Category: 69957-83-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69957-83-1, name is N-Ethyl-4-chlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H12ClN

[4-(2-{[2-(Methoxycarbonyl)phenyl]thio} ethyl) phenoxy] acetic acid (0.200 [G,] 0.577 mmol) was dissolved in DMF (10 ml), [N-(4-CHLOROBENZYL)-N-ETHYLAMINE] (0.108 g, 0.635 mmol) was added and the mixture was cooled to 0 C. N-[(1H-1, 2, 3-benzotriazol-1- yloxy) (dimethylamino) [METHYLENE]-N-METHYLMETHANAMINIUM] tetrafluoroborate (0.204 g, 0.635 mmol) and N-ethyl-N,N-diisopropylamine (0.157 g, 1.212 mmol) were added. The solution was stirred overnight at room temperature. Water (100 [ML)] was added and the water phase was extracted with diethyl ether (3 X 20ml). The organic phase was washed with [NA2CO3] (3 X 20 ml, [AQ)] and HCl (0.5 M, 2 X, 10 [ML).] The organic layer was dried (MgSO4) and the solvent was removed by evaporation. The residue was purified by flash chromatography (started with isocratic heptane/EtOAc 30/70 and then the EtOAc concentration was increased to 100%, (silica gel 60 0.004-0. 063 [MM).] The product containing fractions were pooled and the solvent was removed by evaporation to give 0. [085 G OF METHYL 2-{ [2-(4-{2-[(4-CHLOROBENZYL)] (ethyl) [AMINO]-2-] oxoethoxy} phenyl) ethyl] thio} benzoate (yield 29.6%). [1HNMR] (rotamers, 300 MHz, CDC13) : 8 1.09-1. 21 [(M,] 3H), 2.91-2. 99 [(M,] 2H), 3.11-3. 18 [(M,] 2H), 3.32-3. 43 [(M,] 2H), 3.92 (s, [3H),] 4.57-4. 75 [(M,] 4H), 6.78, 6.92 (d, d, 2H), 7.12- 7.46 [(M,] 9H), 7.96 (d, [1H).]

According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/294; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69957-83-1, name is N-Ethyl-4-chlorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H12ClN

[4-(2-{[2-(Methoxycarbonyl)phenyl]thio} ethyl) phenoxy] acetic acid (0.200 [G,] 0.577 mmol) was dissolved in DMF (10 ml), [N-(4-CHLOROBENZYL)-N-ETHYLAMINE] (0.108 g, 0.635 mmol) was added and the mixture was cooled to 0 C. N-[(1H-1, 2, 3-benzotriazol-1- yloxy) (dimethylamino) [METHYLENE]-N-METHYLMETHANAMINIUM] tetrafluoroborate (0.204 g, 0.635 mmol) and N-ethyl-N,N-diisopropylamine (0.157 g, 1.212 mmol) were added. The solution was stirred overnight at room temperature. Water (100 [ML)] was added and the water phase was extracted with diethyl ether (3 X 20ml). The organic phase was washed with [NA2CO3] (3 X 20 ml, [AQ)] and HCl (0.5 M, 2 X, 10 [ML).] The organic layer was dried (MgSO4) and the solvent was removed by evaporation. The residue was purified by flash chromatography (started with isocratic heptane/EtOAc 30/70 and then the EtOAc concentration was increased to 100%, (silica gel 60 0.004-0. 063 [MM).] The product containing fractions were pooled and the solvent was removed by evaporation to give 0. [085 G OF METHYL 2-{ [2-(4-{2-[(4-CHLOROBENZYL)] (ethyl) [AMINO]-2-] oxoethoxy} phenyl) ethyl] thio} benzoate (yield 29.6%). [1HNMR] (rotamers, 300 MHz, CDC13) : 8 1.09-1. 21 [(M,] 3H), 2.91-2. 99 [(M,] 2H), 3.11-3. 18 [(M,] 2H), 3.32-3. 43 [(M,] 2H), 3.92 (s, [3H),] 4.57-4. 75 [(M,] 4H), 6.78, 6.92 (d, d, 2H), 7.12- 7.46 [(M,] 9H), 7.96 (d, [1H).]

According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/294; (2003); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 69957-83-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 69957-83-1 as follows.

To a solution of N-(4-chlorobenzyl)-JV-ethylamine (0.150 g, 0.88 mmol) and {4-[(25)-2,3- diethoxy-3-oxopropyl]phenoxy}acetic acid (0.270 g, 0.91 mmol) in methylene chloride (10 mL) were added iVyV-diisopropylethylamine (0.34 mL, 1.9 mmol) and O-(benzotriazol-l-yl)- EPO tetrafluoroborate (0.320 g, 1.00 mmol) and the reaction mixture was stirred at room temperature overnight. The resulting solution was diluted with methylene chloride (40 mL) and the organic phase was washed with 5% HCl (50 mL), saturated aqueous NaHCO3 (50 mL), and brine (50 mL), dried over Na2SO4, and concentrated in vacuo. 5 Purification on a prepacked column of silica gel (Isolute SPE Column, 50 g/150 mL) with methylene chloride/ethyl acetate 10:1 as the eluent yielded 0.24 g (61%) of a colourless oil.1H NMR (500 MHz, CDCl3): delta 1.05-1.24 (m, 9H), 2.88-3.00 (m, 2H), 3.28-3.42 (m, 3H), 3.60 (m, IH), 3.96 (m, IH)3 4.12-4.20 (m, 2H), 4.56 and 4.58 (2s, 2H, rotamers), 4.64 and 4.73 (2s, 10 2H, rotamers), 6.75 and 6.88 (2d, 2H, rotamers), 7.09-7.20 (m, 4H), 7.24 and 7.30 (2d, 2H, rotamers).

According to the analysis of related databases, 69957-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; WO2007/8156; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics