Category: 697-73-4

Palladium-Catalyzed Remote meta-Selective C-H Bond Silylation and Germanylation was written by Modak, Atanu;Patra, Tuhin;Chowdhury, Rajdip;Raul, Suman;Maiti, Debabrata. And the article was included in Organometallics in 2017.Reference of 697-73-4 This article mentions the following:

Selective meta-C-H activation of arenes until date has met with a limited number of functionalizations. Expanding the horizon of meta-C-H functionalization, herein the authors disclose an unprecedented meta-silylation and germanylation protocol by employing a simple nitrile based directing template. Longer linker between the target site and the directing template were successfully explored for meta-silylation (sp²ε and sp²ζ). Addnl., synthetic utility was demonstrated with several postsynthetic elaborations and with a formal synthesis of TAC101, a promising drug for the treatment of lung cancer. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Reference of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Palladium(II)-Catalyzed meta-C-H Olefination: Constructing Multisubstituted Arenes through Homo-Diolefination and Sequential Hetero-Diolefination was written by Bera, Milan;Maji, Arun;Sahoo, Santosh K.;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2015.COA of Formula: C7H5ClF2 This article mentions the following:

The palladium-catalyzed synthesis of divinylbenzenes, e.g., I, by meta-C-H olefination of sulfonate-based arenes was reported. Successful sequential olefinations in a position-selective manner provided a novel route for the synthesis of hetero-dialkenylated products, which are difficult to access using conventional methods. Addnl., 1,3,5-trialkenylated compounds can be generated upon successful removal of the directing group. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4COA of Formula: C7H5ClF2).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C7H5ClF2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Discovery of the thieno[2,3-d]pyrimidine-2,4-dione derivative: A potent and orally bioavailable gonadotropin-releasing hormone receptor antagonist was written by Zou, Fangxia;Wang, Yao;Yu, Dawei;Liu, Chunjiao;Lu, Jing;Zhao, Min;Ma, Mingxu;Wang, Wenyan;Jiang, Wanglin;Gao, Yonglin;Zhang, Rui;Zhang, Jianzhao;Ye, Liang;Tian, Jingwei. And the article was included in European Journal of Medicinal Chemistry in 2022.Recommanded Product: 697-73-4 This article mentions the following:

Here, rationally designed and synthesized a series of derivatives (I [R¹ = 2-(2,6-difluorophenyl)ethyl, 2-[2-fluoro-6-(trifluoromethyl)phenyl]ethyl, 2-(3,5-difluoropyridin-4-yl)ethyl; R² = (2-fluoro-3-methoxyphenyl)methyl, [4-(2,2,2-trifluoroethoxy)phenyl]methyl, [3-(difluoromethoxy)-2-fluorophenyl]methyl, etc] and II [R³ = methoxymethyl, cyclobutoxymethyl, (cyclopropylmethoxy)methyl; R⁴ = 2-(dimethylamino)ethyl, 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl, 2-[(3S)-3-methoxypyrrolidin-1-yl]ethyl, etc]) through the modification and structure-activity relationship study of relugolix, which led to the discovery of II [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] as a highly potent GnRH-R antagonist (IC₅₀ = 2.18 nM) with improved membrane permeability (Papp, A-B = 0.98 x 10^-6 cm/s) and oral bioavailability (F % = 44.7). CompoundII [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] showed high binding affinity (IC₅₀ = 0.57 nM) and potent in vitro antagonistic activity (IC₅₀ = 2.18 nM) at GnRH-R. II [R³ = methoxymethyl, R⁴ = 2-{methyl[2-(trifluoromethoxy)ethyl]amino}ethyl] was well tolerated and efficacious in preclin. studies to suppress blood testosterone levels, which merits further investigation as a candidate novel GnRH-R antagonist for clin. studies. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Novel Ferulic Amide Ac6c Derivatives: Design, Synthesis, and Their Antipest Activity was written by Zhang, Renfeng;Guo, Shengxin;Deng, Peng;Wang, Ya;Dai, Ali;Wu, Jian. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:

Thirty-eight novel ferulic amide 1-aminocyclohexane carboxylic acid (Ac6c) derivatives D1-D19 (I) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; and E1-E19 (II) wherein R is CH₃-Ph, Cl-Ph, CF₃-Ph, etc.; were designed and synthesized, and their antibacterial, antifungal, and insecticidal activities were tested. Most of the synthesized compounds displayed excellent activity against Xanthomonas oryzae pv. oryzae (Xoo), with EC₅₀ values ranging from 11.6 to 83.1μg/mL better than that of com. bismerthiazol (BMT, EC₅₀ = 84.3μg/mL), as well as much better performance compared to that of thiediazole copper (TDC, EC₅₀ = 137.8μg/mL). D6 (EC₅₀ = 17.3μg/mL), D19 (EC₅₀ = 29.4μg/mL), E3 (EC₅₀ = 29.7μg/mL), E9 (EC₅₀ = 27.0μg/mL), E10 (EC₅₀ = 18.6μg/mL), and E18 (EC₅₀ = 20.8μg/mL) showed much higher activity on Xanthomonas oryzae pv. oryzicola compared with BMT (EC₅₀ = 80.1μg/mL) and TDC (EC₅₀ = 124.7μg/mL). In relation to controlling the fungus, Rhizoctonia solani, E1, E10, and E13 had much lower EC₅₀ values of 0.005, 0.140, and 0.159μg/mL compared to hymexazol at 74.8μg/mL. Further in vivo experiments demonstrated that E6 and E12 controlled rice bacterial leaf blight disease better than BMT and TDC did. SEM studies revealed that E12 induced the Xoo cell membrane collapse. Moreover, D13 (73.7%), E5 (80.6%), and E10 (73.4%) also showed moderate activity against Plutella xylostella. These results indicated that the synthesized ferulic amide Ac6c derivatives showed promise as candidates for treating crop diseases. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2-(Chloromethyl)-1,3-difluorobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones and their anticonvulsant activities was written by Quan, Zhe-Shan;Wang, Jun-Min;Rho, Jung-Rae;Kwak, Kyung-Chell;Kang, Hee-Cheol;Jun, Chang-Soo;Chai, Kyu-Yun. And the article was included in Bulletin of the Korean Chemical Society in 2005.Application of 697-73-4 This article mentions the following:

A series of 6-alkyloxy-3,4-dihydro-2(1H)-quinolinones were synthesized through nitration, reduction, diazotization, hydrolysis, and alkylation from 3,4-dihydro-2(1H)-quinolinone. Their structures were characterized by IR, ¹H-NMR, and MS. The anticonvulsant activity was evaluated by the maximal electroshock test (MES) and the s.c. pentylenetetrazole (metrazole) test (scMet). The neurotoxicity was measured by the rotarod test (Tox). The result showed that 6-hexyloxy-3,4-dihydro-2(1H)-quinolinone was potent in anti-MES and anti-scMet test with ED₅₀ of 24.0 and 21.2 mg/kg, resp., albeit its TD₅₀ (67.6 mg/kg) revealed the high neurotoxicity. 6-Benzyloxy-3,4-dihydro-2(1H)-quinolinone was less effective against MES-induced seizure with ED₅₀ of 29.6 mg/kg, but no neurotoxicity was observed even <300 mg/kg. Its protective index (PI) was >10 preferable to phenytoin, carbamazepin, phenobarbital, and valproate. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Application of 697-73-4).

2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 697-73-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics