Related Products of 69411-06-9, These common heterocyclic compound, 69411-06-9, name is 4-Chloro-2,6-difluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 24.0 g (147 mmol) of 4-chloro-2,6– difluoroaniline and 22.9 g of 1,2-propanediol was placed in a round bottom flask and heated to 35C with stirring. A mixture of 14.5 g (49 mmol) of 88 percent purity 2-chlorosulfonyl-8-fluoro-5-methoxy[1,2,4]triazolo-[1,5-c]pyrimidine with 29.1 g of dichloromethane was prepared and was added in 1 mL shots over a 4 hour period. The resulting mixture was heated another 4 hours and was then stirred overnight at ambient temperature. It was then cooled to about 20C and filtered, collecting the solids present. The solids were slurried in 30 mL of a 1:1 mix of 2-propanol and water, collected by filtration, washed with 2×30 mL of 2-propanol, and air dried to obtain 14.8 g (75 percent of theory) of the title compound as a white powder of 98 percent purity melting at 203-204C.
The synthetic route of 69411-06-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dow AgroSciences LLC; EP1066289; (2003); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics