Category: 6940-78-9

Electric Literature of 6940-78-9, A common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

7.16 g of 7-hydroxy-2-quinolinone, 51.5 g of 1-bromo 4-chlorobutane, 37.32 g of potassium carbonate and4.18g of ethoxyformylmethylenetriphenylphosphine dissolved in 170mL of acetone, reacted at 45 C for 2.5h,After the reaction, 100 ml of a saturated sodium chloride solution was added, followed by extraction with ethyl acetate.The ethyl acetate extract was washed successively with saturated sodium chloride solution and deionized water.Dry over anhydrous sodium sulfate, concentrate under reduced pressure and dried in vacuo.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Wuhan Xing Hua Knowledge Pharmaceutical Technology Co., Ltd.; Lu Shan; Chen Jingrun; Zhang Chuantao; (16 pag.)CN109988162; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C4H8BrCl

Example (C):1Preparation of 7-(4-cMorobutoxy)-3,4-dihydro carbostyril (III):; The three necked flask was charged with 7-hydroxy-3, 4-dihydro carbostyril (II) (50gm, 0.306moles) in acetone: water mixture (400ml: 25ml). To this mixture was successively added potassium carbonate (50,8gm, 0,367moles), PEG-400 (61.2gm) and stirred at ambient temperature for one hour. The l-bromo-4-chlorobutane (157ml, 0.918moles) was added to mixture over a period of 10 min. Reaction mixture was then stirred at ambient temperature for 15-16 hours. The progress of the reaction was monitored by TLC (eluent: chloroform: methanol (90:10)). Reaction mixture was filtered and the inorganics were washed with acetone (100ml). The solvent was removed under the reduced pressure below 40 0C. The thick oily residue obtained was stirred with n-hexane (500ml) and water (500ml), at 10-15 0C, for a period of 45 min.The solid was filtered, washed with water (500ml) and then with n-hexane (500ml). The resulting solid was dried at 65-70 0C to obtain 7-(4-chlorobutoxy)-3, 4-dihydro carbostyril (III) (72.7gm, 94 %).1H (CDCl3): 1.9 (m, 4H), 2.5 (m, 2H), 2.8 (m, 2H), 3.6 (m, 2H), 3.9 (m, 2H), 6.3 (s, IH), 6.4 (d, IH), 7.0 (d, IH) and 9.3 (s, IH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6940-78-9, its application will become more common.

Reference:
Patent; UNICHEM LABORATORIES LIMITED; WO2007/94009; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-78-9, name is 1-Bromo-4-chlorobutane, A new synthetic method of this compound is introduced below., category: chlorides-buliding-blocks

Step 1 Synthesis of 1-(4-Chlorobutyl)-1,5,6,7-tetrahydroindol-4-one: To a solution of 1,5,6,7-tetrahydroindol-4-one (10.0 g, 74.0 mmol) in acetone (300 mL) was added powdered sodium hydroxide (3.26 g, 81.4 mmol) and the mixture stirred at ambient temperature for 0.25 h. 1-Bromo-4-chlorobutane (9.38 mL, 81.4 mmol) was then added and the resulting mixture stirred at ambient temperature for 7 h after which time TLC (ethyl acetate:dichloromethane 1:1) showed complete reaction. The reaction was gravity filtered to remove salts, and the filtrate concentrated to dryness under vacuum. The resulting residue was dissolved in dichloromethane (200 mL) and gravity filtered again to remove more salts. The filtrate was then washed with water, dried with sodium sulfate, filtered and the solvent removed under vacuum to yield an oil. Flash chromatography using 6 in. of silica gel in a 5.5 cm column eluding with 1:1 followed by 2:1 ethyl acetate:hexane on half of the residue yielded 9.0 g of an oil which contained ~6.0 g of pure product (72%) and ~3.0 g of acetone aldol condensation product (4-hydroxy-4-methyl-2-pentanone). The oil was taken to the next step without further purification.

The synthetic route of 6940-78-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fick, David B.; Foreman, Mark M.; Glasky, Alvin J.; Helton, David R.; US2003/114463; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9, Quality Control of 1-Bromo-4-chlorobutane

In a round bottom flask, 5.0 g of 7-hydroxyquinolin-2(1H)-one, 6.42 g K2CO3 and 25 ml acetone were taken and stirred for 30 minutes at 25-35 C. 5.89 g 1-bromo-4-chloro butane was added into the reaction mixture and stirred for 5-6 hours at 50-55 C. After completion of the reaction, the reaction mixture was cooled to 25-35 C. The reaction mixture was filtered. The solvent was removed by distillation under vacuum. The solid was dried in a hot air oven at 45-50 C. to obtain 7-(4-chlorobutoxy) quinolin-2(1H)-one. Yield: 85%.

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Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Sanjay Jagdish; PARIHAR, Jayprakash Ajitsingh; SHAH, Alpesh Pravinchandra; (21 pag.)US2017/320862; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Related Products of 6940-78-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 6940-78-9, Name is 1-Bromo-4-chlorobutane, SMILES is ClCCCCBr, belongs to chlorides-buliding-blocks compound. In a article, author is Xu, Qingbo, introduce new discover of the category.

A fabric with different functions on its two sides has unparalleled advantages for practical use. However, it is difficult to graft different functional polymers onto the two sides of cotton fabric by conventional modification methods. Herein, we report a novel approach based on a combination of grafting through methodology and the mist polymerization technique to achieve this objective. Acrylic acid (AA) was first linked onto cotton fibers via an esterification reaction. The incorporated AA moieties on the fiber surfaces were further copolymerized with other monomers using the mist polymerization technique to graft different functional coatings. Poly(methacryloxyethyltrimethyl ammonium chloride) was grafted on one side of the cotton fabric, and the opposite surface was modified by the polymerization of AA followed by the esterification of polyethylene glycol-400 (PEG-400). As a result, two functional coatings were constructed on the two sides of the fabric, i.e., antibacterial and antifouling coatings. Skin stimulation tests and toxicity assessments demonstrated that the resulting fabric is safe for skin contact. Moreover, the desired cotton properties were not significantly reduced by the new surface modification process.

Related Products of 6940-78-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 6940-78-9.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In an article, author is Liu, Cuiyu, once mentioned the application of 6940-78-9, Category: chlorides-buliding-blocks, Name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, molecular weight is 171.4633, MDL number is MFCD00001010, category is chlorides-buliding-blocks. Now introduce a scientific discovery about this category.

Backgrounds Pomegranate (Punica granatum L.) is an important commercial fruit tree, with moderate tolerance to salinity. The balance of Cl- and other anions in pomegranate tissues are affected by salinity, however, the accumulation patterns of anions are poorly understood. The chloride channel (CLC) gene family is involved in conducting Cl-, NO3-, HCO3- and I-, but its characteristics have not been reported on pomegranate. Results In this study, we identified seven PgCLC genes, consisting of four antiporters and three channels, based on the presence of the gating glutamate (E) and the proton glutamate (E). Phylogenetic analysis revealed that seven PgCLCs were divided into two clades, with clade I containing the typical conserved regions GxGIPE (I), GKxGPxxH (II) and PxxGxLF (III), whereas clade II not. Multiple sequence alignment revealed that PgCLC-B had a P [proline, Pro] residue in region I, which was suspected to be a NO3-/H+ exchanger, while PgCLC-C1, PgCLC-C2, PgCLC-D and PgCLC-G contained a S [serine, Ser] residue, with a high affinity to Cl-. We determined the content of Cl-, NO3-, H2PO4-, and SO42- in pomegranate tissues after 18 days of salt treatments (0, 100, 200 and 300 mM NaCl). Compared with control, the Cl- content increased sharply in pomegranate tissues. Salinity inhibited the uptake of NO3- and SO42-, but accelerated H2PO4- uptake. The results of real-time reverse transcription PCR (qRT-PCR) revealed that PgCLC genes had tissue-specific expression patterns. The high expression levels of three antiporters PgCLC-C1, PgCLC-C2 and PgCLC-D in leaves might be contributed to sequestrating Cl- into the vacuoles. However, the low expression levels of PgCLCs in roots might be associated with the exclusion of Cl- from root cells. Also, the up-regulated PgCLC-B in leaves indicated that more NO3- was transported into leaves to mitigate the nitrogen deficiency. Conclusions Our findings suggested that the PgCLC genes played important roles in balancing of Cl- and NO3- in pomegranate tissues under salt stress. This study established a theoretical foundation for the further functional characterization of the CLC genes in pomegranate.

If you are interested in 6940-78-9, you can contact me at any time and look forward to more communication. Category: chlorides-buliding-blocks.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6940-78-9, Name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl. In an article, author is Guo, Jianhua,once mentioned of 6940-78-9, Name: 1-Bromo-4-chlorobutane.

The copper doped fluorescent carbon dots (Cu-CDs) with excellent biocompatibility were prepared from L-tryptophan and copper chloride as precursors through a facilely hydrothermal method. As-prepared Cu-CDs exhibited the bright blue fluorescence and excellent optical stability. In the presence of tetracyclines antibiotics (TCs), the intensely fluorescent quenching of Cu-CDs occurred from internal filtration effect (IFE), providing the foundation of TCs quantification. Meanwhile, the fluorescence intensity of Cu-CDs decreased gradually along with the increasing of pH and a sigmoidal curve was well fitted with the pK(a1)2.49 and pK(a2) 6.21, respectively. The Cu-CDs as a multi-functional fluorescence sensing platform demonstrated great accuracy and selectivity for tetracyclines (TCs) and pH. On account of practical application, as-synthesized Cu-CDs not only were effectively employed for determination of TCs in antibiotic tablets and milk products, but also could trace nuclear and had been extended to sense and visualize pH fluctuations in cells due to low toxicity and biocompatibility. As a facile and effective multi-functional fluorescent sensor, the proposed Cu-CDs have a significant potential for biosensing and biomedical imaging.

Interested yet? Keep reading other articles of 6940-78-9, you can contact me at any time and look forward to more communication. Name: 1-Bromo-4-chlorobutane.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 6940-78-9, Name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl. In an article, author is Ye, Jing-Jing,once mentioned of 6940-78-9, Safety of 1-Bromo-4-chlorobutane.

The novel poly(vinyldiphenylphosphine) could be easily prepared by using the reactions of the cheap poly(vinyl chloride) with sodium phosphides. Poly(vinyldiphenylphosphine) is soluble in common solvents while its corresponding phosphine oxide is hardly soluble in the solvents. Taking advantage of this different solubility, poly(vinyldiphenylphosphine) could be used as a soluble phosphinopolymer for the Wittig reactions. The reactions could take place efficiently to produce the corresponding olefins while the isolation of the products were simple since the resulted poly(vinyldiphenylphosphine oxide) was not soluble in the solvent and could be easily removed by filtration. (C) 2021 Elsevier Ltd. All rights reserved.

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Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

In an article, author is Brinzei, Mihaela, once mentioned the application of 6940-78-9, Name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, molecular weight is 171.4633, MDL number is MFCD00001010, category is chlorides-buliding-blocks. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/6940-78-9.html.

In this paper we report new density and viscosity data of L-serine and L-valine in aqueous NaCl solutions as a function of amino acids molality at fixed salt concentration (0.1, 0.2, 0.5, 0.7 and 1.0 mol.kg(-1)) and temperature T = (293.15, 298.15, 303.15, 308.15, 313.15, 318.15 and 323.15) K at atmospheric pressure of p = 0.1 MPa. From density, some derived properties such as the apparent molar volume, V-phi, limiting partial molar volume, V-phi(0), and expansibility, E-phi(0), standard molar volume of transfer, Delta V-phi(0), and hydration number, n(H), were calculated and discussed in terms of solute-solvent interactions and structural effects. The Jones-Dole equation and transition state treatment were used to obtain the viscosity B coefficient, free energy of activation of viscous flow per mole of solvent, Delta mu(0#)(1), and per mole of solute, Delta mu(0#)(2), entropies, Delta S-2(0#) and enthalpies, Delta H-2(0#), of activation of viscous flow for amino acids. All the activation parameters were discussed in terms of transition state theory. The co-sphere overlap model was used to interpret the results. The structure making/breaking ability of the amino acids in solutions was also discussed. (C) 2020 Elsevier Ltd.

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Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics

Chemistry, like all the natural sciences, Recommanded Product: 1-Bromo-4-chlorobutane, begins with the direct observation of nature¡ª in this case, of matter.6940-78-9, Name is 1-Bromo-4-chlorobutane, SMILES is ClCCCCBr, belongs to chlorides-buliding-blocks compound. In a document, author is Koster, Anna K., introduce the new discover.

CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological function in the central nervous system raise questions that remain unresolved, in part due to the absence of precise pharmacological tools for modulating CLC-2 activity. Herein, we describe the development and optimization of AK-42, a specific small-molecule inhibitor of CLC-2 with nanomolar potency (IC50 = 17 +/- 1 nM). AK-42 displays unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and exhibits no off-target engagement against a panel of 61 common channels, receptors, and transporters expressed in brain tissue. Computational docking, validated by mutagenesis and kinetic studies, indicates that AK-42 binds to an extracellular vestibule above the channel pore. In electrophysiological recordings of mouse CA1 hippocampal pyramidal neurons, AK-42 acutely and reversibly inhibits CLC-2 currents; no effect on current is observed on brain slices taken from CLC-2 knockout mice. These results establish AK-42 as a powerful tool for investigating CLC-2 neurophysiology.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 6940-78-9. Recommanded Product: 1-Bromo-4-chlorobutane.

Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics