Category: 70057-67-9

Lu, Yuhan; Han, Yingzhi; Sun, Yadong; Abdukader, Ablimit; Wang, Duozhi; Liu, Chenjiang published the artcile< Application of iodobenzene acetate promoted oxidation in the synthesis of 2-amino-1,3,4-thiadiazole molecules>, Computed Properties of 70057-67-9, the main research area is iodobenzene acetate oxidation amino thiadiazole synthesis.

A highly method for intramol. oxidative coupling reaction of thiosemicarbazone promoted by hypervalent iodine reagent was reported. 2-Amino-1,3,4-thiadiazole derivatives could be synthesized effectively. Hypervalent iodine could be used as a mild reagent with low toxicity, low cost, easy circulation and operation. The reaction had the advantages of easy preparation of raw materials, simple operation and better performance. The applicability of substrates and the reaction mechanism were also preliminarily studied.

Youji Huaxue published new progress about Oxidative coupling reaction catalysts. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Computed Properties of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Alam, Faruk published the artcile< A study on the antimicrobial and antioxidant activities of some new 1, 3, 4-thiadiazole derivatives>, Application In Synthesis of 70057-67-9, the main research area is thiadiazole derivative antioxidant antimicrobial agent.

The various derivatives of thiadiazole were prepared by the reaction of m-chlorophenyl isocyanate and p-chlorophenyl isocyanate with 5-(substituted phenyl) -2-amino-1, 3, 4-thiadiazole in dry acetonitrile. Elemental anal., IR, 1H NMR, mass spectral data confirmed the structure of the newly synthesized compounds All the derivatives of these moieties were evaluated for invitro antimicrobial and invitro antioxidant activity. Most of the synthesized compounds showed potent antimicrobial activity at 100 and 50 μg/mL and antioxidant scavenging activity. Compounds showed most significant antibacterial activity against gram pos. test organism S.aureus and most significant antifungal activity against test organisms Aspergillus niger and Candida albicans. All the compounds were screened for in vitro antioxidant activity by various methods as Scavenging of DPPH, Scavenging of nitric oxide radical inhibitory activity.

International Journal of ChemTech Research published new progress about Antimicrobial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Application In Synthesis of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jakovljevic, Katarina; Joksovic, Milan D.; Botta, Bruno; Jovanovic, Ljiljana S.; Avdovic, Edina; Markovic, Zoran; Mihailovic, Vladimir; Andric, Marijana; Trifunovic, Snezana; Markovic, Violeta published the artcile< Novel 1,3,4-thiadiazole conjugates derived from protocatechuic acid: synthesis, antioxidant activity, and computational and electrochemical studies>, SDS of cas: 70057-67-9, the main research area is thiadiazole amide preparation antioxidant DFT electrochem.

A series of novel 1,3,4-thiadiazole amide derivatives I [R = cyclohexyl, Ph, Bn, etc.] containing a protocatechuic acid moiety were synthesized and structurally characterized. In addition, the corresponding imino and amino analogs of a 1,3,4-thiadiazole amide derivative I [R = Ph] were prepared to compare the effects of the structural changes on the radical-scavenging activity. The obtained compounds I were examined for their antioxidative potential by DPPH and ABTS assays. In addition, selected compounds were studied by d. functional theory (DFT) and cyclic voltammetry experiments The tested compounds showed high potential to scavenging DPPH radical and ABTS radical cation compared with the referent antioxidants ascorbic acid and nordihydroguaiaretic acid (NDGA). On the basis of the calculated thermodn. parameters, it can be concluded that the sequential proton loss electron transfer (SPLET) mechanism represented the most probable reaction path in a polar solvent for DPPH radical-scavenging activity. On the other hand, the single electron transfer followed by proton transfer (SET-PT) could be a likely mechanistic pathway in the case of an ABTS radical cation.

Comptes Rendus Chimie published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, SDS of cas: 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wei, Zeyang; Zhang, Qi; Tang, Meng; Zhang, Siyu; Zhang, Qian published the artcile< Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones>, Quality Control of 70057-67-9, the main research area is triazol thiadiazol selenadiazole preparation; tosylhydrazone tosylhydrazonoyl chloride.

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Organic Letters published new progress about Cyanamides Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Quality Control of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Han, Yingzhi; Sun, Yadong; Abdukader, Ablimit; Liu, Bifu; Wang, Duozhi published the artcile< PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aminothiadiazole preparation; aldehyde thiosemicarbazide iodobenzene catalyst oxidative coupling reaction.

A highly efficient method for the synthesis of thiadiazole derivatives via intramol. oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents was developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields.

Catalysis Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Hanwen; Pei, Wenchou; Tang, Zilong published the artcile< One-pot synthesis of novel 4-[(5-aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol derivatives>, HPLC of Formula: 70057-67-9, the main research area is arylthiadiazolylaminomethylphenol preparation; phenylthiadiazolamine hydroxybenzaldehyde condensation reduction.

A class of 4-[(5-aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol compounds I(R = H, 2-Cl, 3-Cl, 4-Cl, 2-Me, 3-Me, 4-Me, 2-MeO, 3-MeO, 4-MeO, 4-Br, 4-CF3) were synthesized via the nucleophilic addition reaction of 5-phenyl-1,3,4-thiadiazol-2-amine with 4-hydroxybenzaldehyde, dehydration and reduction of unsaturated double bond in one-pot. This procedure has the advantages of short reaction time and simple post treatment. The structures of the products were characterized thoroughly by NMR, IR MS techniques and elemental anal.

Youji Huaxue published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, HPLC of Formula: 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mohan, Jag; Anjaneyulu, G. S. R.; Kiran published the artcile< Heterocyclic systems containing a bridge-head nitrogen atom: reactions of 2-aminothiadiazoles with α-haloketones and ketones in the presence of NBS>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is antimicrobial diarylimidazothiadiazole bromo; imidazothiadiazole diaryl bromo preparation antimicrobial.

Diarylimidazo[2,1-b]-1,3,4-thiadiazoles I (R = Cl, R1 = H, Br, Me, Ph, Cl; R = Me, R1 = Cl, Ph) are prepared by the reaction of α-haloketones with 2-aminothiadiazoles II, or more conveniently, by treating II directly with ketones in the presence of NBS. Bromination of I (R = R1 = Cl) furnishes a 5-bromo-2,6-diarylimidazo[2,1-b]thiadiazole derivative The antimicrobial activity of I (R = R1 = Cl) and a derivative has been evaluated; they were found to be inactive.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 70057-67-9. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ghaffari, Samaneh; Esmaeili, Abbas Ali; Khojastehnezhad, Amir published the artcile< One-pot Three-component Synthesis of Novel 1,3,4-Thiadiazole-thiazolo[3,2-a]pyrimidine Derivatives Catalyzed by Molecular Iodine>, Category: chlorides-buliding-blocks, the main research area is thiadiazole thiazolopyrimidine preparation; amino phenyl thiadiazole dihydrothiazolopyrimidine aryl aldehyde three component reaction.

A new and efficient approach has been reported for the synthesis of novel [1,3,4]thiadiazol-thiazolo[3,2-a]pyrimidines, using the one-pot three-component reaction of 2-amino-5-phenyl[1,3,4]thiadiazoles with 2,3-dihydrothiazolo[3,2-a]pyrimidine and aromatic aldehydes. This was done in the presence of mol. iodine in refluxing acetonitrile.

Organic Preparations and Procedures International published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rajak, Harish; Agarawal, Avantika; Parmar, Poonam; Thakur, Bhupendra Singh; Veerasamy, Ravichandran; Sharma, Prabodh Chander; Kharya, Murli Dhar published the artcile< 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors>, Formula: C8H6ClN3S, the main research area is tetrahydropyranyloxy aryloxadiazolecarboxamide arylthiadiazolecarboxamide preparation histone deacetylase inhibitor antitumor.

The enzymic inhibition of histone deacetylase activity has come out as a novel and effectual means for the treatment of cancer. Two novel series of 2-[5-(4-substituted phenyl)-[1,3,4]-oxadiazol- and -thiadiazol-2-ylamino]pyrimidine-5-carboxylic acid (tetrahydropyran-2-yloxy)amides were designed and synthesized as novel hydroxamic acid based histone deacetylase inhibitors. The antiproliferative activities of the compounds were investigated in vitro using histone deacetylase inhibitory assay and MTT assay. The synthesized compounds were also tested for antitumor activity against Ehrlich ascites carcinoma cells in Swiss albino mice. Efforts were also made to establish structure-activity relationships among synthesized compounds The results of the present study indicate that these compounds are promising surface recognition moieties for development of newer hydroxamic acid based histone deacetylase inhibitor.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Formula: C8H6ClN3S.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Guan, Peng; Wang, Lei; Hou, Xuben; Wan, Yichao; Xu, Wenfang; Tang, Weiping; Fang, Hao published the artcile< Improved antiproliferative activity of 1,3,4-thiadiazole-containing histone deacetylase (HDAC) inhibitors by introduction of the heteroaromatic surface recognition motif>, Quality Control of 70057-67-9, the main research area is antiproliferative thiadiazole preparation histone deacetylase inhibitor structure activity modeling; 1,3,4-Thiadiazole; Antiproliferation; Histone deacetylase inhibitor; Hydroxamic acid; Surface recognition motif.

A series of 1,3,4-thiadiazole-containing hydroxamic acids, in accord with the common pharmacophore of histone deacetylase (HDAC) inhibitors (a Zn2+ binding moiety-a linker-a surface recognition motif), was identified as submicromolar HDAC inhibitors by the authors’ group. In this study, the authors continued the efforts to develop 1,3,4-thiadiazole bearing hydroxamate analogs by modifying the surface recognition motif. The authors found that 1,3,4-thiadiazoles having a heteroaromatic substituent showed better HDAC inhibitory activity in enzymic assay and higher antiproliferative potency in cellular assay compared to SAHA.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Quality Control of 70057-67-9.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics