Category: 697-73-4

Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source was written by Wu, Zhuo;Wei, Feng;Wan, Bin;Zhang, Yanghui. And the article was included in Journal of the American Chemical Society in 2021.Name: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

A Me group can have a profound impact on the pharmacol. properties of organic mols. Hence, developing methylation methods and methylating reagents is essential in medicinal chem. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using di-Me carbonate as a Me source. In the presence of K₂CO₃ as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp³)-H/C(sp³)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biol. and pharmacol. active compounds In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Name: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Evaluation of 5-(o-Tolyl)-1H-tetrazole Derivatives as Potent Anticonvulsant Agents was written by Dong, Shiyang;Wang, Tiantian;Wang, Huayu;Qian, Kun;Zhang, Zhongli;Zuo, Yueming;Luo, Guangming;Jin, Yi;Wang, Zengtao. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2017.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

A series of 5-(o-tolyl)-1H-tetrazole derivatives were synthesized and evaluated for their anticonvulsant activities. 1-(2-Methylbenzyl)-5-(o-tolyl)-1H-tetrazole (3h) showed important anticonvulsant activity against the MES-induced seizures, as well as lower neurotoxicity with an ED₅₀ value of 12.7 mg/kg and a TD₅₀ value of over 500 mg/kg after i.p. injection into mice, providing 3h with a high protective index (TD₅₀/ED₅₀) of over 39.4. The achieved results prove that the distinctive compounds could be valuable as a model for future development, adaptation, and investigation to construct more active analogs. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of 2,6-difluoro-n-alkylbenzenes from 1,3-difluorobenzene. Transformation of 2,6-difluorotoluene to the corresponding benzaldehyde via benzyl chloride was written by Malykhin, Evghenii V.;Shteingarts, Vitalii D.. And the article was included in Journal of Fluorine Chemistry in 1998.SDS of cas: 697-73-4 This article mentions the following:

Reactions of n-alkyl chlorides with the 2,6-difluorophenyl anion, prepared from 1,3-difluorobenzene by the action of sodium amide in liquid ammonia, give 2,6-difluoro-n-alkylbenzenes in high yields. 2,6-Difluorotoluene reacts with chlorine at 80掳 to give 2,6-difluorobenzyl chloride in 92% yield. 2,6-Difluorobenzaldehyde has been obtained from this chloride through Sommelet’s reaction in 62% yield. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4SDS of cas: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.SDS of cas: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cyclic tertiary sulfamates: Selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives was written by De Monte, Celeste;Carradori, Simone;Secci, Daniela;D’Ascenzio, Melissa;Vullo, Daniela;Ceruso, Mariangela;Supuran, Claudiu T.. And the article was included in European Journal of Medicinal Chemistry in 2014.Recommanded Product: 697-73-4 This article mentions the following:

Carbonic anhydrase (hCA) IX and XII isoforms are over-expressed both in primary and in metastatic cell lines of hypoxic tumors and are innovative targets for cancer diagnosis and treatment. On the basis of the importance of the pharmacophoric sulfamate moiety (bioisostere of the sulfonamide group) present in the structure of recent human CA inhibitors, the authors designed N-alkylated I [R = CH₂:CH, MeC(O), EtO₂C, etc.] and O-alkylated derivatives II of acesulfame, a cyclic tertiary sulfamate, assessing the inhibitory activity against the ubiquitous isoforms hCA I and II and the cancer-related isoforms hCA IX and XII. All derivatives were nanomolar inhibitors, with some of them possessing an outstanding selectivity towards the tumor-associated hCA IX and/or hCA XII isoforms. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of a Thieno[2,3-d]pyrimidine-2,4-dione Bearing a p-Methoxyureidophenyl Moiety at the 6-Position: A Highly Potent and Orally Bioavailable Non-Peptide Antagonist for the Human Luteinizing Hormone-Releasing Hormone Receptor was written by Sasaki, Satoshi;Cho, Nobuo;Nara, Yoshi;Harada, Masataka;Endo, Satoshi;Suzuki, Nobuhiro;Furuya, Shuichi;Fujino, Masahiko. And the article was included in Journal of Medicinal Chemistry in 2003.Computed Properties of C7H5ClF2 This article mentions the following:

We have previously disclosed the first potent and orally effective non-peptide antagonist for the human LH-releasing hormone (LHRH) receptor, a thieno[2,3-b]pyridin-4-one derivative, T-98475. Extensive research on developing non-peptide LHRH antagonists has been carried out by employing a strategy of replacing the thienopyridin-4-one nucleus with other heterocyclic surrogates. We describe herein the design and synthesis of a series of thieno[2,3-d]pyrimidine-2,4-dione derivatives containing a biaryl moiety, which led to the discovery of a highly potent and orally active non-peptide LHRH antagonist, 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (I: TAK-013). Compound I showed high binding affinity and potent in vitro antagonistic activity for the human receptor with half-maximal inhibition concentration (IC₅₀) values of 0.1 and 0.06 nM, resp. Oral administration of I caused almost complete suppression of the plasma LH levels in castrated male cynomolgus monkeys at a 30 mg/kg dose with sufficient duration of action (more than 24 h). The results demonstrated that the thienopyrimidine-2,4-dione core is an excellent surrogate for the thienopyridin-4-one and that thienopyrimidine-2,4-diones and thienopyridin-4-ones constitute a new class of potent and orally bioavailable LHRH receptor antagonists. Furthermore, mol. modeling studies indicate that the unique methoxyurea side chain of I preferentially forms an intramol. hydrogen bond between the aniline NH and the methoxy oxygen atom. The hydrogen bond will shield the hydrogen bonding moieties from the solvent and reduce the desolvation energy cost. It is therefore speculated that the intramol. hydrogen bond resulting from judicious incorporation of an oxygen atom into the terminal alkyl group of the urea may increase the apparent lipophilicity to allow increased membrane permeability and consequently to improve the oral absorption of I in monkeys. On the basis of its profile, compound I has been selected as a candidate for clin. trials and it is expected that it will provide a new class of potential therapeutic agents for the clin. treatment of a variety of sex-hormone-dependent diseases. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Computed Properties of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

para-Selective Arylation of Arenes: A Direct Route to Biaryls by Norbornene Relay Palladation was written by Dutta, Uttam;Porey, Sandip;Pimparkar, Sandeep;Mandal, Astam;Grover, Jagrit;Koodan, Adithyaraj;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2020.Electric Literature of C7H5ClF2 This article mentions the following:

Biaryl compounds are extremely important structural motifs in natural products, biol. active components and pharmaceuticals. Selective synthesis of biaryls by distinguishing the subtle reactivity difference of distal arene C-H bonds are significantly challenging. Herein, we describe para-selective C-H arylation, which is acheived by a unique combination of a meta-directing group and norbornene as a transient mediator. Upon direct meta-C-H palladation, one-bond relay palladation occurs in presence of norbornene and subsequently para-C-H arylation is achieved for sulfonates, phosphonates and phenols bearing 2,6-disubstitution patterns. The protocol is amenable to electron-deficient aryl iodides. Multisubstituted arenes and phenols are obtained by postsynthetic modification of the products. The protocol allows the synthesis of hexa-substituted benzene by sequential selective distal C-H functionalization. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Electric Literature of C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Electric Literature of C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic enantioselective synthesis of carboxy-substituted 2-isoxazolines by cascade oxa-Michael-cyclization was written by Lee, Hyo-Jun;Eun, Bora;Sung, Eonseon;Hwang, Gil Tae;Ko, Young Kwan;Cho, Chang-Woo. And the article was included in Organic & Biomolecular Chemistry in 2018.Product Details of 697-73-4 This article mentions the following:

An efficient quinidine-based phase-transfer-catalyzed enantioselective cascade oxa-Michael-cyclization reaction of hydroxylamine with various 尾-carboxy-substituted 伪,尾-unsaturated ketones has been achieved for the preparation of chiral carboxy-substituted 2-isoxazolines. This cascade reaction provided the desired products in good yields (up to 98%) with excellent enantioselectivities (91-96% ee). In addition, the cascade reaction was effectively applied to the first catalytic asym. synthesis of the herbicide (S)-methiozolin. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalytic enantioselective synthesis of carboxy-substituted 2-isoxazolines by cascade oxa-Michael-cyclization was written by Lee, Hyo-Jun;Eun, Bora;Sung, Eonseon;Hwang, Gil Tae;Ko, Young Kwan;Cho, Chang-Woo. And the article was included in Organic & Biomolecular Chemistry in 2018.Product Details of 697-73-4 This article mentions the following:

An efficient quinidine-based phase-transfer-catalyzed enantioselective cascade oxa-Michael-cyclization reaction of hydroxylamine with various β-carboxy-substituted α,β-unsaturated ketones has been achieved for the preparation of chiral carboxy-substituted 2-isoxazolines. This cascade reaction provided the desired products in good yields (up to 98%) with excellent enantioselectivities (91-96% ee). In addition, the cascade reaction was effectively applied to the first catalytic asym. synthesis of the herbicide (S)-methiozolin. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Product Details of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Product Details of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor was written by Borukhova, Svetlana;Noel, Timothy;Metten, Bert;de Vos, Eric;Hessel, Volker. And the article was included in Green Chemistry in 2016.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Rufinamide can be synthesized from 2,6-difluorobenzyl chloride in three steps. The microreactor flow networks have better sustainability profiles in terms of life-cycle assessment than the resp. consecutive processing in a batch. The anal. is based on the results of a single step conversion from batch to continuous mode. An uninterrupted continuous process towards rufinamide is developed, starting from 2,6-difluorobenzyl alc. precursor, which is converted to the corresponding 2,6-difluorobenzyl chloride with hydrogen chloride gas. The chloride is then converted to the corresponding 2,6-difluorobenzyl azide that yields the rufinamide precursor I via cycloaddition to the greenest and cheapest dipolarophile available on the market. The current process demonstrates chem. and process-design intensification aspects encompassed by novel process windows. Single reaction steps are chem. intensified via a wide range of conditions available in a microreactor environment. Meanwhile, the connection of reaction steps and separations results in process-design intensification. With two in-line separations the process consists of five stages resulting in a total yield of 82% and productivity of 9 g h^-1 (11.5 mol h^-1L^-1). The process minimizes the isolation and handling of strong alkylating or energetic intermediates, while minimizing water and organic solvent consumption. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Transition-metal-free persulfuration to construct unsymmetrical disulfides and mechanistic study of the sulfur redox process was written by Xiao, Xiao;Feng, Minghao;Jiang, Xuefeng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

A sulfur redox process has been developed between sulfinate and thiosulfate, which efficiently affords diverse unsym. disulfides and provides a new method to modify pharmaceuticals and natural products without requiring an extra oxidant or reductant. A gram-scale investigation further demonstrates the practicality and application potential of this process. Isolated key intermediates and a series of control experiments afford an unusual process, which reveals the mechanism of comproportionation (i.e., redox reaction) and a transition-metal-free sulfur redox process. The synthesis of the target compounds was achieved using sodium thiosulfate pentahydrate (Na₂S₂O₃.5H₂O) [i.e., thiosulfuric acid (H₂S₂O₃), sodium salt, hydrate] as a starting material in addition to benzenesulfinic acid sodium salt derivatives, 4-chlorobutanenitrile, 1-chlorbutane, (chloromethyl)benzene derivatives (benzyl chloride). Other starting materials included 4-(trifluoromethyl)benzenesulfonic acid sodium salt, 2-naphthalenesulfinic acid sodium salt (naphthalene derivative), 2,5-dichloro-3-thiophenesulfinc acid sodium salt (thiophene derivative), (1S,4R)-7,7-dimethyl-2-(oxo)bicyclo[2.2.1]heptane-1-methanesulfinic acid sodium salt (camphor derivative), 17-(oxo)estra-1,3,5(10)-triene-3-sulfinic acid sodium salt (estrone derivative, estrogen). In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics