracts were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate as eluant to give the light yellow liquid product of N,N-dichlorobenzylamine 2a 850 mg (97%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67952-93-6.

Reference:
Article; Liu, Jia; Xu, Junchao; Ren, Jiangmeng; Zeng, Bu-Bing; Chemistry Letters; vol. 43; 2; (2014); p. 190 – 192;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 67952-93-6,Some common heterocyclic compound, 67952-93-6, name is 3-Chloro-4-methylbenzylamine, molecular formula is C8H10ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-Dichlorophthalazine-6-carbonitrile and 3-chloro-4-methylbenzylamine were stirred at room temperature in 1-methyl-2-pyrrolidinone in the presence of DBU, whereby the title compound was obtained as a less polar compound. 1H-NMR (400 MHz, DMSO-d6) delta; 2.29 (3H, s), 4.73 (2H, d, J=5.2 Hz), 7.28-7.32 (2H, m), 7.45 (1H, d, J=0.8 Hz), 8.20 (1H, dd, J=8.4, 0.4 Hz), 8.34 (1H, d, J=8.4, 1.6 Hz), 8.52 (1H, t, J=5.2 Hz), 9.00 (1H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-4-methylbenzylamine, its application will become more common.

Reference:
Patent; Eisai Co., Ltd.; US6498159; (2002); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

These common heterocyclic compound, 67952-93-6, name is 3-Chloro-4-methylbenzylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H10ClN

General procedure: A mixture of 2-amino-3-nitrobenzoic acid (5.0 mmol), EDCI (6.0 mmol),and HOBt (0.6 mmol) in DCM (30 mL) was stirred at room temperature for 5 mins. Then, amines (6.0 mmol) were added and the reaction was stirred at room temperature overnight. After completion, the mixture was diluted with DCM, washed with water twice, dried over anhydrous Na2SO4, evaporated, and chromatographed (EtOAc – petroleum ether) to afford the compounds 2a-k.

The synthetic route of 3-Chloro-4-methylbenzylamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Yinbo; Le, Vanminh; Xu, Xiaoyong; Shao, Xusheng; Liu, Jianwen; Li, Zhong; Bioorganic and Medicinal Chemistry Letters; vol. 24; 16; (2014); p. 3948 – 3951;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 67952-93-6, name is 3-Chloro-4-methylbenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67952-93-6, Recommanded Product: 3-Chloro-4-methylbenzylamine

11) 3-(tert-butyl)-N-(3-chloro-4-methylbenzyl)-1-methyl-1H-pyrazole-5-carboxamide To a solution of the Acid (257 mg, 1.41 mmol, 1.1 eq) in DMF (10 mL) was added an amine (200 mg, 1.29 mmol, 1.0 eq), DIEA (830 mg, 6.43 mmol, 5 eq) and HBTU (584 mg, 1.54 mmol, 1.2 eq) and the reaction mixture was stirred at rt for 12 h. The reaction mixture was then diluted with ethyl acetate (30 mL) and washed with 10% aqHCl (1*25 mL), sat NaHCO3 (1*25 mL) and water (4*25 mL). Organic layer was collected, dried (MgSO4) and evaporated to give a crude product, which was purified by column chromatography (10% to 50% EtOAc in Hexane) to give the amide as a colorless solid in 66% (165 mg, >95% purity). Mass Spectrum (LCMS, ESI Pos.) Calcd. For C17H23ClN3O: 320.0 (M+H), Found 320.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-methylbenzylamine, and friends who are interested can also refer to it.

Reference:
Patent; Prosetta Antiviral ,Inc.; Selvarajah, Suganya; Paulvannan, Kumar; (58 pag.)US2018/118679; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67952-93-6, name is 3-Chloro-4-methylbenzylamine, A new synthetic method of this compound is introduced below., Safety of 3-Chloro-4-methylbenzylamine

To a solution of (,S)-3-(5-(aminomethyl)-l-oxoisoindolin-2-yl)azepane- 2,7-dione (TFA salt) (68 mg, 0.176 mmol) in DMF (4 mL) was added CDI (29.0 mg, 0.18 mmol) and the suspension was stirred at RT for 14 h. Then (3-chloro-4-methylphenyl) methanamine (28.0 mg, 0.18 mmol) was added and the mixture was stirred at RT for 8 h. The suspension was diluted with water and extracted with DCM. The combined organic layers were dried over sodium sulfate, filtered and concentrated to give the crude product, which was purified by silica gel chromatography eluting with MeOH/DCM from 0% to 10% to give Compound 18 (21.0 mg, 25.1%) as a white solid. MS (ESI) m/z 469 A [M+H] +. MR (400 MHz, DMSO-de) delta 10.69 (s, 1H), 7.66 (d, J=8 Hz , 1H), 7.46 (s, 1H), 7.38 (d, J=8 Hz, 1H), 7.28 (d, J=7.2 Hz, 2H), 7.11 (d, J=8.8 Hz, 1H), 6.64-6.55 (m, 2H), 5.25-5.21 (m, 1H), 4.49 (s, 2H), 4.34 (d, 7 =6 Hz, 2H), 4.19 (d, 7 =6 Hz, 2H), 3.12-3.04 (m, 1H), 2.57 (d, 7 =16.8 Hz, 1H), 2.28-2.23 (m, 1H), 2.29 (s, 3H), 2.12-1.99 (m, 2H), 1.84-1.81 (m, 1H).

The synthetic route of 67952-93-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOTHERYX, INC.; MERCURIO, Frank; CHAN, Kyle, W.H.; SULLIVAN, Robert; ERDMAN, Paul, E.; FUNG, Leah; (105 pag.)WO2018/169777; (2018); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics