Category: 698-01-1

Efficient and Selective N-Methylation of Nitroarenes under Mild Reaction Conditions was written by Pedrajas, Elena;Sorribes, Ivan;Guillamon, Eva;Junge, Kathrin;Beller, Matthias;Llusar, Rosa. And the article was included in Chemistry – A European Journal in 2017.Quality Control of 2-Chloro-N,N-dimethylaniline This article mentions the following:

A straightforward protocol for the preparation of N,N-dimethylated amines from readily available nitro starting materials using formic acid as a renewable C₁ source and silanes as reducing agents was reported. This tandem process was efficiently accomplished in the presence of a cubane-type Mo₃PtS₄ catalyst. A [3+1] building block strategy starting from the trinuclear [Mo₃S₄Cl₃(dmen)₃]⁺ and Pt(PPh₃)₄ complexes was followed for the preparation of the novel [Mo₃Pt(PPh₃)S₄Cl₃(dmen)₃]⁺ (dmen: N,N’-dimethylethylenediamine) compound. The heterobimetallic [Mo₃Pt(PPh₃)S₄Cl₃(dmen)₃]⁺ cation preserved the main structural features of its [Mo₃S₄Cl₃(dmen)₃]⁺ cluster precursor. Interestingly, this catalytic protocol operated at room temperature with high chemoselectivity when the [Mo₃Pt(PPh₃)S₄Cl₃(dmen)₃]⁺ catalyst co-exists with its trinuclear [Mo₃S₄Cl₃(dmen)₃]⁺ precursor. N-heterocyclic arenes, double bonds, ketones, cyanides and ester functional groups were well retained after N-methylation of the corresponding functionalized nitroarenes. In addition, benzylic-type as well as aliphatic nitro compounds were also methylated following this protocol. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Quality Control of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Studies towards DIAD promoted N-demethylation of N,N-dimethylanilines was written by Ren, Jiangmeng;Cao, Fu-Rong;Sun, Xue-Qin;Xu, Xuan;Liu, Gui-Xia;Zeng, Bu-Bing. And the article was included in Tetrahedron Letters in 2022.Computed Properties of C8H10ClN This article mentions the following:

The demethylation of N,N-dimethylanilines promoted by diisopropyl azodicarboxylate (DIAD) to provide N-methylanilines was achieved in this paper. This protocol featured with mild reaction condition, simple operation and moderate to good yield. The intermediates were isolated and identified by means of spectroscopy methods. The reaction mechanism was investigated exptl. and further verified by theor. calculations This method could be applied to the study of the metabolites of medicines containing N,N-dimethylaniline fragments. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Computed Properties of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Computed Properties of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solvatochromism of heteroaromatic compounds: XXVIII. Factors affecting the nonspecific solvatochromic effect in the UV spectra of aromatic nitro compounds in aprotic protophilic solvents was written by Vokin, A. I.;Shulunova, A. M.;Aksamentova, T. N.;Bozhenkov, G. V.;Turchaninov, V. K.. And the article was included in Russian Journal of General Chemistry in 2006.Application of 698-01-1 This article mentions the following:

Examination of the UV spectra of a large series of solvatochromic indicators of the general formula 1-X-4-NO₂-C₆H₄ in aprotic solvents confirmed the proportionality between the dipole moments of these compounds in the ground (渭_g) and first electronically excited (¹A₁, 渭_e) states: 渭_e = r_渭渭_g. The coefficient r_渭 was determined by applying the equation of the Bakhshiev-Bilot-Kawski solvatochromism theory both to nonspecifically solvated mols. and to their H complexes with aprotic protophilic solvents. An anisotropy of the electron redistribution was revealed for low-symmetry 1-substituted 2,4-dinitrobenzenes. The r_渭 value obtained allowed the calculation of the Kamlet-Taft empirical solvatochromic parameter 蟺* on the basis of generalized characteristics of the solvent. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application of 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Can electrochemical oxidation techniques really decontaminate saline dyes wastewater? was written by Ramjaun, Sadiqua N.;Wang, Zhaohui;Yuan, Ruixia;Liu, Jianshe. And the article was included in Journal of Environmental Chemical Engineering in 2015.HPLC of Formula: 698-01-1 This article mentions the following:

Formation of toxic chlorinated organic byproducts is of great concern when selecting electrochem. oxidation (EO) as decontamination technol. for saline dye wastewater, but still not verified. To test the applicability of EO, methyl orange (MO) was used as a model dye for anodic contact glow discharge electrolysis (CGDE) and conventional electrolysis (CE) in the presence of chloride. The degradation kinetics and organic intermediates were analyzed. In the presence of chloride, the rates of dye degradation were significantly increased as CGDE and CE were applied. CE resulted in higher mineralization efficiency than CGDE which needs much energy input. Several refractory chlorinated aromatic and even aliphatic compounds were identified during MO degradation, as well as the other anthraquinone dye, alizarin red S (AR). Therefore, the issues of toxic chlorinated byproducts and energy cost should be preferentially evaluated prior to the selection of EO technologies. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1HPLC of Formula: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kinetics of peroxodisulfate oxidation of ortho-substituted N,N-dimethylanilines, and the mechanism of Boyland-Sims oxidation was written by Srinivasan, Chockalingam;Perumal, Subbu;Arumugam, Natesan. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1985.Application In Synthesis of 2-Chloro-N,N-dimethylaniline This article mentions the following:

The kinetics of oxidation of o-RC₆H₄NMe₂ (I; R = H, MeO, Me, F, Cl, Br, NO₂) by S₂O₈^2- were studied in 50% (volume/volume) H₂O-EtOH containing 0.025 mol/dm³ phosphate buffer (pH 7). The reaction is 2nd-order overall, and 1st-order in each reactant. The rate was not influenced by the presence of the free-radical inhibitor H₂C:CHCH₂OAc. An increase in the polarity of the medium enhances the rate. The reactivities of I lie in the order H > Me ≈ MeO > F > Br > Cl > NO₂. Multiple regression anal. of the rate data reveals that the rate is susceptible to significant electronic and steric effects. All these observations are rationalized on the basis of attack of the oxidant at the ipso-position of the amine. Correlation anal. of reactivity data from the literature also indicates that the mechanism involves ipso-attack and not attack on N. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Application In Synthesis of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Linear relations between thermodynamic parameters. IV. Basicities of some substituted dimethylanilines was written by Lee, Ikchoon;Park, Yong Ja. And the article was included in Taehan Hwahakhoe Chi in 1964.Recommanded Product: 698-01-1 This article mentions the following:

Basicities of 9 dimethylanilines were determined in 50, 70, and 90 volume % EtOH, at 25, 30, 35, and 45°. Temperature coefficients are independent of solvent composition, while they show a linear correlation with basicities of the compounds Thermodynamic parameters obtained were used in the discussion of substituent and solvent effects in conjunction with the general equation derived in the preceding papers. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Development of aqueous oxidative Ugi-type reactions by copper-catalyzed surfactant-promoted C(sp³)-H direct functionalization in water was written by Xie, Chunsong;Han, Laihong. And the article was included in Tetrahedron Letters in 2014.Synthetic Route of C8H10ClN This article mentions the following:

Direct assembly of α-amino amides from N-alkyl amines and isocyanides through oxidative Ugi-type reactions in aqueous conditions, has been achieved in a Cu(I)-TBHP-surfactant catalysis system. Various N-alkyl amines and isocyanides could be tolerated in this reaction and furnish α-amino amides in moderate yields. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Synthetic Route of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Synthetic Route of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrophilic fluorination of N,N-dimethylaniline, N,N-dimethylnaphthalen-1-amine and 1,8-bis(dimethylamino)naphthalene with N-F reagents was written by Sorokin, Vladimir I.;Pozharskii, Alexander F.;Ozeryanskii, Valery A.. And the article was included in Journal of Fluorine Chemistry in 2013.Safety of 2-Chloro-N,N-dimethylaniline This article mentions the following:

Reaction of N,N-dimethylaniline, N,N-dimethylnaphthalen-1-amine and 1,8-bis(dimethylamino)naphthalene (proton sponge) with 1-chloromethyl-4-fluorodiazonia-bicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor) and N-fluorobenzenesulfonimide (NFSI) has been studied under various conditions. Unlike the proton sponge, which is fluorinated rather selectively at the ortho-position to NMe₂ group, producing 2-fluoro derivatives in moderate yield, two other amines react with Selectfluor and NFSI with strong tarring and the formation of complex mixtures of the corresponding biaryls, biarylmethanes and N-demethylated products. 2-Fluoro and 4-fluoro derivatives are also formed in minor quantities with the former isomer being predominant. Using the NFSI-ZrCl₄ system results in competitive chlorination of the aromatic ring. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Safety of 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The study of the ultraviolet absorption of ortho-substituted anilines. II. N-Substituted ortho-halogenated anilines was written by Grammaticakis, P.. And the article was included in Bulletin de la Societe Chimique de France in 1949.Formula: C8H10ClN This article mentions the following:

The qual. relations between the spectra of the N-derivatives of o-toluidine and mesidine are generally retained when the Me group is replaced by Cl or Br. Br causes very slight, if any, shift toward the visible as compared with Cl. Spectra are reported of: o-ClC₆H₄NH₂ (I); 2,4,6-Cl₃C₆H₂NH₂ (II); 2,4,6-Br₃C₆H₂NH₂ (III); the N-mono-Me and N,N-di-Me derivatives of I, II, and III; the N-Ac, N-Bz, and N-formyl derivatives of I, II, and III and their N-mono-Me derivatives; the N,N-di-Ac derivatives of II and III; the N-cyclohexylidene derivatives of I and II; the N-benzylidene derivatives of I, II, and III; the N-phenylcarbamyl derivatives of I, II, and III and their N-mono-Me derivatives; the N-PhSO₂ derivative of I; the N-phenylcarbamyl derivative of mesidine and its mono-Bu derivative; the N-carbamyl derivatives of I and o-toluidine and o-acetotoluide. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Selective N-Monomethylation of Amines and Nitroarenes using Methanol over an Encapsulated Iridium Nanocatalyst was written by Fu, Aixiao;Liu, Qiang;Jiang, Mingxiang;Xu, Guoqiang. And the article was included in Asian Journal of Organic Chemistry in 2019.COA of Formula: C8H10ClN This article mentions the following:

A highly selective N-monomethylation of aniline and nitrobenzene using methanol as methylating reagent was achieved with high efficiency when using an encapsulated iridium nanocatalyst. A wide range of amines and nitro compounds reacted well in the established catalytic system with moderate to excellent product yields and good functional group tolerance. The transfer hydrogenation and successive cyclization coupling reaction of ortho-phenylenediamine with methanol to afford benzimidazole and N-methylbenzimidazole was also efficiently realized under moderate reaction conditions. Recycling experiments showed that the iridium nanocatalyst had a good stability without obvious activity loss. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics