Category: 698-01-1

Yang, Zhenzhen et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2015 | CAS: 698-01-1

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 698-01-1

Azo-functionalized microporous organic polymers: synthesis and applications in CO2 capture and conversion was written by Yang, Zhenzhen;Zhang, Hongye;Yu, Bo;Zhao, Yanfei;Ma, Zhishuang;Ji, Guipeng;Han, Buxing;Liu, Zhimin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Product Details of 698-01-1 This article mentions the following:

Azo-functionalized MOPs (Azo-MOPs) were synthesized via oxidative polymerization of aromatic amines catalyzed by t-BuOCl/NaI (25 °C, 1 h, yield: >95%), which displayed an excellent coordinating ability with a Ru complex. The resulting Ru-coordinated Azo-MOPs displayed high CO2 capacity and high performances for catalyzing the methylation of amines with CO2 under low pressure (0.5 MPa). In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Product Details of 698-01-1).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 698-01-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Galliani, G. et al. published their research in Xenobiotica in 1986 | CAS: 698-01-1

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-Chloro-N,N-dimethylaniline

The rate of N-demethylation of N,N-dimethylanilines and N-methylanilines by rat liver microsomes is related to their first ionization potential, their lipophilicity and to a steric bulk factor was written by Galliani, G.;Nali, M.;Rindone, B.;Tollari, S.;Rocchetti, M.;Salmona, M.. And the article was included in Xenobiotica in 1986.Recommanded Product: 2-Chloro-N,N-dimethylaniline This article mentions the following:

The N-demethylation of a series of 12 p-substituted N,N-dimethylanilines [e.g., 4-fluoro-N,N-dimethylaniline (I) [403-46-3]], 9 m-substituted N,N-dimethylanilines, 1 o-substituted N,N-dimethylaniline, and 4 p-substituted N-methylanilines by rat liver microsomes was studied. For each compound, the apparent Vmax and Km values were determined and these parameters were correlated with their electronic, lipophilicity, and steric bulk parameters reported in the literature. Multi-parameter linear regression anal. showed a good correlation between log Vmax and these parameters for the p-substituted N,N-dimethylanilines. A lower degree of correlation was observed with the m-substituted N,N-dimethylanilines. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Recommanded Product: 2-Chloro-N,N-dimethylaniline).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 2-Chloro-N,N-dimethylaniline

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Leung, Hei-Wun et al. published their research in Journal of the American Chemical Society in 1980 | CAS: 698-01-1

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H10ClN

Specific substituent effects in the dehalogenation of halobenzene derivatives by the gaseous Broensted acid CH5+ was written by Leung, Hei-Wun;Harrison, Alex G.. And the article was included in Journal of the American Chemical Society in 1980.Synthetic Route of C8H10ClN This article mentions the following:

In the methane chem. ionization mass spectra of chlorobenzene derivatives containing an electron-donating substituent meta to the chlorine, the protonated mol. ions, MH+, formed in the initial protonation reaction undergo extensive loss of HCl to form substituted Ph cations. This dehalogenation reaction is not observed when the substituent is ortho or para to the chlorine (except for the p-dimethylamino substituent) nor for electron-withdrawing substituents. For fluorobenzene derivatives loss of HF from MH+ is observed when the substituent is meta or para to the fluorine but not when it is ortho to the fluorine. The origin of these unusual substituent effects is discussed and it is concluded that the substituents act to alter the carbon-halogen bond dipole. This bond dipole in turn exerts a kinetic effect which either alters the activation energy for elimination of the neutral hydrogen halide from MH+ or, more likely, influences the extent of protonation at the halogen through localized ion-bond dipole interactions in the collision complex. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1Synthetic Route of C8H10ClN).

2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Synthetic Route of C8H10ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

September 26, 2021 News The origin of a common compound about 698-01-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-N,N-dimethylaniline, and friends who are interested can also refer to it.

Related Products of 698-01-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 698-01-1 name is 2-Chloro-N,N-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of benzoyl chloride 1a (0.5 mmol), N,N-dimethylaniline 2a (1.5 mmol), KMnO4 (1.5 equiv.) and CH3CN (2.0 mL) was placed in a 25 mL reaction straight tube under air atmosphere. The tube was then placed in an oil bath, stirred and heated at 60 C for 6 h. After cooling to room temperature, the system was flushed to Sand core funnel using dichloroethane (rinsing three times, VDCM < 50 mL), Vacuum filtration, and the volatile solvent was removed in vacuo. The crude product was purified through a silica gel column (ethyl acetate/petroleum ether = 1:5) to afford (93%) a yellow liquid. At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-N,N-dimethylaniline, and friends who are interested can also refer to it. Reference:
Article; Zhang, Zhang; Liu, Yong-Hong; Zhang, Xi; Wang, Xi-Cun; Tetrahedron; vol. 75; 19; (2019); p. 2763 – 2770;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some tips on C8H10ClN

The synthetic route of 2-Chloro-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 698-01-1, name is 2-Chloro-N,N-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Chloro-N,N-dimethylaniline

General procedure: In to an oven-dried flask, N,N-dimethylaniline 1a(2.0 mmol), 1-(isocyanomethylsulfonyl)-4-methylbenzene 2a (1.0mmol), CuCl (0.2 mmol), PPh3 (0.4 mmol), SDS (0.5 mmol) and TBHP (70wt% aqueous, 2.7 mmol) were added at room temperature. In open air, water (5mL) was added and the reaction mixture was allowed to reaction at 70 oCfor 6 h. After the finish of the reaction, the mixture was filtered through apad of celite and the filtrate was extracted by EA three times. The combined organic layers was washed by brine and dried by Na2SO4. Afterthe removing of the organic solvents, the residue was then separated on a silica gel column and the final product was obtained as a yellow powder (174 mg, 52%).

The synthetic route of 2-Chloro-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xie, Chunsong; Han, Laihong; Tetrahedron Letters; vol. 55; 1; (2014); p. 240 – 243;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some tips on 698-01-1

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-N,N-dimethylaniline. I believe this compound will play a more active role in future production and life.

Synthetic Route of 698-01-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 698-01-1, name is 2-Chloro-N,N-dimethylaniline, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of tert-amines in dichloromethane (10 ml), m-chloroperbenzoic acid (70%w/w, 1.5 equiv) was added portion wise at room temperature. The resultant solution wasstirred for 4 h and the progress of reaction was monitored using TLC. After completion, the reaction mixture was directlyloaded on basic alumina column and purified using methanol:chloroform solvent mixture as an eluent. The combined filtrates were concentrated to give corresponding amine N-oxides with approx. 90-95% isolated yield.

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-N,N-dimethylaniline. I believe this compound will play a more active role in future production and life.

Reference:
Article; Gupta, Surabhi; Sureshbabu, Popuri; Singh, Adesh Kumar; Sabiah, Shahulhameed; Kandasamy, Jeyakumar; Tetrahedron Letters; vol. 58; 10; (2017); p. 909 – 913;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The origin of a common compound about C8H10ClN

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-N,N-dimethylaniline, and friends who are interested can also refer to it.

Application of 698-01-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 698-01-1 name is 2-Chloro-N,N-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of benzoyl chloride 1a (0.5 mmol), N,N-dimethylaniline 2a (1.5 mmol), KMnO4 (1.5 equiv.) and CH3CN (2.0 mL) was placed in a 25 mL reaction straight tube under air atmosphere. The tube was then placed in an oil bath, stirred and heated at 60 C for 6 h. After cooling to room temperature, the system was flushed to Sand core funnel using dichloroethane (rinsing three times, VDCM < 50 mL), Vacuum filtration, and the volatile solvent was removed in vacuo. The crude product was purified through a silica gel column (ethyl acetate/petroleum ether = 1:5) to afford (93%) a yellow liquid. At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-N,N-dimethylaniline, and friends who are interested can also refer to it. Reference:
Article; Zhang, Zhang; Liu, Yong-Hong; Zhang, Xi; Wang, Xi-Cun; Tetrahedron; vol. 75; 19; (2019); p. 2763 – 2770;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Some tips on 698-01-1

The synthetic route of 2-Chloro-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 698-01-1, name is 2-Chloro-N,N-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Chloro-N,N-dimethylaniline

General procedure: To a stirred solution of N,N-dimethylanilines (1, 1.0 mmol) and 2,3-dihydrofuran (2, 10 mmol) in MeCN(20 ml), Co(ClO4)2 (10 mol%) was added. The reactions were performed at 50 C under oxygen atmosphere(O2 balloon) and completed in 48 hours. The products 3 were isolated by flash column chromatographic separation (acetone/petroleum ether = 1:40 to 1:30).

The synthetic route of 2-Chloro-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huo, Congde; Chen, Fengjuan; Quan, Zhengjun; Dong, Jie; Wang, Yajun; Tetrahedron Letters; vol. 57; 46; (2016); p. 5127 – 5131;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics