Category: 697-88-1

Reference of 697-88-1,Some common heterocyclic compound, 697-88-1, name is 4-Bromo-2,6-dichloroaniline, molecular formula is C6H4BrCl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pd (OAc) 2 (186 mg), P (o-Tol) 3 (505 mg), Et3N (1.73 ml), 4-bromo-2,6- dichlorobenzeneamine (2.0 g) and acrylamide (885 mg) were dissolved in MECN (15 ml) and N2 was bubbled through the reaction mixture for at least 20 minutes. Then a cooler was mounted strictly under nitrogen atmosphere. The reaction mixture was heated at 70 C overnight. The reaction mixture was allowed to cool to 20 C and was diluted with CH2CI2 and washed with saturated aqueous NAHC03 (2x) and dried with brine and NA2SO4. The residue was sonicated in diisopropyl ether and filtered off. Yield: 0.55 g of intermediate 18 (30%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2,6-dichloroaniline, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ARTS, Theodora, Joanna, Francisca; JANSSEN, Graziella, Maria, Constantina; JANSSEN, Herwig, Josephus, Margareta; JANSSEN, Jasmine, Josee, Werner; JANSSEN, Paul, Peter, Maria; JANSSEN, Maroussia, Godelieve, Frank; WO2004/74266; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 697-88-1, name is 4-Bromo-2,6-dichloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 697-88-1, Formula: C6H4BrCl2N

REFERENCE EXAMPLE 1 N-(4-bromo-2,6-dichlorophenyl)acrylamide A solution of (4-bromo-2,6-dichlorophenyl)amine (4 g) and acryloyl chloride (1.4 mL) in dichloromethane (10 mL) was stirred overnight at room temperature. To the solution were added water and ethyl acetate at 0 degree. The organic layer was washed with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride, subsequently, dried over an anhydrous magnesium sulfate and then concentrated. The residue was washed with diisopropylether to give the title compound (1.96 g) having the following physical data. TLC: Rf 0.25 (hexane:ethyl acetate=5:1); NMR(CDCl3): delta 7.55 (s, 2H), 7.11 (br, 1H), 6.51-6.44 (m, 1H), 6.40-6.20 (m, 1H), 5.85 (d, J=10.5 Hz, 1H).

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Reference:
Patent; Takahashi, Kanji; Sumino, Naoki; Yamamoto, Shingo; Sugitani, Masafumi; Uegaki, Akihiko; Nakatani, Shingo; Matsunaga, Naoki; Inukai, Takayuki; US2007/10529; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of 697-88-1,Some common heterocyclic compound, 697-88-1, name is 4-Bromo-2,6-dichloroaniline, molecular formula is C6H4BrCl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pd (OAc) 2 (186 mg), P (o-Tol) 3 (505 mg), Et3N (1.73 ml), 4-bromo-2,6- dichlorobenzeneamine (2.0 g) and acrylamide (885 mg) were dissolved in MECN (15 ml) and N2 was bubbled through the reaction mixture for at least 20 minutes. Then a cooler was mounted strictly under nitrogen atmosphere. The reaction mixture was heated at 70 C overnight. The reaction mixture was allowed to cool to 20 C and was diluted with CH2CI2 and washed with saturated aqueous NAHC03 (2x) and dried with brine and NA2SO4. The residue was sonicated in diisopropyl ether and filtered off. Yield: 0.55 g of intermediate 18 (30%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2,6-dichloroaniline, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ARTS, Theodora, Joanna, Francisca; JANSSEN, Graziella, Maria, Constantina; JANSSEN, Herwig, Josephus, Margareta; JANSSEN, Jasmine, Josee, Werner; JANSSEN, Paul, Peter, Maria; JANSSEN, Maroussia, Godelieve, Frank; WO2004/74266; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics