Category: 697-86-9

Application of 697-86-9, These common heterocyclic compound, 697-86-9, name is 2-Bromo-4,6-dichloroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

g) [(2,4-dichloro-6-bromophenyl)-hydrazono]propanedinitrile, mp 134-136 C. from 2,4-dichloro-6-bromoaniline (Eur. J. Med. Chem. Clin. Therap. 12, 361 [1977])

Statistics shows that 2-Bromo-4,6-dichloroaniline is playing an increasingly important role. we look forward to future research findings about 697-86-9.

Reference:
Patent; Boehringer Mannheim GmbH; US5215924; (1993); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 697-86-9, name is 2-Bromo-4,6-dichloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 697-86-9

1. 2,3,5-Trichlorobromobenzene Sodium nitrite (3.88 g, 0.056 mole) was added in portions to concentrated sulphuric acid (28.16 ml) stirred below 10 C. A solution of 2-bromo-4,6-dichloroaniline (12 g, 0.05 mole, Lancaster) in glacial acetic acid (126 ml) was added maintaining the temperature below 10 C. The mixture was stirred below 10 C. for 1 hr and then slowly added to a stirred solution of cuprous chloride (10.11 g, 0.10 mole) in concentrated hydrochloric acid (101.05 ml) at room temperature. The mixture was then stirred at room temperature for 17 hrs. The product was filtered, washed with water (3*50 ml), dissolved in chloroform (150 ml), dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated in vacuo to give the desired product. Yield 10 g (77%), M.p. 55-57 C.

The synthetic route of 697-86-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Glaxo Wellcome, Inc.; US6255307; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 697-86-9, name is 2-Bromo-4,6-dichloroaniline, A new synthetic method of this compound is introduced below., Quality Control of 2-Bromo-4,6-dichloroaniline

To a toluene solution (8 mL) of 2-bromo-4,6-dichloroaniline (1 g) (CAS registry number: 697-86-9), 4-fluorophenyl acetyl chloride (788 mg) was added, followed by stirring at 90 C. overnight. The reaction mixture was cooled to room temperature, and precipitate was filtered. The precipitate was washed with toluene and then dried under reduced pressure at 50 C. to obtain the title compound (1.28 g) having the following physical property values. TLC: Rf 0.43 (hexane:ethyl acetate=1:1); 1H-NMR (CD3OD): delta 3.72, 7.02-7.08, 7.38-7.43, 7.58, 7.69.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ono Pharmaceutical Co., Ltd; YASHIRO, Kentaro; WAKAMATSU, Daisuke; SAITO, Tetsuji; (53 pag.)US2017/217888; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics