Category: 6940-78-9

A common heterocyclic compound, 6940-78-9, name is 1-Bromo-4-chlorobutane, molecular formula is C4H8BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6940-78-9.

At 20 ~ 30 C, under stirring to N,N-dimethylformamide (1000 ml) was added 7-hydroxy-1H-quinolin-2-one (200.0 g) and potassium hydroxide (205.3 g, 1.2 eq), 240 ml of pure water was slowly added to the mixed solution at a controlled temperature of <40 C. The mixture was stirred at room temperature for about 15 minutes and 1-chloro-4-bromobutane (422 g, 2.0 eq) was added in one portion and then stirred at 40 C. for 5-6 h . The mixture was stirred for 1 h at room temperature and filtered. The cake was beaten by stirring in 1000 ml of water for 1 h, filtered, and the filter cake was refined in 10 times of methanol to obtain 240 g of the title compound (3) (yield: 77.0%). The synthetic route of 1-Bromo-4-chlorobutane has been constantly updated, and we look forward to future research findings. Reference:
Patent; Anhui Runsheng Pharmaceutical Co., Ltd.; Sun Mingzhe; Fang Cunjie; Zhao Dongsheng; Fang Congbin; Sun Yanbiao; Xu Kui; (4 pag.)CN106496206; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6940-78-9, Adding some certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9.

Add p-nitrophenol (1.39g, 10mmol) and potassium carbonate (1.38g, 10mmol) to 25ml acetonitrile, then add dropwise1-Bromo-4-chlorobutane (1.7 ml, 15 mmol) was refluxed at 80 C overnight. After the reaction is completed, water is added to dissolve potassium carbonate, andExtract with ethyl acetate, wash the organic phase with saturated sodium bicarbonate and brine.Evaporation to dryness gave a white solid (1.98 g, yield 86%).The product was used directly in the next reaction without purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6940-78-9.

Reference:
Patent; Beijing Xinchen Pharmaceutical Technology Co., Ltd.; Yin Yuxin; Zhai Zheng; (37 pag.)CN109593064; (2019); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6940-78-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-bromo-4-chlorobutane (3.4 g, 20 mmol), anhydrous potassium carbonate powder (4.14 g, 30 mmol) and 7-hydroxy-3,4-dihydro-2(1H)quinolinone 10 mmol)Was added to 10 ml of acetone, refluxed for 24 hours,, the reaction solution was evaporated to dryness, and the mixture was partitioned with 20 ml portions of dichloromethane and water. The organic layer was extracted with 20 ml of water * 2 and 20 ml of saturated brine successively, dried over anhydrous magnesium sulfate , Evaporate to dryness to give a pale yellow powder. The obtained powder is washed with slurry with 20 ml * 3 of n-hexane, filtered, and dried to obtain 1.98 g of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)quinolinone. Yield is 78%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.

Reference:
Patent; JIANGSU HENGYI PHARMACEUTICAL COMPANY LIMITED; SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY; Li, JIANQI; PENG, SHAOPING; CAI, WANGPING; GAO, KAI; (39 pag.)JP5714152; (2015); B2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

6940-78-9, Adding some certain compound to certain chemical reactions, such as: 6940-78-9, name is 1-Bromo-4-chlorobutane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-78-9.

General procedure: General procedure for the preparation of omega-naphthyloxyhalo alkanes (3a-c) involves refluxing of mixture of beta-naphthol (1) (20 g, 0.14 mol), anhydrous K2CO3 (100 g, in excess) and bromochloroalkane 2 (0.14 mol) in dry acetone (200 mL) for12-15 h. Reaction mixture was filtered and filtrate was concentrated to get oily compound, which was crystallized with benzene-hexane to give the colourless crystals of pure desired compound (Scheme-I) [48].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6940-78-9.

Reference:
Article; Zaidi, Sadaf; Chaturvedi, Devdutt; Saxena, Mridula; Srivastava, Richa; Asian Journal of Chemistry; vol. 31; 10; (2019); p. 2201 – 2210;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 6940-78-9

Methanol (149 L) , 7-hydroxy-lH-guinolin-2-one (14.87 kg), and potassium hydroxide (6.21 kg) were mixed in a reaction vessel, and the resulting mixture was stirred. After dissolution, l-bromo-4-chlorobutane (47.46 kg) was added thereto, and the resulting mixture was stirred under reflux for seven hours.Thereafter, the mixture was stirred at 10 C for one hour. The precipitated crystal was centrifuged and washed with methanol (15 L). The wet crystal was collected and placed in a tank. Water (149 L) was added thereto, followed by stirring at roomtemperature. After centrifugation, the result was washed with water (30 L). The wet crystal was collected and placed in a tank. After adding methanol (74 L), the mixture was stirred under reflux for one hour, cooled to 10 C, and then stirred. The precipitated crystal was centrifuged and washed with methanol (15 L). The separated crystal was dried at 60 C to obtain 7- (4- chlorobutoxy) -lH-quinolin-2-one (15.07 kg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; KANEKO, Daiki; MATSUDA, Takakuni; HOSHIKA, Yusuke; WO2013/162048; (2013); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 6940-78-9

(1) 3.53 g (20.6 mmol) of 1-bromo-4-chlorobutane was dissolved in 50 ml of absolute ethanol, added to a 250 ml round bottom flask, stirred in an ice bath at 0 C. A constant pressure dropping funnel was slowly added dropwise to a solution containing 3.11 g (22.2 mmol, 1.08 times) of 50% sodium thiomethoxide in anhydrous ethanol, and the temperature was gradually raised to room temperature overnight. The total reaction time was 26 hours. Stirring was carried out, and the ethanol was removed by vacuum at low temperature and extracted three times with n-hexane. The mixture was washed with saturated sodium chloride and dried over anhydrous sodium sulfate. The insoluble material was filtered off. Vacuum at low temperature steaming to remove n-hexane, with a strong mustard odor of 2.69g of colorless oil. The intermediate content of GC-MS was about 81%, and the yield of intermediate was about 76.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.

Reference:
Patent; Shenyang Pharmaceutical University; Sun, Lixin; Li, Binglong; Zhou, Hui; (10 pag.)CN106496086; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics